Nakatsukasa Hiroko 中司寛子

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NAKATSUKASA Hiroko 中司寛子

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Researcher Number	90749334
Other IDs	https://orcid.org/0000-0001-7023-9920
Affiliation (Current)	2024: 千葉大学, 大学院薬学研究院, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 千葉大学, 大学院薬学研究院, 准教授 2018 – 2021: 慶應義塾大学, 医学部(信濃町), 助教 2016: 慶應義塾大学, 医学部(信濃町), 特別研究員(PD) 2015: 慶應義塾大学, 医学部, 日本学術振興会特別研究員(PD)
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator TET / DNAメチル化 / 自己免疫疾患 / エピジェネティクス / 制御性T細胞 / T細胞分化 / Th17細胞 / 腸内細菌 / Tfh細胞 / エピゲノム / T細胞老化 / Treg / AhR … More Except Principal Investigator … More 転写制御因子 / 高病原性Th17 / 関節リウマチ / 歯周病 Less

T細胞老化機構の解明とその制御による健康寿命延伸Principal Investigator
- Principal Investigator
  
  中司寛子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
The role of DNA demethylase TET in Treg/Th17 differentiation.Principal Investigator
- Principal Investigator
  
  Nakatsukasa Hiroko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
  Keio University
Association between pathogenic Th17 in periodontal disease and rheumatoid arthritis onsets.
- Principal Investigator
  
  丸山貴司
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Akita University
The role of DNA demethylase TET in T cell function and differentiation.Principal Investigator
- Principal Investigator
  
  NAKATSUKASA Hiroko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Keio University
The role of TET proteins in stability and function of regulatory T cells.Principal Investigator
- Principal Investigator
  
  Nakatsukasa Hiroko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Keio University

All 2022 2021 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] 臨床免疫・アレルギー科2017
- Author(s)
  中司寛子
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-15K19135
[Book] 実験医学増刊2016
- Author(s)
  吉村昭彦、岡田匡央、金森光広、中司寛子
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15K19135
[Book] 臨床免疫・アレルギー科2016
- Author(s)
  中司寛子、金森光広、岡田匡央、吉村昭彦
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-15K19135
[Journal Article] Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.2022
- Author(s)
  Park SA, Lim YJ, Ku WL, Zhang D, Cui K, Tang LY, Chia C, Zanvit P, Chen Z, Jin W, Wang D, Xu J, Liu O, Wang F, Cain A, Guo N, Nakatsukasa H, Wu C, Zhang YE, Zhao K, Chen W.
- Journal Title
  
  Nat Commun.
  
  Volume: 13(1) Issue: 1 Pages: 6069-6069
- DOI
  10.1038/s41467-022-33733-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07541
[Journal Article] STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals2022
- Author(s)
  Saitoh Kodai、Kashiwakura Jun-ichi、Kagohashi Kota、Sasaki Yuto、Kawahara Shoya、Sekine Yuichi、Kitai Yuichi、Muromoto Ryuta、Ichii Michiko、Nakatsukasa Hiroko、Yoshimura Akihiko、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 209 Issue: 1 Pages: 57-68
- DOI
  10.4049/jimmunol.2101014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08451, KAKENHI-PROJECT-20K07541
[Journal Article] Editorial: Hexose Uptake and Metabolism in Immune Homeostasis and Inflammation.2022
- Author(s)
  Dunfang Zhang, Chaohong Liu, Hiroko Nakatsukasa, WanJun Chen
- Journal Title
  
  Frontiers in immunology
  
  Volume: 12 Pages: 832293-832293
- DOI
  10.3389/fimmu.2021.832293
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07541
[Journal Article] Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure2021
- Author(s)
  Komai Kyoko、Ito Minako、Nomura Seitaro、Shichino Shigeyuki、Katoh Manami、Yamada Shintaro、Ko Toshiyuki、Iizuka-Koga Mana、Nakatsukasa Hiroko、Yoshimura Akihiko
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 763647-763647
- DOI
  10.3389/fimmu.2021.763647
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08891, KAKENHI-PROJECT-18K15129, KAKENHI-PROJECT-19K17587, KAKENHI-PUBLICLY-21H00432, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21H02719, KAKENHI-PROJECT-19J40137, KAKENHI-PROJECT-20K07541, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649
[Journal Article] The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells2021
- Author(s)
  Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
- Journal Title
  
  Frontiers in immunology
  
  Volume: 12 Pages: 687669-687669
- DOI
  10.3389/fimmu.2021.687669
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07541, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K11643
[Journal Article] Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression.2019
- Author(s)
  Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A
- Journal Title
  
  International immunology
  
  Volume: 31 Issue: 5 Pages: 335-347
- DOI
  10.1093/intimm/dxz008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K00562, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-16H06295
[Journal Article] Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery2019
- Author(s)
  Ito Minako、Komai Kyoko、Mise-Omata Setsuko、Iizuka-Koga Mana、Noguchi Yoshiko、Kondo Taisuke、Sakai Ryota、Matsuo Kazuhiko、Nakayama Takashi、Yoshie Osamu、Nakatsukasa Hiroko、Chikuma Shunsuke、Shichita Takashi、Yoshimura Akihiko
- Journal Title
  
  Nature
  
  Volume: 565 Issue: 7738 Pages: 246-250
- DOI
  10.1038/s41586-018-0824-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15129, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05514, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H05096, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-17K19571, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384
[Journal Article] Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status.2018
- Author(s)
  Kanamori M, Nakatsukasa H, Ito M, Chikuma S, Yoshimura A.
- Journal Title
  
  Int Immunol.
  
  Volume: 30 Issue: 8 Pages: 357-373
- DOI
  10.1093/intimm/dxy043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667
[Journal Article] Inhibition of Nr4a receptors enhances anti-tumor immunity by breaking Treg-mediated immune tolerance.2018
- Author(s)
  Hibino S, Chikuma S, Kondo T, Ito M, Nakatsukasa H, Omata-Mise S, Yoshimura A
- Journal Title
  
  Cancer Res
  
  Volume: Epub Issue: 11 Pages: 3027-3040
- DOI
  10.1158/0008-5472.can-17-3102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-18K15198, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-20K20384
[Journal Article] IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse.2018
- Author(s)
  Oike T, Kanagawa H, Sato Y, Kobayashi T, Nakatsukasa H, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Yoshimura A, Iwakura Y, Takeuchi T, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
- Journal Title
  
  Sci Rep.
  
  Volume: - Issue: 1 Pages: 15783-15783
- DOI
  10.1038/s41598-018-34173-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15198, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-16K10917
[Journal Article] Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects.2017
- Author(s)
  Kojima S, Ohshima Y, Nakatsukasa H, Tsukimoto M.
- Journal Title
  
  Dose Response.
  
  Volume: 15 Issue: 1 Pages: 1-11
- DOI
  10.1177/1559325817690638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15K19135
[Journal Article] Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy.2017
- Author(s)
  Kondo T, Morita R, Okuzono Y, Nakatsukasa H, Sekiya T, Chikuma S, Shichita T, Kanamori M, Kubo M, Koga K, Miyazaki T, Kassai Y, and Yoshimura A.
- Journal Title
  
  Nat Commun.
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19135
[Journal Article] Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells.2017
- Author(s)
  Okada M, Kanamori M, Someya K, Nakatsukasa H and Yoshimura A.
- Journal Title
  
  Epigenetics & Chromatin
  
  Volume: 印刷中 Issue: 1 Pages: 24-24
- DOI
  10.1186/s13072-017-0129-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15K19135, KAKENHI-PROJECT-15J07468
[Journal Article] Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells.2016
- Author(s)
  Sekiya T, Nakatsukasa H, Lu Q, and Yoshimura A.
- Journal Title
  
  Microbes Infect.
  
  Volume: 18 Issue: 6 Pages: 378-386
- DOI
  10.1016/j.micinf.2016.02.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-15K19135, KAKENHI-PROJECT-16KT0114
[Journal Article] Induced Regulatory T Cells: Their Development, Stability, and Applications.2016
- Author(s)
  Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A.
- Journal Title
  
  Trends Immunol.
  
  Volume: 37 Issue: 11 Pages: 803-811
- DOI
  10.1016/j.it.2016.08.012
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15K19135
[Presentation] Expression and function of silly Lewis X glycans on mouse regulatory T cells.2022
- Author(s)
  大石かなえ、西田匠吾、石倉晨規、安保博仁、中司寛子、川島博人
- Organizer
  Sialoglyco 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07541
[Presentation] Expression and function of silly Lewis X glycans on mouse regulatory T cells.2022
- Author(s)
  大石かなえ、西田匠吾、石倉晨規、安保博仁、中司寛子、川島博人
- Organizer
  第21回次世代を担う若手のためのファーマ・バイオフォーラム
- Data Source
  KAKENHI-PROJECT-20K07541
[Presentation] Role of Bcl6 in DNA methylation-mediated T cell senescence and tumorigenesis.2022
- Author(s)
  中司寛子、吉村昭彦
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07541
[Presentation] Expression and function of silly Lewis X glycans on mouse regulatory T cells.2022
- Author(s)
  大石かなえ、西田匠吾、石倉晨規、安保博仁、中司寛子、川島博人
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07541
[Presentation] Role of intestinal microbiota in DNA methylation-mediated T cell senescence and tumorigenesis.2021
- Author(s)
  中司寛子、吉村昭彦
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07541
[Presentation] Epigenetics, microbiota, and T cell differentiation2021
- Author(s)
  Hiroko Nakatsukasa
- Organizer
  Nature Cafe: Type 2 immunity: challenges and opportunities
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07541
[Presentation] Role of intestinal microbiota in DNA methylation-mediated T cell senescence and tumorigenesis.2021
- Author(s)
  中司寛子、吉村昭彦
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07541
[Presentation] Gut microbiota mediate T cell senescence in Tet-deficient T cells.2019
- Author(s)
  中司寛子、吉村昭彦
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15198
[Presentation] T細胞分化におけるDNA脱メチル化酵素Tetの機能解明2019
- Author(s)
  中司寛子、吉村昭彦
- Organizer
  大阪大学第13回若手研究フォーラム
- Data Source
  KAKENHI-PROJECT-18K15198
[Presentation] T細胞分化におけるDNA脱メチル化酵素Tetの機能解明2018
- Author(s)
  中司寛子、吉村昭彦
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-18K15198
[Presentation] Tet2 and Tet3 regulate helper T cell differentiation in the periphery.2018
- Author(s)
  Hiroko Nakatsukasa, Akihiko Yoshimura
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15198
[Presentation] TET2 and TET3 regulate stability and homeostasis of regulatory T cells.2017
- Author(s)
  Nakatsukasa H and Yoshimura A.
- Organizer
  第19回武田科学振興財団生命科学シンポジウム
- Place of Presentation
  武田薬品研修所（大阪府吹田市）
- Year and Date
  2017-01-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19135
[Presentation] TET2 and TET3 regulate Treg stability through Treg-specific DNA demethylation.2017
- Author(s)
  Nakatsukasa H and Yoshimura A.
- Organizer
  Keystone Symposia on Molecular and Cellular Biology
- Place of Presentation
  タオス（アメリカ）
- Year and Date
  2017-01-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19135
[Presentation] TET2 and TET3 play essential roles in Treg-specific DNA demethylation and Treg stability2016
- Author(s)
  中司寛子
- Organizer
  International Congress of Immunology 2016
- Place of Presentation
  メルボルン（オーストラリア）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19135
[Presentation] TET2 and TET3 play essential roles in Treg-specific DNA demethylation and Treg stability.2016
- Author(s)
  Nakatsukasa H and Yoshimura A.
- Organizer
  International Congress of Immunology 2016
- Place of Presentation
  メルボルン（オーストラリア）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19135
[Presentation] T細胞特異的Tet2,Tet3遺伝子欠損マウスの解析2016
- Author(s)
  中司寛子
- Organizer
  AMED-CREST「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」研究開発領域第５回領域会議
- Place of Presentation
  メルパルク熊本（熊本県熊本市）
- Year and Date
  2016-01-06
- Data Source
  KAKENHI-PROJECT-15K19135
[Presentation] 制御性T細胞のヒドロキシメチル化による制御2016
- Author(s)
  中司寛子
- Organizer
  第２回病因研究会別府シンポジウム
- Place of Presentation
  別府湾ロイヤルホテル（大分県速見郡）
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-15K19135
[Presentation] 制御性T細胞のDNA脱メチル化による制御2016
- Author(s)
  中司寛子、吉村昭彦
- Organizer
  第１回Clinical Immunology/Inflammation Seminar in Shinanomachi
- Place of Presentation
  慶應義塾大学（東京都新宿区）
- Year and Date
  2016-07-09
- Data Source
  KAKENHI-PROJECT-15K19135

1. 丸山貴司 (10622524)

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2. 前田あずさ (70754662)

# of Collaborated Projects: 1 results

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3. ODA Mayumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小賀麻菜(飯塚麻菜)

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# of Collaborated Products: 1 results
5. 駒井恭子

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6. 竹馬俊介

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7. 柏倉淳一

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8. 吉村昭彦

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Nakatsukasa Hiroko 中司 寛子

NAKATSUKASA Hiroko 中司 寛子

Research Projects

Research Products

Co-Researchers

T細胞老化機構の解明とその制御による健康寿命延伸Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of DNA demethylase TET in Treg/Th17 differentiation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Association between pathogenic Th17 in periodontal disease and rheumatoid arthritis onsets.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of DNA demethylase TET in T cell function and differentiation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of TET proteins in stability and function of regulatory T cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 臨床免疫・アレルギー科2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学増刊2016

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床免疫・アレルギー科2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Editorial: Hexose Uptake and Metabolism in Immune Homeostasis and Inflammation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression.2019

Author(s)

Journal Title

DOI

Data Source

Nakatsukasa Hiroko 中司寛子

NAKATSUKASA Hiroko 中司寛子