SAKAI CHIEMI 坂井千恵美

Researcher Number	90827982
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2023: 広島大学, 医系科学研究科(医), 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 細胞老化 / DNA損傷 / マクロファージ / HFpEF / 炎症 / 心不全 / Endoreduplication / 遺伝子多型 / 多倍体化 / 心肥大 / XRCC3遺伝子多型

細胞老化を基盤としたマクロファージ－心筋細胞連関に着目したHFpEFの病態解明Principal Investigator
- Principal Investigator
  
  坂井千恵美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hiroshima University
Role of XRCC3 polymorphism in the initiation and progression of cardiac hypertrophyPrincipal Investigator
- Principal Investigator
  
  SAKAI CHIEMI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hiroshima University

All 2024 2023 2020

All Journal Article Presentation

[Journal Article] Mitochondrial DNA is a key driver in cigarette smoke extract-induced IL-6 expression2024
- Author(s)
  Kobayashi, Yusuke Sakai, Chiemi Ishida, Takafumi Nagata, Minako Nakano, Yukiko Ishida, Mari
- Journal Title
  
  Hypertension Research
  
  Volume: 47 Issue: 1 Pages: 88-101
- DOI
  10.1038/s41440-023-01463-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16076, KAKENHI-PROJECT-21K08029
[Journal Article] A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks2023
- Author(s)
  Chiemi Sakai, Keitaro Ueda, Kohei Goda, Rikuto Fujita, Junji Maeda, Shinya Nakayama, Yusuke Sotomaru, Satoshi Tashiro, Masao Yoshizumi, Takafumi Ishida, Mari Ishida
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 16470-16470
- DOI
  10.1038/s41598-023-43848-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16076, KAKENHI-PROJECT-21K08029, KAKENHI-PROJECT-21H04927
[Journal Article] Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis2023
- Author(s)
  Ueda Keitaro、Sakai Chiemi、Ishida Takafumi、Morita Kosuke、Kobayashi Yusuke、Horikoshi Yasunori、Baba Akiko、Okazaki Yuma、Yoshizumi Masao、Tashiro Satoshi、Ishida Mari
- Journal Title
  
  Clinical Science
  
  Volume: 137 Issue: 2 Pages: 163-180
- DOI
  10.1042/cs20220525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08029, KAKENHI-PROJECT-21H04927, KAKENHI-PROJECT-20K08494, KAKENHI-PROJECT-22K16076
[Presentation] Role of DNA damage accumulation in cellular senescence and inflammation linked to atherosclerosis2024
- Author(s)
  Chiemi Sakai, Mari Ishida, Yusuke Kobayashi, Takafumi Ishida
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16076
[Presentation] DNA二本鎖切断蓄積はcGAS-STING経路を介して血管平滑筋細胞の炎症と細胞老化を誘導する2023
- Author(s)
  坂井千恵美, 石田万里, 小林佑輔, 田代聡, 石田隆史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K16076
[Presentation] DNA二本鎖切断蓄積はcGAS-STING経路を介して血管平滑筋細胞の炎症を惹起する2023
- Author(s)
  坂井千恵美, 石田隆史, 小林佑輔, 中野由紀子, 石田万里
- Organizer
  第55回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K16076
[Presentation] 動脈硬化発症におけるDNA二本鎖切断の役割2023
- Author(s)
  坂井千恵美、石田隆史、唐崎航平、石田万里
- Organizer
  第45回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-22K16076
[Presentation] DNA damage-induced activation of cGAS-STING mediates inflammation and cellular senescence2023
- Author(s)
  Chiemi Sakai, Mari Ishida, Yusuke Kobayashi, Takafumi Ishida
- Organizer
  BCVR2023
- Data Source
  KAKENHI-PROJECT-22K16076
[Presentation] ゲノム修復関連蛋白XRCC3の遺伝子多型は高血圧性心肥大の発症に関与する2020
- Author(s)
  坂井千恵美、石田万里、田代聡、吉栖正生、石田隆史
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K17526

1. ISHIDA Takafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 石田万里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAI CHIEMI 坂井 千恵美

Research Projects

Research Products

Co-Researchers

細胞老化を基盤としたマクロファージ－心筋細胞連関に着目したHFpEFの病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of XRCC3 polymorphism in the initiation and progression of cardiac hypertrophyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mitochondrial DNA is a key driver in cigarette smoke extract-induced IL-6 expression2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] Role of DNA damage accumulation in cellular senescence and inflammation linked to atherosclerosis2024

Author(s)

Organizer

Data Source

[Presentation] DNA二本鎖切断蓄積はcGAS-STING経路を介して血管平滑筋細胞の炎症と細胞老化を誘導する2023

Author(s)

Organizer

Data Source

[Presentation] DNA二本鎖切断蓄積はcGAS-STING経路を介して血管平滑筋細胞の炎症を惹起する2023

Author(s)

Organizer

Data Source

[Presentation] 動脈硬化発症におけるDNA二本鎖切断の役割2023

Author(s)

Organizer

Data Source

[Presentation] DNA damage-induced activation of cGAS-STING mediates inflammation and cellular senescence2023

Author(s)

Organizer

Data Source

[Presentation] ゲノム修復関連蛋白XRCC3の遺伝子多型は高血圧性心肥大の発症に関与する2020

Author(s)

Organizer

Data Source

SAKAI CHIEMI 坂井千恵美