Fujiwara Yuuki 藤原悠紀

Researcher Number	90794925
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院連合小児発達学研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院連合小児発達学研究科, 助教 2021: 大阪大学, 連合小児発達学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator 細胞内分解系 / プロテオスタシス / DUMP / 非典型オートファジー / オートファジー / リソソーム / 細胞内恒常性 / 細胞内分解 / 神経発達 / プロテオリシス / 恒常性 / 細胞内代謝

Research Projects
(2 results)
Research Products
(25 results)

発達期神経における細胞内分解の包括的理解に向けた非典型オートファジー経路の研究Principal Investigator
- Principal Investigator
  
  藤原悠紀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka University
Studies on regulatory mechanisms of newly identified intracellular proteolytic pathwayPrincipal Investigator
- Principal Investigator
  
  Fujiwara Yuuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Expression of RNautophagy/DNautophagy-related genes is regulated under control of an innate immune receptor2024
- Author(s)
  Fujiwara Yuuki、Oroku Kazuki、Zhou Yinping、Takahashi Masayuki、Katayama Taiichi、Wada Keiji、Tsutsumi Nobuyuki、Sato Tetsuo、Kabuta Tomohiro
- Journal Title
  
  RNA Biology
  
  Volume: 21 Issue: 1 Pages: 1-9
- DOI
  10.1080/15476286.2023.2291610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14453, KAKENHI-PLANNED-19H05710
[Journal Article] 非典型オートファジーの研究から見える生体恒常性の姿 ―新たな細胞内分解経路のメカニズムと病態生理的意義2023
- Author(s)
  藤原悠紀
- Journal Title
  
  月刊「細胞」
  
  Volume: 55 Pages: 61-64
- Data Source
  KAKENHI-PROJECT-21K15367
[Journal Article] Nucleic acid uptake occurs independent of lysosomal acidification but dependent on ATP consumption during RNautophagy/DNautophagy2023
- Author(s)
  Contu Viorica Raluca、Sakai Ryohei、Fujiwara Yuuki、Kabuta Chihana、Wada Keiji、Kabuta Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 644 Pages: 105-111
- DOI
  10.1016/j.bbrc.2022.12.090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-21K15367, KAKENHI-PLANNED-19H05710
[Journal Article] TMEM67 is required for the gating function of the transition zone that controls entry of membrane-associated proteins ARL13B and INPP5E into primary cilia2022
- Author(s)
  Yinsheng Zhuoma、Miyoshi Ko、Qin Yuanyuan、Fujiwara Yuuki、Yoshimura Takeshi、Katayama Taiichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 636 Pages: 162-169
- DOI
  10.1016/j.bbrc.2022.10.078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15367
[Journal Article] 特集リソソーム研究の新展開 Ⅰ.リソソームの新しい機能リソソームによる高分子の新たな取り込み機構2022
- Author(s)
  藤原悠紀、株田智弘
- Journal Title
  
  生体の科学
  
  Volume: 73 Issue: 3 Pages: 212-215
- DOI
  10.11477/mf.2425201504
- ISSN
  0370-9531, 1883-5503
- Year and Date
  2022-06-15
- Data Source
  KAKENHI-PROJECT-21K15367
[Journal Article] 細胞内構成因子の新たな分解経路ーそのメカニズムと病態生理的意義ー2022
- Author(s)
  藤原悠紀
- Journal Title
  
  日本病態生理学会雑誌
  
  Volume: 31 Pages: 33-35
- Data Source
  KAKENHI-PROJECT-21K15367
[Journal Article] （総説）リソソームによる高分子の新たな取り込み機構2022
- Author(s)
  藤原悠紀, 株田智弘
- Journal Title
  
  生体の科学
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-21K15367
[Journal Article] Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients2022
- Author(s)
  Fujiwara Yuuki、Kabuta Chihana、Sano Terunori、Murayama Shigeo、Saito Yuko、Kabuta Tomohiro
- Journal Title
  
  Neurochemistry International
  
  Volume: 152 Pages: 105243-105243
- DOI
  10.1016/j.neuint.2021.105243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15367, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-22K07550, KAKENHI-PROJECT-19K07988, KAKENHI-PROJECT-22H04923
[Journal Article] Elongation of primary cilia by expression of serotonin receptor type 6 is mediated by cyclin-dependent kinase 52022
- Author(s)
  Sho Shikada, Ko Miyoshi, Sarina Han, Zhuoma Yinsheng, Yuanyuan Qin, Yuuki Fujiwara, Takeshi Yoshimura, Taiichi Katayama
- Journal Title
  
  Journal of Brain Science
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15367
[Journal Article] 輝け次代の担い手たち　生体高分子のリソソームへの新たな輸送・分解経路2022
- Author(s)
  藤原悠紀
- Journal Title
  
  神経化学
  
  Volume: 61 Pages: 7-13
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] 新たに発見した細胞内物質分解経路とその破綻を原因とする神経・筋疾患2023
- Author(s)
  藤原悠紀
- Organizer
  2023年度文部科学省学術変革領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-23K14453
[Presentation] リソソームによる核酸の新たな直接取り込み・分解経路の重要因子の発現は自然免疫応答関連因子の制御を受ける2023
- Author(s)
  藤原悠紀, 小祿和希, 髙橋昌幸, 片山泰一, 和田圭司, 堤信幸, 佐藤哲朗, 株田智弘
- Organizer
  第32回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-23K14453
[Presentation] Novel proteolytic pathway in lysosomes required for neuromuscular homeostasis2023
- Author(s)
  Yuuki Fujiwara
- Organizer
  17th Meeting of the Asian-Pacific Society for Neurochemistry (APSN2023), Workshop/Invited Young Investigators’ Colloquium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14453
[Presentation] Identification of a novel protein-degradation pathway by lysosomes required for neuromuscular homeostasis2023
- Author(s)
  Yuuki Fujiwara
- Organizer
  The Joint Meeting of the International Society of Neurochemistry and the European Society of Neurochemistry (ISN-ESN2023), Emerging Group Leaders Symposia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14453
[Presentation] Novel proteolytic pathway in lysosomes required for neuromuscular homeostasis2023
- Author(s)
  Yuuki Fujiwara
- Organizer
  17th Meeting of the Asian-Pacific Society for Neurochemistry (APSN2023), Invited Young Investigators’ Colloquium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] A new and unexpected pathway in lysosomes for degradation of intracellular substances: Its physiological/pathophysiological roles in neuromuscular metabolism2023
- Author(s)
  Yuuki Fujiwara
- Organizer
  APSN Webinar Series - Understanding the Molecular Mechanisms of Lysosomal Homeostasis and Implication in Diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14453
[Presentation] 新たな細胞内分解系の同定とその病態生理的意義2023
- Author(s)
  藤原悠紀
- Organizer
  大阪大学蛋白質研究所セミナー「生命のしなやかさに着目したタンパク質研究の現状と展望」
- Data Source
  KAKENHI-PROJECT-23K14453
[Presentation] Novel intracellular proteolytic pathway required for maintenance of neuromuscular homeostasis2023
- Author(s)
  Yuuki Fujiwara, Viorica Raluca Contu, Chihana Kabuta, Megumu Ogawa, Hiromi Fujita, Hisae Kikuchi, Ryohei Sakai, Katsunori Hase, Mari Suzuki, Ikuko Koyama-Honda, Michio Inoue, Yasishi Oya, Yukiko U. Inoue, Takayoshi Inoue, Ryosuke Takahashi, Ichizo Nishino, Keiji Wada, Satoru Noguchi, Tomohiro Kabuta
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] 細胞内新規タンパク質分解経路の発見とその破綻を原因とする神経・筋疾患2023
- Author(s)
  藤原悠紀
- Organizer
  第2回日本医学会連合Rising Starリトリート
- Invited
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] A newly identified intracellular degradation system in lysosomes and its physiological significances2023
- Author(s)
  Yuuki Fujiwara
- Organizer
  第９回日独６大学ネットワーク (HeKKSaGOn) 学長会議 Working Group 1 "New-Generation Biomedical Science"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14453
[Presentation] 神経・筋恒常性に必須の新たな細胞内タンパク質分解経路の同定2022
- Author(s)
  藤原悠紀, Viorica Raluca Contu, 株田千華, 小川恵, 宮城美月, 酒井了平, 長谷勝徳, 鈴木マリ, 小山郁子, 井上道雄, 大矢寧, 井上由紀子, 川野竜司, 井上高良, 高橋良輔, 西野一三, 和田圭司, 野口悟, 株田智弘
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] 脳・神経系の恒常性維持に関わる新たな細胞内分解経路の発見2022
- Author(s)
  藤原悠紀, Viorica Raluca Contu, 周寅平, 株田千華, 小川恵, 酒井了平, 長谷勝徳, 小山郁子, 井上道雄, 大矢寧, 井上由紀子, 井上高良, 高橋良輔, 西野一三, 和田圭司, 野口悟, 株田智弘, 片山泰一
- Organizer
  第49回日本脳科学会
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] リソソームを介した新たな細胞内分解システム DUMP の破綻を原因とする進行性神経・筋疾患2022
- Author(s)
  藤原悠紀, 西野一三, 和田圭司, 野口悟, 株田智弘
- Organizer
  第30回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] 細胞内構成因子の新たな分解経路 ―そのメカニズムと病態生理的意義―2022
- Author(s)
  藤原悠紀
- Organizer
  第31回日本病態生理学会大会　ビジョナリーシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K15367
[Presentation] Novel uptake and degradation pathway of proteins by lysosomes required for neuromuscular homeostasis2022
- Author(s)
  Yuuki Fujiwara, Viorica Raluca Contu, Chihana Kabuta, Megumu Ogawa, Hiromi Fujita, Hisae Kikuchi, Ryohei Sakai, Katsunori Hase, Mari Suzuki, Ikuko Koyama Honda, Michio Inoue, Yasushi Oya, Yukiko U. Inoue, Takayoshi Inoue, Ryosuke Takahashi, Ichizo Nishino, Keii Wada, Satoru Noguchi, Tomohiro Kabuta
- Organizer
  The joint meeting of the International Society for Neurochemistry and the Asian Pacific Society for Neurochemistry (ISN-APSN2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15367

Fujiwara Yuuki 藤原 悠紀

Research Projects

Research Products

発達期神経における細胞内分解の包括的理解に向けた非典型オートファジー経路の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on regulatory mechanisms of newly identified intracellular proteolytic pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Expression of RNautophagy/DNautophagy-related genes is regulated under control of an innate immune receptor2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 非典型オートファジーの研究から見える生体恒常性の姿 ―新たな細胞内分解経路のメカニズムと病態生理的意義2023

Author(s)

Journal Title

Data Source

[Journal Article] Nucleic acid uptake occurs independent of lysosomal acidification but dependent on ATP consumption during RNautophagy/DNautophagy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TMEM67 is required for the gating function of the transition zone that controls entry of membrane-associated proteins ARL13B and INPP5E into primary cilia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 リソソーム研究の新展開 Ⅰ.リソソームの新しい機能 リソソームによる高分子の新たな取り込み機構2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] 細胞内構成因子の新たな分解経路 ーそのメカニズムと病態生理的意義ー2022

Author(s)

Journal Title

Data Source

[Journal Article] （総説）リソソームによる高分子の新たな取り込み機構2022

Author(s)

Journal Title

Data Source

[Journal Article] Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elongation of primary cilia by expression of serotonin receptor type 6 is mediated by cyclin-dependent kinase 52022

Author(s)

Journal Title

Data Source

[Journal Article] 輝け次代の担い手たち 生体高分子のリソソームへの新たな輸送・分解経路2022

Author(s)

Journal Title

Data Source

[Presentation] 新たに発見した細胞内物質分解経路とその破綻を原因とする神経・筋疾患2023

Author(s)

Organizer

Data Source

[Presentation] リソソームによる核酸の新たな直接取り込み・分解経路の重要因子 の発現は自然免疫応答関連因子の制御を受ける2023

Author(s)

Organizer

Data Source

[Presentation] Novel proteolytic pathway in lysosomes required for neuromuscular homeostasis2023

Author(s)

Organizer

Data Source

[Presentation] Identification of a novel protein-degradation pathway by lysosomes required for neuromuscular homeostasis2023

Author(s)

Organizer

Data Source

[Presentation] Novel proteolytic pathway in lysosomes required for neuromuscular homeostasis2023

Author(s)

Fujiwara Yuuki 藤原悠紀

[Journal Article] 特集リソソーム研究の新展開 Ⅰ.リソソームの新しい機能リソソームによる高分子の新たな取り込み機構2022

[Journal Article] 細胞内構成因子の新たな分解経路ーそのメカニズムと病態生理的意義ー2022

[Journal Article] 輝け次代の担い手たち　生体高分子のリソソームへの新たな輸送・分解経路2022

[Presentation] リソソームによる核酸の新たな直接取り込み・分解経路の重要因子の発現は自然免疫応答関連因子の制御を受ける2023