Kawaguchi Yohei 川口洋平

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KAWAGUCHI Yohei 川口洋平

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Researcher Number	90766734
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 講師
Affiliation (based on the past Project Information) *help	2019 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 助教 2018: 名古屋市立大学, 大学院医学研究科, 助教 2016: 名古屋市立大学, 大学院医学研究科, 臨床研究医
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related Except Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 56070:Plastic and reconstructive surgery-related / Orthopaedic surgery
Keywords	Principal Investigator グリオスタチン / 関節リウマチ / 軟骨細胞 / RANKL / リウマチ / 滑膜細胞 / 線維芽細胞様滑膜細胞 Except Principal Investigator グリオスタチン / 滑膜細胞 / 関節リウマチ … More / rheumatoid arthritis / thymidine phosphorylase / gliostatin / osteoclast / osteoblast / 骨びらん / 破骨細胞 / RANKL / interferon gamma / janus kinase / synoviocytes / インターフェロン　ガンマ / STAT / 滑膜 / 治療 / 幹細胞 / nail matrix / regeneration / rat / mouse / nail / 皮膚間様細胞 / ポリカプロラクトン / 再生 / コラーゲンゲル / 爪母間様細胞 / 爪母上皮細胞 / 抗ハードケラチン抗体 / ハードケラチン / 硬性ケラチン / 再生医療 / 線維芽細胞 / 上皮細胞 / 爪 / チミジンホスホリラーぜ / 滑膜炎 / 線維芽細胞様滑膜細胞 / テネイシンC / MMP-3 / チミジンホスフォリアーゼ / TNF alfa / チミジンホスポリラーゼ / マトリックスメタロプロテイナーゼ / マトリックスメタロプロテアーゼ / チミジンホスホリラーゼ Less

Molecular mechanisms of gliostatin and bone metabolic factors in bone erosions of rheumatoid arthritis
- Principal Investigator
  
  永谷祐子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya City University
RA関節破壊の制圧に向けた、新規治療ターゲットとしてのグリオスタチンの可能性Principal Investigator
- Principal Investigator
  
  川口洋平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya City University
Developing novel rheumatoid arthritis treatments through gliostatin regulation targeting transcription factors
- Principal Investigator
  
  Nagaya Yuko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya City University
Regeneration of the nail -development of the new treatment for nail deficiency using nail stem cell-
- Principal Investigator
  
  Okamoto Hideki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Nagoya City University
The role and potential of gliostatin as a new therapeutic molecular target in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Kawaguchi Yohei
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya City University
Molecular mechanism of gliostatin and tenascin C in rheumatoid synoviocytes
- Principal Investigator
  
  Yusuke Oguri
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya City University
Gliostatin as a novel therapeutic target for rheumatoid arthritis
- Principal Investigator
  
  NAGAYA Yuko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya City University

All 2023 2022 2021 2020 2019 2018 2016 2015 Other

All Journal Article Presentation

[Journal Article] Nerve Recovery and Morphological Change on MRI at 24 Months after Open Carpal Tunnel Release.2023
- Author(s)
  Hattori Y, Kawaguchi Y, Usami T, Waguri-Nagaya Y, Murakami H, Okamoto H
- Journal Title
  
  J Hand Surg Asian Pac
  
  Volume: 28 Issue: 02 Pages: 197-204
- DOI
  10.1142/s2424835523500212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08702, KAKENHI-PROJECT-19K10032
[Journal Article] IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells2023
- Author(s)
  Otsuka Yuto、Kondo Takao、Aoki Hiromasa、Goto Yoh、Kawaguchi Yohei、Waguri-Nagaya Yuko、Miyazawa Ken、Goto Shigemi、Aoyama Mineyoshi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 151 Issue: 1 Pages: 1-8
- DOI
  10.1016/j.jphs.2022.10.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08211, KAKENHI-PROJECT-21K16403, KAKENHI-PROJECT-23K08702, KAKENHI-PROJECT-20K09465
[Journal Article] Transforming Growth Factor-β Induces Interleukin-6 Secretion from Human Ligamentum Flavum-Derived Cells through Partial Activation of p38 and p44/42 Mitogen-Activated Protein Kinases2023
- Author(s)
  Goto Y, Kato K, Yagi K, Kawaguchi Y, Yonezu H, Koshimae T, Waguri-Nagaya Y, Murakami H, Suzuki N.
- Journal Title
  
  Asian Spine J
  
  Volume: 17 Issue: 6 Pages: 997-1003
- DOI
  10.31616/asj.2023.0025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08702, KAKENHI-PROJECT-19K18506
[Journal Article] Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia2022
- Author(s)
  Kondo Takao、Aoki Hiromasa、Otsuka Yuto、Kawaguchi Yohei、Waguri-Nagaya Yuko、Aoyama Mineyoshi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 149 Issue: 3 Pages: 93-99
- DOI
  10.1016/j.jphs.2022.03.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22715, KAKENHI-PROJECT-20K08211, KAKENHI-PROJECT-21K16403, KAKENHI-PROJECT-20K09465
[Journal Article] ―運動・食生活・社会参加の自由記述調査から―2022
- Author(s)
  安岡実佳子、渡邉良太、渡邉美貴、鈴木貞夫、小嶋雅代、肥田武、藤川寛之、永谷祐子、川口洋平、黒柳元、上用祐士、坂井宏章、三井祐人
- Journal Title
  
  Tokai Journal of Public Health
  
  Volume: 10 Issue: 1 Pages: 196-202
- DOI
  10.24802/tpha.2022-15
- ISSN
  2187-736X, 2434-0421
- Year and Date
  2022-07-02
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09465
[Journal Article] The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes2022
- Author(s)
  Joyo Yuji、Kawaguchi Yohei、Yonezu Hiroki、Senda Hiroya、Yasuma Sanshiro、Shiraga Hiroo、Nozaki Masahiro、Aoyama Mineyoshi、Asai Kiyofumi、Murakami Hideki、Waguri-Nagaya Yuko
- Journal Title
  
  Immunologic Research
  
  Volume: 70 Issue: 2 Pages: 208-215
- DOI
  10.1007/s12026-022-09261-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08211, KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18473
[Journal Article] N-acetyl-seryl-aspartyl-lysyl-proline: A new potential serum biomarker of rheumatoid arthritis2021
- Author(s)
  Oguri, Y, Kawaguchi Y, Tatematsu N, Joyo Y, Mizuguchi K, Yonezu H, Okamoto H, Nozaki M, Kobayashi M, Kuroyanagi G, Aiba H, Asai K, Inoue K, Murakami H, Waguri-Nagaya Y
- Journal Title
  
  Medical Mass Spectrometry
  
  Volume: 5 Pages: 1-10
- NAID
  130008062713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09465
[Journal Article] The Inducible Nitric Oxide Synthase Pathway Promotes Osteoclastogenesis under Hypoxic Culture Conditions2021
- Author(s)
  Kondo Takao、Otsuka Yuto、Aoki Hiromasa、Goto Yoh、Kawaguchi Yohei、Waguri-Nagaya Yuko、Miyazawa Ken、Goto Shigemi、Aoyama Mineyoshi
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 191 Issue: 12 Pages: 2072-2079
- DOI
  10.1016/j.ajpath.2021.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22715, KAKENHI-PROJECT-20K08211, KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-21K16403
[Journal Article] Anterolateral ligament reconstruction in addition to primary double-bundle anterior cruciate ligament reconstruction for grade 3 pivot shift improves residual knee instability during surgery2021
- Author(s)
  Kawanishi Yusuke、Kobayashi Makoto、Yasuma Sanshiro、Fukushima Hiroaki、Kato Jiro、Murase Atsunori、Takenaga Tetsuya、Yoshida Masahito、Kuroyanagi Gen、Kawaguchi Yohei、Nagaya Yuko、Murakami Hideki、Nozaki Masahiro
- Journal Title
  
  Journal of Experimental Orthopaedics
  
  Volume: 8 Issue: 1 Pages: 51-51
- DOI
  10.1186/s40634-021-00369-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18471
[Journal Article] Impact of social support on severity of depressive symptoms by remission status in patients with rheumatoid arthritis2021
- Author(s)
  Yasuoka Mikako、Kojima Toshihisa、Waguri-Nagaya Yuko、Saito Tami、Takahashi Nobunori、Asai Shuji、Sobue Yasumori、Nishiume Tsuyoshi、Suzuki Mochihito、Mitsui Hiroto、Kawaguchi Yohei、Kuroyanagi Gen、Kamiji Koto、Watanabe Miki、Suzuki Sadao、Kondo Katsunori、Ojima Toshiyuki、Kojima Masayo
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 3 Pages: 528-533
- DOI
  10.1093/mr/roab001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-23K20339
[Journal Article] N-acetyl-seryl-aspartyl-lysyl-proline: A new potential serum biomarker of rheumatoid arthritis2021
- Author(s)
  Yusuke Oguri, Yohei Kawaguchi , Naoe Tatematsu, Yuji Joyo, Ken Mizuguchi, Hiroki Yonezu, Hideki Okamoto, Masahiro Nozaki, Makoto Kobayashi, Gen Kuroyanagi, Hisaki Aiba, Kiyofumi Asai, Koichi Inoue, Hideki Murakami, Yuko Waguri-Nagaya
- Journal Title
  
  Medical Mass Spectrometry
  
  Volume: 5 Pages: 28-37
- NAID
  130008062713
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09114
[Journal Article] p38 Mitogen-Activated Protein Kinase Is Involved in Interleukin-6 Secretion from Human Ligamentum Flavum?Derived Cells Stimulated by Tumor Necrosis Factor-α2021
- Author(s)
  Yagi Kiyoshi、Goto Yuta、Kato Kenji、Suzuki Nobuyuki、Kondo Akira、Waseda Yuya、Mizutani Jun、Kawaguchi Yohei、Joyo Yuji、Waguri-Nagaya Yuko、Murakami Hideki
- Journal Title
  
  Asian Spine Journal
  
  Volume: 15 Issue: 6 Pages: 713-720
- DOI
  10.31616/asj.2020.0425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18506
[Journal Article] <i>N</i>-acetyl-seryl-aspartyl-lysyl-proline: A new potential serum biomarker of rheumatoid arthritis2021
- Author(s)
  Yusuke Oguri, Yohei Kawaguchi, Naoe Tatematsu, Yuji Joyo, Ken Mizuguchi, Hiroki Yonezu
- Journal Title
  
  Medical Mass Spectrometry
  
  Volume: 5 Issue: 1 Pages: 28-37
- DOI
  10.24508/mms.2021.06.004
- NAID
  130008062713
- ISSN
  2432-7441, 2432-745X
- Year and Date
  2021-06-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18473
[Journal Article] バイク事故による橈骨遠位端骨折に合併した月状骨脱臼の1例2021
- Author(s)
  加藤明裕, 福田誠, 川口洋平, 五島隆宏, 松嶋麻子
- Journal Title
  
  日本救急医学会雑誌
  
  Volume: 32 Pages: 73-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09114
[Journal Article] Diagnosis of medial meniscal ramp lesion is difficult by pre-operative magnetic resonance imaging evaluation and needs a methodical arthroscopic exploration2021
- Author(s)
  Yasuma Sanshiro、Kobayashi Makoto、Kawanishi Yusuke、Fukushima Hiroaki、Kato Jiro、Takenaga Tetsuya、Yoshida Masahito、Kuroyanagi Gen、kawaguchi Yohei、Nagaya Yuko、Murakami Hideki、Nozaki Masahiro
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: - Issue: 6 Pages: 1271-1277
- DOI
  10.1016/j.jos.2021.07.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18471
[Journal Article] An Analysis of the Femoral Drilling Angle to Avoid Tunnel Collision during Double-Bundle Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction on the Knee2021
- Author(s)
  Kawanishi Yusuke、Kobayashi Makoto、Yasuma Sanshiro、Fukushima Hiroaki、Kato Jiro、Murase Atsunori、Takenaga Tetsuya、Yoshida Masahito、Kuroyanagi Gen、Kawaguchi Yohei、Nagaya Yuko、Murakami Hideki、Nozaki Masahiro
- Journal Title
  
  The Journal of Knee Surgery
  
  Volume: - Issue: 05 Pages: 0-0
- DOI
  10.1055/s-0041-1736196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18471
[Journal Article] Three-dimensional spheroid culture induces apical-basal polarity and the original characteristics of immortalized human renal proximal tubule epithelial cells2021
- Author(s)
  Mizuguchi Ken、Aoki Hiromasa、Aoyama Mineyoshi、Kawaguchi Yohei、Waguri-Nagaya Yuko、Ohte Nobuyuki、Asai Kiyofumi
- Journal Title
  
  Experimental Cell Research
  
  Volume: 404 Issue: 1 Pages: 112630-112630
- DOI
  10.1016/j.yexcr.2021.112630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22715, KAKENHI-PROJECT-20K08211, KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-20K17252, KAKENHI-PROJECT-21K16403
[Journal Article] 重度不安定性を呈する肘関節脱臼骨折における,尺骨鈎状突起骨折・前方軟部組織再建の意義2020
- Author(s)
  早川和男, 遠藤浩二郎, 川口洋平, 岡本秀貴
- Journal Title
  
  日本手外科学会雑誌
  
  Volume: 37 Pages: 113-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09114
[Journal Article] Pyogenic tenosynovitis of the wrist due to Corynebacterium striatum in a patient with dermatomyositis. A case report.2020
- Author(s)
  Kawaguchi Y, Okamoto H, Endo K, Iwata H, Joyo Y, Nozaki, M, Tamechika S, Waguri-Nagaya Y, Murakami H.
- Journal Title
  
  Medicine
  
  Volume: 99 Issue: 3 Pages: e18761-e18761
- DOI
  10.1097/md.0000000000018761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09114, KAKENHI-PROJECT-17K11020, KAKENHI-PROJECT-20K09465
[Journal Article] 気胸、細菌性肺炎を繰り返し治療に難渋した間質性肺疾患合併RAの1例2020
- Author(s)
  小栗雄介, 川口洋平, 黒柳元, 上用祐士, 野崎正浩, 小林真, 永谷祐子
- Journal Title
  
  中部リウマチ
  
  Volume: 50 Pages: 9-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09114
[Journal Article] Preoperative Knee Instability Affects Residual Instability as Evaluated by Quantitative Pivot-Shift Measurements During Double-Bundle ACL Reconstruction2020
- Author(s)
  Kawanishi Yusuke、Nozaki Masahiro、Kobayashi Makoto、Yasuma Sanshiro、Fukushima Hiroaki、Murase Atsunori、Takenaga Tetsuya、Yoshida Masahito、Kuroyanagi Gen、Kawaguchi Yohei、Nagaya Yuko、Murakami Hideki
- Journal Title
  
  Orthopaedic Journal of Sports Medicine
  
  Volume: 8 Issue: 10 Pages: 1-7
- DOI
  10.1177/2325967120959020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09465, KAKENHI-PROJECT-19K18471
[Journal Article] Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis2020
- Author(s)
  Kojima Masayo、Kojima Toshihisa、Waguri-Nagaya Yuko、Takahashi Nobunori、Asai Shuji、Sobue Yasumori、Nishiume Tsuyoshi、Suzuki Mochihito、Mitsui Hiroto、Kawaguchi Yohei、Kuroyanagi Gen、Yasuoka Mikako、Watanabe Miki、Suzuki Sadao、Arai Hidenori
- Journal Title
  
  Modern Rheumatology
  
  Volume: 2 Issue: 5 Pages: 1-8
- DOI
  10.1080/14397595.2020.1838402
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114, KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-23K20339
[Journal Article] Anterolateral ligament reconstruction as an augmented procedure for double-bundle anterior cruciate ligament reconstruction restores rotational stability: Quantitative evaluation of the pivot shift test using an inertial sensor.2020
- Author(s)
  Yasuma S, Nozaki M, Murase A, Kobayashi M, Kawanishi Y, Fukushima H, Takenaga T, Yoshida M, Kuroyanagi G, Kawaguchi Y, Nagaya Y, Murakami H.
- Journal Title
  
  Knee
  
  Volume: S0968-0160 Issue: 2 Pages: 30053-3
- DOI
  10.1016/j.knee.2020.02.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114, KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-20K09465
[Journal Article] The Janus kinase inhibitor tofacitinib inhibits TNF-α-induced gliostatin expression in rheumatoid fibroblast-like synoviocytes2018
- Author(s)
  Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Oguri Y, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T
- Journal Title
  
  Clin Exp Rheumatol
  
  Volume: 36 Pages: 559-567
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09114
[Journal Article] Mithramycin has inhibitory effects on gliostatin and matrix metalloproteinase expression induced by gliostatin in rheumatoid fibroblast-like synoviocytes.2018
- Author(s)
  Tatematsu N, Waguri-Nagaya Y, Kawaguchi Y, Oguri Y, Ikuta K, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 28(3) Issue: 3 Pages: 495-505
- DOI
  10.1080/14397595.2017.1350332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10101, KAKENHI-PROJECT-16K10913, KAKENHI-PROJECT-17K11020, KAKENHI-PROJECT-18K09114
[Presentation] The JAK inhibitor (baricitinib) inhibits IFNγ-induced gliostatin expression in human fibroblast-like synoviocytes.2023
- Author(s)
  Joyo Y, Kawaguchi Y, Yonezu H, Yasuma S, Shiraga H, Nozaki M, Aoyama M, Murakami H, Waguri-Nagaya Y.
- Organizer
  43th SICOT Orthopaedic World Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09465
[Presentation] コラーゲン製人工神経を用いた末梢神経再生と神経再生の未来2023
- Author(s)
  岡本秀貴、川口洋平、上用祐士、平田　仁、村上英樹、関谷勇人
- Organizer
  第38回中部日本手外科研究会
- Data Source
  KAKENHI-PROJECT-19K10032
[Presentation] The JAK inhibitor (baricitinib) inhibits IFNγ-induced gliostatin expression in human fibroblast-like synoviocytes2023
- Author(s)
  Joyo Y, Kawaguchi Y, Yonezu H, Yasuma S, Shiraga H, Nozaki M, Aoyama M, Murakami H, Waguri-Nagaya Y
- Organizer
  43th SICOT Orthopaedic World Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08702
[Presentation] 手根管開放術後2年間の臨床経過とMRIによる形態学的変化の検討2023
- Author(s)
  服部勇介、川口洋平、上用祐士、永谷祐子、遠藤浩二郎、村上英樹、岡本秀貴
- Organizer
  第66回日本手外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10032
[Presentation] 神経誘導術の歴史と人工神経を用いた神経誘導術2023
- Author(s)
  岡本秀貴、川口洋平、五十棲秀幸、上用祐士、服部勇介、加藤健太、村上英樹
- Organizer
  第49回日本マイクロサージャリー学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10032
[Presentation] 関節リウマチ患者の予後予測指標としてのフレイルの妥当性検証.2022
- Author(s)
  小嶋雅代，安岡実佳子，浅井秀司，祖父江康司, 西梅剛, 鈴木望人，高橋伸典，黒柳元, 川口洋平, 上用祐士, 坂井宏章, 永谷祐子, 小嶋俊久.
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09465
[Presentation] 関節リウマチ合併骨粗鬆症患者におけるロモソズマブの治療経験2022
- Author(s)
  宇佐美琢也, 上用祐士, 川口洋平, 永谷祐子.
- Organizer
  第33回中部リウマチ学会
- Data Source
  KAKENHI-PROJECT-20K09465
[Presentation] 関節リウマチ線維芽細胞様滑膜細胞においてIL-6によるグリオスタチン発現はトシリズマブにより抑制される2021
- Author(s)
  米津大貴, 川口洋平, 上用祐士, 野崎正浩, 小林真, 浅井清文, 村上英樹, 永谷祐子
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K18473
[Presentation] IL-6はRA由来線維芽細胞様滑膜細胞においてグリオスタチンを誘導する2021
- Author(s)
  米津大貴, 川口洋平, 上用祐士, 浅井清文, 永谷祐子
- Organizer
  日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-19K18473
[Presentation] リウマチ滑膜細胞においてバリシチニブはSTAT1のリン酸化阻害でGLS産生を抑制する2020
- Author(s)
  上用祐士, 川口洋平, 黒柳元, 小林真, 野崎正浩, 浅井清文, 永谷祐子, 村上英樹
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K18473
[Presentation] グリオスタチン産生からみた滑膜細胞に対するバリシチニブの新規作用2020
- Author(s)
  上用祐士, 川口洋平, 黒柳元, 浅井清文, 永谷祐子
- Organizer
  第64回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] グリオスタチン産生からみた滑膜細胞に対するバリシチニブに対する新規作用.2020
- Author(s)
  上用祐士, 川口洋平, 黒柳元, 浅井清文, 永谷祐子.
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09465
[Presentation] 関節リウマチに関する鏡視下滑膜切除術の意義.2020
- Author(s)
  松井宣夫, 黒柳元, 坂井宏章,宇佐美琢也, 永谷祐子, 川口洋平, 上用祐士, 植木美乃, 村上英樹.
- Organizer
  第35回日本臨床リウマチ学会.
- Data Source
  KAKENHI-PROJECT-20K09465
[Presentation] グリオスタチン産生からみた滑膜細胞に対するバリシチニブの新規作用2020
- Author(s)
  上用祐士、川口洋平, 黒柳元, 浅井清文, 永谷祐子
- Organizer
  日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-19K18473
[Presentation] リウマチ滑膜細胞においてバリシチニブはSTAT1のリン酸化阻害でGLS産生を抑制する2020
- Author(s)
  上用祐士, 川口洋平, 黒柳元, 小林真, 野崎正浩, 浅井清文, 永谷祐子, 村上英樹
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] リウマチ滑膜細胞においてバリシチニブはSTAT1のリン酸化阻害でGLS産生を抑制する.2020
- Author(s)
  上用祐士, 川口洋平, 黒柳元, 小林真, 野崎正浩, 浅井清文, 永谷祐子, 村上英樹.
- Organizer
  第35回日本整形外科学学会基礎学術集会.
- Data Source
  KAKENHI-PROJECT-20K09465
[Presentation] 関節リウマチ患者におけるフレイル関連要因の探索.2020
- Author(s)
  小嶋雅代, 永谷祐子, 三井裕人, 川口洋平, 黒柳元, 高橋伸典, 浅井秀司, 祖父江康司, 西梅剛, 鈴木望人, 小嶋俊久. 関節リウマチ患者におけるフレイル関連要因の探索.
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09465
[Presentation] Novel anti-angiogenic effects of tofacitinib in fibroblast-like synoviocytes derived from patients with RA.2019
- Author(s)
  Kawaguchi Y, Oguri Y, Nozaki M, Asai K, Waguri-Nagaya Y.
- Organizer
  Annual European Congress of Rheumatology EULAR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] The JAK inhibitor (baricitinib) inhibits IFNγ-induced gliostatin expression in human fibroblast-like synoviocytes.2019
- Author(s)
  Joyo Y, Kawaguchi Y, Oguri Y, Nozaki M, Asai K, Waguri-Nagaya Y.
- Organizer
  Annual European Congress of Rheumatology EULAR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] 生物学的製剤導入時の胸部CT検査で悪性腫瘍が発見された関節リウマチの2例2019
- Author(s)
  上用祐士, 川口洋平, 小栗雄介, 三井裕人, 黒柳元, 永谷祐子.
- Organizer
  第63回日本リウマチ学会総会・学術集会.
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] Circulating gliostatin correlates with serological feature and response to IL-6 inhibitor therapy in patients with RA.2018
- Author(s)
  Oguri Y, Kawaguchi Y, Nozaki M, Asai K, Waguri-Nagaya Y
- Organizer
  39th SICOT Orthopaedic World Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] Serum GLS levels were significantly decreased in patients with RA who were treated with tofacitinib2018
- Author(s)
  Kawaguchi Y, Oguri Y, Nozaki M, Asai K, Waguri-Nagaya Y
- Organizer
  39th SICOT Orthopaedic World Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] トシリズマブを使用した関節リウマチ患者血清中グリオスタチン濃度と疾患活動性の推移.2018
- Author(s)
  小栗雄介, 永谷祐子, 川口洋平, 立松尚衞, 小林正明, 浅井清文, 大塚隆信.
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K09114
[Presentation] Sp1 interference prevents joint destruction of RA through inhibitory effects of gliostatin and matrix metalloproteinase-3.2016
- Author(s)
  Ikuta K, Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology (EULAR2016)
- Place of Presentation
  ExCel London, London, United Kingdom)
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] The JAK inhibitor (Tofacitinib) inhibits TNF-induced gliostatin/thymidine phosphorylase expression in human fibroblast-like synoviocytes.2016
- Author(s)
  Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Ikuta K, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology (EULAR2016)
- Place of Presentation
  ExCel London, London (United Kingdom)
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] Sp1 inhibitor modulates the autocrine action of gliostatin/thymidine phosphorylase (GLS/TYMP) in rheumatoid fibroblast-like synoviocytes.2016
- Author(s)
  Tatematsu N, Waguri-Nagaya Y, Kawaguchi Y, Ikuta K, Kobayashi M, Goto H, Nozaki M, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology (EULAR2016)
- Place of Presentation
  ExCel London, London (United Kingdom)
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] 関節リウマチ線維芽細胞様滑膜細胞に置いてグリオスタチンによって誘導されたMMPsはSp１阻害剤によって抑制される.2016
- Author(s)
  立松尚衞, 永谷祐子, 川口洋平, 生田憲史, 小栗雄介, 小林正明,野崎正浩, 青山峰芳, 浅井清文, 大塚隆信.
- Organizer
  第31回日本整形外科基礎学術集会
- Place of Presentation
  福岡国際会議場 (福岡県, 福岡市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] Sp1 inhibitor modulates the autocrine action of gliostatin/thymidine phosphorylase (GLS/TYMP) in rheumatoid fibroblast-like synoviocytes.2016
- Author(s)
  Tatematsu N, Waguri-Nagaya Y, Kawaguchi Y, Ikuta K, Kobayashi M, Goto H, Nozaki M, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology (EULAR2016)
- Place of Presentation
  ExCel London, London, United Kingdom)
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] 関節リウマチ患者の血清 N-acetyl-seryl-aspartyl-lysyl-proline(AcSDKP) 濃度は治療の有効性を反映している.2016
- Author(s)
  立松尚衞, 永谷祐子, 川口洋平, 井之上浩一, 浅井清文, 大塚隆信.
- Organizer
  第89回日本整形外科学会学術集会
- Place of Presentation
  パシフィコ横浜, 横浜
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] 関節リウマチ患者の血清 N-acetyl-seryl-aspartyl-lysyl-proline(AcSDKP) 濃度は治療の有効性を反映している.2016
- Author(s)
  立松尚衞, 永谷祐子, 川口洋平, 井之上浩一, 浅井清文, 大塚隆信.
- Organizer
  第89回日本整形外科学会学術集会.
- Place of Presentation
  パシフィコ横浜 (神奈川県, 横浜市)
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] 関節リウマチ線維芽細胞様滑膜細胞においてTNF alfaによるグリオスタチンの発現は JAK阻害剤により抑制される.2016
- Author(s)
  川口洋平, 永谷祐子, 小林正明, 後藤英之, 野崎正浩, 青山峰芳, 浅井清文, 大塚隆信.
- Organizer
  第160回名古屋市立大学医学会例会.
- Place of Presentation
  名古屋市立大学大学院医学研究科研究棟 (愛知県 .名古屋市)
- Year and Date
  2016-06-20
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] トファシチニブ投与RA患者の臨床像と血清グリオスタチンへの影響の検討.2016
- Author(s)
  川口洋平, 永谷祐子, 立松尚衛, 小林正明, 後藤英之, 野崎正浩, 小栗雄介, 浅井清文, 大塚隆信.
- Organizer
  第60回日本リウマチ学会総会・学術集会.
- Place of Presentation
  パシフィコ横浜 (神奈川県, 横浜市)
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] トファシチニブ投与RA患者の臨床像と血清グリオスタチンへの影響の検討.2016
- Author(s)
  川口洋平, 永谷祐子, 立松尚衛, 小林正明, 後藤英之, 野崎正浩, 小栗雄介, 浅井清文, 大塚隆信.
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜, 横浜
- Year and Date
  2016-04-22
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] Sp1 interference prevents joint destruction of RA through inhibitory effects of gliostatin and matrix metalloproteinase-3.2016
- Author(s)
  Ikuta K, Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology (EULAR2016)
- Place of Presentation
  ExCel London, London (United Kingdom)
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] グリオスタチン発現抑制はリウマチ滑膜細胞に対するJAK阻害剤の新規作用機序である.2016
- Author(s)
  川口洋平, 永谷祐子, 立松尚衞, 小林正明, 後藤英之, 野崎正浩, 青山峰芳, 浅井清文, 大塚隆信.
- Organizer
  第31回日本整形外科基礎学術集会
- Place of Presentation
  福岡国際会議場 (福岡県, 福岡市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] The JAK inhibitor (Tofacitinib) inhibits TNF-induced gliostatin/thymidine phosphorylase expression in human fibroblast-like synoviocytes.2015
- Author(s)
  Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Ikuta K, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology (EULAR2016)
- Place of Presentation
  ExCel London, London, United Kingdom)
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] 関節リウマチ線維芽細胞様滑膜細胞においてTNF-によるグリオスタチン発現はJAK阻害剤により抑制される.2015
- Author(s)
  川口洋平,　永谷祐子, 立松尚衛, 小林正明, 後藤英之，野崎正浩, 青山峰芳, 浅井清文, 大塚隆信.
- Organizer
  第30回日本整形外科基礎学術集会
- Place of Presentation
  富山国際会議場, 富山
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] The inhibitory effect of synthetic disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes.2015
- Author(s)
  Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Ikuta K, Aoyama M, Asai K, Otsuka T
- Organizer
  Annual European Congress of Rheumatology (EULAR2015)
- Place of Presentation
  Fiera Roma, Roma, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] A Role For P38 Mitogen-Activated Protein Kinase (Mapk) In Gliostatin Production In Rheumatoid Fibroblast-Like Synoviocytes.2015
- Author(s)
  Ikuta K, Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology (EULAR2015)
- Place of Presentation
  Fiera Roma, Roma, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] A Role For P38 Mitogen-Activated Protein Kinase (Mapk) In Gliostatin Production In Rheumatoid Fibroblast-Like Synoviocytes.
- Author(s)
  Ikuta K, Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Fiera Roma (Roma, Italy)
- Year and Date
  2015-06-10 – 2015-06-13
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] The inhibitory effect of synthetic disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes.
- Author(s)
  Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Ikuta K, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Fiera Roma (Roma, Italy)
- Year and Date
  2015-06-10 – 2015-06-13
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] 液体クロマトグラフィー・タンデム質量分析法による関節リウマチ患者の血清中AcSDKPの検討.
- Author(s)
  立松直衛, 永谷祐子, 川口洋平, 菊池可絵, 青山峰芳, 井之上浩一, 浅井清文, 大塚隆信.
- Organizer
  第29回日本整形外科基礎学術集会
- Place of Presentation
  城山観光ホテル (鹿児島県、鹿児島市)
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] The importance of gliostatin as an indicator of disease activity in patients with rheumatoid arthritis.
- Author(s)
  Ikuta K, Waguri-Nagaya Y, Tatematsu N, Kawaguchi Y, Kobayashi M, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Le Palais des Congres de Paris (Paris, France)
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26462309
[Presentation] Gliostatin regulates vascular endothelial growth-factor production in human fibroblast-like synoviocytes.
- Author(s)
  Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Kobayashi M, Goto H, Nozaki M, Ikuta K, Aoyama M, Asai K, Otsuka T.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Le Palais des Congres de Paris (Paris, France)
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26462309

1. NAGAYA Yuko (90291583)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 浅井清文 (70212462)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
3. OGURI Yusuke (80528969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. Okamoto Hideki (00453069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 大塚隆信 (10185316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
6. 黒柳元 (80790831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. 野崎正浩 (00509309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. 米津大貴 (20893209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 青山峰芳 (70363918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. TATEMATSU Naoe

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
11. KAKITA Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 和栗祐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 53 results
13. 青木啓将

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kawaguchi Yohei 川口 洋平

KAWAGUCHI Yohei 川口 洋平

Research Projects

Research Products

Co-Researchers

Molecular mechanisms of gliostatin and bone metabolic factors in bone erosions of rheumatoid arthritis

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RA関節破壊の制圧に向けた、新規治療ターゲットとしてのグリオスタチンの可能性Principal Investigator

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Developing novel rheumatoid arthritis treatments through gliostatin regulation targeting transcription factors

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Regeneration of the nail -development of the new treatment for nail deficiency using nail stem cell-

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The role and potential of gliostatin as a new therapeutic molecular target in rheumatoid arthritisPrincipal Investigator

Principal Investigator

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Review Section

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Molecular mechanism of gliostatin and tenascin C in rheumatoid synoviocytes

Principal Investigator

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Review Section

Research Institution

Gliostatin as a novel therapeutic target for rheumatoid arthritis

Principal Investigator

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Research Institution

[Journal Article] Nerve Recovery and Morphological Change on MRI at 24 Months after Open Carpal Tunnel Release.2023

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[Journal Article] IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells2023

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[Journal Article] Transforming Growth Factor-β Induces Interleukin-6 Secretion from Human Ligamentum Flavum-Derived Cells through Partial Activation of p38 and p44/42 Mitogen-Activated Protein Kinases2023

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[Journal Article] Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia2022

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[Journal Article] ―運動・食生活・社会参加の自由記述調査から―2022

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[Journal Article] The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes2022

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Kawaguchi Yohei 川口洋平

KAWAGUCHI Yohei 川口洋平