Hayashi Yohei 林洋平

Researcher Number	90780130
Other IDs	https://orcid.org/0000-0001-5490-7052
Affiliation (Current)	2024: 国立研究開発法人理化学研究所, バイオリソース研究センター, チームリーダー
Affiliation (based on the past Project Information) *help	2018 – 2024: 国立研究開発法人理化学研究所, バイオリソース研究センター, チームリーダー 2020: 筑波大学, 医学医療系, 助教 2016 – 2017: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator General medical chemistry Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 43010:Molecular biology-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 48040:Medical biochemistry-related / Basic Section 43050:Genome biology-related / Medium-sized Section 28:Nano/micro science and related fields / General medical chemistry
Keywords	Principal Investigator 再生医学 / バイオテクノロジー / 細胞・組織 / 発現制御 / iPS細胞 / ゲノム / 染色体 / 染色体欠失 / 片親性ダイソミー / 染色体異常 … More / 蛋白質 / タンパク質工学 / KLF4 / タンパク質構造 / 転写因子 / リプログラミング … More Except Principal Investigator iPS細胞 / Klf4 / 転写因子 / 神経堤細胞 / 疾患特異的iPS細胞 / 量依存性 / エピジェネティクス / エピゲノム / 転写制御 / iPS / TRNT1 / 染色体欠失症候群 / 胆管発生 / 胆管上皮細胞 / CPM陽性肝前駆細胞 / 特性解析 / 全ゲノム解析 / 胆道閉鎖症 / pathophysiology / hepatic progenitor cell / whole genome analysis / BA specific iPS cell / biliary atresia / 22q11.2欠失症候群 / Nanog / X染色体再活性化 / KLF4 / 転写 / 多能性 / 画像解析 / ゲノム編集 / バーコーディング / 表現型解析 / サイトメトリー / ネットワーク化計測 / リプリログラミング / 代謝変換 / クロマチン / 遺伝子発現 / 間葉上皮転換 / INHAT / uORF / アポトーシス / X 染色体 / サイレンシング / EMT / iPS 細胞 / 細胞分化 / 間葉上皮変換 / MET / XCR / リプログラミング / レトロウイルス / X染色体 / 代謝 / センダイウイルス / 再生医学 Less

Genomic conformational changes in a pathological model using iPS cells derived from patients with chromosome deletion syndrome
- Principal Investigator
  
  高崎真美
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Institute of Physical and Chemical Research
Research for the Pathological Understanding and Therapeutic Development of SIFD Using iPS Cells
- Principal Investigator
  
  長森恒久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Asahikawa Medical College
Cell fate decision by dose of transcription factors
- Principal Investigator
  
  西村健
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  University of Tsukuba
Phenotypic screening of genome-edited Induced pluripotent stem cells
- Principal Investigator
  
  太田禎生
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  The University of Tokyo
22q11.2症候群特異的iPS細胞由来神経堤の病態モデルでのゲノム編集応用
- Principal Investigator
  
  高崎真美
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of bile duct development and its disorder mechanism using biliary atresia-specific iPS cells
- Principal Investigator
  
  Suzuki Kan
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Dokkyo Medical University
  The University of Tokyo
Molecular dynamics of epigenomic transcriptional regulation by Klf4 in iPSC generation
- Principal Investigator
  
  Nishimura Ken
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  University of Tsukuba
Reprogramming of cell morphology and functions by Klf4 during iPSC generation
- Principal Investigator
  
  Hisatake Koji
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  University of Tsukuba
Development of chromosome editingPrincipal Investigator
- Principal Investigator
  
  Hayashi Yohei
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Institute of Physical and Chemical Research
  University of Tsukuba
KLF4DNA結合部位アミノ酸残基の機能解析から改良リプログラミング因子の開発Principal Investigator
- Principal Investigator
  
  林洋平
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  University of Tsukuba

All 2022 2021 2020 2019 2018 2016

All Journal Article Presentation

[Journal Article] Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming2022
- Author(s)
  Aizawa Shiho、Nishimura Ken、Mondejar Gonzalo Seminario、Kumar Arun、Bui Phuong Linh、Tran Yen Thi Hai、Kuno Akihiro、Muratani Masafumi、Kobayashi Shin、Nabekura Tsukasa、Shibuya Akira、Sugihara Eiji、Sato Taka-Aki、Fukuda Aya、Hayashi Yohei、Hisatake Koji
- Journal Title
  
  Stem Cell Reports
  
  Volume: 17 Issue: 1 Pages: 53-67
- DOI
  10.1016/j.stemcr.2021.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02678, KAKENHI-PROJECT-19H03203
[Journal Article] Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming2022
- Author(s)
  Anh Le Phuong Hoang、Nishimura Ken、Kuno Akihiro、Linh Nguyen Thuy、Kato Tetsuo、Ohtaka Manami、Nakanishi Mahito、Sugihara Eiji、Sato Taka-Aki、Hayashi Yohei、Fukuda Aya、Hisatake Koji
- Journal Title
  
  Stem Cells
  
  Volume: 40 Issue: 4 Pages: 397-410
- DOI
  10.1093/stmcls/sxac012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02678, KAKENHI-PROJECT-19H03203
[Journal Article] Generation of human induced pluripotent stem cell lines derived from four DiGeorge syndrome patients with 22q11.2 deletion2022
- Author(s)
  Shimizu Tomoya、Matsuo-Takasaki Mami、Luijkx Dorian、Takami Miho、Arai Yutaka、Noguchi Michiya、Nakamura Yukio、Hayata Tadayoshi、Saito Megumu K.、Hayashi Yohei
- Journal Title
  
  Stem Cell Research
  
  Volume: 61 Pages: 102744-102744
- DOI
  10.1016/j.scr.2022.102744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03642, KAKENHI-PROJECT-21K06831, KAKENHI-PROJECT-23K21633
[Journal Article] Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency2022
- Author(s)
  Borisova Evgeniia、Nishimura Ken、An Yuri、Takami Miho、Li Jingyue、Song Dan、Matsuo-Takasaki Mami、Luijkx Dorian、Aizawa Shiho、Kuno Akihiro、Sugihara Eiji、Sato Taka-aki、Yumoto Fumiaki、Terada Tohru、Hisatake Koji、Hayashi Yohei
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 1 Pages: 103525-103525
- DOI
  10.1016/j.isci.2021.103525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02678, KAKENHI-PROJECT-19H03203
[Journal Article] Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations2021
- Author(s)
  Kuramochi Yuji、Awaya Tomonari、Matsuo-Takasaki Mami、Takami Miho、An Yuri、Li Jingyue、Hemmi Yasuko、Wakabayashi Tamami、Arai Yutaka、Inoue Jun、Noguchi Michiya、Nakamura Yukio、Asaka Isao、Akimoto Kazunori、Saito Megumu K.、Hayashi Yohei
- Journal Title
  
  Stem Cell Research
  
  Volume: 53 Pages: 102337-102337
- DOI
  10.1016/j.scr.2021.102337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03642, KAKENHI-PROJECT-17H05063
[Journal Article] Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion2020
- Author(s)
  Arai Yutaka、Takami Miho、An Yuri、Matsuo-Takasaki Mami、Hemmi Yasuko、Wakabayashi Tamami、Inoue Jun、Noguchi Michiya、Nakamura Yukio、Sugimoto Keisuke、Takemura Tsukasa、Okita Keisuke、Osafune Kenji、Takasato Minoru、Hayata Tadayoshi、Hayashi Yohei
- Journal Title
  
  Stem Cell Research
  
  Volume: 45 Pages: 101815-101815
- DOI
  10.1016/j.scr.2020.101815
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07887, KAKENHI-PROJECT-18K09053, KAKENHI-PROJECT-17H05063
[Journal Article] Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells2020
- Author(s)
  Hayashi Yohei、Takami Miho、Matsuo-Takasaki Mami
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 14 Pages: 224-224
- DOI
  10.3389/fncel.2020.00224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05063
[Journal Article] Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP7202019
- Author(s)
  Fukuda Aya、Honda Shiho、Fujioka Norie、Sekiguchi Yuya、Mizuno Seiya、Miwa Yoshihiro、Sugiyama Fumihiro、Hayashi Yohei、Nishimura Ken、Hisatake Koji
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 11 Pages: 0225213-0225213
- DOI
  10.1371/journal.pone.0225213
- NAID
  120007132627
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-17H05063
[Journal Article] Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells2019
- Author(s)
  Nishimura Ken、Ishiwata Hiroshi、Sakuragi Yuta、Hayashi Yohei、Fukuda Aya、Hisatake Koji
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1777-1777
- DOI
  10.1038/s41598-018-37779-x
- NAID
  120007128201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-16K07244, KAKENHI-PROJECT-17K19339
[Journal Article] Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming2019
- Author(s)
  Bui Phuong Linh、Nishimura Ken、Seminario Mondejar Gonzalo、Kumar Arun、Aizawa Shiho、Murano Kensaku、Nagata Kyosuke、Hayashi Yohei、Fukuda Aya、Onuma Yasuko、Ito Yuzuru、Nakanishi Mahito、Hisatake Koji
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 7 Pages: 1909-1922
- DOI
  10.1016/j.celrep.2019.10.010
- NAID
  120007127699
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-19J11416, KAKENHI-PROJECT-17K08644, KAKENHI-PROJECT-19H03203, KAKENHI-PROJECT-17H05063
[Journal Article] Live cell imaging of X chromosome reactivation during somatic cell reprogramming2018
- Author(s)
  Tran Thi Hai Yen、Fukuda Aya、Aizawa Shiho、Bui Phuong Linh、Hayashi Yohei、Nishimura Ken、Hisatake Koji
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 15 Pages: 86-92
- DOI
  10.1016/j.bbrep.2018.07.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-16K07244, KAKENHI-PROJECT-17K19339, KAKENHI-PROJECT-16K08610
[Journal Article] BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence2016
- Author(s)
  Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 113(46) Issue: 46 Pages: 13057-13062
- DOI
  10.1073/pnas.1603668113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08610, KAKENHI-PROJECT-16H06662
[Presentation] 非公表2020
- Author(s)
  林　洋平
- Organizer
  日本レーザー学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H05063
[Presentation] 非公表2019
- Author(s)
  林　洋平
- Organizer
  日本腎臓学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H05063
[Presentation] 非公表2019
- Author(s)
  林　洋平
- Organizer
  日本動物実験代替法学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H05063
[Presentation] KLF4-dose dependent metabolic shift through TCL1 during iPSC generation2018
- Author(s)
  Nishimura K, Kumar BA, Hayashi Y, Fukuda A, Hisatake K
- Organizer
  ISSCR2018
- Data Source
  KAKENHI-PROJECT-17H04036
[Presentation] Structure-based Discovery of NANOG Variant with Enhanced Properties to Promote Self-Renewal and Reprogramming of Pluripotent Stem Cells2016
- Author(s)
  Yohei Hayashi
- Organizer
  第39回日本分子生物学会大会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H06662

1. Nishimura Ken (80500610)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 福田綾 (50436276)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. 久野朗広 (60830122)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 高崎真美 (80392009)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Hisatake Koji (70271236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. Suzuki Kan (80598508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 太田禎生 (70731214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 木戸丈友 (00401034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤代準 (60528438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 長森恒久 (40400098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐藤雅之 (00624181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 甲賀大輔 (30467071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石羽澤映美 (90516402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAITOH Megumu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 高里実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Yohei 林 洋平

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of chromosome editingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

KLF4DNA結合部位アミノ酸残基の機能解析から改良リプログラミング因子の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of human induced pluripotent stem cell lines derived from four DiGeorge syndrome patients with 22q11.2 deletion2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations2021

Author(s)

Journal Title

DOI

Hayashi Yohei 林洋平