Toyonaga Kenji 豊永憲司

Researcher Number	90791567
Other IDs
Affiliation (Current)	2025: 福岡歯科大学, 口腔歯学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 福岡歯科大学, 口腔歯学部, 助教 2020: 大阪大学, 微生物病研究所, 特任助教(常勤) 2018 – 2019: 大阪大学, 微生物病研究所, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 自然免疫 / 真菌感染症 / 感染制御 / 口腔カンジダ症 / 抗酸菌 / Th1応答 / 抗酸菌感染 / 宿主防御 / C型レクチン受容体 / 自然免疫受容体

Functional analysis of the signaling adaptor protein during oral candidiasisPrincipal Investigator
- Principal Investigator
  
  豊永憲司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Fukuoka Dental College
Analysis of CARD9 function in pulmonary mycobacterial infectionPrincipal Investigator
- Principal Investigator
  
  Toyonaga Kenji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Fukuoka Dental College
  Osaka University
A novel regulatory mechanism of C-type lectin receptor-mediated antifungal immunityPrincipal Investigator
- Principal Investigator
  
  Toyonaga Kenji
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Efficient lipidomic approach for the discovery of lipid ligands for immune receptors by combining LC-HRMS/MS analysis with fractionation and reporter cell assay.2024
- Author(s)
  Tomiyasu N, Takahashi M, Toyonaga K, Yamasaki S, Bamba T, Izumi Y*.
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: - Issue: 25 Pages: 5445-5456
- DOI
  10.1007/s00216-023-05111-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18924, KAKENHI-PROJECT-22KJ2427, KAKENHI-PLANNED-22H05185, KAKENHI-PROJECT-23K23151, KAKENHI-PROJECT-23K27766
[Journal Article] Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome2022
- Author(s)
  Nagao J, Kishikawa S, Tanaka H, Toyonaga K, Narita Y, Negoro-Yasumatsu K, Tasaki S, Arita-Morioka K, Nakayama J, Tanaka Y
- Journal Title
  
  Cell Rep
  
  Volume: 40 Issue: 10 Pages: 111314-111314
- DOI
  10.1016/j.celrep.2022.111314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09850, KAKENHI-PROJECT-20KK0130, KAKENHI-PROJECT-20H00555, KAKENHI-PROJECT-20K16256, KAKENHI-PROJECT-20K16285, KAKENHI-PROJECT-22K19136
[Journal Article] C型レクチン受容体はHelicobacter pyloriの代謝産物を認識して胃炎の増悪に寄与する2021
- Author(s)
  豊永憲司、山﨑晶
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 76 (1) Pages: 84-92
- NAID
  40022634563
- Data Source
  KAKENHI-PROJECT-20K16285
[Journal Article] Helicobacter metabolites exacerbate gastritis through C-type lectin receptors.2021
- Author(s)
  Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B L, Timmer M S M, Smith D G M, Williams S J, Bamba T, Miyamoto T, Arita M, Appelmelk B J, Yamasaki S*.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 218(1) Issue: 1
- DOI
  10.1084/jem.20200815
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05167, KAKENHI-PROJECT-20K16285, KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-20H00495
[Journal Article] TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation.2021
- Author(s)
  Iizasa, E., Chuma, Y., Uematsu, T., Kubota, M., Kawaguchi, H., Umemura, M., Toyonaga, K., Kiyohara, H., Yano, I., Colonna, M., Sugita, M., Matsuzaki, G., Yamasaki, S., Yoshida, H., Hara, H.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 2299-2314
- DOI
  10.1038/s41467-021-22620-3
- NAID
  120007170570
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07117, KAKENHI-PROJECT-19K07627, KAKENHI-PROJECT-19K08935, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-20K07551, KAKENHI-PROJECT-20K16285
[Journal Article] IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2.2020
- Author(s)
  Kamohara A, Hirata H, Xu X, Shiraki M, Yamada S, Zhang JQ, Kukita T, Toyonaga K, Hara H, Urano Y, Yamashita Y, Miyamoto H, Kukita A.
- Journal Title
  
  Int Immunol. 2020 Feb 7;32(2):89-104.
  
  Volume: 32 Issue: 2 Pages: 89-104
- DOI
  10.1093/intimm/dxz063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09506, KAKENHI-PROJECT-19K09553, KAKENHI-PROJECT-18K15195
[Journal Article] Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR2020
- Author(s)
  Omahdi Zakaria、Horikawa Yuto、Nagae Masamichi、Toyonaga Kenji、Imamura Akihiro、Takato Koichi、Teramoto Takamasa、Ishida Hideharu、Kakuta Yoshimitsu、Yamasaki Sho
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 17 Pages: 5807-5817
- DOI
  10.1074/jbc.ra120.012491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04087, KAKENHI-PROJECT-17K07303, KAKENHI-PROJECT-18K15195, KAKENHI-PROJECT-20K06575, KAKENHI-PROJECT-19H00922
[Journal Article] Recognition of Mycobacteria by Dendritic Cell Immunoactivating Receptor2020
- Author(s)
  Toyonaga K, Yamasaki S.
- Journal Title
  
  Current topics in microbiology and immunology
  
  Volume: 429 Pages: 103-115
- DOI
  10.1007/82_2020_203
- ISBN
  9783030622367, 9783030622374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16285, KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-19H00922
[Journal Article] C型レクチン受容体のリガンド認識と免疫調節機構2019
- Author(s)
  豊永　憲司、山﨑　晶
- Journal Title
  
  医学のあゆみ
  
  Volume: 269(9) Pages: 743-748
- Data Source
  KAKENHI-PROJECT-18K15195
[Patent] ヘリコバクター属菌に起因する疾患または状態を処置する方法、およびその利用2020
- Inventor(s)
  山崎　晶、豊永　憲司
- Industrial Property Rights Holder
  山崎　晶、豊永　憲司
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-157742
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Mucosal immune network of Th17 cells via oral-gut axis exacerbates the development of periodontitis2024
- Author(s)
  Jun-ichi Nagao, Masanobu Nakagami, Sari Kishikawa, Kenji Toyonaga, Emi Kaji, Aoba Iwanuma, Kanae Negoro-Yasumatsu, Sonoko Tasaki, Satoru Iwai, Yoshihiko Tanaka
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] Analysis of periodontal disease-induced cognitive impairment behavior in mice2024
- Author(s)
  Sari Kishikawa, Jun-ichi Nagao, Kenji Toyonaga, Emi Kaji, Masahiro Nakagami, Aoba Iwanuma, Sonoko Tasaki, Kanae Negoro, Satoru Iwai, Yoshihiko Tanaka
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] Functional analysis of signaling adaptor in a murine oral candidiasis model2024
- Author(s)
  Kenji Toyonaga, Jun-ichi Nagao, Sonoko Tasaki, Masayuki Umemura, Sari Kishikawa, Emi Kaji, Aoba Iwanuma, Masanobu Nakagami, Kanae Negoro-Yasumatsu, Satoru Iwai, Yoshihiko Tanaka
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] 口腔感染症による脳への神経免疫学的影響の解析2023
- Author(s)
  岸川咲吏, 永尾潤一, 豊永憲司, 加地英美, 中上昌信, 岩沼青葉, 田崎園子, 根来香奈江, 田中芳彦
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] 口腔と腸管の免疫ネットワークによる歯周病の病態形成機構2023
- Author(s)
  永尾潤一, 中上昌信, 岸川咲吏, 豊永憲司, 加地英美, 岩沼青葉, 根来香奈江[安松], 田崎園子, 田中芳彦
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] 口腔カンジダ症に対するTh17細胞による病態制御機構の解明2023
- Author(s)
  加地英美, 豊永憲司, 田崎園子, 永尾潤一, 岸川咲吏, 中上昌信, 岩沼青葉, 田中芳彦
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] ミュータンス連鎖球菌によって誘導される免疫応答の解析2023
- Author(s)
  岩沼青葉, 豊永憲司, 永尾潤一, 岸川咲吏, 加地英美, 中上昌信, 岡暁子, 田中芳彦
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] Candida albicans口腔感染における免疫受容体シグナル関連分子の役割2023
- Author(s)
  豊永憲司, 永尾潤一, 田崎園子, 加地英美, 岸川咲吏, 中上昌信, 岩沼青葉, 根来香奈江, 田中芳彦
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] 歯周病の病態形成を制御する腸内細菌の役割の解明2023
- Author(s)
  中上昌信, 永尾潤一, 岸川咲吏, 豊永憲司, 加地英美, 岩沼青葉, 吉永泰周, 坂上竜資, 田中芳彦
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K27766
[Presentation] Analysis of host responses against secondary infection of Candida albicans2022
- Author(s)
  Mizukami K、Toyonaga K、Tanaka Y
- Organizer
  The 64th Annual Meeting of Japanese Association for Oral Biology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Analysis of immune responses to Candida albicans in a murine oral infection model2022
- Author(s)
  Toyonaga K、Nagao J、Mizukami K、Tasaki S、Kishikawa S、Kaji E、Negoro K、Tanaka Y
- Organizer
  The 64th Annual Meeting of Japanese Association for Oral Biology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Analysis of immune responses in a murine oral candidiasis model2022
- Author(s)
  Kenji Toyonaga、Emi Kaji、Jun-ichi Nagao、Sonoko Tasaki、Sari Kishikawa、Kanae Negoro-Yasumatsu、Yoshihiko Tanaka
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Analysis of Card9 function in pulmonary mycobacterial infection2022
- Author(s)
  Kenji Toyonaga, Masayuki Umemura, Goro Matsuzaki, Hiromitsu Hara, Yoshihiko Tanaka, and Sho Yamasaki
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Immunological analysis of periodontal disease-induced cognitive disorders in mice2022
- Author(s)
  Sari Kishikawa、Jun-ichi Nagao、Kenji Toyonaga、Emi Kaji、Kanae Negoro-Yasumatsu、Sonoko Tasaki、Yoshihiko Tanaka
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Neuroimmunological analysis using the mouse model of periodontal disease2022
- Author(s)
  Kishikawa S、Nagao J、Toyonaga K、Kaji E、Negoro K、Tasaki S、Tanaka Y
- Organizer
  The 64th Annual Meeting of Japanese Association for Oral Biology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Investigation of Th17-cell mediated immune response against the pathogenic fungus Candida albicans2022
- Author(s)
  Emi Kaji、Kenji Toyonaga、Sonoko Tasaki、Jun-ichi Nagao、Sari Kishikawa、Mizuko Ikeda、Yosihiko Tanaka
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Investigation of immunological systems regulating the pathogenesis of periodontitis2022
- Author(s)
  Nagao J、Kishikawa S、Toyonaga K、Kaji E、Negoro-Yasumatsu K、Tasaki S、Tanaka Y
- Organizer
  The 64th Annual Meeting of Japanese Association for Oral Biology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Development of periodontitis mediated by T-cell immune response against periodontal bacteria2022
- Author(s)
  Jun-ichi Nagao、Sari Kishikawa、Kenji Toyonaga、Emi Kaji、Kanae Negoro-Yasumatsu、Sonoko Tasaki、Yoshihiko Tanaka
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Exploration of antigens from the pathogenic fungus Candida albicans that regulate the pathogenesis of oral candidiasis2022
- Author(s)
  Kaji E、Toyonaga K、Tasaki S、Nagao J、Kisikawa S、Tanaka Y
- Organizer
  The 64th Annual Meeting of Japanese Association for Oral Biology
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] 口腔内細菌脂質成分の自然免疫活性化能の解析2021
- Author(s)
  豊永憲司、永尾潤一、岸川咲吏、田中芳彦
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] 抗酸菌の糖脂質はどのようにして宿主免疫を活性化するのか2021
- Author(s)
  豊永憲司
- Organizer
  第96回日本結核・非結核性抗酸菌症学会総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16285
[Presentation] Analysis of Card9 function in Mycobacterium bovis BCG infection2020
- Author(s)
  Kenji Toyonaga, Hiromitsu Hara, Sho Yamasaki
- Organizer
  8th ITAM WS
- Data Source
  KAKENHI-PROJECT-18K15195
[Presentation] Analysis of PGL-mediated innate immune responses2019
- Author(s)
  Kenji Toyonaga, Ei’ichi Iizasa, Hiromitsu Hara
- Organizer
  7th ITAM WS
- Data Source
  KAKENHI-PROJECT-18K15195
[Presentation] Analysis of mycobacterial phenolic glycolipid-induced innate immune responses2019
- Author(s)
  Kenji Toyonaga, Ei’ichi Iizasa, Hiromitsu Hara
- Organizer
  第12回寄生虫感染免疫研究会
- Data Source
  KAKENHI-PROJECT-18K15195
[Presentation] BCG感染におけるCard9の機能解析2019
- Author(s)
  豊永　憲司、原　博満、山﨑　晶
- Organizer
  第4回抗酸菌研究会
- Data Source
  KAKENHI-PROJECT-18K15195
[Presentation] Identification of innate immune receptor for the mycobacterial virulence factor phenolic glycolipid2018
- Author(s)
  Kenji Toyonaga, Ei’ichi Iizasa, Yasushi Chuma, Hideyasu Kiyohara, Kazuhiro Matsuo, Hiromitsu Hara
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15195
[Presentation] PGL受容体の機能解析2018
- Author(s)
  豊永憲司、飯笹英一、中馬康志、清原秀泰、松尾和浩、原博満
- Organizer
  第29回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15195

1. 永尾潤一 (30509047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. 梅村正幸 (90359985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 岸川咲吏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 久木田明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 久木田敏夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 和泉自泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 山崎晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松崎吾朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toyonaga Kenji 豊永 憲司

Research Projects

Research Products

Co-Researchers

Functional analysis of the signaling adaptor protein during oral candidiasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of CARD9 function in pulmonary mycobacterial infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel regulatory mechanism of C-type lectin receptor-mediated antifungal immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Efficient lipidomic approach for the discovery of lipid ligands for immune receptors by combining LC-HRMS/MS analysis with fractionation and reporter cell assay.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C型レクチン受容体はHelicobacter pyloriの代謝産物を認識して胃炎の増悪に寄与する2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Helicobacter metabolites exacerbate gastritis through C-type lectin receptors.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recognition of Mycobacteria by Dendritic Cell Immunoactivating Receptor2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] C型レクチン受容体のリガンド認識と免疫調節機構2019

Author(s)

Journal Title

Data Source

[Patent] ヘリコバクター属菌に起因する疾患または状態を処置する方法、およびその利用2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] Mucosal immune network of Th17 cells via oral-gut axis exacerbates the development of periodontitis2024

Author(s)

Organizer

Data Source

[Presentation] Analysis of periodontal disease-induced cognitive impairment behavior in mice2024

Toyonaga Kenji 豊永憲司