Miyake Kensuke 三宅健介

Researcher Number	90814533
Other IDs	https://orcid.org/0000-0003-1149-3755
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 東京医科歯科大学, 統合研究機構, 特任助教 2018 – 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related
Keywords	Principal Investigator アレルギー / 好塩基球 / 1細胞RNAシーケンス / M2マクロファージ / アトピー性皮膚炎 / IL-4受容体 / 炎症収束 / 分化経路 / 単球由来マクロファージ / 転写因子 … More / 分化 / RNAシーケンス / 寄生虫感染 / 前駆細胞 / 成熟好塩基球 / 未熟好塩基球 / マクロファージ / アレルギー炎症 / 好中球 / 免疫学 / 炎症抑制 / IL-1α / 死細胞 / IL-4 Less

The regulatory roles of basophils in skin allergic inflammation by using single-cell RNA-seq analysisPrincipal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of mechanisms for basophil maturation by using RNA-seqPrincipal Investigator
- Principal Investigator
  
  Miyake Kensuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of mechanisms how M2 macrophages induced by basophils dampen excess inflammationPrincipal Investigator
- Principal Investigator
  
  Miyake Kensuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Recent advances in understanding of basophil function and differentiation2024
- Author(s)
  Miyake Kensuke、Ito Junya、Karasuyama Hajime
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 159 Issue: 1 Pages: 32-38
- DOI
  10.1254/fpj.23084
- ISSN
  0015-5691, 1347-8397
- Year and Date
  2024-01-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07115
[Journal Article] Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model2024
- Author(s)
  Miyake Kensuke、Ito Junya、Takahashi Kazufusa、Nakabayashi Jun、Brombacher Frank、Shichino Shigeyuki、Yoshikawa Soichiro、Miyake Sachiko、Karasuyama Hajime
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 1666-1666
- DOI
  10.1038/s41467-024-46148-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ0837, KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-22K07119, KAKENHI-PROJECT-21K18255, KAKENHI-PLANNED-22H05064, KAKENHI-PROJECT-21H02964, KAKENHI-PROJECT-23K24107
[Journal Article] Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice2024
- Author(s)
  Strakosha Maria、Vega-Mendoza Daniela、Kane Jennifer、Jain Ashish、Sun Liang、Rockowitz Shira、Elkins Megan、Miyake Kensuke、Chou Janet、Karasuyama Hajime、Geha Raif S.、Leyva-Castillo Juan-Manuel
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: － Issue: 8 Pages: 1784-1797.e4
- DOI
  10.1016/j.jid.2023.12.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-23K24107
[Journal Article] Topical Application of a PDE4 Inhibitor Ameliorates Atopic Dermatitis through Inhibition of Basophil IL-4 Production2024
- Author(s)
  Takahashi Kazufusa、Miyake Kensuke、Ito Junya、Shimamura Hinano、Suenaga Tadahiro、Karasuyama Hajime、Ohashi Kenichi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 144 Issue: 5 Pages: 1048-1057.e8
- DOI
  10.1016/j.jid.2023.09.272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ0837, KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-23K06564, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-23K24107
[Journal Article] Basophils are important for development of allergic skin inflammation2024
- Author(s)
  Leyva-Castillo Juan-Manuel、Vega-Mendoza Daniela、Strakosha Maria、Deng Liwen、Choi Samantha、Miyake Kensuke、Karasuyama Hajime、Chiu Isaac M.、Phipatanakul Wanda、Geha Raif S.
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 153 Issue: 5 Pages: 1344-1354.e5
- DOI
  10.1016/j.jaci.2024.01.022
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-23K24107
[Journal Article] Cutaneous basophil infiltration in atopic dermatitis is associated with abundant epidermal infiltration of helper T cells: A preliminary retrospective study2023
- Author(s)
  Nagashima Natsumi、Ugajin Tsukasa、Miyake Kensuke、Walls Andrew F.、Namiki Takeshi、Yokozeki Hiroo、Karasuyama Hajime、Okiyama Naoko
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 51 Issue: 1 Pages: 130-134
- DOI
  10.1111/1346-8138.16987
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-23K24107
[Journal Article] An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis2023
- Author(s)
  LaMarche Nelson M.、…、Miyake Kensuke、…、Merad Miriam
- Journal Title
  
  Nature
  
  Volume: 625 Issue: 7993 Pages: 166-174
- DOI
  10.1038/s41586-023-06797-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-23K24107
[Journal Article] 【蕁麻疹・血管性浮腫】蕁麻疹と好塩基球2023
- Author(s)
  三宅健介, 吉川宗一郎, 烏山一
- Journal Title
  
  皮膚科
  
  Volume: 3 Pages: 130-137
- Data Source
  KAKENHI-PROJECT-22K07115
[Journal Article] Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils2023
- Author(s)
  Miyake Kensuke、Ito Junya、Nakabayashi Jun、Shichino Shigeyuki、Ishiwata Kenji、Karasuyama Hajime
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2694-2694
- DOI
  10.1038/s41467-023-38356-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ0837, KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-21K18255, KAKENHI-PLANNED-22H05064, KAKENHI-PROJECT-23K24107
[Journal Article] 【肺免疫から肺疾患を考える】アレルギー疾患や寄生虫感染症における好塩基球の役割2022
- Author(s)
  三宅健介, 烏山一
- Journal Title
  
  呼吸器内科
  
  Volume: 40 Pages: 535-542
- Data Source
  KAKENHI-PROJECT-20K16277
[Journal Article] 【ファゴサイトーシスとトロゴサイトーシス】免疫細胞におけるトロゴサイトーシスの役割2022
- Author(s)
  三宅健介, 烏山一
- Journal Title
  
  臨床免疫・アレルギー科.
  
  Volume: 77 Pages: 168-175
- Data Source
  KAKENHI-PROJECT-20K16277
[Journal Article] Role of Basophils in a Broad Spectrum of Disorders2022
- Author(s)
  Miyake Kensuke、Ito Junya、Karasuyama Hajime
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 902494-902494
- DOI
  10.3389/fimmu.2022.902494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-23K24107
[Journal Article] CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development2022
- Author(s)
  Tchen John、Simon Quentin、Chapart L?a、Pellefigues Christophe、Karasuyama Hajime、Miyake Kensuke、Blank Ulrich、Benhamou Marc、Daugas Eric、Charles Nicolas
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 900532-900532
- DOI
  10.3389/fimmu.2022.900532
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07115, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-23K24107
[Journal Article] E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates2021
- Author(s)
  Wanet, A., Bassal, M. A., Patel, S. B., Marchi, F., Mariani, S. A., Ahmed, N., Zhang, H., Borchiellini, M., Chen, S., Zhang, J., Di Ruscio, A., Miyake, K., Tsai, M., Paranjape, A., Park, S. Y., Karasuyama, H., Schroeder, T., Dzierzak, E., Galli, S. J., Tenen, D. G., Welner, R. S.
- Journal Title
  
  Science Immunology
  
  Volume: 6 Issue: 56
- DOI
  10.1126/sciimmunol.aba0178
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16277, KAKENHI-PROJECT-19H01025
[Journal Article] いま知りたい!!かじる?呑み込む?貪食の多様性　トロゴサイトーシスとエフェロサイトーシス　トロゴサイトーシスによる免疫細胞機能の調節2021
- Author(s)
  三宅健介, 烏山一.
- Journal Title
  
  実験医学
  
  Volume: 39 Pages: 2229-2232
- Data Source
  KAKENHI-PROJECT-20K16277
[Journal Article] Basophils, a neglected minority in the immune system, have come into the limelight at last2021
- Author(s)
  Karasuyama Hajime、Shibata Sho、Yoshikawa Soichiro、Miyake Kensuke
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 809-813
- DOI
  10.1093/intimm/dxab021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-20K16277, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-21K18255, KAKENHI-PROJECT-21K16137
[Journal Article] The Role of Trogocytosis in the Modulation of Immune Cell Functions2021
- Author(s)
  Miyake Kensuke、Karasuyama Hajime
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 5 Pages: 1255-1255
- DOI
  10.3390/cells10051255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16277, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-21K18255
[Journal Article] 好塩基球の分化および活性化による2型免疫反応2021
- Author(s)
  三宅　健介、吉川　宗一郎、柴田　翔、烏山　一
- Journal Title
  
  血液内科
  
  Volume: 82 Pages: 54-61
- Data Source
  KAKENHI-PROJECT-20K16277
[Journal Article] アレルギー炎症における好塩基球の役割2021
- Author(s)
  三宅　健介、烏山　一
- Journal Title
  
  アレルギーの臨床
  
  Volume: 41 Pages: 25-28
- Data Source
  KAKENHI-PROJECT-20K16277
[Journal Article] Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting.2020
- Author(s)
  Yang Y, Nagai S, Kang S, Xia Y, Kawano Y, Miyake K, Karasuyama H, Azuma M.
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 8 Pages: 509-518
- DOI
  10.1093/intimm/dxaa014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04066, KAKENHI-PROJECT-17H04376, KAKENHI-PROJECT-18K15180, KAKENHI-PROJECT-19H01025
[Journal Article] 【アレルギーのエフェクター細胞研究の進展】好塩基球2020
- Author(s)
  三宅健介, 吉川宗一郎, 柴田翔, 山西吉典, 烏山一.
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 73 Pages: 6-13
- Data Source
  KAKENHI-PROJECT-18K15180
[Journal Article] Basophils and their effector molecules in allergic disorders2020
- Author(s)
  Miyake Kensuke、Shibata Sho、Yoshikawa Soichiro、Karasuyama Hajime
- Journal Title
  
  Allergy
  
  Volume: - Issue: 6 Pages: 1693-1706
- DOI
  10.1111/all.14662
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-20K16277, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-21K18255
[Journal Article] Skin‐infiltrating basophils promote atopic dermatitis‐like inflammation via IL‐4 production in mice2020
- Author(s)
  Yamanishi Yoshinori、Mogi Kotone、Takahashi Kazufusa、Miyake Kensuke、Yoshikawa Soichiro、Karasuyama Hajime
- Journal Title
  
  Allergy
  
  Volume: 75 Issue: 10 Pages: 2613-2622
- DOI
  10.1111/all.14362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-20K16277, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-19K07501
[Journal Article] Immunobiology of Acquired Resistance to Ticks2020
- Author(s)
  Karasuyama Hajime、Miyake Kensuke、Yoshikawa Soichiro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 601504-601504
- DOI
  10.3389/fimmu.2020.601504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-20K16277, KAKENHI-PROJECT-19H01025
[Journal Article] The role of basophils in acquired protective immunity to tick infestation2020
- Author(s)
  Yoshikawa Soichiro、Miyake Kensuke、Kamiya Atsunori、Karasuyama Hajime
- Journal Title
  
  Parasite Immunology
  
  Volume: - Issue: 5
- DOI
  10.1111/pim.12804
- NAID
  120006937520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-20K16277, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-21K18255
[Journal Article] 好塩基球による、トロゴサイトーシスを介した新たな抗原提示メカニズム2019
- Author(s)
  三宅　健介, 烏山　一
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 49 Pages: 61-64
- Data Source
  KAKENHI-PROJECT-18K15180
[Journal Article] Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3?stimulated murine basophils2019
- Author(s)
  Yoshikawa Soichiro、Oh-hora Masatsugu、Hashimoto Ryota、Nagao Toshihisa、Peters Louis、Egawa Mayumi、Ohta Takuya、Miyake Kensuke、Adachi Takahiro、Kawano Yohei、Yamanishi Yoshinori、Karasuyama Hajime
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 576
- DOI
  10.1126/scisignal.aav2060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-18K07178, KAKENHI-PROJECT-19K07501, KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-18K15180
[Journal Article] Th2型免疫応答における好塩基球の役割2019
- Author(s)
  三宅　健介、吉川　宗一郎、山西　吉典、烏山　一
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 177-184
- NAID
  40021798131
- Data Source
  KAKENHI-PROJECT-18K15180
[Journal Article] Basophils trigger emphysema development in a murine model of COPD through IL-4?mediated generation of MMP-12?producing macrophages2018
- Author(s)
  Shibata Sho、Miyake Kensuke、Tateishi Tomoya、Yoshikawa Soichiro、Yamanishi Yoshinori、Miyazaki Yasunari、Inase Naohiko、Karasuyama Hajime
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 51 Pages: 13057-13062
- DOI
  10.1073/pnas.1813927115
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15180, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-17K15719
[Journal Article] Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice2018
- Author(s)
  Nagao Toshihisa、Yamanishi Yoshinori、Miyake Kensuke、Teranishi Mio、Takahashi Saori、Yoshikawa Soichiro、Kawano Yohei、Karasuyama Hajime
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 1 Pages: 41-49
- DOI
  10.1093/intimm/dxy062
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15180, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-17K15719
[Journal Article] トロゴサイトーシスを介した好塩基球による抗原提示機構2018
- Author(s)
  三宅　健介、山西吉典、烏山　一
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 70 Pages: 623-630
- NAID
  40021747556
- Data Source
  KAKENHI-PROJECT-18K15180
[Journal Article] How do basophils contribute to Th2 cell differentiation and allergic responses?2018
- Author(s)
  Karasuyama Hajime、Miyake Kensuke、Yoshikawa Soichiro、Kawano Yohei、Yamanishi Yoshinori
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 9 Pages: 391-396
- DOI
  10.1093/intimm/dxy026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15180, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-17K15719
[Journal Article] 免疫学のABC(第8回)　顆粒球の作用と役割2018
- Author(s)
  三宅　健介
- Journal Title
  
  分子リウマチ治療
  
  Volume: 11 Pages: 148-151
- NAID
  40021650431
- Data Source
  KAKENHI-PROJECT-18K15180
[Journal Article] Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice2018
- Author(s)
  Tabakawa Yuya、Ohta Takuya、Yoshikawa Soichiro、Robinson Elisabeth J.、Yamaji Kayoko、Ishiwata Kenji、Kawano Yohei、Miyake Kensuke、Yamanishi Yoshinori、Ohtsu Hiroshi、Adachi Takahiro、Watanabe Naohiro、Kanuka Hirotaka、Karasuyama Hajime
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9
- DOI
  10.3389/fimmu.2018.01540
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15180, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-17K15719
[Journal Article] Multifaceted roles of basophils in health and disease2017
- Author(s)
  Karasuyama H, Miyake K, Yoshikawa S, Yamanishi Y
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: S0091-6749 Issue: 2 Pages: 31894-31898
- DOI
  10.1016/j.jaci.2017.10.042
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20969, KAKENHI-PROJECT-18K15180, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-17K15719
[Presentation] Pro-Resolving Roles for Basophils and Monocyte-Derived Macrophages in IgE-Mediated Skin Allergy.2024
- Author(s)
  Kensuke Miyake.
- Organizer
  2024 Food Allergy Conference GRC
- Invited
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] FoxO1 regulates the number of basophils in the peripheral tissues and basophil-dependent allergic inflammation.2024
- Author(s)
  Junya Ito, Kensuke Miyake, Kazufusa Takahashi, Shigeyuki Shichino, Hajime Karasuyama.
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] Classical monocyte-derived macrophages display high efferocytic ability and contribute to the resolution of basophil-dependent skin allergic inflammation.2024
- Author(s)
  Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Shigeyuki Shichino, Hajime Karasuyama.
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 喘息　動物モデル　好塩基球由来IL-4は急性呼吸促迫症候群モデルの肺炎症を抑制する.2023
- Author(s)
  高澤聖子, 三宅健介, 杉原潤, 柴田翔, 立石知也, 烏山一, 宮崎泰成
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 増悪と抑制を司るアレルギーメディエーター　好塩基球由来IL-4は急性呼吸促迫症候群モデルの肺炎症を抑制する.2023
- Author(s)
  高澤聖子, 三宅健介, 杉原潤, 柴田翔, 立石知也, 烏山一, 宮崎泰成.
- Organizer
  第72回日本アレルギー学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] Classical monocyte differentiate into pro-resolving macrophages with high efferocytic capacity in basophil-dependent skin allergy.2023
- Author(s)
  Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Shigeyuki Shichino, Hajime Karasuyama.
- Organizer
  The 46th Annual Meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 新規PDE4阻害薬ジファミラストは好塩基球活性化を阻害し、アトピー性皮膚炎モデルに対し治療効果を示す.2022
- Author(s)
  高橋和総, 三宅健介, 烏山一
- Organizer
  第71回日本アレルギー学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] M2 macrophages generated in the termination phase of skin allergic inflammation display high efferocytic capacity and promote resolution of inflammation.2022
- Author(s)
  Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Shigeyuki Shichino, Hajime Karasuayma.
- Organizer
  51st Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 炎症後期に出現するM2マクロファージは高い死細胞貪食能を持ち、好塩基球依存的皮膚アレルギー炎症の収束に寄与する2022
- Author(s)
  三宅健介、伊藤潤哉、髙橋和総、中林潤、七野成之、烏山一.
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] Difamilast, a selective phosphodiesterase 4 inhibitor, suppresses IL-4 production by basophils and ameliorates atopic dermatitis in a murine model.2022
- Author(s)
  Kazufusa Takahashi, Kensuke Miyake, Junya Ito, Hinano Shimamura, Hajime Karasuyama.
- Organizer
  51st Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 精神的ストレスによるアレルギー皮膚炎症増悪メカニズムの解明2022
- Author(s)
  吉川宗一郎, 浦上仁志, 藤田悠紀, 長尾圭, 日野翔太, 松井奎吾, 三宅健介, 烏山一, 森実実, 神谷厚範, 三宅幸子.
- Organizer
  第34回日本神経免疫学会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 好塩基球浸潤による成人アトピー性皮膚炎患者層別化の検討2022
- Author(s)
  長島夏実, 宇賀神つかさ, 三宅健介, 烏山一, 並木剛.
- Organizer
  第121回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 新規PDE4阻害薬のジファミラストは好塩基球のIL-4産生を抑制し,アトピー性皮膚炎モデルへの治療効果を示す.2022
- Author(s)
  三宅健介, 高橋和総, 伊藤潤哉, 島村雛乃, 烏山一
- Organizer
  第52回日本皮膚免疫アレルギー学会総会学術大会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] Psychological stress exacerbates skin allergic inflammation by dysfunction of anti-inflammatory M2 macrophages via β2-adrenergic receptor2022
- Author(s)
  Urakami Hitoshi, Fujita Yuki, Komura Ayaka, Nagao Kei, Matsui Keigo, Hino Shota, Miyake Kensuke, Karasuyama Hajime, Yoshikawa Soichiro, Kamiya Atsunori, Morizane Shin.
- Organizer
  日本研究皮膚科学会年次学術大会・総会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] hronic psychological stress exacerbates IgE-dependent chronic allergic inflammation by supressing M2 macrophage-mediated efferocytosis.2022
- Author(s)
  Hitoshi Urakami, Yuki Fujita, Kei Nagao, Kensuke Miiyake, Hajime Karasuyama, Sachiko Miyake, Soichiro Yoshikawa.
- Organizer
  51st Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] Transcriptomic and functional analyses uncover an immature subpopulation of basophils in the bone marrow and FoxO1 as a transcription factor involved in the regulation of basophil responsiveness.2022
- Author(s)
  Junya Ito, Kensuke Miyake, Kazufusa Takahashi, Shigeyuki Shichino, Hajime Karasuyama.
- Organizer
  51st Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] The clinical and histological characteristics of 'basophil-high' atopic dermatiti2022
- Author(s)
  Nagashima Natsumi, Ugajin Tsukasa, Miyake Kensuke, Karasuyama Hajime, Namiki Takeshi, Okiyama Naoko.
- Organizer
  日本研究皮膚科学会年次学術大会・総会
- Data Source
  KAKENHI-PROJECT-22K07115
[Presentation] 好塩基球由来IL-4はマクロファージのCCL24産生を促し，好酸球浸潤を誘導する2021
- Author(s)
  高橋和総、三宅健介、須田真未、大橋健一、烏山一
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Basophils promote the generation of highly phagocytic M2 macrophages which dampen excess inflammation at the resolution phase of allergic inflammation.2021
- Author(s)
  Miyake K. Takahashi K, Ito J, Nakabayashi J, Shichino S, Yoshikawa S, Karasuyama H..
- Organizer
  50th Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] 麻疹の活動期に見られる好塩基球減少に関する動物モデルからの検証.2021
- Author(s)
  岸本泉、馬尼、谷崎英昭、中嶋千紗、大塚篤司、三宅健介、烏山一、神戸直智
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Basophil dynamics during the activate phase of urticaria using an Oxazolone-induced contact hypersensitivity mouse model2021
- Author(s)
  Ma N, Kishimoto I, Kambe N, Nakashima C, Otsuka A, Miyake K, Karasuyama H, Tanizaki H.
- Organizer
  50th Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Sphingosine kinase 1 contributes to IgE-dependent basophil activation and the development of basophil-dependent delayed-onset skin allergic inflammation.2021
- Author(s)
  Takahashi K, Miyake K, Karasuyama H.
- Organizer
  50th Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Basophil-derived IL-4 induces the generation of M2 macrophages which dampen skin chronic allergic inflammation via the efferocytic clearance of dead cells.2021
- Author(s)
  Kensuke Miyake、Kazufusa Takahashi、Junya Ito、Jun Nakabayashi、Shigeyuki Shichino、Soichiro Yoshikawa、Hajime Karasuyama.
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Basophils gain the capacity of antigen presentation via trogocytosis-mediated transfer of peptide-MHC class II complexes from DCs2021
- Author(s)
  Miyake K, Karasuyama H.
- Organizer
  第44回日本分子生物学会年会（MBSJ2021）
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] 熟好塩基球とは異なる活性化能を呈する未熟好塩基球の新規同定.2021
- Author(s)
  伊藤潤哉、三宅健介、中林潤、七野成之、烏山一.
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Single-cell RNA-seq analysis provides novel insights into the mechanism underlying the termination of basophil-elicited allergic inflammation in the skin.2021
- Author(s)
  Miyake K
- Organizer
  50th Annual Meeting of Japanese Society for Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Single-cell RNA-seq analysis identified a novel subpopulation of basophils with immature phenotypes and unique functionality.2021
- Author(s)
  Ito J, Miyake K, Nakabayashi J, Shichino S, Karasuyama H.
- Organizer
  50th Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] マウス，ヒトにおいて好中球エラスターゼは好塩基球からのIL-4分泌を促進する.2021
- Author(s)
  柴田翔、三宅健介、立石知也、烏山一、宮崎泰成.
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Chronic psychological stress exacerbates IgE-dependent chronic allergic inflammation via symphathetic nerve.2021
- Author(s)
  Urakami H, Fujita Y, Komura A, Nagao K, Okutani R, Miyake K, Karasuyama H, Yoshikawa S.
- Organizer
  50th Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation2020
- Author(s)
  Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Basophils present antigens to T cells via trogocytosis-mediated acquisition of MHC class II2020
- Author(s)
  Kensuke Miyake, Hajime Karasuyama.
- Organizer
  第43回日本分子生物学会年会（MBSJ2020）
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] Identification of two distinct subpopulations among basophils in the bone marrow2020
- Author(s)
  Junya Ito, Kensuke Miyake, Shigeyuki Shichino, Yoshinori Yamanishi, Hajime Karasuyama
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16277
[Presentation] 好塩基球は炎症抑制型のM2マクロファージを誘導することで、アレルギー炎症の悪化を妨げる2019
- Author(s)
  三宅　健介
- Organizer
  2019年先端モデル動物支援若手技術支援講習会
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis2019
- Author(s)
  Mogi K, Takahashi K, Miyake K, Yoshikawa S, Karasuyama H, Yamanishi Y
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] 慢性閉塞性肺疾患(COPD)患者の肺組織に好塩基球が浸潤している2019
- Author(s)
  柴田翔, 立石知也, 小林正嗣, 大久保憲一, 明石巧, 三宅健介, 山西吉典, 烏山一, 宮崎泰成
- Organizer
  第68回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils2019
- Author(s)
  Yoshikawa S, Oh-hora M, Hashimoto R, Miyake K, Adachi T, Kawano Y, Yamanish Y, Kamiya A, Karasuyama H
- Organizer
  17th IUIS 2019 (International Congress of Immunology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] Basophils promote the differentiation of monocytes into M2-like macrophages which dampen IL-1α-mediated aggravation of allergic inflammation2019
- Author(s)
  Miyake K, Yoshikawa S, Yamanishi Y, Karasuyama H.
- Organizer
  17th IUIS 2019 (International Congress of Immunology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property2019
- Author(s)
  Ito J, Miyake K, Shichino S, Yamanishi Y, Karasuyama H
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation2019
- Author(s)
  Miyake K, Yoshikawa S, Yamanishi Y, Karasuyama H
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance.2018
- Author(s)
  Kensuke Miyake、 Ayako Fukui、 Soichiro Yoshikawa、 Yoshinori Yamanishi、 Hajime Karasuyama
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15180
[Presentation] Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice.2018
- Author(s)
  Toshihisa Nagao、 Yoshinori Yamanishi、 Kensuke Miyake、 Mio Teranishi、 Soichiro Yoshikawa、 Yohei Kawano、 Hajime Karasuyama
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15180

1. 永井重徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 河野洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 東みゆき

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 吉川宗一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
5. 烏山一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山西吉典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyake Kensuke 三宅 健介

Research Projects

Research Products

Co-Researchers

The regulatory roles of basophils in skin allergic inflammation by using single-cell RNA-seq analysisPrincipal Investigator

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Elucidation of mechanisms for basophil maturation by using RNA-seqPrincipal Investigator

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Elucidation of mechanisms how M2 macrophages induced by basophils dampen excess inflammationPrincipal Investigator

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[Journal Article] Recent advances in understanding of basophil function and differentiation2024

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[Journal Article] Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model2024

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[Journal Article] Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice2024

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[Journal Article] Topical Application of a PDE4 Inhibitor Ameliorates Atopic Dermatitis through Inhibition of Basophil IL-4 Production2024

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[Journal Article] Basophils are important for development of allergic skin inflammation2024

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[Journal Article] Cutaneous basophil infiltration in atopic dermatitis is associated with abundant epidermal infiltration of helper T cells: A preliminary retrospective study2023

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[Journal Article] An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis2023

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[Journal Article] 【蕁麻疹・血管性浮腫】蕁麻疹と好塩基球2023

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[Journal Article] Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils2023

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[Journal Article] 【肺免疫から肺疾患を考える】アレルギー疾患や寄生虫感染症における好塩基球の役割2022

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[Journal Article] 【ファゴサイトーシスとトロゴサイトーシス】免疫細胞におけるトロゴサイトーシスの役割2022

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[Journal Article] Role of Basophils in a Broad Spectrum of Disorders2022

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Miyake Kensuke 三宅健介

[Journal Article] いま知りたい!!かじる?呑み込む?貪食の多様性　トロゴサイトーシスとエフェロサイトーシス　トロゴサイトーシスによる免疫細胞機能の調節2021