Asaoka Nozomi 浅岡希美

Researcher Number	90826091
Other IDs	https://orcid.org/0000-0003-4854-2100
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 京都大学, 医学研究科, 助教 2020 – 2023: 京都大学, 医学研究科, 助教 2018 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 51030:Pathophysiologic neuroscience-related / 0802:Biomedical structure and function and related fields Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator 習慣 / 線条体 / 強迫性障害 / 記憶固定化 / 強迫的意思決定 / 仕事中毒 / 強迫性 / 前頭皮質 / 強迫 / D2受容体 … More / 活性酸素産生酵素 / ドパミンD2受容体 / 活性酸素 / 眼窩前頭皮質 … More Except Principal Investigator AI創薬 / ドラッグリポジショニング / 有害事象 / 臨床予測性 / 臨床検査値 / 創薬 / 薬理学 / 電子カルテ / ビッグデータ / レセプト / リアルワールドデータ / 神経発達障害 / プルキンエ細胞 / 小脳 / 母体免疫活性化 / 自閉症様行動 / NOX1 / 精神疾患 / NADPHオキシダーゼ / ASD / 活性酸素種 / 発達障害 Less

強迫の共通メカニズムとしての習慣「実行」の異常解明と治療応用Principal Investigator
- Principal Investigator
  
  浅岡希美
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto University
タスク経験の記憶固定化に着目した仕事中毒の神経基盤の解析Principal Investigator
- Principal Investigator
  
  浅岡希美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto University
Elucidation of role of NOX1/NADPH oxidase in the development of neurodevelopment disorders.
- Principal Investigator
  
  Ibi Masakazu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kinjo Gakuin University
  Kyoto Prefectural University of Medicine
Pathophysiological mechanisms and therapeutic targets for abnormal habit formation-related obsessive-compulsive symptomsPrincipal Investigator
- Principal Investigator
  
  Asaoka Nozomi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto University
  Kyoto Prefectural University of Medicine
Drug target finding based on the analysis of real world data
- Principal Investigator
  
  Kaneko Shuji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kyoto University
Pathophysiological roles of ventral striatal ROS signaling in obsessive compulsive disorderPrincipal Investigator
- Principal Investigator
  
  Asaoka Nozomi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor2024
- Author(s)
  Hatakama Hikari、Asaoka Nozomi、Nagayasu Kazuki、Shirakawa Hisashi、Kaneko Shuji
- Journal Title
  
  Translational Psychiatry
  
  Volume: 14 Issue: 1 Pages: 27-27
- DOI
  10.1038/s41398-024-02731-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15291, KAKENHI-PROJECT-21K07266, KAKENHI-PROJECT-20K07064, KAKENHI-PROJECT-20H00491
[Journal Article] Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via β-arrestin signaling2023
- Author(s)
  Nagaoka Koki、Asaoka Nozomi、Nagayasu Kazuki、Shirakawa Hisashi、Kaneko Shuji
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 1082375-1082375
- DOI
  10.3389/fnins.2022.1082375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07064, KAKENHI-PROJECT-20H00491
[Journal Article] Bortezomib is an effective enhancer for chemical probe-dependent superoxide detection.2022
- Author(s)
  Matsumoto M, Sawada H, Iwata K, Ibi M, Asaoka N, Katsuyama M, Shintani-Ishida K, Ikegaya H, Takegami S, Umemura A, Yabe-Nishimura C.
- Journal Title
  
  Front Med (Lausanne)
  
  Volume: 9 Pages: 941180-941180
- DOI
  10.3389/fmed.2022.941180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07087, KAKENHI-PROJECT-21K06523, KAKENHI-PROJECT-20K07294, KAKENHI-PROJECT-20K10558
[Journal Article] A selective serotonin reuptake inhibitor ameliorates obsessive compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex2022
- Author(s)
  Hatakama Hikari、Asaoka Nozomi、Nagayasu Kazuki、Shirakawa Hisashi、Kaneko Shuji
- Journal Title
  
  Neuropharmacology
  
  Volume: 206 Pages: 108926-108926
- DOI
  10.1016/j.neuropharm.2021.108926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16009, KAKENHI-PUBLICLY-20H04774, KAKENHI-PROJECT-20K07064
[Journal Article] Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonists-induced orofacial dyskinesia2021
- Author(s)
  Nagaoka Koki、Nagashima Takuya、Asaoka Nozomi、Yamamoto Hiroki、Toda Chihiro、Kayanuma Gen、Siswanto Soni、Funahashi Yasuhiro、Kuroda Keisuke、Kaibuchi Kozo、Mori Yasuo、Nagayasu Kazuki、Shirakawa Hisashi、Kaneko Shuji
- Journal Title
  
  JCI Insight
  
  Volume: in press Issue: 10 Pages: 1-16
- DOI
  10.1172/jci.insight.145632
- NAID
  120007038817
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0216, KAKENHI-PROJECT-19H03417, KAKENHI-PROJECT-18K14816, KAKENHI-PUBLICLY-20H04774, KAKENHI-PROJECT-19H03377, KAKENHI-PROJECT-20K07064, KAKENHI-PROJECT-20K07965, KAKENHI-PROJECT-19K22582, KAKENHI-PROJECT-20H00491, KAKENHI-PROJECT-19H03540
[Journal Article] Clioquinol inhibits dopamine-beta-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neurobla2021
- Author(s)
  Katsuyama M, Kimura E, Ibi M, Iwata K, Matsumoto M, Asaoka N and Yabe-Nishimura C.
- Journal Title
  
  Arch Toxicol.
  
  Volume: 95 Issue: 1 Pages: 135-148
- DOI
  10.1007/s00204-020-02894-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07087
[Journal Article] NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis2021
- Author(s)
  Matsumoto M, Liu J, Iwata K, Ibi M, Asaoka N, Zhang X, Katsuyama M, Matsuda M, Nabe T, Scroder K, Yabe-Nishimura C.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 146 (2) Issue: 2 Pages: 88-97
- DOI
  10.1016/j.jphs.2021.01.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07294, KAKENHI-PROJECT-20K07087
[Journal Article] NOX1/NADPH oxidase affects the development of autism-like behaviors in a maternal immune activation model.2021
- Author(s)
  Zhang X, Ibi M, Haga R, Iwata K, Matsumoto M, Asaoka N, Liu J, Katsuyama M and Yabe-Nishimura C.
- Journal Title
  
  Bochem Biophys Res Commun .
  
  Volume: 534 Pages: 59-66
- DOI
  10.1016/j.bbrc.2020.11.070
- NAID
  130008001324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07087
[Journal Article] NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D2 Receptor Stimulation: Involvement in Behavioral Repetition2021
- Author(s)
  Asaoka Nozomi、Ibi Masakazu、Hatakama Hikari、Nagaoka Koki、Iwata Kazumi、Matsumoto Misaki、Katsuyama Masato、Kaneko Shuji、Yabe-Nishimura Chihiro
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 41 Issue: 12 Pages: 2780-2794
- DOI
  10.1523/jneurosci.2121-20.2021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16009, KAKENHI-PROJECT-20K07087
[Journal Article] An Adenosine A2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis.2019
- Author(s)
  Asaoka N, Nishitani N, Kinoshita H, Nagai Y, Hatakama H, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S
- Journal Title
  
  eNeuro
  
  Volume: 6 Issue: 1 Pages: ENEURO.0366-18.2019
- DOI
  10.1523/eneuro.0366-18.2019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14919, KAKENHI-PUBLICLY-18H04616, KAKENHI-PROJECT-16H05091, KAKENHI-PROJECT-19K21244
[Presentation] Region-specific cortical plasticity during habit formation determines individuality2023
- Author(s)
  Nozomi Asaoka, Yasunori Hayashi
- Organizer
  記憶研究会2023
- Data Source
  KAKENHI-PROJECT-22K15291
[Presentation] Region-specific cortical plasticity during habit formation determines individuality in habit strength2023
- Author(s)
  Nozomi Asaoka, Yasunori Hayashi
- Organizer
  第４６回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K15291
[Presentation] Region- and circuit-specific synaptic plasticity in the prefrontal cortex determine the individuality in habit execution2023
- Author(s)
  Nozomi Asaoka, Yasunori Hayashi
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K15291
[Presentation] Region- and proficiency-specific synaptic potentiation in the prefrontal cortex during learning of normal and workaholic-like operant behavior2022
- Author(s)
  浅岡希美、林康紀
- Organizer
  第45回日本神経科学大会／第65回日本神経化学会大会／第32回日本神経回路学会大会
- Data Source
  KAKENHI-PROJECT-22K15291
[Presentation] Region-specific plastic changes in the prefrontal cortex drive compulsive task performance2022
- Author(s)
  浅岡希美、林康紀
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15291
[Presentation] Region- and proficiency-specific synaptic potentiation in the prefrontal cortex during learning of normal and compulsive operant behavior2022
- Author(s)
  浅岡希美、林康紀
- Organizer
  第2回国際シンポジウムマルチスケール脳/MCCS-Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15291
[Presentation] NOX1/NADPH oxidase regulates compulsive-like repetitive behaviors through promoting D2 receptor-mediated synaptic facilitation in the striatum2021
- Author(s)
  Nozomi Asaoka, Shuji Kaneko, Chihiro Yabe-Nishimura
- Organizer
  第43回日本生物学的精神医学会第51回日本神経精神薬理学会
- Data Source
  KAKENHI-PROJECT-20K16009
[Presentation] NOX1/NADPH oxidase regulates compulsive-like repetitive behaviors through promoting D2 receptor-mediated synaptic facilitation in the striatum2021
- Author(s)
  Nozomi Asaoka, Masakazu Ibi, Shuji Kaneko, Chihiro Yabe-Nishimura
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16009
[Presentation] NOX1/NADPH oxidase regulates compulsive-like repetitive behaviors through promoting D2 receptor-mediated synaptic facilitation in the striatum2021
- Author(s)
  Nozomi Asaoka, Shuji Kaneko, Chihiro Yabe-Nishimura
- Organizer
  第44回日本神経科学大会 CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16009
[Presentation] NOX1/NADPH oxidase regulates compulsive-like repetitive behaviors through promoting D2 receptor-mediated synaptic facilitation in the striatum2021
- Author(s)
  浅岡希美、衣斐督和、金子周司、矢部千尋
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16009
[Presentation] NOX1/NADPH oxidaseはドパミンD2受容体を介した線条体のシナプス増強を促進することで強迫様行動の誘発に関与する2021
- Author(s)
  浅岡希美, 金子周司, 矢部千尋
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K16009
[Presentation] Nox1 deficiency alleviated behavioral abnormalities in obsessive-compulsive disorder model mice via inhibition of D2 receptor/β-arrestin pathway-mediated synaptic facilitation2020
- Author(s)
  Nozomi Asaoka, Chihiro Yabe-Nishimura, Shuji Kaneko
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K21244
[Presentation] An adenosine A2A receptor antagonist, istradefylline, improves multiple symptoms reflecting obsessive-compulsive disorder in mice2020
- Author(s)
  Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Hikari Hatakama, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Chihiro Yabe-Nishimura, Shuji Kaneko
- Organizer
  第10回武田科学振興財団薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K21244
[Presentation] An adenosine A2A receptor antagonist, istradefylline, improves multiple symptoms reflecting obsessive-compulsive disorder in mice2019
- Author(s)
  Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Hikari Hatakama, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Chihiro Yabe-Nishimura, Shuji Kaneko
- Organizer
  The 6th Asian College of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21244
[Presentation] Blockade of adenosine A2A receptor improves repeated dopamine D2 receptor stimulation-induced multiple abnormalities reflecting obsessive-compulsive disorder2019
- Author(s)
  Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Hikari Hatakama, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Chihiro Yabe-Nishimura, Shuji Kaneko
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19K21244
[Presentation] An adenosine A2A receptor antagonist improves multiple symptoms reflecting obsessive-compulsive disorder2019
- Author(s)
  Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Hikari Hatakama, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Chihiro Yabe-Nishimura, Shuji Kaneko
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K21244
[Presentation] Developing novel treatment strategies for OCD by utilizing rodent models: a therapeutic potential of adenosine A2A receptor antagonism2019
- Author(s)
  Nozomi Asaoka, Chihiro Yabe-Nishimura, Shuji Kaneko
- Organizer
  The 6th Asian College of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21244
[Presentation] An adenosine A2A receptor antagonist, istradefylline, improves multiple symptoms reflecting obsessive-compulsive disorder in a novel murine model2018
- Author(s)
  Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21244

1. Ibi Masakazu (10336539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. Kaneko Shuji (60177516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 永安一樹 (00717902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 浅井聰 (80231108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIRAKAWA Hisashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 宗可奈子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 岩田和実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松本みさき

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Asaoka Nozomi 浅岡 希美

Research Projects

Research Products

Co-Researchers

強迫の共通メカニズムとしての習慣「実行」の異常解明と治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タスク経験の記憶固定化に着目した仕事中毒の神経基盤の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of role of NOX1/NADPH oxidase in the development of neurodevelopment disorders.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological mechanisms and therapeutic targets for abnormal habit formation-related obsessive-compulsive symptomsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug target finding based on the analysis of real world data

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological roles of ventral striatal ROS signaling in obsessive compulsive disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via β-arrestin signaling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bortezomib is an effective enhancer for chemical probe-dependent superoxide detection.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A selective serotonin reuptake inhibitor ameliorates obsessive compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonists-induced orofacial dyskinesia2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Clioquinol inhibits dopamine-beta-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neurobla2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NOX1/NADPH oxidase affects the development of autism-like behaviors in a maternal immune activation model.2021

Author(s)

Journal Title

DOI

Asaoka Nozomi 浅岡希美

[Presentation] NOX1/NADPH oxidaseはドパミンD2受容体を介した線条体のシナプス増強を促進することで強迫様行動の誘発に関与する2021