Seki Masahide 関真秀

Researcher Number	90749326
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院新領域創成科学研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 大学院新領域創成科学研究科, 特任准教授 2019 – 2021: 東京大学, 大学院新領域創成科学研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 43060:System genome science-related Except Principal Investigator Transformative Research Areas, Section (III) / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 57:Oral science and related fields / Basic Section 38060:Applied molecular and cellular biology-related
Keywords	Principal Investigator ナノポアシークエンサー / エピジェネティクス / DNAメチル化 / ナノポアシークエンス / 乳がん / エピゲノム / トランスクリプトーム Except Principal Investigator 環境応答 / 植物 / 生活習慣病 … More / ダイレクトリプログラミング / 線維芽細胞 / 心筋再生 / 一細胞CRISPRスクリーニング / SNP / 一細胞解析 / CRISPRスクリーニング / GWAS / CRISPR / １細胞解析 / エンハンサー / 神経細胞死制御 / 神経細胞死 / 不均一光環境 / 転写開始点制御 / レジリエンス / 不均一環境 Less

Elucidation of the pathogenic mechanism of heart failure caused by lifestyle diseases and development of novel treatment by direct reprogramming
- Principal Investigator
  
  貞廣威太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Keio University
Development of a method for targeted long-read methylation analysis and application to breast cancer specimensPrincipal Investigator
- Principal Investigator
  
  関真秀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  The University of Tokyo
Research on retrograde signalling for neuronal survival
- Principal Investigator
  
  Hisatsune Tatsuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  The University of Tokyo
Development of a functional GWAS-SNP detection method using single-cell CRISPR screening method
- Principal Investigator
  
  Hojo Hironori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  The University of Tokyo
Development of method for long-read whole genome methylation analysis from small amount of DNAPrincipal Investigator
- Principal Investigator
  
  Seki Masahide
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  The University of Tokyo
Multi-layered regulatory system of plant resilience under fluctuating environment
- Principal Investigator
  
  松下智直
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
植物の不均一環境変動へのレジリエンスを支える転写開始点制御機構
- Principal Investigator
  
  松下智直
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Development of novel measurement methods for RNA synthesis and degradation using nanopore sequencingPrincipal Investigator
- Principal Investigator
  
  Seki Masahide
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2019

All Journal Article Presentation Book

[Book] 実験医学別冊実験デザインからわかる　シングルセル研究実践テキスト (担当:分担執筆, 範囲:シングルセル解析実施前の予備検討：バルクRNA-Seq)2024
- Author(s)
  関真秀、鈴木穣
- Total Pages
  11
- Publisher
  羊土社
- ISBN
  9784758122702
- Data Source
  KAKENHI-PROJECT-23K27160
[Book] がんゲノムデータ解析 (担当:分担執筆, 範囲:がんのゲノム解析のロングリード解析)2022
- Author(s)
  三宅修平、岡美穂、坂本祥駿、関真秀、鈴木絢子、鈴木穣
- Total Pages
  34
- Publisher
  メディカル・サイエンス・インターナショナル
- ISBN
  9784815730529
- Data Source
  KAKENHI-PROJECT-21K15074
[Journal Article] Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development2023
- Author(s)
  Tani Shoichiro, Okada Hiroyuki, Onodera Shoko, Chijimatsu Ryota, Seki Masahide, Suzuki Yutaka, Xin Xiaonan, Rowe David W., Saito Taku, Tanaka Sakae, Chung Ung-il, Ohba Shinsuke, Hojo Hironori
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 4 Pages: 112276-112276
- DOI
  10.1016/j.celrep.2023.112276
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05318, KAKENHI-PROJECT-22K08773, KAKENHI-PROJECT-22K10212, KAKENHI-PROJECT-21J12970, KAKENHI-PROJECT-20K18053, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-21K19589, KAKENHI-PROJECT-21H04952, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-23K21494, KAKENHI-PROJECT-23K27718
[Journal Article] Whole-genome Methylation Analysis of APOBEC Enzyme-converted DNA (~5 kb) by Nanopore Sequencing2022
- Author(s)
  Suzuko Zaha、Sakamoto Yoshitaka、Nagasawa Satoi、Sugano Sumio、Suzuki Ayako、Suzuki Yutaka、Seki Masahide
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 12 Issue: 3
- DOI
  10.21769/bioprotoc.4345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15074, KAKENHI-PROJECT-16H06279
[Journal Article] Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages2022
- Author(s)
  Hojo Hironori, Saito Taku, He Xinjun, Guo Qiuyu, Onodera Shoko, Azuma Toshifumi, Koebis Michinori, Nakao Kazuki, Aiba Atsu, Seki Masahide, Suzuki Yutaka, Okada Hiroyuki, Tanaka Sakae, Chung Ung-il, McMahon Andrew P., Ohba Shinsuke
- Journal Title
  
  Cell Reports
  
  Volume: 40 Issue: 10 Pages: 111315-111315
- DOI
  10.1016/j.celrep.2022.111315
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05318, KAKENHI-PROJECT-22K10212, KAKENHI-PROJECT-22K10261, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-21K19589, KAKENHI-PROJECT-22KK0272, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H04952, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-17K11932, KAKENHI-PROJECT-21K19883, KAKENHI-PROJECT-23K21494, KAKENHI-PROJECT-21H03146
[Journal Article] Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell-cell interactions underlying the bone repair process2022
- Author(s)
  Nakayama Mika、Okada Hiroyuki、Seki Masahide、Suzuki Yutaka、Chung Ung-il、Ohba Shinsuke、Hojo Hironori
- Journal Title
  
  Regenerative Therapy
  
  Volume: 21 Pages: 9-18
- DOI
  10.1016/j.reth.2022.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10212, KAKENHI-PROJECT-22K10261, KAKENHI-PROJECT-21K19589, KAKENHI-PROJECT-22KK0272, KAKENHI-PROJECT-21H04952, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-17K11932, KAKENHI-PROJECT-21K19883, KAKENHI-PROJECT-23K21494
[Journal Article] Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer.2021
- Author(s)
  Oka M, Xu L, Suzuki T, Yoshikawa T, Sakamoto H, Uemura H, Yoshizawa AC, Suzuki Y, Nakatsura T, Ishihama Y, Suzuki A, Seki M
- Journal Title
  
  Genome Biol.
  
  Volume: 22(1):9 Issue: 1 Pages: 1-9
- DOI
  10.1186/s13059-020-02240-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09297, KAKENHI-PLANNED-17H06306, KAKENHI-PROJECT-19K16108, KAKENHI-PROJECT-19K16792, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K08637, KAKENHI-ORGANIZER-17H06299
[Journal Article] ナノポアシークエンサーによるDNAメチル化解析2021
- Author(s)
  関　真秀、坂本　祥駿、座波　紗子、鈴木　穣
- Journal Title
  
  月刊「細胞」
  
  Volume: 53 Pages: 818-820
- NAID
  40022757051
- Data Source
  KAKENHI-PROJECT-21K15074
[Journal Article] Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing2021
- Author(s)
  Sakamoto Yoshitaka、Zaha Suzuko、Nagasawa Satoi、Miyake Shuhei、Kojima Yasuyuki、Suzuki Ayako、Suzuki Yutaka、Seki Masahide
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 14 Pages: e81-e81
- DOI
  10.1093/nar/gkab397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16108, KAKENHI-PROJECT-21J13203, KAKENHI-PROJECT-21K15074, KAKENHI-PROJECT-16H06279
[Journal Article] Transcript Identification Through Long-Read Sequencing2021
- Author(s)
  Seki Masahide、Oka Miho、Xu Liu、Suzuki Ayako、Suzuki Yutaka
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2284 Pages: 531-541
- DOI
  10.1007/978-1-0716-1307-8_29
- ISBN
  9781071613061, 9781071613078
- Data Source
  KAKENHI-PROJECT-19K16108, KAKENHI-PROJECT-16H06279
[Journal Article] Recent advances in the detection of base modifications using the Nanopore sequencer2019
- Author(s)
  Xu Liu、Seki Masahide
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65 Issue: 1 Pages: 25-33
- DOI
  10.1038/s10038-019-0679-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16108, KAKENHI-PROJECT-16H06279
[Presentation] 微量DNAから実施可能なターゲット特異的な長鎖DNAメチル解析法の開発2023
- Author(s)
  関真秀、鈴木穣
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27160
[Presentation] Targeted long-read methylation sequencing using nanopore sequencing with hybridization capture2023
- Author(s)
  Masahide Seki, Yutaka Suzuki
- Organizer
  The 14th International Workshop on Advanced Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27160
[Presentation] Targeted long-read methylation sequencing using nanopore sequencing with hybridization capture.2023
- Author(s)
  Masahide Seki, Yutaka Suzuki
- Organizer
  The General Meeting, AGBT 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15074
[Presentation] 次世代シークエンス技術の現状と展望2022
- Author(s)
  関真秀、鈴木穣
- Organizer
  第8回日本HTLV-1学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15074
[Presentation] 微量DNAからの長鎖DNAメチル化解析手法の開発2022
- Author(s)
  関真秀
- Organizer
  第15回　日本エピジェネティックス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15074
[Presentation] 微量DNAからの長鎖DNAのメチル化解析手法の開発2021
- Author(s)
  関　真秀、坂本　祥駿、座波　紗子、永澤　慧、鈴木　絢子、鈴木　穣
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15074

1. 松下智直 (20464399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 多田安臣 (40552740)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 花田耕介 (50462718)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 鈴木孝征 (50535797)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Hisatsune Tatsuhiro (10238298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Hojo Hironori (80788422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 松林嘉克 (00313974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 児玉豊 (00455213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 稲垣宗一 (00597883)

# of Collaborated Projects: 1 results

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10. 吉田聡子 (20450421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 杉本慶子 (30455349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 打田直行 (40467692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 壽崎拓哉 (40575825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 木下俊則 (50271101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 佐瀬英俊 (70510006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 芦苅基行 (80324383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 望田啓子 (70624352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 関根俊一 (50321774)

# of Collaborated Projects: 1 results

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19. 鈴木邦律 (20373194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岡田寛之 (10883481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 大庭伸介 (20466733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 貞廣威太郎 (60571130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 永澤慧 (20773039)

# of Collaborated Projects: 1 results

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24. 吉川聡明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seki Masahide 関 真秀

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenic mechanism of heart failure caused by lifestyle diseases and development of novel treatment by direct reprogramming

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a method for targeted long-read methylation analysis and application to breast cancer specimensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on retrograde signalling for neuronal survival

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a functional GWAS-SNP detection method using single-cell CRISPR screening method

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of method for long-read whole genome methylation analysis from small amount of DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multi-layered regulatory system of plant resilience under fluctuating environment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

植物の不均一環境変動へのレジリエンスを支える転写開始点制御機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel measurement methods for RNA synthesis and degradation using nanopore sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学別冊 実験デザインからわかる シングルセル研究実践テキスト (担当:分担執筆, 範囲:シングルセル解析実施前の予備検討：バルクRNA-Seq)2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] がんゲノムデータ解析 (担当:分担執筆, 範囲:がんのゲノム解析のロングリード解析)2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Whole-genome Methylation Analysis of APOBEC Enzyme-converted DNA (~5 kb) by Nanopore Sequencing2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell-cell interactions underlying the bone repair process2022

Seki Masahide 関真秀

[Book] 実験医学別冊実験デザインからわかる　シングルセル研究実践テキスト (担当:分担執筆, 範囲:シングルセル解析実施前の予備検討：バルクRNA-Seq)2024