Kume Shinichiro 粂慎一郎

Researcher Number	90794579
Other IDs	https://orcid.org/0000-0001-6947-7294
Affiliation (Current)	2025: 大分大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 大分大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related / General physiology
Keywords	Principal Investigator 電気生理学 / 分子生物学 / 構造機能連関 / hERGチャネル / イオンチャネル

Analyses of the gating mechanisms based on the Non-domain swapped architecture of the hERG channelPrincipal Investigator
- Principal Investigator
  
  粂慎一郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Oita University
Analyses of the structure-function relationship based on the characteristic interaction among the intracellular domains in the hERG channelPrincipal Investigator
- Principal Investigator
  
  Kume Shinichiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Oita University
The analyses of the interaction between the intracellular domains to control the slow deactivation of hERG channelPrincipal Investigator
- Principal Investigator
  
  Kume Shinichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Oita University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Detection and identification of factors in the atrium responsible for blood pressure regulation in patients with hypertension2024
- Author(s)
  Yoshimura Kenshi、Mengyan Wei、Kume Shinichiro、Kurokawa Tatsuki、Miyamoto Shinji、Mizukami Yoichi、Ono Katsushige
- Journal Title
  
  Heart and Vessels
  
  Volume: 39 Issue: 5 Pages: 464-474
- DOI
  10.1007/s00380-024-02362-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06771, KAKENHI-PROJECT-21K06784, KAKENHI-PROJECT-20H00632, KAKENHI-PROJECT-21H03358
[Journal Article] Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel2023
- Author(s)
  Wei Mengyan、Wang Pu、Zhu Xiufang、Morishima Masaki、Liu Yangong、Zheng Mingqi、Liu Gang、Osanai Hiroki、Yoshimura Kenshi、Kume Shinichiro、Kurokawa Tatsuki、Ono Katsushige
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 2 Pages: e0280656-e0280656
- DOI
  10.1371/journal.pone.0280656
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06771, KAKENHI-PROJECT-21K06784, KAKENHI-PROJECT-20K11636, KAKENHI-PROJECT-19K16491, KAKENHI-PROJECT-23K10815
[Journal Article] Disruption of asparagine-linked glycosylation to rescue and alter gating of the Nav1.5-Na+ channel2021
- Author(s)
  Wang P, Zhu X, Wei M, Liu Y, Yoshimura K, Zheng M, Liu G, Kume S, Kurokawa T, Ono K
- Journal Title
  
  Heart and Vessels
  
  Volume: 36 Issue: 4 Pages: 589-596
- DOI
  10.1007/s00380-020-01736-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-21K06771, KAKENHI-PROJECT-21K06784, KAKENHI-PROJECT-19K16491
[Journal Article] Nitric oxide down-regulates voltage-gated Na+ channel in cardiomyocytes possibly through S-nitrosylation-mediated signaling2021
- Author(s)
  Wang P, Wei M, Zhu X, Liu Y, Yoshimura K, Zheng M, Liu G, Kume S, Morishima M, Kurokawa T, Ono K
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 11273-11273
- DOI
  10.1038/s41598-021-90840-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-20K11636, KAKENHI-PROJECT-21K06771, KAKENHI-PROJECT-21K06784, KAKENHI-PROJECT-19K16491
[Journal Article] Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel2019
- Author(s)
  Liu Yangong、Wang Pu、Ma Fangfang、Zheng Mingqi、Liu Gang、Kume Shinichiro、Kurokawa Tatsuki、Ono Katsushige
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 69 Issue: 2 Pages: 335-343
- DOI
  10.1007/s12576-018-0650-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08498, KAKENHI-PROJECT-16K08494, KAKENHI-PROJECT-19K16491, KAKENHI-PROJECT-17K15567
[Journal Article] Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain2018
- Author(s)
  Shinichiro Kume, Takushi Shimomura, Michihiro Tateyama, Yoshihiro Kubo
- Journal Title
  
  The Journal of Physiology
  
  Volume: 596 Pages: 4629-4650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] Electrophysiological analysis of an anticancer drug gemcitabine on hERG channel2023
- Author(s)
  Wei Mengyan、粂慎一郎、Wang Pu、Zhu Xiufang、森島真幸、Liu Yangong、Zheng Mingqi、 Liu Gang、小山内博基、吉村健司、黒川竜紀、小野克重
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K06771
[Presentation] 細胞内Ca2+はMEK1,2-ERK1,2経路およびCaM-CaMK経路を介する転写制御作用によってhERGチャネル電流を調節する2022
- Author(s)
  魏孟厳、粂慎一郎、小山内博基、吉村健司、黒川竜紀、小野克重
- Organizer
  第73回西日本生理学会
- Data Source
  KAKENHI-PROJECT-21K06771
[Presentation] 細胞内Ca2+はMEK1,2-ERK1,2経路およびCaM-CaMK経路を介する転写制御作用によってhERGチャネル電流を調節する2022
- Author(s)
  魏孟厳、粂慎一郎、小山内博基、吉村健司、黒川竜紀、小野克重
- Organizer
  第73回西日本生理学会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] 心筋細胞内Ca2+濃度の上昇はPKCとCaMKシグナルを介してhERGチャネル発現を制御する2021
- Author(s)
  魏孟厳、小山内博基、吉村健司、粂慎一郎、黒川竜紀、小野克重
- Organizer
  第30回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-21K06771
[Presentation] 心筋細胞内Ca2+濃度の上昇はPKCとCaMKシグナルを介してhERGチャネル発現を制御する2021
- Author(s)
  魏孟厳、小山内博基、吉村健司、粂慎一郎、黒川竜紀、小野克重
- Organizer
  第30回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] An anti-cancer drug gemcitabine inhibits and modifies N-glycosylation of the hERG channel resulting in a suppression of IhERG2021
- Author(s)
  Mengyan Wei, Kenshi Yoshimura, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第72回西日本生理学会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] Mechanisms of hERG channel current inhibition by an anticonvulsant valproic acid2021
- Author(s)
  Shinichiro Kume, Xiufang Zhu, Pu Wang, Mengyan Wei, Kenshi Yoshimura, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会　合同大会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] An anti-cancer drug gemcitabine inhibits and modifies N-glycosylation of the hERG channel resulting in a suppression of IhERG2021
- Author(s)
  Mengyan Wei, Kenshi Yoshimura, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第72回西日本生理学会
- Data Source
  KAKENHI-PROJECT-21K06771
[Presentation] Asparagine-linked glycosylation modifies voltage-dependent gating properties of Cav3.1-T-type Ca2+ channel2020
- Author(s)
  Shinichiro Kume, Yangong Liu, Pu Wang, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] Asparagine-linked glycosylation modifies voltage-dependent gating properties of Cav3.1-T-type Ca2+ channel2020
- Author(s)
  Shinichiro Kume, Yangong Liu, Pu Wang, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] N-glycosylation inhibition attenuates heart automaticity by deranging T-type Ca2+ current and HCN current2020
- Author(s)
  Yangong Liu, Pu Wang, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] α-mannosidase I-dependent N-linked glycosylation modifies distinct gating properties of the hERG channel2020
- Author(s)
  Mengyan Wei, Yangong Liu, Pu Wang, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] Asparagine-linked glycosylation as a key regulator of gating properties in cardiac Nav1.5 channels2020
- Author(s)
  Pu Wang, Yangong Liu, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] α-mannosidase I-dependent N-linked glycosylation modifies distinct gating properties of the hERG channel2020
- Author(s)
  Mengyan Wei, Yangong Liu, Pu Wang, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] Asparagine-linked glycosylation as a key regulator of gating properties in cardiac Nav1.5 channels2020
- Author(s)
  Pu Wang, Yangong Liu, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] An anticonvulsant valproate decreases hERG K+ channel current IKr through the histone deacetylase inhibition2020
- Author(s)
  Xiufang Zhu, Pu Wang, Mengyan Wei, Kenji Yoshimura, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第71回西日本生理学会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] N-glycosylation inhibition attenuates heart automaticity by deranging T-type Ca2+ current and HCN current2020
- Author(s)
  Yangong Liu, Pu Wang, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] N-glycosylation inhibition attenuates heart automaticity by deranging T-type Ca2+ current and HCN current2019
- Author(s)
  Yangong Liu, Pu Wang, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第29回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] N-glycosylation inhibition attenuates heart automaticity by deranging T-type Ca2+ current and HCN current2019
- Author(s)
  Yangong Liu, Pu Wang, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono
- Organizer
  第29回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] hERGチャネルの細胞内ドメインに関するFRET解析を用いた構造機能連関の研究2019
- Author(s)
  粂　慎一郎、下村　拓史、立山　充博、久保　義弘
- Organizer
  第70回西日本生理学会
- Data Source
  KAKENHI-PROJECT-19K16491
[Presentation] hERGチャネルの細胞内ドメインに関するFRET解析を用いた構造機能連関の研究2019
- Author(s)
  粂　慎一郎、下村　拓史、立山　充博、久保　義弘
- Organizer
  第70回西日本生理学会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] hERG チャネルの環状ヌクレオチド結合相同ドメインに存在する Phe860 の役割の解析2018
- Author(s)
  粂　慎一郎、久保　義弘
- Organizer
  第28回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] FRET Analyses of the Mechanisms of Accelerated Deactivation by Phe860 Mutations in hERG Channel2018
- Author(s)
  Shinichiro Kume, Yoshihiro Kubo
- Organizer
  第65回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-17K15567
[Presentation] FRET analyses of the effect of Phe860Glu mutation on the interaction between the N- and C- terminal cytoplasmic domains in hERG channel2018
- Author(s)
  粂　慎一郎
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K15567

1. 小野克重

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kume Shinichiro 粂 慎一郎

Research Projects

Research Products

Co-Researchers

Analyses of the gating mechanisms based on the Non-domain swapped architecture of the hERG channelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses of the structure-function relationship based on the characteristic interaction among the intracellular domains in the hERG channelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analyses of the interaction between the intracellular domains to control the slow deactivation of hERG channelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Detection and identification of factors in the atrium responsible for blood pressure regulation in patients with hypertension2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disruption of asparagine-linked glycosylation to rescue and alter gating of the Nav1.5-Na+ channel2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nitric oxide down-regulates voltage-gated Na+ channel in cardiomyocytes possibly through S-nitrosylation-mediated signaling2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain2018

Author(s)

Journal Title

Data Source

[Presentation] Electrophysiological analysis of an anticancer drug gemcitabine on hERG channel2023

Author(s)

Organizer

Data Source

[Presentation] 細胞内Ca2+はMEK1,2-ERK1,2経路およびCaM-CaMK経路を介する転写制御作用によってhERGチャネル電流を調節する2022

Author(s)

Organizer

Data Source

[Presentation] 細胞内Ca2+はMEK1,2-ERK1,2経路およびCaM-CaMK経路を介する転写制御作用によってhERGチャネル電流を調節する2022

Author(s)

Organizer

Data Source

[Presentation] 心筋細胞内Ca2+濃度の上昇はPKCとCaMKシグナルを介してhERGチャネル発現を制御する2021

Author(s)

Organizer

Data Source

[Presentation] 心筋細胞内Ca2+濃度の上昇はPKCとCaMKシグナルを介してhERGチャネル発現を制御する2021

Author(s)

Organizer

Data Source

[Presentation] An anti-cancer drug gemcitabine inhibits and modifies N-glycosylation of the hERG channel resulting in a suppression of IhERG2021

Author(s)

Organizer

Data Source

[Presentation] Mechanisms of hERG channel current inhibition by an anticonvulsant valproic acid2021

Author(s)

Organizer

Data Source

[Presentation] An anti-cancer drug gemcitabine inhibits and modifies N-glycosylation of the hERG channel resulting in a suppression of IhERG2021

Kume Shinichiro 粂慎一郎