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WADA FUMITO  和田 郁人

ORCIDConnect your ORCID iD *help
Researcher Number 90760843
Other IDs
Affiliation (based on the past Project Information) *help 2021: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員
2018 – 2019: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員
Review Section/Research Field
Principal Investigator
Basic Section 37030:Chemical biology-related
Except Principal Investigator
Basic Section 53020:Cardiology-related / Basic Section 47060:Clinical pharmacy-related
Keywords
Principal Investigator
核酸医薬 / 安全性 / DDS / リガンド / アンチセンス
Except Principal Investigator
DDS / 家族性高コレステロール血症 / 核酸医薬 / 糖鎖リガンド / ドラッグデリバリー … More / ゲノム編集治療 / 表面受容体 / 脂質異常症 / オリゴヌクレオチド / 糖リガンド / アシアロ糖タンパク質 / CRISPR/Cas / ドラッグデリバリーシステム / 遺伝子編集技術 / ゲノム編集技術 / 核酸 / CRISPR/Cas9 / ゲノム編集 / 安全性 / アンチセンス / 経口投与 Less
  • Research Projects

    (3 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (4 People)
  •  Establishment of a new platform for nucleic acid oral formulation technology to realize patient-friendly nucleic acid medicines

    • Principal Investigator
      Harada-Shiba Mariko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of drug delivery system for CRISPR/Cas9 for the treatment of familial hypercholesterolemia

    • Principal Investigator
      Yamamoto Tsuyoshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Nagasaki University
  •  Development of novel designs for avoiding the renal accumulation of antisense oligonucleotidesPrincipal Investigator

    • Principal Investigator
      WADA FUMITO
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      National Cardiovascular Center Research Institute

All 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides2021

    • Author(s)
      Yamamoto Tsuyoshi、Mukai Yahiro、Wada Fumito、Terada Chisato、Kayaba Yukina、Oh Kaho、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
    • Journal Title

      Pharmaceutics

      Volume: 13 Issue: 6 Pages: 817-817

    • DOI

      10.3390/pharmaceutics13060817

    • NAID

      120007168845

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
  • [Journal Article] Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides2021

    • Author(s)
      Wada Fumito、Yamamoto Tsuyoshi、Kobayashi Tadayuki、Tachibana Keisuke、Ito Kosuke Ramon、Hamasaki Mayumi、Kayaba Yukina、Terada Chisato、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: 26 Pages: 957-969

    • DOI

      10.1016/j.omtn.2021.10.008

    • Data Source
      KAKENHI-PROJECT-19H03393
  • [Journal Article] Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides2021

    • Author(s)
      Terada Chisato、Wada Fumito、Uchida Mei、Yasutomi Yukari、Oh Kaho、Kawamoto Seiya、Kayaba Yukina、Yamayoshi Asako、Harada-Shiba Mariko、Obika Satoshi、Yamamoto Tsuyoshi
    • Journal Title

      Nucleic Acid Therapeutics

      Volume: 31 Issue: 6 Pages: 404-416

    • DOI

      10.1089/nat.2021.0036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
  • [Journal Article] Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides2019

    • Author(s)
      Yamamoto Tsuyoshi、Sawamura Motoki、Terada Chisato、Kashiwada Koki、Wada Fumito、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids

      Volume: 39 Issue: 1-3 Pages: 1-10

    • DOI

      10.1080/15257770.2019.1677911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02087, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656, KAKENHI-PROJECT-18K14363
  • [Journal Article] Synthesis of Monovalent N ‐Acetylgalactosamine Phosphoramidite for Liver‐Targeting Oligonucleotides2019

    • Author(s)
      Yamamoto Tsuyoshi、Terada Chisato、Kashiwada Koki、Yamayoshi Asako、Harada‐Shiba Mariko、Obika Satoshi
    • Journal Title

      Current Protocols in Nucleic Acid Chemistry

      Volume: 78 Issue: 1 Pages: 1-18

    • DOI

      10.1002/cpnc.99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02087, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
  • [Presentation] 肝臓指向型アンチセンス核酸の動態改善に向けた 新規GalNAcリガンドの構築と活性評価2021

    • Author(s)
      寺田知邑・和田郁人・山吉麻子・斯波真理子・小比賀聡・山本剛史
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19H03656
  • [Presentation] 肝臓標的型アンチセンス核酸のためのリガンド/リンカー構造の最適化研究2020

    • Author(s)
      寺田知邑・和田郁人・ 山吉麻子・ 和田健彦・ 斯波真理子・山本剛史
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-19H03656
  • [Presentation] 3-Amino-1,2-Propanediol-Linked Monomeric GalNAc Phosphoramidite For Efficient Delivery Of Antisense Oligonucleotides To Hepatocytes2020

    • Author(s)
      Terada Chisato; Wada Fumito; Yamayoshi Asako; Harada-shiba Mariko; Obika Satoshi; Yamamoto Tsuyoshi
    • Organizer
      16th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03656
  • [Presentation] ヒト肝臓キメラマウスを核酸医薬の評価モデルに応用するための基礎検討と実用性評価.2019

    • Author(s)
      和田郁人, 加国雅和, 斯波真理子
    • Organizer
      日本核酸医薬学会第5回年会
    • Data Source
      KAKENHI-PROJECT-19H03393
  • [Presentation] Evaluation of Antisense Oligonucleotides Targeting Human mRNA Using Chimeric Mice with Humanized Liver.2019

    • Author(s)
      Wada F, Kakuni M, Harada-Shiba M
    • Organizer
      15th OTS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03393
  • [Presentation] 脂質異常症を対象としたアンチセンスの開発2019

    • Author(s)
      斯波真理子, 和田郁人, 山本剛史
    • Organizer
      第35回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03393
  • 1.  Harada-Shiba Mariko (70271575)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 2.  Yamamoto Tsuyoshi (80636994)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  橘 敬祐 (30432446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  山吉 麻子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results

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