Maeda Ryo 前田亮

Researcher Number	90814575
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 特任助教(常勤)
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 大学院生命機能研究科, 特任助教(常勤) 2022: 大阪大学, 大学院生命機能研究科, 特任助教(常勤) 2021: 大阪大学, 生命機能研究科, 特任助教(常勤) 2019 – 2020: 大阪大学, 生命機能研究科, 特別研究員(PD) 2018: 徳島大学, 先端酵素学研究所(次世代), 特別研究員(PD) 2017 – 2018: 徳島大学, 先端酵素学研究所, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 43050:Genome biology-related / Basic Section 43010:Molecular biology-related
Keywords	Principal Investigator H3K9メチル化 / HP1 / ヘテロクロマチン / H3K9me3 / 転写制御 / 体細胞分裂 / ES細胞 / MDM2 / transcription factor / TLP … More / p53 / がん抑制遺伝子 / 遺伝子発現抑制 / レトロトランスポゾン Less

ほ乳類におけるヘテロクロマチン解除機構の解明Principal Investigator
- Principal Investigator
  
  前田亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Osaka University
Mechanism of HP1-mediated heterochromatin formation in mammalsPrincipal Investigator
- Principal Investigator
  
  Maeda Ryo
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Osaka University
Molecular mechanism of heterochromatin patterning involved in gene regulationPrincipal Investigator
- Principal Investigator
  
  Maeda Ryo
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Osaka University
  The University of Tokushima
ＥＳ細胞における染色体構造の安定性を担保するヘテロクロマチン形成機構Principal Investigator
- Principal Investigator
  
  前田亮
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
  The University of Tokushima
ｐ５３のがん抑制機構における転写因子ＴＬＰの機能の解明Principal Investigator
- Principal Investigator
  
  前田亮
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokushima
  Chiba University

All 2022 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] HP1 maintains protein stability of H3K9 methyltransferases and demethylases2022
- Author(s)
  Ryo Maeda, Makoto Tachibana
- Journal Title
  
  EMBO Reports
  
  Volume: 23 Issue: 4
- DOI
  10.15252/embr.202153581
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06424, KAKENHI-PROJECT-21K15067, KAKENHI-PROJECT-21K19221, KAKENHI-PROJECT-21H04769, KAKENHI-PUBLICLY-22H04671, KAKENHI-ORGANIZER-17H06423
[Journal Article] H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline2020
- Author(s)
  Kuroki Shunsuke、Maeda Ryo、Yano Masashi、Kitano Satsuki、Miyachi Hitoshi、Fukuda Mikiko、Shinkai Yoichi、Tachibana Makoto
- Journal Title
  
  Stem Cell Reports
  
  Volume: 15 Issue: 2 Pages: 424-438
- DOI
  10.1016/j.stemcr.2020.06.013
- NAID
  120007146093
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05364, KAKENHI-PROJECT-18H02419, KAKENHI-PROJECT-20H03262, KAKENHI-PROJECT-18J00586, KAKENHI-PROJECT-19K22388, KAKENHI-ORGANIZER-17H06423, KAKENHI-PLANNED-17H06424
[Journal Article] The mouse Sry locus harbors a cryptic exon that is essential for male sex determination2020
- Author(s)
  Miyawaki Shingo、Kuroki Shunsuke、Maeda Ryo、Okashita Naoki、Koopman Peter、Tachibana Makoto
- Journal Title
  
  Science
  
  Volume: 370 Issue: 6512 Pages: 121-124
- DOI
  10.1126/science.abb6430
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05364, KAKENHI-PROJECT-18H02419, KAKENHI-PROJECT-20H03262, KAKENHI-PROJECT-18J00586, KAKENHI-PROJECT-20J40132, KAKENHI-PROJECT-19K22388, KAKENHI-PROJECT-19K16490, KAKENHI-ORGANIZER-17H06423, KAKENHI-PLANNED-17H06424
[Journal Article] TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.2019
- Author(s)
  Okashita N, Kuroki S, Maeda R, *Tachibana M.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 13462-13462
- DOI
  10.1038/s41598-019-50058-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22388, KAKENHI-PROJECT-18J00586, KAKENHI-PROJECT-18K14675, KAKENHI-PROJECT-18K14676
[Journal Article] Combined loss of JMJD1A and JMJD1B reveals critical roles for H3K9 demethylation in the maintenance of embryonic stem cells and early embryogenesis.2018
- Author(s)
  Kuroki, S., Nakai, Y., Maeda, R., Okashita, N., Akiyoshi, M., Yamaguchi, Y., Kitano, S., Miyachi, H., Nakato, R., Ichiyanagi, K., Shirahige, K., Kimura, H., Shinkai, Y., and Tachibana, M.
- Journal Title
  
  Stem Cell Rep.
  
  Volume: 10 Issue: 4 Pages: 1340-1354
- DOI
  10.1016/j.stemcr.2018.02.002
- NAID
  120006463740
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07726, KAKENHI-PROJECT-18K14675, KAKENHI-PROJECT-18K14676, KAKENHI-ORGANIZER-17H06423, KAKENHI-PROJECT-16H04817, KAKENHI-PROJECT-18H02419, KAKENHI-PROJECT-18J00586, KAKENHI-PLANNED-17H06424
[Journal Article] TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.2017
- Author(s)
  Maeda R., Tamashira H., Takano K., Takahashi H., Suzuki H., Saito S., Hojima W., Adachi N., U ra K ., E ndo T . and *Tam ura T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 8 Pages: 3201-3212
- DOI
  10.1074/jbc.m116.763318
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01345, KAKENHI-PROJECT-15H04323, KAKENHI-PROJECT-15H04348, KAKENHI-PROJECT-15J02670, KAKENHI-PROJECT-16J04091, KAKENHI-PROJECT-26440045
[Journal Article] Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA2016
- Author(s)
  Isogai M, Suzuki H, Maeda R, Tamura T.
- Journal Title
  
  Genes Cells
  
  Volume: 21 Issue: 11 Pages: 1223-1232
- DOI
  10.1111/gtc.12441
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J02670, KAKENHI-PROJECT-16J04091
[Journal Article] TBP-like protein (TLP) represses myogenesis via inhibition of the myogenin promoter.2016
- Author(s)
  Nakazato A, Maeda R, Ishikawa K, Suzuki H, Tamura T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 479 Issue: 4 Pages: 814-819
- DOI
  10.1016/j.bbrc.2016.09.127
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J02670, KAKENHI-PROJECT-16J04091
[Journal Article] TBP-like protein (TLP) interferes with Taspase1-mediated processing of TFIIA and represses TATA box gene expression.2015
- Author(s)
  Suzuki H, Isogai M, Maeda R, Ura K, Tamura T.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 43 Issue: 13 Pages: 6285-6298
- DOI
  10.1093/nar/gkv576
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J02670, KAKENHI-PROJECT-13J04583, KAKENHI-PROJECT-24570193, KAKENHI-PLANNED-22131003, KAKENHI-PUBLICLY-15H01345
[Presentation] H3K9me2/3 represses the expression of 2-cell-stage-specific genes in mESCs2022
- Author(s)
  前田亮
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15067
[Presentation] H3K9 methylation-mediated gene repression in mESCs2022
- Author(s)
  前田亮
- Organizer
  遺伝研研究会「有性生殖における染色体・クロマチン・核動態に関する若手研究者の会」
- Invited
- Data Source
  KAKENHI-PROJECT-21K15067
[Presentation] H3K9メチル化hubとしてはたらくHP1の機能2019
- Author(s)
  前田亮
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K14675
[Presentation] H3K9メチル化hubとしてはたらくHP1の機能2019
- Author(s)
  前田　亮
- Organizer
  分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18J00586
[Presentation] ES細胞におけるレトロトランスポゾンを起点とした転写抑制領域の構築機構2017
- Author(s)
  前田亮
- Organizer
  生命情報若手の会第9回研究会
- Data Source
  KAKENHI-PROJECT-15J02670
[Presentation] p53-TLP相互作用：MDM2の機能抑制によるp53活性化維持機構2016
- Author(s)
  前田亮
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-15J02670
[Presentation] Competitive p53 Binding of TBP-Like Protein (TLP) Against MDM2 Induces Stabilization of p53 and Promotes p53-Mediated Cell Growth Regulation2015
- Author(s)
  Ryo Maeda
- Organizer
  8th International MDM2 Workshop
- Place of Presentation
  ニューオリンズ（アメリカ合衆国）
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J02670
[Presentation] MDM2との結合競合を介した転写因子TLPによるp53安定化機構2015
- Author(s)
  前田亮
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸ポートアリーナ（兵庫県・神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15J02670

1. NAKAI Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 立花誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 青田聖恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 黒木俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Maeda Ryo 前田 亮

Research Projects

Research Products

Co-Researchers

ほ乳類におけるヘテロクロマチン解除機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of HP1-mediated heterochromatin formation in mammalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of heterochromatin patterning involved in gene regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ＥＳ細胞における染色体構造の安定性を担保するヘテロクロマチン形成機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ｐ５３のがん抑制機構における転写因子ＴＬＰの機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] HP1 maintains protein stability of H3K9 methyltransferases and demethylases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The mouse Sry locus harbors a cryptic exon that is essential for male sex determination2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined loss of JMJD1A and JMJD1B reveals critical roles for H3K9 demethylation in the maintenance of embryonic stem cells and early embryogenesis.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TBP-like protein (TLP) represses myogenesis via inhibition of the myogenin promoter.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TBP-like protein (TLP) interferes with Taspase1-mediated processing of TFIIA and represses TATA box gene expression.2015

Author(s)

Journal Title

DOI

Maeda Ryo 前田亮