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Kato Hisaya  加藤 尚也

Researcher Number 90841974
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-5964-6856
Affiliation (Current) 2025: 千葉大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help 2020 – 2024: 千葉大学, 医学部附属病院, 助教
2019 – 2020: 千葉大学, 大学院医学研究院, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 52010:General internal medicine-related / 0902:General internal medicine and related fields
Except Principal Investigator
Medium-sized Section 52:General internal medicine and related fields / Basic Section 52010:General internal medicine-related
Keywords
Principal Investigator
ウェルナー症候群 / 老化 / 早老症 / iPS細胞 / 間葉系幹細胞 / 代謝異常 / ミトコンドリア / 細胞老化 / 核酸代謝 / エピゲノム / エクソソーム / 線維芽細胞 … More
Except Principal Investigator
… More 老化 / ウェルナー症候群 / Werner症候群 / Pericyte / 尿細管細胞 / ポドサイト / 線維芽細胞 / 線維化 / 細胞老化 Less
  • Research Projects

    (7 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (9 People)
  •  Accelerating Aging Effects of Mitochondrial Metabolic Abnormalities in Human Aging ModelsPrincipal Investigator

    • Principal Investigator
      加藤 尚也
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Chiba University
  •  Exploring Novel Anti-Aging and Rejuvenation Mechanisms Through Human Aging ModelsPrincipal Investigator

    • Principal Investigator
      加藤 尚也
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Chiba University
  •  早老症の多角的解析に基づく老化と疾患の病態解明

    • Principal Investigator
      横手 幸太郎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Chiba University
  •  Elucidation of the relationship between aberrant nucleic acid metabolism and accelerated aging in Werner syndromePrincipal Investigator

    • Principal Investigator
      Kato Hisaya
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Chiba University
  •  The role of Pericyte Senescence in Diabetic Complications

    • Principal Investigator
      Maezawa Yoshiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Chiba University
  •  Deciphering the aging mechanism directed by exosomes in the adult progeria Werner syndromePrincipal Investigator

    • Principal Investigator
      Kato Hisaya
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Chiba University
  •  The effects of mechanical stress on cellular senescence in adult progeria Werner syndromePrincipal Investigator

    • Principal Investigator
      Kato Hisaya
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0902:General internal medicine and related fields
    • Research Institution
      Chiba University

All 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Other

  • [Journal Article] Case of Werner syndrome with significant improvement of refractory skin ulcer despite fibroblast cellular senescence2023

    • Author(s)
      Kinoshita Daisuke、Kato Hisaya、Kaneko Hiyori、Ishikawa Takahiro、Teramoto Naoya、Tsukagoshi Ayano、Maeda Yukari、Minamizuka Takuya、Hayashi Aiko、Shoji Mayumi、Sawada Daisuke、Funayama Shinichiro、Koshizaka Masaya、Ogata Hideyuki、Kubota Yoshitaka、Mitsukawa Nobuyuki、Takemoto Minoru、Yokote Koutaro、Maezawa Yoshiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 23 Issue: 3 Pages: 239-241

    • DOI

      10.1111/ggi.14546

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-20K07810
  • [Journal Article] Identification of Novel Senescent Markers in Small Extracellular Vesicles2023

    • Author(s)
      Misawa Tomoka、Hitomi Kazuhiro、Miyata Kenichi、Tanaka Yoko、Fujii Risa、Chiba Masatomo、Loo Tze Mun、Hanyu Aki、Kawasaki Hiroko、Kato Hisaya、Maezawa Yoshiro、Yokote Koutaro、Nakamura Asako J.、Ueda Koji、Yaegashi Nobuo、Takahashi Akiko
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 3 Pages: 2421-2421

    • DOI

      10.3390/ijms24032421

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07222, KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-22KJ0248, KAKENHI-PROJECT-20K16344
  • [Journal Article] Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases2022

    • Author(s)
      Miller Danny E.、Lee Lin、Galey Miranda、Kandhaya-Pillai Renuka、Tischkowitz Marc、Amalnath Deepak、Vithlani Avadh、Yokote Koutaro、Kato Hisaya、Maezawa Yoshiro、Takada-Watanabe Aki、Takemoto Minoru、Martin George M.、Eichler Evan E.、Hisama Fuki M.、Oshima Junko
    • Journal Title

      Journal of Medical Genetics

      Volume: 59 Issue: 11 Pages: 1087-1094

    • DOI

      10.1136/jmedgenet-2022-108485

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-20K07810
  • [Journal Article] RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells2022

    • Author(s)
      Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A.
    • Journal Title

      Commun Biol

      Volume: 5 Issue: 1 Pages: 1420-1420

    • DOI

      10.1038/s42003-022-04369-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-22KJ3105, KAKENHI-PROJECT-21K19419, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-19H03156, KAKENHI-PLANNED-18H05532, KAKENHI-PLANNED-17H06426, KAKENHI-PUBLICLY-22H05599, KAKENHI-PROJECT-23K23810
  • [Journal Article] Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes2022

    • Author(s)
      Kato Hisaya、Maezawa Yoshiro
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 29 Issue: 4 Pages: 439-447

    • DOI

      10.5551/jat.RV17061

    • NAID

      130008086716

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-04-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16542, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-20H03572
  • [Journal Article] Lifetime extension and the recent cause of death in Werner syndrome: a retrospective study from 2011 to 20202022

    • Author(s)
      Kato Hisaya、Koshizaka Masaya、Kaneko Hiyori、Maezawa Yoshiro、Yokote Koutaro
    • Journal Title

      Orphanet Journal of Rare Diseases

      Volume: 17 Issue: 1 Pages: 226-226

    • DOI

      10.1186/s13023-022-02383-w

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-20H03572
  • [Journal Article] A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency2022

    • Author(s)
      Kato Hisaya、Ogawa Seishi, et al.
    • Journal Title

      Experimental Hematology

      Volume: 109 Pages: 11-17

    • DOI

      10.1016/j.exphem.2022.02.005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-20K07810, KAKENHI-PLANNED-19H05746
  • [Journal Article] Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome2021

    • Author(s)
      Kato H, Maezawa Y, Takayama N, Ouchi Y, Kaneko H, Kinoshita D, Takada-Watanabe A, Oshima M, Koshizaka M, Ogata H, Kubota Y, Mitsukawa N, Eto K, Iwama A, Yokote K.
    • Journal Title

      Aging (Albany NY)

      Volume: 13 Issue: 4 Pages: 4946-4961

    • DOI

      10.18632/aging.202696

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07651, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-19K23939, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-20K16542, KAKENHI-PROJECT-18H04164
  • [Journal Article] Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome2021

    • Author(s)
      Kato Hisaya、Maezawa Yoshiro、Ouchi Yasuo、Takayama Naoya、Sone Masamitsu、Sone Kanako、Takada-Watanabe Aki、Tsujimura Kyoko、Koshizaka Masaya、Nagasawa Sayaka、Saitoh Hisako、Ohtaka Manami、Nakanishi Mahito、Tahara Hidetoshi、Shimamoto Akira、Iwama Atsushi、Eto Koji、Yokote Koutaro
    • Journal Title

      Stem Cell Research

      Volume: 53 Pages: 102360-102360

    • DOI

      10.1016/j.scr.2021.102360

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16542, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-18H04164, KAKENHI-PROJECT-20K07651
  • [Journal Article] Time gap between the onset and diagnosis in Werner syndrome: a nationwide survey and the 2020 registry in Japan2020

    • Author(s)
      Koshizaka M, Maezawa Y, Maeda Y, Shoji M, Kato H, Kaneko H, Ishikawa T, Kinoshita D, Kobayashi K, Kawashima J, Sekiguchi A, Motegi SI, Nakagami H, Yamada Y, Tsukamoto S, Taniguchi A, Sugimoto K, Shoda Y, Hashimoto K, Yoshimura T, Suzuki D, Kuzuya M, Takemoto M, Yokote K.
    • Journal Title

      Aging

      Volume: 12 Issue: 24 Pages: 24940-24956

    • DOI

      10.18632/aging.202441

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07810, KAKENHI-PROJECT-20K11599, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-20H03572
  • [Journal Article] NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome2019

    • Author(s)
      Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Kato H, et al.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1-8

    • DOI

      10.1038/s41467-019-13172-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23939, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17K09687
  • [Presentation] 早老症ウェルナー症候群の革新的治療開発2023

    • Author(s)
      加藤 尚也, 大内, 靖夫, 前澤, 善朗, 横手 幸太郎
    • Organizer
      革新的医療技術創出拠点 令和4年度成果報告会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K15682
  • [Presentation] Progeroid syndrome and insulin resistance2022

    • Author(s)
      加藤尚也,前澤善朗,横手幸太郎
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03572
  • [Presentation] 「老化」を治療する ~早老症研究から見た抗老化医療の今後の展望~2022

    • Author(s)
      加藤尚也, 前澤善朗, 横手幸太郎
    • Organizer
      第64回 日本老年医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K15682
  • [Presentation] 早老症ウェルナー症候群におけるメタボロミクスを介した老化機序解明および老化バイオマーカーの開発2022

    • Author(s)
      加藤尚也
    • Organizer
      第64回 日本老年医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K15682
  • [Presentation] 遺伝性早老症ウェルナー症候群に見る老化のメカニズム2022

    • Author(s)
      前澤善朗、加藤尚也、横手幸太郎
    • Organizer
      第95回日本生化学会
    • Data Source
      KAKENHI-PROJECT-20H03572
  • [Presentation] Progeroid syndrome and insulin resistance2022

    • Author(s)
      Hisaya Kato, Yoshiro Maezawa, Koutaro Yokote
    • Organizer
      第65回 日本糖尿病学会年次学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K15682
  • [Presentation] 「老化」を治療する ~早老症研究から見た抗老化医療の今後の展望~2022

    • Author(s)
      加藤尚也,前澤善朗,横手幸太郎
    • Organizer
      第64回日本老年医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03572
  • [Presentation] 早老症ウェルナー症候群皮膚線維芽細胞は体幹と足部で異なる表現型を示す2021

    • Author(s)
      加藤尚也, 前澤善朗, 高山直也, 大内靖夫, 緒方英之, 窪田吉孝, 三川信之, 江藤浩之, 岩間厚志, 横手幸太郎
    • Organizer
      第63回日本老年医学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23939
  • [Presentation] シンポジウム9 DNA損傷応答と老化の表現型「早老症に見る細胞老化と個体老化」2020

    • Author(s)
      前澤 善朗、加藤 尚也、越坂 理也、横手幸太郎
    • Organizer
      第20回抗加齢医学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03572
  • [Presentation] NMN添加による早老症コケイン症候群iPS細胞のアポトーシス抑制2020

    • Author(s)
      金子ひより、加藤尚也、木下大輔、前澤喜朗、横手幸太郎
    • Organizer
      第62回日本老年医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03572
  • []

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  • 1.  Maezawa Yoshiro (80436443)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 2.  越坂 理也 (30466700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  横手 幸太郎 (20312944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  小野 啓 (10570616)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  TAKUBO Keiyo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  OUCHI Yasuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  竹本 稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  小川 誠司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  田中 陽子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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