Shimonaka Shotaro 下中翔太郎

Researcher Number	90778747
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主任研究員 2025: 順天堂大学, 大学院医学研究科, 非常勤助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 特任助教 2020: 順天堂大学, 医学(系)研究科(研究院), 特任助教 2017 – 2020: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / General medical chemistry
Keywords	Principal Investigator Tauopathy / Tau / 凝集 / 異常凝集 / Tau strain / タンパク凝集 / Alzheimer病 / tau-strain / seed / 進行性核上性麻痺 … More / 皮質基底核変性症 / Tau-strain / strain / tau凝集 / tauopathy / tau / アルツハイマー病 / 伝播 / PICALM / Seed / Aggregation Less

Tauopathyにおける構造多型に着目したtau凝集の特異的阻害法開発Principal Investigator
- Principal Investigator
  
  下中翔太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
The role of the specific tau sequence on the formation of tau strainPrincipal Investigator
- Principal Investigator
  
  Shimonaka Shotaro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
The role of Alzheimer's disease risk factor PICALM on the propagation of Tau aggregatesPrincipal Investigator
- Principal Investigator
  
  Shimonaka Shotaro
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Juntendo University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates2024
- Author(s)
  Imtiaz Ahmed、Shimonaka Shotaro、Uddin Mohammad Nasir、Elahi Montasir、Ishiguro Koichi、Hasegawa Masato、Hattori Nobutaka、Motoi Yumiko
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 16 Pages: 01-15
- DOI
  10.3389/fnagi.2024.1368291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07428, KAKENHI-PROJECT-20K16160
[Journal Article] α-Synuclein V15A variant in familial Parkinson's disease exhibits a weaker lipid-binding property.2022
- Author(s)
  Daida K, Shimonaka S, Shiba-Fukushima K, Ogata J, Yoshino H, Okuzumi A, Hatano T, Motoi Y, Hirunagi T, Katsuno M, Shindou H, Funayama M, Nishioka K, Hattori N, Imai Y.
- Journal Title
  
  Mov Disord.
  
  Volume: 37 Issue: 10 Pages: 2075-2085
- DOI
  10.1002/mds.29162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21K07424, KAKENHI-PROJECT-22K07542, KAKENHI-PROJECT-20K16160, KAKENHI-PROJECT-22K15649, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-21K19443
[Journal Article] Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer’s Disease Brain Extract in Mouse Brains2021
- Author(s)
  Tetsuo Hayashi, Shotaro Shimonaka, Montasir Elahia, Shin-Ei Matsumoto, Koichi Ishiguro, Masashi Takanashi, Nobutaka Hattori and Yumiko Motoi
- Journal Title
  
  Journal of Alzheimer’s Disease
  
  Volume: 79 Issue: 4 Pages: 1701-1711
- DOI
  10.3233/jad-201002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07456, KAKENHI-PROJECT-17K15606, KAKENHI-PROJECT-20K16160
[Journal Article] High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology2021
- Author(s)
  Elahi Montasir、Motoi Yumiko、Shimonaka Shotaro、Ishida Yoko、Hioki Hiroyuki、Takanashi Masashi、Ishiguro Koichi、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Issue: 18 Pages: 1693-1710
- DOI
  10.1093/hmg/ddab115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-20K16160
[Journal Article] Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy2021
- Author(s)
  Mohammad Nasir Uddin , Montasir Elahi, Shotaro Shimonaka, Soichiro Kakuta, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 543 Pages: 65-71
- DOI
  10.1016/j.bbrc.2020.12.113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07456, KAKENHI-PROJECT-17K15606, KAKENHI-PROJECT-20K16160
[Journal Article] Seeding Assay Using Cultured Cells2021
- Author(s)
  Ogata Jun、Takemoto Daisaku、Shimonaka Shotaro、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2322 Pages: 27-39
- DOI
  10.1007/978-1-0716-1495-2_3
- ISBN
  9781071614945, 9781071614952
- Data Source
  KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-20K16160
[Journal Article] Astrocytic 3-Repeat Tau Pathologies in Progressive Supranuclear Palsy2020
- Author(s)
  Taniguchi Daisuke、Takanashi Masashi、Hatano Taku、Kishikawa Satsuki、Shimonaka Shotaro、Motoi Yumiko、Yao Takashi、Hattori Nobutaka
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 79 Issue: 9 Pages: 1015-1018
- DOI
  10.1093/jnen/nlaa073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16160, KAKENHI-PROJECT-17K15606
[Journal Article] Asparagine residue 368 is involved in Alzheimer's disease tau strain specific aggregation2020
- Author(s)
  Shimonaka Shotaro、Matsumoto Shin-Ei、Elahi Montasir、Ishiguro Koichi、Hasegawa Masato、Hattori Nobutaka、Motoi Yumiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 41 Pages: 13996-14014
- DOI
  10.1074/jbc.ra120.013271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16160, KAKENHI-PROJECT-17K15606
[Presentation] Tau-strainを区別する人工変異導入tauが持つ凝集阻害効果の検証2023
- Author(s)
  下中翔太郎, 石黒幸一, 中村衣里, 多田昇弘, 本井ゆみ子, 服部信孝
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16160
[Presentation] Tau-strainの分子病理と凝集阻害戦略2022
- Author(s)
  下中翔太郎、石黒幸一、本井ゆみ子、服部信孝
- Organizer
  第41回　日本認知症学会学術集会、シンポジウム(日本語、口頭発表)
- Data Source
  KAKENHI-PROJECT-20K16160
[Presentation] Identification of the residue of tau involved in tauopathy strain formation2022
- Author(s)
  Shotaro Shimonaka, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori
- Organizer
  第41回　日本認知症学会学術集会、ポスター発表(英語、学会奨励賞候補演題)
- Data Source
  KAKENHI-PROJECT-20K16160
[Presentation] Identification of the amino-acid residue of tau involved in four-repeat tauopathy strain formation2022
- Author(s)
  Shotaro Shimonaka, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori
- Organizer
  第63回　日本神経学会学術大会、展示 (英語)
- Data Source
  KAKENHI-PROJECT-20K16160
[Presentation] Asparagine residue 368 is involved in Alzheimer’s disease tau strain-specific aggregation2021
- Author(s)
  Shotaro Shimonaka, Montasir Elahi, Shin-Ei Matsumoto, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi
- Organizer
  第62回　日本神経病理学会総会学術集会
- Data Source
  KAKENHI-PROJECT-20K16160
[Presentation] Asparagine residue 368 is involved in Alzheimer’s disease tau strain-specific aggregation2020
- Author(s)
  Shotaro Shimonaka, Montasir Elahi, Shin-Ei Matsumoto, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi
- Organizer
  Alzheimer’s Association International Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15606
[Presentation] Asparagine residue 368 is involved in Alzheimer’s disease tau strain-specific aggregation2020
- Author(s)
  Shotaro Shimonaka, Montasir Elahi, Shin-Ei Matsumoto, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi
- Organizer
  Alzheimer’s Association International Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16160
[Presentation] TauのAsn368変異はアルツハイマー病由来seedによる凝集のみを低下させる2019
- Author(s)
  下中翔太郎、Elahi Montasir、松本信英、石黒幸一、本井ゆみ子、服部信孝
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15606
[Presentation] TauのC末端領域における凝集責任配列の同定とその性質の解析2018
- Author(s)
  下中翔太郎、松本信英、本井ゆみ子、服部信孝
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15606
[Presentation] The Identification of the Tau C-terminal Sequences Involved in Aggregates Formation.2018
- Author(s)
  Shotaro Shimonaka, Shin-ei Matsumoto, Yumiko Motoi, Nobutaka Hattori
- Organizer
  Society for Neuroscience 2018 annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15606
[Presentation] Tauopathy培養細胞モデルを用いたTauの凝集・伝播に関わるアミノ酸配列の同定2017
- Author(s)
  下中翔太郎、松本信英、本井ゆみ子、服部信孝
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15606

1. 本井ゆみ子 (60338407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. KAHORI Shiba

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 今居譲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 服部信孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimonaka Shotaro 下中 翔太郎

Research Projects

Research Products

Co-Researchers

Tauopathyにおける構造多型に着目したtau凝集の特異的阻害法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of the specific tau sequence on the formation of tau strainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Alzheimer's disease risk factor PICALM on the propagation of Tau aggregatesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] α-Synuclein V15A variant in familial Parkinson's disease exhibits a weaker lipid-binding property.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer’s Disease Brain Extract in Mouse Brains2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Seeding Assay Using Cultured Cells2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Astrocytic 3-Repeat Tau Pathologies in Progressive Supranuclear Palsy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Asparagine residue 368 is involved in Alzheimer's disease tau strain specific aggregation2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Tau-strainを区別する人工変異導入tauが持つ凝集阻害効果の検証2023

Author(s)

Organizer

Data Source

[Presentation] Tau-strainの分子病理と凝集阻害戦略2022

Author(s)

Organizer

Data Source

[Presentation] Identification of the residue of tau involved in tauopathy strain formation2022

Author(s)

Organizer

Data Source

[Presentation] Identification of the amino-acid residue of tau involved in four-repeat tauopathy strain formation2022

Author(s)

Organizer

Data Source

[Presentation] Asparagine residue 368 is involved in Alzheimer’s disease tau strain-specific aggregation2021

Shimonaka Shotaro 下中翔太郎