Kawata Miho 河田美穂

Researcher Number	90761601
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 藤田医科大学, 医学部, 助教 2017: 星薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Anesthesiology Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator バゾプレシン / 軸索誘導 / 下垂体 / 視床下部 / マウス ES 細胞 / ES 細胞 / マウスES細胞 / 軸索ガイダンス / 軸索伸長 / トランスレーショナルリサーチ … More / 臨床 / 脳・神経 / 薬理学 / 神経科学 / ドパミン / 緩和医療 / オキシトシン … More Except Principal Investigator ES細胞 / 老化 / 肥満 / オルガノイド / タニサイト / 視床下部 / 視床下部オルガノイド / 転写制御因子 / ダイレクトリプログラミング / 発生 / ダイレクト・リプログラミング / RNA-seq / 分散培養 / SFEBq法 / AVP / 直接分化誘導 / Notchシグナル / SFEBｑ法 / 幹細胞ニッチ / 分化誘導 / Rax / 神経幹細胞 / 下垂体 / 再生医療 / 組織幹細胞 / 下垂体腫瘍 / ヒトiPS細胞 / ヒト胚葉性幹細胞 / 下垂体組織幹細胞 / pituitary stem cell / regenerative medicine / pituitary tumor / ミクログリア / 炎症 / 視床下部性肥満 / 血糖値 / IRS-1 / HOMA-IRインデックス / インスリン受容体 / インスリン / 2型糖尿病 / TNF受容体 Less

神経下垂体発生過程の解明：軸索誘導における IgCAM の役割Principal Investigator
- Principal Investigator
  
  河田美穂
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Fujita Health University
肥満と老化をコントロールする中枢神経幹細胞の発達過程の解明
- Principal Investigator
  
  小谷侑
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Fujita Health University
Induction of hypothalamic neurons by neuronal direct reporogramming
- Principal Investigator
  
  亀山俊樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Fujita Health University
Isolation of adult tissue stem cell in the human anterior pituitary
- Principal Investigator
  
  Nagasaki Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Fujita Health University
抗肥満・抗老化機能を担う成体神経幹細胞ニッチの解明
- Principal Investigator
  
  小谷侑
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Fujita Health University
Elucidation of the axon guidance and elongation mechanisms in the hypothalamic neurons: Investigation in the differentiation of mouse ES cellsPrincipal Investigator
- Principal Investigator
  
  Kawata Miho
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Fujita Health University
Elucidation of mechanism to detect neutral fat in food and maintain homeostasis-Search for lifestyle-related disease improvement method
- Principal Investigator
  
  KANEKO Yoko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gihu University of Medical Science
  Fujita Health University
Integrated molecular analysis the utility of oxytocin for comprehensive palliative care.Principal Investigator
- Principal Investigator
  
  Kawata Miho
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Fujita Health University
  Hoshi University

All 2024 2023 2022 2021 2020 2019 2017

All Journal Article Presentation Patent

[Journal Article] EpCAM Is a Surface Marker for Enriching Anterior Pituitary Cells From Human Hypothalamic-Pituitary Organoids2022
- Author(s)
  Kodani Yu、Kawata Miho、Suga Hidetaka、Kasai Takatoshi、Ozone Chikafumi、Sakakibara Mayu、Kuwahara Atsushi、Taga Shiori、Arima Hiroshi、Kameyama Toshiki、Saito Kanako、Nakashima Akira、Nagasaki Hiroshi
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 13 Pages: 941166-941166
- DOI
  10.3389/fendo.2022.941166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11658, KAKENHI-PROJECT-22K08637
[Journal Article] Long-range axonal projectons of transplanted mouse enbryonic stem cell-derived hypothalamic neurons into adult mouse brain.2022
- Author(s)
  Kawata M, Kodani Y, Ohkuma M, Miyachi E, Kaneko YS, Nakashima A, Suga H, Kameyama T, Saito K, Nagasaki H
- Journal Title
  
  PLoS ONE
  
  Volume: 17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11655
[Journal Article] Characterization of hypothalamic MCH neuron development in a 3D differentiation system of mouse embryonic stem cells2022
- Author(s)
  Yu Kodani, Kodani Y, Kawata M, Suga H, Kaneko YS, Nakashima A, Kameyama T, Saito K, Nagasaki H
- Journal Title
  
  eNeuro
  
  Volume: 9 Issue: 2 Pages: 1-20
- DOI
  10.1523/eneuro.0442-21.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11655, KAKENHI-PROJECT-20K08896, KAKENHI-PROJECT-20K11658, KAKENHI-PROJECT-22K08637
[Journal Article] Long-range axonal projections of transplanted mouse embryonic stem cell-derived hypothalamic neurons into adult mouse brain2022
- Author(s)
  Kawata Miho、Kodani Yu、Ohkuma Mahito、Miyachi Ei-ichi、Kaneko Yoko S.、Nakashima Akira、Suga Hidetaka、Kameyama Toshiki、Saito Kanako、Nagasaki Hiroshi
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 11 Pages: 1-20
- DOI
  10.1371/journal.pone.0276694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09838, KAKENHI-PROJECT-22K08637, KAKENHI-PROJECT-20K15917, KAKENHI-PROJECT-20K08896
[Journal Article] NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity.2020
- Author(s)
  Nakashima A, Yamaguchi H, Kondo M, Furumura T, Kodani Y, Kaneko YS, Kawata M, Nagasaki H, Ngatsu T, Ota A
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 127 Issue: 12 Pages: 1631-1340
- DOI
  10.1007/s00702-020-02236-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11655, KAKENHI-PROJECT-18K11004
[Journal Article] Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.2019
- Author(s)
  Nakashima A, Yamaguchi H, Kodani Y, Kaneko YS, Kawata M, Nagasaki H, Nagatsu T, Ota A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 516(4) Issue: 4 Pages: 1060-1065
- DOI
  10.1016/j.bbrc.2019.06.156
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11004, KAKENHI-PROJECT-19K11655
[Patent] 細胞表面マーカーを用いた下垂体細胞及び視床下部細胞の分離法2021
- Inventor(s)
  小谷侑, 河田美穂、長崎弘、須賀英隆
- Industrial Property Rights Holder
  小谷侑, 河田美穂、長崎弘、須賀英隆
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-158406
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K08896
[Presentation] バソプレシン神経の分化誘導におけるNotchシグナルの関与2024
- Author(s)
  久野萌花、鈴木つくし、梅本梨花、塚本舜也、目良義也、河田美穂、小谷侑、齋藤加奈子、中島昭、亀山俊樹、長崎弘
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] 転写制御因子の遺伝子導入によるマウスES細胞の弓状核神経への分化誘導2024
- Author(s)
  梅本梨花、塚本舜也、目良義也、久野萌花、鈴木つくし、河田美穂、小谷侑、齋藤加奈子、中島昭、亀山俊樹、長崎弘
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] 空間的培養条件の違いによる視床下部神経細胞分化能の分子的差異2023
- Author(s)
  鈴木つくし、久野萌花、塚本舜也、目良義也、梅本梨花、河田美穂、小谷侑、中島昭、亀山俊樹、長崎弘
- Organizer
  第55回藤田学園医学会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] 転写制御因子群強制発現による視床下部神経細胞の分化誘導2023
- Author(s)
  亀山俊樹、梅本梨花、塚本舜也、目良義也、鈴木つくし、久野萌花、河田美穂、小谷侑、斎藤加奈子、中島昭、長崎弘
- Organizer
  第49回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] 空間的培養条件による視床下部神経分化能の差異をもたらす分子機構2023
- Author(s)
  2.鈴木つくし、塚本舜也、目良義也、久野萌花、河田美穂、小谷侑、斎藤加奈子、中島昭、亀山俊樹、長崎弘
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-20K11658
[Presentation] Pax6 expression analysis in anterior pituitary stem cells of adult rodent.2023
- Author(s)
  齋藤加奈子、亀山俊樹、国田勝行、河田美穂、小谷　侑、中島　昭、長崎　弘
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-20K08896
[Presentation] Molecular differences in the differentiation potential of hypothalamic neurons induced by different spatial culture conditions2023
- Author(s)
  鈴木つくし、塚本舜也、目良義也、久野萌花、河田美穂、小谷侑、斎藤加奈子、中島昭、亀山俊樹、長崎弘
- Organizer
  第100回日本生理学会記念大会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] Induction of hypothalamic paraventricular nucleus and supraoptic nucleus neuron by direct reprogramming.2022
- Author(s)
  亀山俊樹、目良義也、塚本舜也、鈴木つくし、河田美穂、小谷　侑、齋藤加奈子、中島　昭、長崎　弘
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K08896
[Presentation] 転写制御因子群強制発現による視床下部神経細胞の分化誘導2022
- Author(s)
  亀山俊樹、目良義也、塚本舜也、鈴木つくし、河田美穂、小谷侑、斉藤加奈子、中島昭、長崎弘
- Organizer
  第54回藤田学園医学会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] Induction of mouse ES cells into hypothalamic ventral medial nucleus and arcuate nucleus nerves by gene transfer of transcription factors.2022
- Author(s)
  塚本舜也、目良義也、鈴木つくし、河田美穂、小谷　侑、齋藤加奈子、中島　昭、亀山俊樹、長崎　弘
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K08896
[Presentation] 転写制御因子群強制発現による視床下部室傍核・視索上核神経細胞の分化誘導2022
- Author(s)
  亀山俊樹、目良義也、塚本舜也、鈴木つくし、河田美穂、小谷侑、齋藤加奈子、中島昭、長崎弘
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K11658
[Presentation] Differentiation of hypothalamic paraventricular neurons from direct reprogramming by gene transfer using mouse ES cells.2022
- Author(s)
  目良義也、塚本舜也、鈴木つくし、河田美穂、小谷　侑、齋藤加奈子、中島　昭、亀山俊樹、長崎　弘
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K08896
[Presentation] ヒト多能性幹細胞由来の視床下部・下垂体オルガノイドにおける下垂体幹/前駆細胞の探索2022
- Author(s)
  6.野々山葵、河田美穂、小谷侑、亀山俊樹、齋藤加奈子、須賀英隆、長崎弘
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-20K11658
[Presentation] 転写制御因子の遺伝子導入によるマウスES細胞の視床下部腹内側核および弓状核神経への分化誘導2022
- Author(s)
  塚本舜也、目良義也、鈴木つくし、河田美穂、小谷侑、斉藤加奈子、中島昭、亀山俊樹、長崎弘
- Organizer
  第54回藤田学園医学会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] マウスES細胞を用いた遺伝子導入による視床下部室傍核神経の直接分化誘導2022
- Author(s)
  目良義也、塚本舜也、鈴木つくし、河田美穂、小谷侑、斉藤加奈子、中島昭、亀山俊樹、長崎弘
- Organizer
  第54回藤田学園医学会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] ヒト視床下部・下垂体オルガノイドから分離した接着性細胞の下垂体幹細胞性の検討2022
- Author(s)
  3.野々山葵、河田美穂、小谷侑、亀山俊樹、齋藤加奈子、須賀英隆、長崎弘
- Organizer
  第48回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11658
[Presentation] ヒト視床下部・下垂体オルガノイドから分離した接着性細胞の下垂体幹細胞性の検討2022
- Author(s)
  野々山葵, 河田美穂, 小谷侑, 亀山俊樹, 齋藤加奈子, 須賀英隆, 長崎弘
- Organizer
  第 48 回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08896
[Presentation] 空間的培養条件検討による視床下部神経分化誘導因子の探索2022
- Author(s)
  鈴木つくし、塚本舜也、目良義也、久野萌花、河田美穂、小谷侑、斎藤加奈子、中島昭、亀山俊樹、長崎弘
- Organizer
  第69回中部日本生理学会
- Data Source
  KAKENHI-PROJECT-22K08637
[Presentation] ES細胞分化誘導系を用いた視床下部タニサイト発生過程の再現2021
- Author(s)
  小谷侑、河田美穂、金子葉子、中島昭、長崎弘
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K11658
[Presentation] マウス ES 細胞由来視床下部神経の正所性移植と軸索投射の解析2021
- Author(s)
  河田　美穂、小谷　侑、亀山　俊樹、齋藤　加奈子、中島　昭、長崎　弘
- Organizer
  第 47 回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K15917
[Presentation] マウスES細胞由来視床下部神経の正所性移植と軸索投射の解析2021
- Author(s)
  河田美穂、小谷侑、亀山俊樹、齋藤加奈子、中島昭、長崎弘
- Organizer
  第47回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11658
[Presentation] 同種移植されたマウス ES 細胞由来視床下部神経は下垂体後葉に軸索投射する2020
- Author(s)
  河田美穂, 小谷　侑, 亀山俊樹, 中島　昭, 長崎　弘
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-20K15917
[Presentation] 下垂体腺腫摘出検体からのヒト下垂体幹細胞の同定2020
- Author(s)
  齋藤加奈子、西山悠也、武藤淳、河田美穂、小谷侑、亀山俊樹、長崎弘
- Organizer
  第67回　中部日本生理学会
- Data Source
  KAKENHI-PROJECT-20K08896
[Presentation] 同種移植したマウス ES 細胞由来視床下部神経の軸索投射様式の解析2020
- Author(s)
  河田美穂, 小谷　侑, 亀山俊樹, 齋藤加奈子, 中島　昭, 長崎　弘
- Organizer
  第52回藤田学園医学会
- Data Source
  KAKENHI-PROJECT-20K15917
[Presentation] TNF受容体のサブタイプとインスリン抵抗性発症の関連性の解明2019
- Author(s)
  金子葉子、小谷侑、河田美穂、中島昭、長崎弘
- Organizer
  第97回日本生理学会
- Data Source
  KAKENHI-PROJECT-19K11655
[Presentation] マウスES細胞を用いた視床下部タニサイト発生モデルの構築2019
- Author(s)
  小谷侑、金子葉子、河田美穂、中島昭、長崎弘
- Organizer
  第97回日本生理学会
- Data Source
  KAKENHI-PROJECT-19K11655
[Presentation] 移植したマウスES細胞由来視床下部神経の長期生存と適切な軸索伸長2019
- Author(s)
  河田美穂、小谷侑、金子葉子、中島昭、長崎弘
- Organizer
  第97回日本生理学会
- Data Source
  KAKENHI-PROJECT-19K11655
[Presentation] がん性疼痛ならびに神経障害性疼痛に対するオキシトシンによる鎮痛効果とその発現機序の解析2017
- Author(s)
  渡邉萌、目黒由行、濱田祐輔、近藤貴茂、河田美穂、成田道子、葛巻直子、成田年
- Organizer
  第11回日本緩和医療薬学会年会
- Data Source
  KAKENHI-PROJECT-17K16759

1. Nagasaki Hiroshi (30420384)

# of Collaborated Projects: 6 results

# of Collaborated Products: 28 results
2. 小谷侑 (60644622)

# of Collaborated Projects: 6 results

# of Collaborated Products: 28 results
3. KANEKO Yoko (20319263)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. 亀山俊樹 (60298544)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. 齋藤加奈子 (50746906)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OHKUMA Mahito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. NAKASHIMA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 田崎加奈子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kawata Miho 河田 美穂

Research Projects

Research Products

Co-Researchers

神経下垂体発生過程の解明：軸索誘導における IgCAM の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肥満と老化をコントロールする中枢神経幹細胞の発達過程の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of hypothalamic neurons by neuronal direct reporogramming

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Isolation of adult tissue stem cell in the human anterior pituitary

Principal Investigator

Project Period (FY)

Research Category

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抗肥満・抗老化機能を担う成体神経幹細胞ニッチの解明

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Elucidation of the axon guidance and elongation mechanisms in the hypothalamic neurons: Investigation in the differentiation of mouse ES cellsPrincipal Investigator

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Elucidation of mechanism to detect neutral fat in food and maintain homeostasis-Search for lifestyle-related disease improvement method

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Integrated molecular analysis the utility of oxytocin for comprehensive palliative care.Principal Investigator

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[Journal Article] EpCAM Is a Surface Marker for Enriching Anterior Pituitary Cells From Human Hypothalamic-Pituitary Organoids2022

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[Journal Article] Long-range axonal projectons of transplanted mouse enbryonic stem cell-derived hypothalamic neurons into adult mouse brain.2022

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[Journal Article] Characterization of hypothalamic MCH neuron development in a 3D differentiation system of mouse embryonic stem cells2022

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[Journal Article] Long-range axonal projections of transplanted mouse embryonic stem cell-derived hypothalamic neurons into adult mouse brain2022

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[Journal Article] NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity.2020

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[Journal Article] Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.2019

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Kawata Miho 河田美穂