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Hayashi Yohei  林 洋平

Researcher Number 90780130
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-5490-7052
Affiliation (Current) 2025: 公益財団法人京都大学iPS細胞研究財団(研究開発センター), 研究開発センター, ユニット長
Affiliation (based on the past Project Information) *help 2018 – 2024: 国立研究開発法人理化学研究所, バイオリソース研究センター, チームリーダー
2020: 筑波大学, 医学医療系, 助教
2016 – 2017: 筑波大学, 医学医療系, 助教
Review Section/Research Field
Principal Investigator
General medical chemistry
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 43010:Molecular biology-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 48040:Medical biochemistry-related / Basic Section 43050:Genome biology-related / Medium-sized Section 28:Nano/micro science and related fields / General medical chemistry
Keywords
Principal Investigator
再生医学 / バイオテクノロジー / 細胞・組織 / 発現制御 / iPS細胞 / ゲノム / 染色体 / 染色体欠失 / 片親性ダイソミー / 染色体異常 … More / 蛋白質 / タンパク質工学 / KLF4 / タンパク質構造 / 転写因子 / リプログラミング … More
Except Principal Investigator
iPS細胞 / Klf4 / 転写因子 / 神経堤細胞 / 疾患特異的iPS細胞 / 量依存性 / エピジェネティクス / エピゲノム / 転写制御 / iPS / TRNT1 / 染色体欠失症候群 / 胆管発生 / 胆管上皮細胞 / CPM陽性肝前駆細胞 / 特性解析 / 全ゲノム解析 / 胆道閉鎖症 / pathophysiology / hepatic progenitor cell / whole genome analysis / BA specific iPS cell / biliary atresia / 22q11.2欠失症候群 / Nanog / X染色体再活性化 / KLF4 / 転写 / 多能性 / 画像解析 / ゲノム編集 / バーコーディング / 表現型解析 / サイトメトリー / ネットワーク化計測 / リプリログラミング / 代謝変換 / クロマチン / 遺伝子発現 / 間葉上皮転換 / INHAT / uORF / アポトーシス / X 染色体 / サイレンシング / EMT / iPS 細胞 / 細胞分化 / 間葉上皮変換 / MET / XCR / リプログラミング / レトロウイルス / X染色体 / 代謝 / センダイウイルス / 再生医学 Less
  • Research Projects

    (10 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (15 People)
  •  Genomic conformational changes in a pathological model using iPS cells derived from patients with chromosome deletion syndrome

    • Principal Investigator
      高崎 真美
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Research for the Pathological Understanding and Therapeutic Development of SIFD Using iPS Cells

    • Principal Investigator
      長森 恒久
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Asahikawa Medical College
  •  Cell fate decision by dose of transcription factors

    • Principal Investigator
      西村 健
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      University of Tsukuba
  •  Phenotypic screening of genome-edited Induced pluripotent stem cells

    • Principal Investigator
      太田 禎生
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 28:Nano/micro science and related fields
    • Research Institution
      The University of Tokyo
  •  Genome editing applications in pathological models of 22q11.2 syndrome-specific iPS cell-derived neural crest

    • Principal Investigator
      Takasaki Mami
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Elucidation of bile duct development and its disorder mechanism using biliary atresia-specific iPS cells

    • Principal Investigator
      Suzuki Kan
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Dokkyo Medical University
      The University of Tokyo
  •  Molecular dynamics of epigenomic transcriptional regulation by Klf4 in iPSC generation

    • Principal Investigator
      Nishimura Ken
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43050:Genome biology-related
    • Research Institution
      University of Tsukuba
  •  Reprogramming of cell morphology and functions by Klf4 during iPSC generation

    • Principal Investigator
      Hisatake Koji
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba
  •  Development of chromosome editingPrincipal Investigator

    • Principal Investigator
      Hayashi Yohei
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Institute of Physical and Chemical Research
      University of Tsukuba
  •  KLF4DNA結合部位アミノ酸残基の機能解析から改良リプログラミング因子の開発Principal Investigator

    • Principal Investigator
      林 洋平
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba

All 2022 2021 2020 2019 2018 2016

All Journal Article Presentation

  • [Journal Article] Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming2022

    • Author(s)
      Aizawa Shiho、Nishimura Ken、Mondejar Gonzalo Seminario、Kumar Arun、Bui Phuong Linh、Tran Yen Thi Hai、Kuno Akihiro、Muratani Masafumi、Kobayashi Shin、Nabekura Tsukasa、Shibuya Akira、Sugihara Eiji、Sato Taka-Aki、Fukuda Aya、Hayashi Yohei、Hisatake Koji
    • Journal Title

      Stem Cell Reports

      Volume: 17 Issue: 1 Pages: 53-67

    • DOI

      10.1016/j.stemcr.2021.11.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02678, KAKENHI-PROJECT-19H03203
  • [Journal Article] Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming2022

    • Author(s)
      Anh Le Phuong Hoang、Nishimura Ken、Kuno Akihiro、Linh Nguyen Thuy、Kato Tetsuo、Ohtaka Manami、Nakanishi Mahito、Sugihara Eiji、Sato Taka-Aki、Hayashi Yohei、Fukuda Aya、Hisatake Koji
    • Journal Title

      Stem Cells

      Volume: 40 Issue: 4 Pages: 397-410

    • DOI

      10.1093/stmcls/sxac012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02678, KAKENHI-PROJECT-19H03203
  • [Journal Article] Generation of human induced pluripotent stem cell lines derived from four DiGeorge syndrome patients with 22q11.2 deletion2022

    • Author(s)
      Shimizu Tomoya、Matsuo-Takasaki Mami、Luijkx Dorian、Takami Miho、Arai Yutaka、Noguchi Michiya、Nakamura Yukio、Hayata Tadayoshi、Saito Megumu K.、Hayashi Yohei
    • Journal Title

      Stem Cell Research

      Volume: 61 Pages: 102744-102744

    • DOI

      10.1016/j.scr.2022.102744

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03642, KAKENHI-PROJECT-21K06831, KAKENHI-PROJECT-23K21633
  • [Journal Article] Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency2022

    • Author(s)
      Borisova Evgeniia、Nishimura Ken、An Yuri、Takami Miho、Li Jingyue、Song Dan、Matsuo-Takasaki Mami、Luijkx Dorian、Aizawa Shiho、Kuno Akihiro、Sugihara Eiji、Sato Taka-aki、Yumoto Fumiaki、Terada Tohru、Hisatake Koji、Hayashi Yohei
    • Journal Title

      iScience

      Volume: 25 Issue: 1 Pages: 103525-103525

    • DOI

      10.1016/j.isci.2021.103525

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02678, KAKENHI-PROJECT-19H03203
  • [Journal Article] Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations2021

    • Author(s)
      Kuramochi Yuji、Awaya Tomonari、Matsuo-Takasaki Mami、Takami Miho、An Yuri、Li Jingyue、Hemmi Yasuko、Wakabayashi Tamami、Arai Yutaka、Inoue Jun、Noguchi Michiya、Nakamura Yukio、Asaka Isao、Akimoto Kazunori、Saito Megumu K.、Hayashi Yohei
    • Journal Title

      Stem Cell Research

      Volume: 53 Pages: 102337-102337

    • DOI

      10.1016/j.scr.2021.102337

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03642, KAKENHI-PROJECT-17H05063
  • [Journal Article] Generation of two human induced pluripotent stem cell lines derived from two juvenile nephronophthisis patients with NPHP1 deletion2020

    • Author(s)
      Arai Yutaka、Takami Miho、An Yuri、Matsuo-Takasaki Mami、Hemmi Yasuko、Wakabayashi Tamami、Inoue Jun、Noguchi Michiya、Nakamura Yukio、Sugimoto Keisuke、Takemura Tsukasa、Okita Keisuke、Osafune Kenji、Takasato Minoru、Hayata Tadayoshi、Hayashi Yohei
    • Journal Title

      Stem Cell Research

      Volume: 45 Pages: 101815-101815

    • DOI

      10.1016/j.scr.2020.101815

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07887, KAKENHI-PROJECT-18K09053, KAKENHI-PROJECT-17H05063
  • [Journal Article] Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells2020

    • Author(s)
      Hayashi Yohei、Takami Miho、Matsuo-Takasaki Mami
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 14 Pages: 224-224

    • DOI

      10.3389/fncel.2020.00224

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H05063
  • [Journal Article] Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP7202019

    • Author(s)
      Fukuda Aya、Honda Shiho、Fujioka Norie、Sekiguchi Yuya、Mizuno Seiya、Miwa Yoshihiro、Sugiyama Fumihiro、Hayashi Yohei、Nishimura Ken、Hisatake Koji
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 11 Pages: 0225213-0225213

    • DOI

      10.1371/journal.pone.0225213

    • NAID

      120007132627

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-17H05063
  • [Journal Article] Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells2019

    • Author(s)
      Nishimura Ken、Ishiwata Hiroshi、Sakuragi Yuta、Hayashi Yohei、Fukuda Aya、Hisatake Koji
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1777-1777

    • DOI

      10.1038/s41598-018-37779-x

    • NAID

      120007128201

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-16K07244, KAKENHI-PROJECT-17K19339
  • [Journal Article] Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming2019

    • Author(s)
      Bui Phuong Linh、Nishimura Ken、Seminario Mondejar Gonzalo、Kumar Arun、Aizawa Shiho、Murano Kensaku、Nagata Kyosuke、Hayashi Yohei、Fukuda Aya、Onuma Yasuko、Ito Yuzuru、Nakanishi Mahito、Hisatake Koji
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 7 Pages: 1909-1922

    • DOI

      10.1016/j.celrep.2019.10.010

    • NAID

      120007127699

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-19J11416, KAKENHI-PROJECT-17K08644, KAKENHI-PROJECT-19H03203, KAKENHI-PROJECT-17H05063
  • [Journal Article] Live cell imaging of X chromosome reactivation during somatic cell reprogramming2018

    • Author(s)
      Tran Thi Hai Yen、Fukuda Aya、Aizawa Shiho、Bui Phuong Linh、Hayashi Yohei、Nishimura Ken、Hisatake Koji
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 15 Pages: 86-92

    • DOI

      10.1016/j.bbrep.2018.07.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04036, KAKENHI-PROJECT-16K07244, KAKENHI-PROJECT-17K19339, KAKENHI-PROJECT-16K08610
  • [Journal Article] BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence2016

    • Author(s)
      Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 113(46) Issue: 46 Pages: 13057-13062

    • DOI

      10.1073/pnas.1603668113

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08610, KAKENHI-PROJECT-16H06662
  • [Presentation] 非公表2020

    • Author(s)
      林 洋平
    • Organizer
      日本レーザー学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H05063
  • [Presentation] 非公表2019

    • Author(s)
      林 洋平
    • Organizer
      日本腎臓学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H05063
  • [Presentation] 非公表2019

    • Author(s)
      林 洋平
    • Organizer
      日本動物実験代替法学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H05063
  • [Presentation] KLF4-dose dependent metabolic shift through TCL1 during iPSC generation2018

    • Author(s)
      Nishimura K, Kumar BA, Hayashi Y, Fukuda A, Hisatake K
    • Organizer
      ISSCR2018
    • Data Source
      KAKENHI-PROJECT-17H04036
  • [Presentation] Structure-based Discovery of NANOG Variant with Enhanced Properties to Promote Self-Renewal and Reprogramming of Pluripotent Stem Cells2016

    • Author(s)
      Yohei Hayashi
    • Organizer
      第39回日本分子生物学会大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H06662
  • 1.  Nishimura Ken (80500610)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 2.  福田 綾 (50436276)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 3.  Takasaki Mami (80392009)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  久野 朗広 (60830122)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  Hisatake Koji (70271236)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 6.  Suzuki Kan (80598508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  太田 禎生 (70731214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  木戸 丈友 (00401034)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  藤代 準 (60528438)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  長森 恒久 (40400098)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  佐藤 雅之 (00624181)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  甲賀 大輔 (30467071)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  石羽澤 映美 (90516402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SAITOH Megumu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 15.  高里 実
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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