Higashi Katsumasa 東克匡

Researcher Number	90778846
Affiliation (based on the past Project Information) *help	2016 – 2017: 九州大学, 大学病院, 後期研修医 2016: 九州大学, 歯学研究科(研究院), 医員
Review Section/Research Field	Principal Investigator Periodontology Except Principal Investigator Conservative dentistry
Keywords	Principal Investigator 歯周組織再生 / Runx2 / Smad1/5/8 / RhoA/ROCKシグナル / S1PR2シグナル Except Principal Investigator 脂肪細胞 / 骨芽細胞 / 間葉系幹細胞分化制御 / 脂質メディエーター / Wnt5a … More / 骨組織 / 未分化間葉系幹細胞 / スフィンゴシン-1-リン酸 / 分化 / 骨 Less

脂質メディエーターによる新たな骨形成促進機序の解明と歯周組織再生療法への応用Principal Investigator
- Principal Investigator
  
  東克匡
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Periodontology
- Research Institution
  Kyushu University
Molecular mechanism of sphingosine-1-phosphate-modulated MSC differentiation for hard tissue regenerative therapy
- Principal Investigator
  
  Matsuzaki Etsuko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Fukuoka Dental College

All 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts2016
- Author(s)
  Higashi, K., Matsuzaki, E., Hashimoto, Y., Takahashi-Yanaga, F., Takano, A., Anan, H., Hirata, M. and Nishimura, F.
- Journal Title
  
  Bone
  
  Volume: 93 Pages: 1-11
- DOI
  10.1016/j.bone.2016.09.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229009, KAKENHI-PROJECT-16H07066, KAKENHI-PROJECT-26462886, KAKENHI-PROJECT-26670824
[Journal Article] Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells2016
- Author(s)
  Hashimoto, Y,. Kobayashi, M., Matsuzaki, E., Higashi, K., Takahashi-Yanaga, F., Takano, A., Hirata, M. and Nishimura, F.
- Journal Title
  
  Cell Biol. Int.
  
  Volume: 40 Issue: 10 Pages: 1129-1136
- DOI
  10.1002/cbin.10652
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229009, KAKENHI-PROJECT-26462886, KAKENHI-PROJECT-26670824
[Journal Article] Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte.2015
- Author(s)
  Hashimoto Y, Matsuzaki E, Higashi K, Takahashi-Yanaga F, Takano A, Hirata M, Nishimura F.
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 401(1-2) Issue: 1-2 Pages: 39-47
- DOI
  10.1007/s11010-014-2290-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462886, KAKENHI-PROJECT-24229009
[Presentation] 骨形成における新規S1PR2/Smad1/5/8シグナル伝達経路の役割2017
- Author(s)
  松﨑英津子, 東　克匡, 橋本陽子,西村英紀, 阿南　壽
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] A novel S1PR1/R2 signaling induces osteoblast differentiation2016
- Author(s)
  Matsuzaki E, Hashimoto Y, Higashi K, Takano A, Nishimura F, Anan H
- Organizer
  IADR/PBRG
- Place of Presentation
  名古屋市
- Year and Date
  2016-06-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] スフィンゴシン-1-リン酸受容体2作動薬による骨形成促進作用とそのメカニズム2016
- Author(s)
  松崎英津子, 東　克匡, 橋本陽子,阿南　壽
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子市
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] スフィンゴシン-1-リン酸による骨芽細胞分化促進メカニズム2016
- Author(s)
  松﨑英津子, 橋本陽子, 東克匡, 高野愛子, 西村英紀, 阿南壽
- Organizer
  第23回日本歯科医学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-10-21
- Data Source
  KAKENHI-PROJECT-16H07066
[Presentation] スフィンゴシン-1-リン酸による骨芽細胞分化促進メカニズム2016
- Author(s)
  松崎英津子, 橋本陽子, 東　克匡, 高野愛子, 西村英紀, 阿南　壽
- Organizer
  第23回日本歯科医学会総会
- Place of Presentation
  福岡市
- Year and Date
  2016-10-21
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] S1PR1/R2 を介した新たなS1Pシグナル伝達経路は骨芽細胞分化を促進する2016
- Author(s)
  松﨑英津子, 橋本陽子, 東　克匡, 阿南　壽, 西村英紀
- Organizer
  第89回日本薬理学会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] 新規スフィンゴシン-1-リン酸シグナル伝達経路によるSmad1/5/8リン酸化促進2015
- Author(s)
  東　克匡, 松﨑英津子, 橋本陽子, 高野愛子, 西村英紀
- Organizer
  日本歯科保存学会2015年度春季学術大会（第142回）
- Place of Presentation
  北九州市
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] 骨芽細胞分化に関わるS1Pシグナル伝達経路の解析2015
- Author(s)
  松﨑英津子, 橋本陽子, 東　克匡, 高野愛子, 西村英紀, 阿南　壽
- Organizer
  第42回福岡歯科大学学会総会
- Place of Presentation
  福岡市
- Year and Date
  2015-12-13
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] The involvement of Wnt5a in sphingosine-1-phosphate-modulated mesenchymal stem cell differentiation into osteoblast2015
- Author(s)
  Hashimoto Y, Matsuzaki E, Higashi K, Takano A, Nishimura F
- Organizer
  第58回日本歯周病学会秋季学術大会（国際セッション）
- Place of Presentation
  浜松市
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] スフィンゴシン-1-リン酸によるC3H10T1/2細胞における脂肪細胞分化における分化抑制機構の解明
- Author(s)
  橋本陽子，松﨑英津子，東　克匡，高野愛子，西村英紀
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] 骨芽細胞におけるBMP-2シグナル伝達経路に関与するスフィンゴシン-1-リン酸(S1P)受容体の検索
- Author(s)
  東　克匡，松﨑英津子，橋本陽子，西村英紀
- Organizer
  日本歯科保存学会 2014年度春季学術大会（第140回）
- Place of Presentation
  滋賀県立芸術劇場びわ湖ホール（滋賀県大津市）
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] 未分化間葉系幹細胞の脂肪細胞分化における脂質メディエーターの役割
- Author(s)
  橋本陽子，松﨑英津子，東　克匡，高野愛子，西村英紀
- Organizer
  第57回春季日本歯周病学会学術大会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26462886
[Presentation] スフィンゴシン-1-リン酸(S1P)はS1PR2受容体を介して骨芽細胞におけるSmad1/5/8リン酸化及びRunx2発現を促進する
- Author(s)
  東　克匡，松﨑英津子，橋本陽子，西村英紀
- Organizer
  日本歯科保存学会 2014年度秋季学術大会（第141回）
- Place of Presentation
  山形テルサ（山形県山形市）
- Year and Date
  2014-10-30 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-26462886

1. Matsuzaki Etsuko (20432924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. Higashi Yoko (90755042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 高橋富美 (50274436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 西村英紀 (80208222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
5. 橋本陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 13 results
6. 平田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 弥永富美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higashi Katsumasa 東 克匡

Research Projects

Research Products

Co-Researchers

脂質メディエーターによる新たな骨形成促進機序の解明と歯周組織再生療法への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of sphingosine-1-phosphate-modulated MSC differentiation for hard tissue regenerative therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 骨形成における新規S1PR2/Smad1/5/8シグナル伝達経路の役割2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] A novel S1PR1/R2 signaling induces osteoblast differentiation2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] スフィンゴシン-1-リン酸受容体2作動薬による骨形成促進作用とそのメカニズム2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] スフィンゴシン-1-リン酸による骨芽細胞分化促進メカニズム2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] スフィンゴシン-1-リン酸による骨芽細胞分化促進メカニズム2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] S1PR1/R2 を介した新たなS1Pシグナル伝達経路は骨芽細胞分化を促進する2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 新規スフィンゴシン-1-リン酸シグナル伝達経路によるSmad1/5/8リン酸化促進2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 骨芽細胞分化に関わるS1Pシグナル伝達経路の解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The involvement of Wnt5a in sphingosine-1-phosphate-modulated mesenchymal stem cell differentiation into osteoblast2015

Higashi Katsumasa 東克匡