Amatsu Sho 阿松翔

Researcher Number	90827346
Other IDs	https://orcid.org/0000-0003-0692-264X
Affiliation (based on the past Project Information) *help	2018 – 2023: 金沢大学, 医学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / 0803:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator ヘマグルチニン / ボツリヌス毒素複合体 / 腸管吸収 / ボツリヌス毒素 / ムチン / カドヘリン・フロー / E-カドヘリン / 腸管バリア破壊 / アクチンフロー / 細胞外輸送経路 … More / カドヘリンフロー / E-cadherin / 腸上皮細胞 / 受容体 / トランスサイトーシス Less

Mechanism of Intestinal Absorption of Hyper-virulent Botulinum Toxin ComplexPrincipal Investigator
- Principal Investigator
  
  阿松翔
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kanazawa University
Analysis of transport mechanism of hemagglutinin of botulinum toxin complex to adherens junctionsPrincipal Investigator
- Principal Investigator
  
  Amatsu Sho
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kanazawa University
Analysis of intestinal absorption of botulinum toxin complex type BPrincipal Investigator
- Principal Investigator
  
  Amatsu Sho
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin2023
- Author(s)
  Amatsu Sho、Matsumura Takuhiro、Zuka Masahiko、Fujinaga Yukako
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 3 Pages: 102944-102944
- DOI
  10.1016/j.jbc.2023.102944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16240, KAKENHI-PROJECT-21K07021
[Journal Article] Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro2022
- Author(s)
  Kobayashi Nobuhide、Abe Kimihiro、Akagi Sachiyo、Kitamura Mayu、Shiraishi Yoshitake、Yamaguchi Aki、Yutani Masahiro、Amatsu Sho、Matsumura Takuhiro、Nomura Nobuhiko、Ozaki Noriyuki、Obana Nozomu、Fujinaga Yukako
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 13 Pages: 720308-720308
- DOI
  10.3389/fmicb.2022.720308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17462, KAKENHI-PROJECT-19K05762, KAKENHI-PROJECT-21K06731, KAKENHI-PROJECT-21K07018, KAKENHI-PROJECT-20K16240, KAKENHI-PLANNED-19H05682
[Journal Article] Botulinum Hemagglutinin: Critical Protein for Adhesion and Absorption of Neurotoxin Complex in Host Intestine2020
- Author(s)
  Sho Amatsu and Yukako Fujinaga
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2132 Pages: 183-190
- DOI
  10.1007/978-1-0716-0430-4_19
- ISBN
  9781071604298, 9781071604304
- Data Source
  KAKENHI-PROJECT-19K21257, KAKENHI-PROJECT-20K16240
[Journal Article] Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B2020
- Author(s)
  Matsumura Takuhiro、Amatsu Sho、Misaki Ryo、Yutani Masahiro、Du Anariwa、Kohda Tomoko、Fujiyama Kazuhito、Ikuta Kazuyoshi、Fujinaga Yukako
- Journal Title
  
  Toxins
  
  Volume: 12 Issue: 5 Pages: 302-302
- DOI
  10.3390/toxins12050302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16240, KAKENHI-PROJECT-18K07107
[Presentation] Endogenous production and neurotoxicity of novel botulinum neurotoxin (BoNT/X) in a clinical isolate2023
- Author(s)
  松村拓大, 阿松翔, 小林英伸, 藤永由佳子
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] A型ボツリヌス神経毒素に対するヒト型モノクローナル抗体の開発・解析2023
- Author(s)
  山口アキ, 松村拓大, 小林伸英, 阿松翔, 藤永由佳子
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] ボツリヌス菌の遺伝子改変方法の開発2023
- Author(s)
  阿松翔, 斎藤和樹, 成谷宏文, 藤永由佳子
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] Development of Genetic Manipulation methods for Group I Clostridium botulinum2022
- Author(s)
  Sho Amatsu, Kazuki Saito, Hirofumi Nariya, Yukako Fujinaga
- Organizer
  59th Intergency Botulism Research Coordinating Committee (IBRCC) meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] 腸管ボツリヌス症モデルマウスからのボツリヌス菌検出方法の検討2022
- Author(s)
  阿松翔, 塚正彦
- Organizer
  第106次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] ボツリヌス毒素複合体と腸管ムチンとの相互作用解析2022
- Author(s)
  阿松翔, 松村拓大, 森本ちよの, 北村真悠, 藤永由佳子
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] 強毒型ボツリヌス毒素複合体の腸管吸収機構2021
- Author(s)
  阿松翔, 松村拓大, 森本ちよの, 北村真悠, 藤永由佳子
- Organizer
  第67回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] 糞便サンプルからのボツリヌス菌の検出方法の検討2021
- Author(s)
  阿松翔, 塚正彦
- Organizer
  第105次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-20K16240
[Presentation] ボツリヌス毒素複合体のヘマグルチニンがアドへレンスジャンクションへ移行するための輸送経路の解析2020
- Author(s)
  阿松翔, 藤永由佳子
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] E-cadherin機能阻害活性を維持した最小化ボツリヌス菌ヘマグルチニンの開発2019
- Author(s)
  阿松翔, 松村拓大, 油谷雅広, 藤永由佳子
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] ボツリヌス毒素複合体の無毒成分ヘマグルチニン(HA)を利用したiPS細胞の大量培養技術と最小化HAの開発2019
- Author(s)
  阿松翔, 金美海, 松村拓大, 紀ノ岡正博, 藤永由佳子
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] Molecular engineering of Nano-HA, a minimal protein that inhibits E-cadherin-mediated cell-cell adhesion derived from Clostridium botulinum hemagglutinin2019
- Author(s)
  Sho Amatsu, Takuhiro Matsumura, Yukako Fujinaga
- Organizer
  56th Intergency Botulisum Research Coordinating Committee (IBRCC) meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] ボツリヌスHAはどのようにしてアドへレンスジャンクションへたどり着くのか2019
- Author(s)
  阿松翔, 藤永由佳子
- Organizer
  第66回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] E-cadherin機能阻害活性を有するボツリヌス菌由来ヘマグルチニンの最小化とその作用機序2019
- Author(s)
  阿松翔, 松村拓大, 油谷雅広, 藤永由佳子
- Organizer
  第71回日本細胞生物学会大会-第19回日本蛋白質科学会年会合同年次大会
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] 乳児ボツリヌス症検索の試みとB型ボツリヌス毒素複合体ヘマグルチニン成分の解析2019
- Author(s)
  阿松翔, 塚正彦
- Organizer
  第103次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] E-cadherin機能阻害活性を維持した最小化ボツリヌス菌由来ヘマグルチニンの開発2019
- Author(s)
  阿松翔, 松村拓大, 油谷雅広, 藤永由佳子
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] E-cadherin機能阻害活性を維持した最小化ボツリヌス菌ヘマグルチニン由来物質の開発2018
- Author(s)
  阿松翔, 松村拓大, 油谷雅広, 藤永由佳子
- Organizer
  第65回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-19K21257
[Presentation] B型ボツリヌス毒素複合体を構成するHA成分の多価性が上皮細胞間バリア破壊活性に与える影響2018
- Author(s)
  阿松翔, 松村拓大, 油谷雅広, 藤永由佳子
- Organizer
  第55回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-19K21257

1. 小林伸英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Amatsu Sho 阿松 翔

Research Projects

Research Products

Co-Researchers

Mechanism of Intestinal Absorption of Hyper-virulent Botulinum Toxin ComplexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of transport mechanism of hemagglutinin of botulinum toxin complex to adherens junctionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of intestinal absorption of botulinum toxin complex type BPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Botulinum Hemagglutinin: Critical Protein for Adhesion and Absorption of Neurotoxin Complex in Host Intestine2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Endogenous production and neurotoxicity of novel botulinum neurotoxin (BoNT/X) in a clinical isolate2023

Author(s)

Organizer

Data Source

[Presentation] A型ボツリヌス神経毒素に対するヒト型モノクローナル抗体の開発・解析2023

Author(s)

Organizer

Data Source

[Presentation] ボツリヌス菌の遺伝子改変方法の開発2023

Author(s)

Organizer

Data Source

[Presentation] Development of Genetic Manipulation methods for Group I Clostridium botulinum2022

Author(s)

Organizer

Data Source

[Presentation] 腸管ボツリヌス症モデルマウスからのボツリヌス菌検出方法の検討2022

Author(s)

Organizer

Data Source

[Presentation] ボツリヌス毒素複合体と腸管ムチンとの相互作用解析2022

Author(s)

Organizer

Data Source

[Presentation] 強毒型ボツリヌス毒素複合体の腸管吸収機構2021

Author(s)

Organizer

Data Source

[Presentation] 糞便サンプルからのボツリヌス菌の検出方法の検討2021

Author(s)

Organizer

Data Source

[Presentation] ボツリヌス毒素複合体のヘマグルチニンがアドへレンスジャンクションへ移行するための輸送経路の解析2020

Author(s)

Organizer

Data Source

[Presentation] E-cadherin機能阻害活性を維持した最小化ボツリヌス菌ヘマグルチニンの開発2019

Amatsu Sho 阿松翔