Hayashi Tomohiko 林智彦

Researcher Number	90838070
Other IDs
Affiliation (Current)	2025: 新潟大学, 自然科学系, 准教授
Affiliation (based on the past Project Information) *help	2025: 新潟大学, 自然科学系, 准教授 2022 – 2023: 新潟大学, 自然科学系, 准教授 2019 – 2021: 新潟大学, 自然科学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
Keywords	Principal Investigator 形態計測学的アプローチ / 積分方程式理論 / 自由エネルギー計算 / 天然変性ペプチド / ペプチド薬 / 自由エネルギー関数 / 水和自由エネルギー / ペプチド抗癌剤

次世代バイオ医薬品の物理理論に基づく高速設計法の開発Principal Investigator
- Principal Investigator
  
  林智彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Niigata University
次世代ペプチド薬の物理理論に基づく高速デザイン法の開発Principal Investigator
- Principal Investigator
  
  林智彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Niigata University
Development of a physics-based fast screening method for detecting the cancer-therapeutic peptidesPrincipal Investigator
- Principal Investigator
  
  Hayashi Tomohiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Niigata University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Physical pictures of rotation mechanisms of F1- and V1-ATPases: Leading roles of translational, configurational entropy of water2023
- Author(s)
  Yasuda Satoshi、Hayashi Tomohiko、Murata Takeshi、Kinoshita Masahiro
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 10 Pages: 1-23
- DOI
  10.3389/fmolb.2023.1159603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K03547, KAKENHI-PROJECT-21K06108, KAKENHI-PROJECT-21H02409
[Journal Article] Nonadditivities of the Particle Sizes Hidden in Model Pair Potentials and Their Effects on Physical Adsorptions2023
- Author(s)
  Amano Ken-ichi、Furukawa Satoshi、Kubo Yuto、Nakamura Yuka、Ishii Rina、Tanase Ayane、Maebayashi Masahiro、Hayashi Tomohiko、Nishi Naoya、Sakka Tetsuo
- Journal Title
  
  Langmuir
  
  Volume: 39 Issue: 37 Pages: 12999-13007
- DOI
  10.1021/acs.langmuir.3c00968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K03547, KAKENHI-PROJECT-21K18935, KAKENHI-PLANNED-23H03829, KAKENHI-PROJECT-21H02046
[Journal Article] A methodology for creating mutants of G‐protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering2022
- Author(s)
  Yamamoto Taisei、Yasuda Satoshi、Kasai Rinshi S.、Nakano Ryosuke、Hikiri Simon、Sugaya Kanna、Hayashi Tomohiko、Ogasawara Satoshi、Shiroishi Mitsunori、Fujiwara Takahiro K.、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  Protein Science
  
  Volume: 31 Issue: 10
- DOI
  10.1002/pro.4425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06108, KAKENHI-PROJECT-22K03547, KAKENHI-PLANNED-21H05252, KAKENHI-PROJECT-20H03225, KAKENHI-PLANNED-18H05424, KAKENHI-PLANNED-18H05425
[Journal Article] Development of an Outward Proton Pumping Rhodopsin with a New Record in Thermostability by Means of Amino Acid Mutations2022
- Author(s)
  Yasuda Satoshi、Akiyama Tomoki、Kojima Keiichi、Ueta Tetsuya、Hayashi Tomohiko、Ogasawara Satoshi、Nagatoishi Satoru、Tsumoto Kouhei、Kunishima Naoki、Sudo Yuki、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 126 Issue: 5 Pages: 1004-1015
- DOI
  10.1021/acs.jpcb.1c08684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K14674, KAKENHI-PLANNED-18H05425, KAKENHI-PUBLICLY-21H00404, KAKENHI-PROJECT-21H02446, KAKENHI-PROJECT-20K21482, KAKENHI-PROJECT-21K15054, KAKENHI-PROJECT-20H02531
[Journal Article] Controlling the Rigidity of Kinesin-Propelled Microtubules in an In Vitro Gliding Assay Using the Deep-Sea Osmolyte Trimethylamine N-Oxide2022
- Author(s)
  Kabir Arif Md. Rashedul、Munmun Tasrina、Hayashi Tomohiko、Yasuda Satoshi、Kimura Atsushi P.、Kinoshita Masahiro、Murata Takeshi、Sada Kazuki、Kakugo Akira
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 4 Pages: 3796-3803
- DOI
  10.1021/acsomega.1c06699
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674, KAKENHI-PLANNED-18H05425, KAKENHI-PROJECT-21K04846, KAKENHI-PLANNED-20H05972, KAKENHI-PROJECT-21H04434
[Journal Article] A methodology for creating thermostabilized mutants of G‐protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering2022
- Author(s)
  Sugaya Kanna、Yasuda Satoshi、Sato Shingo、Sisi Chen、Yamamoto Taisei、Umeno Daisuke、Matsuura Tomoaki、Hayashi Tomohiko、Ogasawara Satoshi、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  Protein Science
  
  Volume: 31 Issue: 9
- DOI
  10.1002/pro.4404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06108, KAKENHI-PROJECT-22K03547, KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-21H05228
[Journal Article] Hydration properties of a protein at low and high pressures: Physics of pressure denaturation2020
- Author(s)
  Inoue Masao、Hayashi Tomohiko、Hikiri Simon、Ikeguchi Mitsunori、Kinoshita Masahiro
- Journal Title
  
  The Journal of Chemical Physics
  
  Volume: 152 Issue: 6 Pages: 065103-065103
- DOI
  10.1063/1.5140499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K14674, KAKENHI-PLANNED-18H05426, KAKENHI-PROJECT-17H03663
[Journal Article] Accurate and rapid calculation of hydration free energy and its physical implication for biomolecular functions2020
- Author(s)
  Kinosita Masahiro、Hayashi Tomohiko
- Journal Title
  
  Biophysical Reviews
  
  Volume: 12 Issue: 2 Pages: 469-480
- DOI
  10.1007/s12551-020-00686-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-17H03663
[Journal Article] Theoretical identification of thermostabilizing amino acid mutations for G-protein-coupled receptors2020
- Author(s)
  Takeshi Murata、Satoshi Yasuda、Tomohiko Hayashi、Masahiro Kinoshita
- Journal Title
  
  Biophysical Reviews
  
  Volume: － Issue: 2 Pages: 323-332
- DOI
  10.1007/s12551-020-00678-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-17H03663, KAKENHI-PLANNED-18H05425
[Journal Article] Comparison based on statistical thermodynamics between globule-to-coil transition of poly(N-isopropylacrylamide) and cold denaturation of a protein2020
- Author(s)
  Inoue Masao、Hayashi Tomohiko、Hikiri Simon、Ikeguchi Mitsunori、Kinoshita Masahiro
- Journal Title
  
  Journal of Molecular Liquids
  
  Volume: 317 Pages: 114129-114129
- DOI
  10.1016/j.molliq.2020.114129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K14674
[Journal Article] Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein2020
- Author(s)
  Mashima Tsukasa、Lee Joon-Hwa、Kamatari Yuji O.、Hayashi Tomohiko、Nagata Takashi、Nishikawa Fumiko、Nishikawa Satoshi、Kinoshita Masahiro、Kuwata Kazuo、Katahira Masato
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 4934-4934
- DOI
  10.1038/s41598-020-61966-4
- NAID
  120006813315
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674, KAKENHI-PUBLICLY-18H04550, KAKENHI-PROJECT-17H03663, KAKENHI-PROJECT-16K07269, KAKENHI-PUBLICLY-17H05878, KAKENHI-PROJECT-20H04285, KAKENHI-PROJECT-17K07307, KAKENHI-PROJECT-20K21477, KAKENHI-PROJECT-18K19397
[Journal Article] Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained2020
- Author(s)
  Yasuda Satoshi、Akiyama Tomoki、Nemoto Sayaka、Hayashi Tomohiko、Ueta Tetsuya、Kojima Keiichi、Tsukamoto Takashi、Nagatoishi Satoru、Tsumoto Kouhei、Sudo Yuki、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 60 Issue: 3 Pages: 1709-1716
- DOI
  10.1021/acs.jcim.0c00063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-19K16090, KAKENHI-PLANNED-18H05425, KAKENHI-PUBLICLY-19H04727, KAKENHI-PUBLICLY-19H05396, KAKENHI-PROJECT-17H03663, KAKENHI-PROJECT-18H02082, KAKENHI-PROJECT-18H02411
[Journal Article] How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?2020
- Author(s)
  Hayashi Tomohiko、Yasuda Satoshi、Suzuki Kano、Akiyama Tomoki、Kanehara Kanae、Kojima Keiichi、Tanabe Mikio、Kato Ryuichi、Senda Toshiya、Sudo Yuki、Murata Takeshi、Kinoshita Masahiro
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 124 Issue: 6 Pages: 990-1000
- DOI
  10.1021/acs.jpcb.9b10700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-19K16090, KAKENHI-PLANNED-18H05425, KAKENHI-PUBLICLY-19H04727, KAKENHI-PUBLICLY-19H05396, KAKENHI-PROJECT-17H03663, KAKENHI-PROJECT-18H02411, KAKENHI-PROJECT-17H06264
[Journal Article] How Does the Recently Discovered Peptide MIP Exhibit Much Higher Binding Affinity than an Anticancer Protein p53 for an Oncoprotein MDM22019
- Author(s)
  Yamada Tatsuya、Hayashi Tomohiko、Hikiri Simon、Kobayashi Naohiro、Yanagawa Hiroshi、Ikeguchi Mitsunori、Katahira Masato、Nagata Takashi、Kinoshita Masahiro
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 59 Issue: 8 Pages: 3533-3544
- DOI
  10.1021/acs.jcim.9b00226
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-19K14674, KAKENHI-PLANNED-18H05426, KAKENHI-PROJECT-17H03663, KAKENHI-PUBLICLY-17H05878, KAKENHI-PROJECT-17K07307
[Journal Article] An Accurate and Rapid Method for Calculating Solvation Free Energies of a Variety of Solutes Including Proteins2019
- Author(s)
  S. Hikiri, T. Hayashi, M. Inoue, T. Ekimoto, M. Ikeguchi, M. Kinoshita
- Journal Title
  
  Journal of Chemical Physics
  
  Volume: 150 Issue: 17 Pages: 175101-175101
- DOI
  10.1063/1.5093110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03663, KAKENHI-PROJECT-19K14674, KAKENHI-PLANNED-18H05426
[Journal Article] Mechanism of globule-to-coil transition of poly(N-isopropylacrylamide) in water: Relevance to cold denaturation of a protein2019
- Author(s)
  Inoue Masao、Hayashi Tomohiko、Hikiri Simon、Ikeguchi Mitsunori、Kinoshita Masahiro
- Journal Title
  
  Journal of Molecular Liquids
  
  Volume: 292 Pages: 111374-111374
- DOI
  10.1016/j.molliq.2019.111374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-17H03663
[Patent] 自由エネルギーの計算方法2023
- Inventor(s)
  村田武士、安田賢司、木下正弘、林智彦
- Industrial Property Rights Holder
  村田武士、安田賢司、木下正弘、林智彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-221583
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K03547
[Presentation] 膜輸送タンパク質-グルコース複合体の水和および揺らぎダイナミクス2023
- Author(s)
  Tatsuki Kawauchi, Tomohiko Hayashi
- Organizer
  日本物理学会第78回年次大会
- Data Source
  KAKENHI-PROJECT-22K03547
[Presentation] A methodology for designing peptide drugs by combining structure prediction methods and statistical thermodynamics2023
- Author(s)
  Shunsuke Miyamoto, Tomohiko Hayashi
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-22K03547
[Presentation] Computational study for designing peptide drugs based on statistical thermodynamics2022
- Author(s)
  Shunsuke Miyamoto, Tomohiko Hayashi
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-22K03547
[Presentation] Theoretical study based on statistical mechanics for predicting native-like poses of a protein-peptide complex2021
- Author(s)
  Shunsuke Miyamoto, Masato Kawamura, Tomohiko Hayashi
- Organizer
  The 59th Annual Meeting of Biophysical Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674
[Presentation] Structural and physical basis for anti-prion activity and destruction of the Alzheimer’s disease-related complex of an RNA-aptamer2021
- Author(s)
  Takashi Nagata, Tsukasa Mashima, Joon-Hwa Lee, Yuji O. Kamatari, Tomohiko Hayashi, Masahiro Kinoshita, Kazuo Kuwata, Masato Katahira
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674
[Presentation] Calculation of hydration free energy of a protein with sufficient accuracy and remarkably high speed2021
- Author(s)
  Masato Kawamura, Shunsuke Miyamoto, Tomohiko Hayashi, Masahiro Kinoshita
- Organizer
  The 59th Annual Meeting of Biophysical Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674
[Presentation] Statistical thermodynamics on the weakening of binding affinity of myosin for actin at low temperatures2021
- Author(s)
  Tomohiko Hayashi, Masahiro Kinoshita
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674
[Presentation] Statistical thermodynamics on the weakening of binding affinity of myosin for actin at low temperatures2019
- Author(s)
  Tomohiko Hayashi, Masahiro Kinoshita
- Organizer
  The 57th Annual Meeting of Biophysical Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674
[Presentation] Structural and Physical Basis for the Higher Affinity to Oncoprotein MDM2 of a Peptide Selected with MRNA Display Over Tumor Suppressor p532019
- Author(s)
  Takashi Nagata, Tatsuya Yamada, Tomohiko Hayashi, Simon Hikiri, Naohiro Kobayashi, Mitsunori Ikeguchi, Masato Katahira, Masahiro Kinoshita, Hiroshi Yanagawa
- Organizer
  Biophysical Society 64th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674
[Presentation] Physics of drastic decrease in water solubility upon coil-to-globule transition of poly(N-isopropylacrylamide)2019
- Author(s)
  Masao INOUE, Tomohiko Hayashi, Simon Hikiri, Masahiro Kinoshita
- Organizer
  The 57th Annual Meeting of Biophysical Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K14674

1. 小林直宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 木下正弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 安田賢司

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

Hayashi Tomohiko 林 智彦

Research Projects

Research Products

Co-Researchers

次世代バイオ医薬品の物理理論に基づく高速設計法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

次世代ペプチド薬の物理理論に基づく高速デザイン法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a physics-based fast screening method for detecting the cancer-therapeutic peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Physical pictures of rotation mechanisms of F1- and V1-ATPases: Leading roles of translational, configurational entropy of water2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonadditivities of the Particle Sizes Hidden in Model Pair Potentials and Their Effects on Physical Adsorptions2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A methodology for creating mutants of G‐protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an Outward Proton Pumping Rhodopsin with a New Record in Thermostability by Means of Amino Acid Mutations2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Controlling the Rigidity of Kinesin-Propelled Microtubules in an In Vitro Gliding Assay Using the Deep-Sea Osmolyte Trimethylamine N-Oxide2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A methodology for creating thermostabilized mutants of G‐protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydration properties of a protein at low and high pressures: Physics of pressure denaturation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accurate and rapid calculation of hydration free energy and its physical implication for biomolecular functions2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Theoretical identification of thermostabilizing amino acid mutations for G-protein-coupled receptors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison based on statistical thermodynamics between globule-to-coil transition of poly(N-isopropylacrylamide) and cold denaturation of a protein2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained2020

Author(s)

Hayashi Tomohiko 林智彦