KINOSHITA Manao 木下真直

… Alternative Names

Manao Kinoshita 木下真直

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Researcher Number	90813717
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 山梨大学, 大学院総合研究部, 臨床助教 2019 – 2021: 山梨大学, 大学院総合研究部, 助教 2018: 山梨大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related
Keywords	Principal Investigator NETs / 好中球 / 中毒性表皮壊死症 / Stevens-Johnson症候群 / スティーブンジョンソン症候群 / 大量免疫グロブリン療法 / LL-37 / ネクロプトーシス / 表皮細胞死 / スティーブンス・ジョンソン症候群 … More / 重症薬疹 / TEN / SJS / 表皮細胞 / 抗菌ペプチド / NETosis Less

好中球を標的とした重症薬疹の治療機序解明と治療戦略の創出Principal Investigator
- Principal Investigator
  
  木下真直
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  University of Yamanashi
The elucidation of mechanisms underlying severe cutaneous adverse drug reactions induced by neutrophils and the establishment of early diagnostic markersPrincipal Investigator
- Principal Investigator
  
  Manao Kinoshita
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  University of Yamanashi

All 2024 2023 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] RIP3 as a diagnostic and severity marker for Stevens-Johnson syndrome and toxic epidermal necrolysis2020
- Author(s)
  Hasegawa Akito、Shinkuma Satoru、Hayashi Ryota、Hama Natsumi、Watanabe Hideaki、Kinoshita Manao、Ogawa Youichi、Abe Riichiro
- Journal Title
  
  The Journal of Allergy and Clinical Immunology: In Practice
  
  Volume: 8 Issue: 5 Pages: 1768-1771
- DOI
  10.1016/j.jaip.2020.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04047, KAKENHI-PROJECT-18K16022
[Journal Article] Zinc transporters in the epidermis2019
- Author(s)
  Ogawa Y, Kinoshita M, Shimada S, Kambe T, Kawamura T.
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 30 Pages: 1-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16022
[Journal Article] Downregulation of integrin‐αvβ6 on keratinocytes in the scar of lichen planopilaris and folliculitis decalvans: Relevance for the disappearance of epidermal Langerhans cells2019
- Author(s)
  Kinoshita Manao、Ogawa Youichi、Yamamoto Saori、Simada Shinji、Harada Kazutoshi、Kawamura Tatsuyoshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 46 Issue: 7 Pages: 610-614
- DOI
  10.1111/1346-8138.14945
- Data Source
  KAKENHI-PROJECT-18K16022
[Journal Article] Galectin-7 as a potential biomarker of Stevens-Johnson syndrome/ toxic epidermal necrolysis: Identification by targeted proteomics using causative drug-exposed peripheral blood cells2019
- Author(s)
  Natsumi Hama, Keiko Nishimura, Akito Hasegawa, Akihiko Yuki, Hideaki Kume, Jun Adachi, Manao Kinoshita, Youichi Ogawa, Saeko Nakajima, Takashi Nomura, Hideaki Watanabe, Yoshiko Mizukawa, Takeshi Tomonaga, Hiroshi Shimizu, Riichiro Abe
- Journal Title
  
  J Allergy Clin Immunol Pract
  
  Volume: 印刷中 Issue: 8 Pages: 2894-2897
- DOI
  10.1016/j.jaip.2019.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16020, KAKENHI-PROJECT-19K08755, KAKENHI-PROJECT-18K16022, KAKENHI-PROJECT-18H04047
[Journal Article] Biotin Is Required for the Zinc Homeostasis in the Skin.2019
- Author(s)
  Ogawa Y, Kinoshita M, Sato T, Shimada S, Kawamura T.
- Journal Title
  
  Nutrients.
  
  Volume: 11 Pages: 919-919
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16022
[Journal Article] Impetigo herpetiformis with IL-36RN mutation successfully treated with secukinumab.2018
- Author(s)
  Kinoshita M, Ogawa Y, Takeichi T, Okamoto T, Osada A, Shimada S, Sugiura K, Akiyama M, Kawamura T, Tsukamoto K.
- Journal Title
  
  Eur J Dermatol.
  
  Volume: 28 Pages: 381-382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16022
[Journal Article] Zinc and Skin Disorders2018
- Author(s)
  Youichi Ogawa、Manao Kinoshita、Shinji Shimada、Tatsuyoshi Kawamura
- Journal Title
  
  Nutrients
  
  Volume: 10 Issue: 2 Pages: 199-199
- DOI
  10.3390/nu10020199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16022
[Journal Article] Purinergic Molecules in the Epidermis2018
- Author(s)
  Ogawa Youichi、Kinoshita Manao、Mizumura Nao、Miyazaki Shiho、Aoki Rui、Momosawa Akira、Shimada Shinji、Kambe Taiho、Kawamura Tatsuyoshi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 138 Issue: 11 Pages: 2486-2488
- DOI
  10.1016/j.jid.2018.04.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16022
[Journal Article] Deficiency of the interleukin-36 receptor antagonist dramatically improved by secukinumab.2018
- Author(s)
  Kinoshita M, Okamoto T, Sano S, Mitsui H, Takeichi T, Sugiura K, Akiyama M, Shimada S, Kawamura T.
- Journal Title
  
  J Dermatol
  
  Volume: 45 Issue: 10
- DOI
  10.1111/1346-8138.14330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08281, KAKENHI-PROJECT-18K16022, KAKENHI-PROJECT-18K16058, KAKENHI-PROJECT-16K19717, KAKENHI-PROJECT-15H04886
[Journal Article] Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis2018
- Author(s)
  Ogawa Youichi、Kinoshita Manao、Shimada Shinji、Kawamura Tatsuyoshi
- Journal Title
  
  Journal of Immunology Research
  
  Volume: 2018 Pages: 1-11
- DOI
  10.1155/2018/5404093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16022
[Journal Article] Anti-depressant fluoxetine reveals its therapeutic effects via astrocytes.2018
- Author(s)
  M. Kinoshita, Y. Hirayama, K. Fujishita, K Shibata, Y. Shinozaki, E. Shigetomi, A. Takeda, HP Ngoc Le, H. Hayashi, M. Hiasa, Y. Moriyama, K. Ikenaka, KF Tanaka, S. Koizumi.
- Journal Title
  
  EBioMedicine
  
  Volume: 32 Pages: 72-83
- DOI
  10.1016/j.ebiom.2018.05.036
- NAID
  130007901327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06481, KAKENHI-PROJECT-18K16022, KAKENHI-PUBLICLY-18H05121, KAKENHI-PROJECT-18H02407, KAKENHI-PROJECT-16K08230, KAKENHI-PROJECT-16H04669
[Patent] スティーブンス・ジョンソン症候群及び又は中毒性表皮壊死症の評価方法、評価のためのデータ取得方法、及び評価用キット2019
- Inventor(s)
  木下真直
- Industrial Property Rights Holder
  木下真直
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K16022
[Patent] スティーブンス・ジョンソン症候群及び／又は中毒性表皮壊死症の評価方法、評価のためのデータ取得方法、及び評価用キット2019
- Inventor(s)
  木下　真直
- Industrial Property Rights Holder
  木下　真直
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-037418
- Filing Date
  2019
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-18K16022
[Presentation] スティーヴンス・ジョンソン症候群・中毒性表皮壊死症におけるNETsの分解機構2024
- Author(s)
  木下真直
- Organizer
  第123回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16223
[Presentation] SJS/TENにおけるNETsの分解機構2024
- Author(s)
  木下真直
- Organizer
  第196回鹿児島地方会金蔵拓郎教授退任記念地方会
- Data Source
  KAKENHI-PROJECT-21K16223
[Presentation] Degradation of aberrant NETs by DNases is a promising therapeutic strategy for SJS/TEN2023
- Author(s)
  Manao Kinoshita
- Organizer
  International Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-21K16223
[Presentation] Update in the Role of NETosis in SJS/TEN2023
- Author(s)
  Youichi Ogawa, Manao Kinoshita
- Organizer
  SJSTEN 2023
- Data Source
  KAKENHI-PROJECT-21K16223
[Presentation] Degradation of aberrant NETs by DNases is a promising therapeutic strategy for SJS/TEN2023
- Author(s)
  Manao Kinoshita
- Organizer
  International Society for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16223
[Presentation] The axis of drug-specific CD8 T cells-neutrophils trigger Stevens Johnson syndrome and toxic epidermal necrolysis2020
- Author(s)
  Manao Kinoshita
- Organizer
  The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16022
[Presentation] Novel Markers To Diagnose Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis2020
- Author(s)
  Manao Kinoshita, Youichi Ogawa, Natsumi Hama, Inkin Ujiie, Akito Hasegawa, Saeko Nakajima, Takashi Nomura, Takuya Sato, Shinji Shimada, Yasuyuki Fujita, Hayato Takahashi, Yoshiko Mizukawa, Keisuke Nagao, Riichiro Abe, and Tatsuyoshi Kawamura
- Organizer
  The 119th Annual Meeting of the Japanese Dermatological Association
- Data Source
  KAKENHI-PROJECT-18K16022
[Presentation] Neutrophil extracellular traps initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis2019
- Author(s)
  Manao Kinoshita, Youichi Ogawa, Natsumi Hama, Inkin Ujiie, Jun Adachi, Shinji Shimada, Yasuyuki Fujita, Hayato Takahashi, TakeshiTomonaga, Riichiro Abe, Tatsuyoshi Kawamura
- Organizer
  The Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16022
[Presentation] Anti-depressant fluoxetine reveals its therapeutic effect via astrocytes2018
- Author(s)
  Manao Kinoshita
- Organizer
  The 23rd Annual Meeting of the Japan Glia
- Data Source
  KAKENHI-PROJECT-18K16022
[Presentation] Anti-depressant fluoxetine reveals its therapeutic effect via astrocytes2018
- Author(s)
  Manao Kinoshita, Kayoko Fujishita, Keisuke Shibata, Yuri Hirayama, Youichi Shinozaki, Eiji Shigetomi, Yoshinori Moriyama, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16022
[Presentation] NETosis-necroptosis axis mediated by LL-37 initiates and exacerbates Stevens- Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN)2018
- Author(s)
  Manao Kinoshita
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16022

1. SHINKUMA Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. SHINOZAKI Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 阿部理一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 杉浦一充

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 濱菜摘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KINOSHITA Manao 木下 真直

Manao Kinoshita 木下 真直

Research Projects

Research Products

Co-Researchers

好中球を標的とした重症薬疹の治療機序解明と治療戦略の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of mechanisms underlying severe cutaneous adverse drug reactions induced by neutrophils and the establishment of early diagnostic markersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] RIP3 as a diagnostic and severity marker for Stevens-Johnson syndrome and toxic epidermal necrolysis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zinc transporters in the epidermis2019

Author(s)

Journal Title

Data Source

[Journal Article] Downregulation of integrin‐αvβ6 on keratinocytes in the scar of lichen planopilaris and folliculitis decalvans: Relevance for the disappearance of epidermal Langerhans cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Galectin-7 as a potential biomarker of Stevens-Johnson syndrome/ toxic epidermal necrolysis: Identification by targeted proteomics using causative drug-exposed peripheral blood cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biotin Is Required for the Zinc Homeostasis in the Skin.2019

Author(s)

Journal Title

Data Source

[Journal Article] Impetigo herpetiformis with IL-36RN mutation successfully treated with secukinumab.2018

Author(s)

Journal Title

Data Source

[Journal Article] Zinc and Skin Disorders2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purinergic Molecules in the Epidermis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deficiency of the interleukin-36 receptor antagonist dramatically improved by secukinumab.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-depressant fluoxetine reveals its therapeutic effects via astrocytes.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Patent] スティーブンス・ジョンソン症候群及び又は中毒性表皮壊死症の評価方法、評価のためのデータ取得方法、及び評価用キット2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] スティーブンス・ジョンソン症候群及び／又は中毒性表皮壊死症の評価方法、評価のためのデータ取得方法、及び評価用キット2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

KINOSHITA Manao 木下真直

Manao Kinoshita 木下真直