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tsuchiya hikaru  土屋 光

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TSUCHIYA Hikaru  土屋 光

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Researcher Number 90760132
Other IDs
Affiliation (Current) 2020: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主任研究員
2020: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員
Affiliation (based on the past Project Information) *help 2020: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主任研究員
2019 – 2020: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員
2015 – 2018: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員
Review Section/Research Field
Principal Investigator
Functional biochemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 43030:Functional biochemistry-related
Except Principal Investigator
Biological pharmacy
Keywords
Principal Investigator
タンパク質分解 / ユビキチン / 蛋白質分解
Except Principal Investigator
ユビキチン / 翻訳後修飾 / タンパク質分解 / タンパク質 / シグナル伝達 / プロテアソーム / 蛋白質
  • Research Projects

    (4 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (10 People)
  •  プロテアソーム結合ユビキチンリガーゼによるタンパク質分解制御Principal InvestigatorOngoing

    • Principal Investigator
      土屋 光
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Elucidation of the proteasome activity by shuttle factorsPrincipal Investigator

    • Principal Investigator
      TSUCHIYA Hikaru
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  分岐型ユビキチン鎖が司る新たなシグナル伝達機構Ongoing

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hoshi University
      Tokyo Metropolitan Institute of Medical Science
  •  A method for determining ubiquitin chain length in cellsPrincipal Investigator

    • Principal Investigator
      TSUCHIYA Hikaru
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome.2020

    • Author(s)
      Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
    • Journal Title

      Nature

      Volume: 578 Pages: 296-300

    • DOI

      10.1038/s41586-020-1982-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K14913
  • [Journal Article] Methods to measure ubiquitin chain length and linkage.2019

    • Author(s)
      Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
    • Journal Title

      Methods Enzymol.

      Volume: 618 Pages: 105-133

    • DOI

      10.1016/bs.mie.2018.12.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997
  • [Journal Article] Detection of ubiquitnation activity and identification of ubiquitinated substrates using TR-TUBE2019

    • Author(s)
      Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
    • Journal Title

      Methods in Enzymology

      Volume: 618 Pages: 135-147

    • DOI

      10.1016/bs.mie.2018.12.032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-16K07705, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926
  • [Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.2019

    • Author(s)
      Sato Yusuke、Tsuchiya Hikaru、Yamagata Atsushi、Okatsu Kei、Tanaka Keiji、Saeki Yasushi、Fukai Shuya
    • Journal Title

      Nat Commun.

      Volume: 10 Pages: 1-13

    • DOI

      10.1038/s41467-019-13697-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H03162, KAKENHI-PROJECT-18K14913
  • [Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018

    • Author(s)
      Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 115 Pages: 1401-1408

    • DOI

      10.1073/pnas.1716673115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
  • [Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells.2018

    • Author(s)
      Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., and Tanaka, K.*, and Saeki, Y. * (*Correspondence)
    • Journal Title

      Nat. Commun.

      Volume: 9 Pages: 524-524

    • DOI

      10.1038/s41467-018-02869-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PUBLICLY-17H05681, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
  • [Journal Article] The emerging complexity of ubiquitin architecture2017

    • Author(s)
      Ohtake, F., and Tsuchiya, H
    • Journal Title

      Journal of Biochemistry

      Volume: 161 Pages: 125-133

    • DOI

      10.1093/jb/mvw088

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H06882, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
  • [Journal Article] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-linked Chain Specificity of the Proteasome2017

    • Author(s)
      Hikaru Tsuchiya, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Sayaka Yasuda, Keiji Tanaka, and Yasushi Saeki
    • Journal Title

      Molecular Cell

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H06882
  • [Presentation] Stress and ubiquitylation-dependent phase separation of the proteasome2019

    • Author(s)
      Tsuchiya, H
    • Organizer
      EMBO Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14913
  • [Presentation] ストレス依存的なプロテアソーム液-液相分離2019

    • Author(s)
      土屋 光
    • Organizer
      第4回 LLPS研究会
    • Data Source
      KAKENHI-PROJECT-18K14913
  • [Presentation] ユビキチン鎖長決定法の開発2018

    • Author(s)
      土屋 光、新井 直子、海保 愛、田中 啓二、佐伯 泰
    • Organizer
      第91回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K14913
  • [Presentation] Ubiquitin chain selectivity of ubiquitin-binding proteins in yeast2016

    • Author(s)
      Hikaru Tsuchiya
    • Organizer
      7th PROTEASOME and AUTOPHAGY WORKSHOP
    • Place of Presentation
      Clermont-Ferrand, France
    • Year and Date
      2016-04-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06882
  • [Presentation] プロテアソーム依存的タンパク質分解経路におけるユビキチン鎖選択制の解析2015

    • Author(s)
      土屋 光、吉原英人、新井直子、海保愛、田中啓二、佐伯泰
    • Organizer
      第38回 日本分子生物学会 第88回 日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15H06882
  • 1.  大竹 史明 (60447373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  SAEKI Yasushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 3.  KAIHO Ai
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  田中 啓二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 5.  吉田 雪子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  村田 茂穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  稲田 利文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  新井 大祐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  深井 周也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  山形 敦史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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