Machitani Mitsuhiro 町谷充洋

… Alternative Names

町谷充洋マチタニミツヒロ

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Researcher Number	90759523
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2020 – 2024: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2016: 大阪大学, 薬学研究科, 招へい研究員 2015: 大阪大学, 薬学研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Physical pharmacy
Keywords	Principal Investigator RNA依存性RNAポリメラーゼ / 二本鎖RNA / スプライシング / hTERT / ncRNA / テロメラーゼ / R-loop / TERRA / RNA依存性RNAポリメラーゼ (RdRP) / テロメラーゼ逆転写酵素hTERT … More / 自然免疫応答 / 自然免疫 / がん / NF-kB / バイオテクノロジー / 遺伝子治療 / アデノウイルス Less

テロメラーゼ逆転写酵素による新規スプライシング制御機構の解明Principal Investigator
- Principal Investigator
  
  町谷充洋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
Identification of genes regulated by human telomerase reverse transcriptasePrincipal Investigator
- Principal Investigator
  
  Machitani Mistuhiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
Study about the innate immune response against double-stranded RNAs in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Machitani Mitsuhiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
ウイルス遺伝子の非特異的な発現を抑制可能な次世代アデノウイルスベクターの作製Principal Investigator
- Principal Investigator
  
  町谷充洋
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University

All 2024 2023 2021 2020 2016 2015

All Journal Article Presentation

[Journal Article] Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.2024
- Author(s)
  Machitani M, Nomura A, Yamashita T, Yasukawa M, Ueki S, Fujita K, Ueno T, Yamashita A, Tanzawa Y, Watanabe M, Taniguchi T, Saitoh N, Kaneko S, Kato Y, Mano H, Masutomi K.
- Journal Title
  
  Nature Cell Biology
  
  Volume: In press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15550
[Journal Article] NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector.2016
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Kahori Shimizu, Masashi Tachibana and Hiroyuki Mizuguchi
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 19922-19922
- DOI
  10.1038/srep19922
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06363, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-15K18939
[Journal Article] Quantitative Analysis of Virus-associated RNAI Expression following Transduction with a Replication-incompetent Adenovirus Vector In Vitro and In Vivo.2015
- Author(s)
  Wakabayashi K., Machitani M., Shimizu K., Tachibana M., Sakurai F., Mizuguchi H.
- Journal Title
  
  J. Mol. Genet. Med.
  
  Volume: 9 Issue: 02 Pages: 169-169
- DOI
  10.4172/1747-0862.1000169
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-15H06363, KAKENHI-PROJECT-26293118
[Presentation] Maintenance of R-loop structures by phosphorylated hTERT to preserve genome integrity.2023
- Author(s)
  Machitani M, Nomura A, Yamashita T, Ueno T, Yamashita A, Taniguchi T, Kaneko S, Kato Y, Mano H, Masutomi K.
- Organizer
  CSHL Meeting-Telomeres & Telomeras-
- Data Source
  KAKENHI-PROJECT-22K15550
[Presentation] R-loop regulation by RNA-dependent RNA polymerase activity of hTERT.2023
- Author(s)
  Machitani M, Nomura A, Yamashita T, Yamashita A, Saitoh N, Masutomi K.
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-22K15550
[Presentation] Maintenance of genome integrity by RNA-dependent RNA polymerase activity of hTERT.2023
- Author(s)
  Machitani M, Nomura A, Yamashita T, Yamashita A, Saitoh N, Masutomi K.
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15550
[Presentation] Synthetic lethality by inhibition of RNA dependent RNA polymerase activity and the Fanconi anemia/BRCA pathway.2023
- Author(s)
  Machitani M, Nomura A, Yamashita T, Ueno T, Yamashita A, Taniguchi T, Saitoh N, Kaneko S, Kato Y, Mano H, Masutomi K.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15550
[Presentation] hTERT exhibits RNA dependent RNA polymerase activity but not telomerase activity in ALT cells.2021
- Author(s)
  Nomura A, Machitani M, Masutomi K.
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16320
[Presentation] 肉腫細胞株におけるhTERT-RdRP活性の生物学的意義2021
- Author(s)
  野村祥, 町谷充洋, 丹澤義一, 佐藤正人, 渡辺雅彦, 増富健吉.
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K16320
[Presentation] Phosphorylated hTERT regulates expression of a tumor suppressor gene.2020
- Author(s)
  Mitsuhiro Machitani, Kenkichi Masutomi
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16320
[Presentation] Inhibition of NF-κB leads to suppression of Ad vector-mediated hepatotoxicities via reduction in the leaky expression of Ad genes2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡県福岡市)
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15H06363
[Presentation] Expression profile of virus-associated RNAI following transduction with a replication-incompetent adenovirus vector in vitro and in vivo.2015
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Kahori Shimizu, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡県福岡市)
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15H06363
[Presentation] Reduction in the leaky expression of Ad genes from a replication-incompetent adenovirus vector by inhibition of NF-κB2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第74回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場 (愛知県名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H06363
[Presentation] アデノウイルス由来小分子RNAの機能特性に立脚した遺伝子治療用組み換えウイルスの開発2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学 (大阪府富田林市)
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H06363

1. 水口裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 櫻井文教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 立花雅史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Machitani Mitsuhiro 町谷 充洋

町谷 充洋 マチタニ ミツヒロ

Research Projects

Research Products

Co-Researchers

テロメラーゼ逆転写酵素による新規スプライシング制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of genes regulated by human telomerase reverse transcriptasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study about the innate immune response against double-stranded RNAs in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ウイルス遺伝子の非特異的な発現を抑制可能な次世代アデノウイルスベクターの作製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.2024

Author(s)

Journal Title

Data Source

[Journal Article] NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative Analysis of Virus-associated RNAI Expression following Transduction with a Replication-incompetent Adenovirus Vector In Vitro and In Vivo.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Maintenance of R-loop structures by phosphorylated hTERT to preserve genome integrity.2023

Author(s)

Organizer

Data Source

[Presentation] R-loop regulation by RNA-dependent RNA polymerase activity of hTERT.2023

Author(s)

Organizer

Data Source

[Presentation] Maintenance of genome integrity by RNA-dependent RNA polymerase activity of hTERT.2023

Author(s)

Organizer

Data Source

[Presentation] Synthetic lethality by inhibition of RNA dependent RNA polymerase activity and the Fanconi anemia/BRCA pathway.2023

Author(s)

Organizer

Data Source

[Presentation] hTERT exhibits RNA dependent RNA polymerase activity but not telomerase activity in ALT cells.2021

Author(s)

Organizer

Data Source

[Presentation] 肉腫細胞株におけるhTERT-RdRP活性の生物学的意義2021

Author(s)

Organizer

Data Source

[Presentation] Phosphorylated hTERT regulates expression of a tumor suppressor gene.2020

Author(s)

Organizer

Data Source

[Presentation] Inhibition of NF-κB leads to suppression of Ad vector-mediated hepatotoxicities via reduction in the leaky expression of Ad genes2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Expression profile of virus-associated RNAI following transduction with a replication-incompetent adenovirus vector in vitro and in vivo.2015

Author(s)

Organizer

Machitani Mitsuhiro 町谷充洋

町谷充洋マチタニミツヒロ