tsuchiya hikaru 土屋光

… Alternative Names

Researcher Number	90760132
Other IDs
Affiliation (Current)	2022: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主任研究員 2022: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員
Affiliation (based on the past Project Information) *help	2020 – 2021: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主任研究員 2019 – 2020: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員 2015 – 2018: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator タンパク質分解 / 蛋白質分解 / ユビキチン Except Principal Investigator ユビキチン / 標的タンパク質分解 / プロテアソーム / アポトーシス / PROTAC / 翻訳後修飾 / タンパク質分解 / タンパク質 / シグナル伝達 / 蛋白質

プロテアソーム結合ユビキチンリガーゼによるタンパク質分解制御Principal Investigator
- Principal Investigator
  
  土屋光
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidation of the proteasome activity by shuttle factorsPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Hikaru
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidating the role of branched ubiquitin code
- Principal Investigator
  
  Ohtake Fumiaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hoshi University
  Tokyo Metropolitan Institute of Medical Science
A method for determining ubiquitin chain length in cellsPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Hikaru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome.2020
- Author(s)
  Yasuda, S., * Tsuchiya, S., * Kaiho, A., * Guo, Q., Ikeuchi, K., Endo, A., Arai, N., Ohtake, F., Murata, S., Inada, T., Baumeister, B., Fernandez-Busnadiego, R., Tanaka, K. **, and Saeki, Y. ** (*These authors contributed equally, **Corresponding authors)
- Journal Title
  
  Nature
  
  Volume: 578 Pages: 296-300
- DOI
  10.1038/s41586-020-1982-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-19H00997
[Journal Article] Methods to measure ubiquitin chain length and linkage.2019
- Author(s)
  Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Methods in Enzymology
  
  Volume: 618 Pages: 105-133
- DOI
  10.1016/bs.mie.2018.12.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-16K14702
[Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE.2019
- Author(s)
  Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
- Journal Title
  
  Methods Enzymol.
  
  Volume: 618 Pages: 135-147
- DOI
  10.1016/bs.mie.2018.12.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-16K07705, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-26000014
[Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Np14.2019
- Author(s)
  Sato, Y., Tsuchiya, H., Yamagata, A., Okatsu, K., Tanaka, K., Saeki, Y., and Fukai, S.
- Journal Title
  
  Nat Commun.
  
  Volume: 10 Pages: 1-13
- DOI
  10.1038/s41467-019-13697-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H03162, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014
[Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018
- Author(s)
  Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 115 Pages: 1401-1408
- DOI
  10.1073/pnas.1716673115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells.2018
- Author(s)
  Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., and Tanaka, K.*, and Saeki, Y. * (*Correspondence)
- Journal Title
  
  Nat. Commun.
  
  Volume: 9 Pages: 524-524
- DOI
  10.1038/s41467-018-02869-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PUBLICLY-17H05681, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] The emerging complexity of ubiquitin architecture2017
- Author(s)
  Ohtake, F., and Tsuchiya, H
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 161 Pages: 125-133
- DOI
  10.1093/jb/mvw088
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06882, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
[Journal Article] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-linked Chain Specificity of the Proteasome2017
- Author(s)
  Hikaru Tsuchiya, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Sayaka Yasuda, Keiji Tanaka, and Yasushi Saeki
- Journal Title
  
  Molecular Cell
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06882
[Presentation] The ubiquitin ligase UBE3A negatively regulates the 26S proteasome by ubiquitylation of PSMD42021
- Author(s)
  Tsuchiya Hikaru, Kei Okatsu, Fukai Shuya, Yasushi Saeki
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03214
[Presentation] Stress and ubiquitylation-dependent phase separation of the proteasome2019
- Author(s)
  Tsuchiya, H
- Organizer
  EMBO Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14913
[Presentation] ストレス依存的なプロテアソーム液-液相分離2019
- Author(s)
  土屋光
- Organizer
  第4回 LLPS研究会
- Data Source
  KAKENHI-PROJECT-18K14913
[Presentation] ケモテクノロジーと質量分析計を活用したユビキチンコードの解読2019
- Author(s)
  佐伯泰、遠藤彬則、土屋光、大竹史明
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] ユビキチン鎖長決定法の開発2018
- Author(s)
  土屋光、新井直子、海保愛、田中啓二、佐伯泰
- Organizer
  第91回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14913
[Presentation] Ubiquitin chain selectivity of ubiquitin-binding proteins in yeast2016
- Author(s)
  Hikaru Tsuchiya
- Organizer
  7th PROTEASOME and AUTOPHAGY WORKSHOP
- Place of Presentation
  Clermont-Ferrand, France
- Year and Date
  2016-04-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06882
[Presentation] プロテアソーム依存的タンパク質分解経路におけるユビキチン鎖選択制の解析2015
- Author(s)
  土屋光、吉原英人、新井直子、海保愛、田中啓二、佐伯泰
- Organizer
  第38回日本分子生物学会第88回　日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H06882

1. Ohtake Fumiaki (60447373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. SAEKI Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
3. KAIHO Ai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
5. 吉田雪子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村田茂穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 稲田利文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 新井大祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 深井周也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山形敦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

tsuchiya hikaru 土屋 光

TSUCHIYA Hikaru 土屋 光

Research Projects

Research Products

Co-Researchers

プロテアソーム結合ユビキチンリガーゼによるタンパク質分解制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the proteasome activity by shuttle factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the role of branched ubiquitin code

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A method for determining ubiquitin chain length in cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methods to measure ubiquitin chain length and linkage.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Np14.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The emerging complexity of ubiquitin architecture2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-linked Chain Specificity of the Proteasome2017

Author(s)

Journal Title

Data Source

[Presentation] The ubiquitin ligase UBE3A negatively regulates the 26S proteasome by ubiquitylation of PSMD42021

Author(s)

Organizer

Data Source

[Presentation] Stress and ubiquitylation-dependent phase separation of the proteasome2019

Author(s)

Organizer

Data Source

[Presentation] ストレス依存的なプロテアソーム液-液相分離2019

Author(s)

Organizer

Data Source

tsuchiya hikaru 土屋光

TSUCHIYA Hikaru 土屋光