Furugen Ayako 古堅彩子

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FURUGEN Ayako 古堅彩子

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Researcher Number	90767261
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 准教授
Affiliation (based on the past Project Information) *help	2024: 慶應義塾大学, 薬学部(芝共立), 准教授 2016 – 2023: 北海道大学, 薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 0801:Pharmaceutical sciences and related fields / Medical pharmacy Except Principal Investigator Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator 胎盤 / トロホブラスト / トランスポーター / バルプロ酸 / ラモトリギン / トランスポータ / 抗てんかん薬 / 薬物 / ヒト胎盤幹細胞 / Syncytiotrophoblast … More / MRP / BCRP / P-gp / 薬物治療 / 妊娠 / 睡眠薬 / 抗不安薬 / trophoblast / ホルモン / 分化 / Benzodiazepine / 抗不安・睡眠薬 / Trophoblast / 脳機能リスク / 妊娠ラット / 医療系薬学 / 新規抗てんかん薬 / 葉酸 / ガバペンチン … More Except Principal Investigator 周産期 / 精神神経科系薬剤 Less

周産期の安全な精神神経科系薬剤の服薬支援のためのエビデンス構築
- Principal Investigator
  
  小林正紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hokkaido University
胎盤幹細胞由来syncytiotrophoblastを用いた薬物の胎盤通過性評価とメカニズムの解明Principal Investigator
- Principal Investigator
  
  古堅彩子
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Hokkaido University
Risk assessment of the use of anti-anxiety and hypnotic drug during pregnancy on placental trophoblastic functionsPrincipal Investigator
- Principal Investigator
  
  Furugen Ayako
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hokkaido University
Antiepileptic drug risk assessment and harm reduction strategy for fetal brain function: Focus on cross-placental substance exchangePrincipal Investigator
- Principal Investigator
  
  Furugen Ayako
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hokkaido University
Transport mechanism of antiepileptic drugs in the placenta and multidirectional approaches for risk reduction to the fetusPrincipal Investigator
- Principal Investigator
  
  FURUGEN Ayako
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Effects of valproic acid on syncytialization in human placental trophoblast cell lines2023
- Author(s)
  Nanami Ohyama、Ayako Furugen、Riko Sawada、Ryoichi Aoyagi、Ayako Nishimura、Takeshi Umazume、Katsuya Narumi、Masaki Kobayashi
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 474 Pages: 116611-116611
- DOI
  10.1016/j.taap.2023.116611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07149
[Journal Article] Cellular uptake properties of lamotrigine in human placental cell lines: Investigation of involvement of organic cation transporters (SLC22A1-5)2020
- Author(s)
  Nami Hasegawa, Ayako Furugen, Kanako Ono, Mai Koishikawa, Yuki Miyazawa, Ayako Nishimura, Takeshi Umazume, Katsuya Narumi, Masaki Kobayashi, Ken Iseki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: - Issue: 3 Pages: 266-273
- DOI
  10.1016/j.dmpk.2020.01.005
- NAID
  120006954276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14972
[Journal Article] Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding2020
- Author(s)
  古堅　彩子
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 10 Pages: 1199-1206
- DOI
  10.1248/yakushi.20-00140
- NAID
  130007920215
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2020-10-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07149
[Journal Article] Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period2020
- Author(s)
  Naoko Jinno, Ayako Furugen, Yuko Kurosawa, Yuki Kanno, Katsuya Narumi, Masaki Kobayashi, Ken Iseki
- Journal Title
  
  Reproductive Toxicology
  
  Volume: - Pages: 47-56
- DOI
  10.1016/j.reprotox.2020.04.077
- NAID
  120007034041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14972
[Journal Article] Valproic acid transport in the choriocarcinoma placenta cell line JEG-3 proceeds independently of the proton-dependent transporters MCT1 and MCT42018
- Author(s)
  Yuri Ishiguro, Ayako Furugen, Katsuya Narumi, Ayako Nishimura, Takeshi Hirano, Masaki Kobayashi, Ken Iseki.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 印刷中 Issue: 6 Pages: 270-274
- DOI
  10.1016/j.dmpk.2018.03.004
- NAID
  210000170209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18929, KAKENHI-PROJECT-16K08408
[Journal Article] Involvement of L-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells.2017
- Author(s)
  Furugen A, Ishiguro Y, Kobayashi M, Narumi K, Nishimura A, Hirano T, Iseki K.
- Journal Title
  
  Reproductive Toxicology
  
  Volume: 67 Pages: 48-55
- DOI
  10.1016/j.reprotox.2016.11.002
- NAID
  120006727626
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K18929
[Presentation] 定量・毒性解析を基盤とした、妊娠・授乳期の薬物治療における安全性評価2024
- Author(s)
  古堅彩子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-20K07149
[Presentation] ヒト胎盤幹細胞におけるトランスポーター発現・機能評価2024
- Author(s)
  澤田理子, 古堅彩子, 植田彩文, 西村あや子, 馬詰武, 鳴海克哉, 岡本敬介, 小林正紀
- Organizer
  日本薬学会北海道支部第151 回例会
- Data Source
  KAKENHI-PROJECT-23K19417
[Presentation] 定量・毒性解析を基盤とした、妊娠・授乳期の薬物治療における安全性評価2024
- Author(s)
  古堅彩子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K19417
[Presentation] 周産期における精神神経疾患治療への貢献を目指した医療薬科学研究2023
- Author(s)
  古堅彩子
- Organizer
  第17回次世代を担う若手のための医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K19417
[Presentation] 周産期における精神神経疾患治療への貢献を目指した医療薬科学研究2023
- Author(s)
  古堅彩子
- Organizer
  第17回次世代を担う若手のための医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07149
[Presentation] 胎盤Trophoblastの分化・ホルモン分泌機能に着目した薬剤の影響評価2022
- Author(s)
  大山七海、古堅彩子、澤田理子、西村あや子、鳴海克哉、小林正紀
- Organizer
  第32回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-20K07149
[Presentation] Risk assessment of the use of antiepileptic drugs during pregnancy on placental trophoblastic functions2021
- Author(s)
  Ayako Furugen, Nanami Ohyama, Yuki Miyazawa, Mai Koishikawa, Naoko Jinno, Kanako Ono, Yuko Kurosawa, Nami Hasegawa, Katsuya Narumi, Masaki Kobayashi
- Organizer
  第15回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07149
[Presentation] バルプロ酸が胎盤SLCトランスポーター発現に及ぼす影響――妊娠期と性別による解析2019
- Author(s)
  神野菜緒子、古堅彩子、黒澤優子、菅野裕希、鳴海克哉、小林正紀、井関健
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18K14972
[Presentation] 多価不飽和脂肪酸が胎盤細胞のトランスポーター発現に及ぼす影響2019
- Author(s)
  小野　佳菜子、古堅　彩子、黒澤　優子、神野　菜緒子、鳴海　克哉、小林　正紀、井関　健
- Organizer
  日本薬学会北海道支部第146回例会
- Data Source
  KAKENHI-PROJECT-18K14972
[Presentation] バルプロ酸がラット胎盤ABCトランスポーター発現に及ぼす影響2019
- Author(s)
  神野菜緒子、古堅彩子、黒澤優子、菅野裕希、鳴海克哉、小林正紀、井関健
- Organizer
  日本薬学会北海道支部第146回例会
- Data Source
  KAKENHI-PROJECT-18K14972
[Presentation] 胎盤細胞への葉酸輸送に及ぼす抗てんかん薬の影響の評価2018
- Author(s)
  黒澤優子, 古堅彩子, 西村あや子, 鳴海克哉, 小林正紀, 井関健
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-16K18929
[Presentation] ヒト胎盤絨毛癌由来細胞におけるラモトリギンの輸送機構2018
- Author(s)
  長谷川奈美、古堅彩子、黒澤優子、西村あや子、鳴海克哉、小林正紀、井関健
- Organizer
  第32回北海道薬物作用談話会
- Data Source
  KAKENHI-PROJECT-18K14972
[Presentation] ヒト胎盤絨毛癌由来JEG-3 細胞におけるバルプロ酸の輸送機構2017
- Author(s)
  石黒由梨, 古堅彩子, 西村あや子, 小林正紀, 鳴海克哉, 井関健
- Organizer
  日本薬学会　第137年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K18929
[Presentation] Involvement of L-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells2017
- Author(s)
  Ayako Furugen, Yuri Ishiguro, Masaki Kobayashi, Katsuya Narumi, Ayako Nishimura, Ken Iseki.
- Organizer
  2017 紫禁城国際薬剤師フォーラム (北京)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18929
[Presentation] 母体―胎児間および母体―乳児間の物質輸送に着目した、中枢神経系用薬の適正使用に向けた研究2017
- Author(s)
  古堅　彩子
- Organizer
  第1回薬学会北海道支部主催若手シンポジウム (札幌)
- Data Source
  KAKENHI-PROJECT-16K18929
[Presentation] THE TRANSPORT MECHANISM OF NEWER ANTIEPILEPTIC DRUGS IN PLACENTAL CELLS : INVOLVEMENT OF L-TYPE AMINO ACID TRANSPORTER 1 IN THE TRANSPORT OF GABAPENTIN2016
- Author(s)
  Furugen A, Ishiguro Y, Kobayashi M, Narumi K, Nishimura A, Iseki K.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール (長野県松本市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K18929

1. 小林正紀 (70431319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 石川修平 (30880091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Furugen Ayako 古堅 彩子

FURUGEN Ayako 古堅 彩子

Research Projects

Research Products

Co-Researchers

周産期の安全な精神神経科系薬剤の服薬支援のためのエビデンス構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胎盤幹細胞由来syncytiotrophoblastを用いた薬物の胎盤通過性評価とメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Risk assessment of the use of anti-anxiety and hypnotic drug during pregnancy on placental trophoblastic functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Antiepileptic drug risk assessment and harm reduction strategy for fetal brain function: Focus on cross-placental substance exchangePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transport mechanism of antiepileptic drugs in the placenta and multidirectional approaches for risk reduction to the fetusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of valproic acid on syncytialization in human placental trophoblast cell lines2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular uptake properties of lamotrigine in human placental cell lines: Investigation of involvement of organic cation transporters (SLC22A1-5)2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Valproic acid transport in the choriocarcinoma placenta cell line JEG-3 proceeds independently of the proton-dependent transporters MCT1 and MCT42018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Involvement of L-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 定量・毒性解析を基盤とした、妊娠・授乳期の薬物治療における安全性評価2024

Author(s)

Organizer

Data Source

[Presentation] ヒト胎盤幹細胞におけるトランスポーター発現・機能評価2024

Author(s)

Organizer

Furugen Ayako 古堅彩子

FURUGEN Ayako 古堅彩子

[Presentation] 母体―胎児間および母体―乳児間の物質輸送に着目した、中枢神経系用薬の適正使用に向けた研究2017