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Shigeta Shogo  重田 昌吾

ORCIDConnect your ORCID iD *help
Researcher Number 90842633
Other IDs
Affiliation (Current) 2025: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2024: 東北大学, 医学系研究科, 准教授
2022 – 2023: 東北大学, 大学病院, 講師
2021 – 2023: 東北大学, 医学系研究科, 助教
2020: 東北大学, 医学系研究科, 大学院非常勤講師
2019: 東北大学, 大学病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56040:Obstetrics and gynecology-related / 0901:Oncology and related fields
Except Principal Investigator
Basic Section 56040:Obstetrics and gynecology-related / Basic Section 58080:Gerontological nursing and community health nursing-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords
Principal Investigator
卵巣明細胞癌 / エピゲノム / 個別化医療 / マルチオミックス / プロテオーム / メタボローム / メタボローム解析 / 全ゲノム解析 / 全エクソーム解析 / 婦人科癌 … More / SWI/SNF / 凝固 / ARID1A / BAZ2A / EZH2 / 婦人科悪性腫瘍 / オルガノイド / ブロモドメイン / 癌オルガノイド / 明細胞癌 / 卵巣癌 … More
Except Principal Investigator
卵巣癌 / セラミド / ネクロプトーシス / 白金製剤 / フェロトーシス / がん / 脂質生物学 / 細胞死 / スフィンゴ脂質 / MLKL / ネクロトーシス / 白金抵抗性 / 明細胞癌 / 卵巣がん / メタボローム / クロマチンリモデリング / 薬剤耐性 / 鑑別診断 / 難治性 / 化学療法抵抗性 / 粘液性癌 / 難治性癌 / プロテオーム解析 / オミックス解析 / 難治性がん / 多層的オミックス解析 / メタボローム解析 / 婦人科難治性希少がん / 卵巣粘液性癌 / プラチナ耐性 / オルガノイドモデル / プラチナ感受性 / オルガノイド / CHD4 / 治療抵抗性 Less
  • Research Projects

    (9 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (11 People)
  •  上皮性卵巣癌におけるネクロプトーシスの臨床的意義と治療標的としての可能性

    • Principal Investigator
      橋本 千明
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Tohoku University
  •  フェロミクス解析を用いた褥瘡形成における鉄の病態生理学的役割の解明

    • Principal Investigator
      西田 健太朗
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58080:Gerontological nursing and community health nursing-related
    • Research Institution
      Setsunan University
  •  A multi-omics investigation of novel therapeutic strategies for clear cell carcinoma of the ovary focusing on cancer metabolismPrincipal Investigator

    • Principal Investigator
      重田 昌吾
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tohoku University
  •  ネクロプトーシスの脂質性制御とセラミド分子認識の解明

    • Principal Investigator
      北谷 和之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Setsunan University
  •  Development of a New Treatment Strategy for Refractory Ovarian Mucinous Carcinoma

    • Principal Investigator
      SHIMADA Muneaki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Tohoku University
  •  Elucidation of the mechanism of drug resistance in ovarian cancer with poor prognosis and development of new therapeutic targets

    • Principal Investigator
      TOKUNAGA Hideki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Tohoku University
  •  Targeting epigenetic regulators as a novel combination therapy for gynecologic malignancies harboring SWI/SNF alteration.Principal Investigator

    • Principal Investigator
      Shigeta Shogo
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Tohoku University
  •  An investigation of novel therapeutic strategies for platinum-resistant ovarian cancer using cancer organoid originated from disseminating ovarian carcinoma

    • Principal Investigator
      TSUJI Keita
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Tohoku University
  •  Targeting bromodomains as a novel therapeutic strategy for clear cell carcinoma of the ovary.Principal Investigator

    • Principal Investigator
      Shigeta Shogo
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Tohoku University

All 2023 2022 2021 2020 Other

All Journal Article Presentation Other

  • [Journal Article] Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling2023

    • Author(s)
      Hishinuma Eiji、Shimada Muneaki、Matsukawa Naomi、Shima Yoshiko、Li Bin、Motoike Ikuko N.、Shibuya Yusuke、Hagihara Tatsuya、Shigeta Shogo、Tokunaga Hideki、Saigusa Daisuke、Kinoshita Kengo、Koshiba Seizo、Yaegashi Nobuo
    • Journal Title

      Cancer & Metabolism

      Volume: 11 Issue: 1

    • DOI

      10.1186/s40170-023-00317-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-23K24478, KAKENHI-PROJECT-23K27316
  • [Journal Article] An Attempt to Develop a New Treatment Strategy for Rare Refractory Gynecological Malignancies: The Japanese Gynecologic Oncology Group2023

    • Author(s)
      Shigeta S, Shimada M, Suzuki S, Kajiyama H, Oda K, Takehara K, Mandai M, Aoki D, Enomoto T, Okamoto A.
    • Journal Title

      JMA Journal

      Volume: 6 Issue: 4 Pages: 527-531

    • DOI

      10.31662/jmaj.2023-0024

    • ISSN
      2433-328X, 2433-3298
    • Year and Date
      2023-10-16
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21H03074, KAKENHI-PROJECT-23K21473
  • [Journal Article] Comparison of treatment outcomes between first-line chemotherapy with or without bevacizumab for advanced ovarian, fallopian tube, and primary peritoneal cancer (Tohoku gynecologic cancer unit: TGCU-RS001 study)2022

    • Author(s)
      Takatori E, Nagasawa T, Kagabu M, Baba T, Shigeto T, Matsumura Y, Shimizu D, Terada Y, Seino M, Ohta T, Nagase S, Shigeta S, Tokunaga H, Shimada M, Kaiho-Sakuma M, Furukawa S, Soeda S, Watanabe T, Takahashi F, Yokoyama Y.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 27 Issue: 12 Pages: 1874-1880

    • DOI

      10.1007/s10147-022-02246-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-21K09548
  • [Journal Article] A Retrospective Analysis of Clinical Biomarkers for Olaparib Maintenance Therapy in Patients with Recurrent Ovarian Cancer2022

    • Author(s)
      Endo Shun、Shigeta Shogo、Tokunaga Hideki、Shimizu Takanori、Hasegawa-Minato Junko、Hashimoto Chiaki、Ishibashi Masumi、Nagai Tomoyuki、Shiga Naomi、Shimada Muneaki、Yaegashi Nobuo
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 258 Issue: 1 Pages: 1-9

    • DOI

      10.1620/tjem.2022.J050

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09531
  • [Journal Article] CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.2021

    • Author(s)
      Oyama Y, Shigeta S, Tokunaga H, Tsuji K, Ishibashi M, Shibuya Y, Shimada M, Yasuda J, Yaegashi N.
    • Journal Title

      PLoS One.

      Volume: 16(6) Issue: 6 Pages: 0251079-0251079

    • DOI

      10.1371/journal.pone.0251079

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-19K09747, KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-20K18211
  • [Presentation] FDAの動物実験義務化撤廃と医学研究における動物実験の代替手段について2023

    • Author(s)
      重田 昌吾
    • Organizer
      第20回 婦人科がん会議
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K18211
  • [Presentation] 子宮体癌における血漿メタボローム解析による新規バイオマーカーの探索2023

    • Author(s)
      萩原達也,島田宗昭, 菱沼英史, 李 賓, 橋本栄文, 栃木実佳子, 遠藤 俊, 清水孝規, 湊 純子, 渋谷祐介, 橋本千明, 石橋ますみ, 重田昌吾, 徳永英樹, 八重樫伸生
    • Organizer
      第65回日本婦人科腫瘍学会 高得点演題
    • Data Source
      KAKENHI-PROJECT-21K09486
  • [Presentation] リスク低減卵管卵巣摘出術待機中にIIIA1(ii)期の卵管癌を発症した遺伝性乳癌卵巣癌症候群の一例2022

    • Author(s)
      村川 真理弥,湊 純子, 熊谷 奈津美, 萩原 達也, 橋本 栄文, 高橋 友梨, 栃木 実佳子, 橋本 千明, 石橋 ますみ, 重田 昌吾, 永井 智之, 徳永 英樹, 島田 宗昭, 八重樫 伸生
    • Organizer
      第151回東北連合産科婦人科学会総会
    • Data Source
      KAKENHI-PROJECT-21K09531
  • [Presentation] 進行卵巣癌における初回化学療法後の維持療法選択に関する後方視的検討2022

    • Author(s)
      橋本栄文,萩原 達也, 遠藤 俊, 清水 孝規, 湊 敬道, 湊 純子, 橋本 千明, 石橋 ますみ, 重田 昌吾, 徳永 英樹, 島田 宗昭, 八重樫 伸生
    • Organizer
      第74回日本産科婦人科学会
    • Data Source
      KAKENHI-PROJECT-21K09531
  • [Presentation] 当院における遺伝性乳癌卵巣癌症候群に対するリスク低減卵管卵巣摘出術の経験2022

    • Author(s)
      湊 純子,島田 宗昭, 萩原 達也, 橋本 栄文, 湊 敬道, 橋本 千明, 石橋 ますみ, 重田 昌吾, 永井 智之, 徳永 英樹, 八重樫 伸生
    • Organizer
      第74回日本産科婦人科学会
    • Data Source
      KAKENHI-PROJECT-21K09531
  • [Presentation] 卵巣癌既発症のBRCA病的バリアント保持者に対する乳房サーベイランスの現状2022

    • Author(s)
      湊 純子,島田 宗昭, 橋本 栄文, 萩原 達也, 湊 敬道, 橋本 千明, 石橋 ますみ, 重田 昌吾, 永井 智之, 徳永 英樹, 八重樫 伸生
    • Organizer
      第64回日本婦人科腫瘍学会
    • Data Source
      KAKENHI-PROJECT-21K09531
  • [Presentation] チロシンキナーゼ受容体型蛋白TIE-1の卵巣癌に対する抗腫瘍効果の検討2022

    • Author(s)
      石橋 ますみ,徳永 英樹, 重田 昌吾, 永井 智之, 島田 宗昭, 八重樫 伸生
    • Organizer
      第64回日本婦人科腫瘍学会
    • Data Source
      KAKENHI-PROJECT-21K09531
  • [Presentation] ブロモドメインを中心とした卵巣明細胞癌に対する新規個別化医療確立に向けた橋渡し研究2021

    • Author(s)
      重田 昌吾
    • Organizer
      第63回 日本婦人科腫瘍学会学術講演会 公募シンポジウム
    • Data Source
      KAKENHI-PROJECT-20K18211
  • [Presentation] Functional analysis of ZFHX4 as a novel therapeutic target in ovarian cancer2020

    • Author(s)
      Yoshiko Oyama, Shigeta Shogo, Keita Tsuji, Muneaki Shimada, Nobuo Yaegashi
    • Organizer
      American Association for cancer research Annual Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09747
  • [Presentation] Functional analysis of ZFHX4 as a novel therapeutic target in ovarian cancer2020

    • Author(s)
      Yoshiko Oyama, Shogo Shigeta, Keita Tsuji, Hideki Tokunaga, Muneaki Shimada, Nobuo Yaegashi
    • Organizer
      AACR Virtual Annual Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23904
  • [Presentation] RNAi及び薬剤スクリーニングを用いた卵巣明細胞癌に対する新規治療標的分子の同定2020

    • Author(s)
      重田 昌吾, Christopher Kemp, 八重樫 伸生
    • Organizer
      第8回 婦人科がんバイオマーカー研究会学術集会
    • Data Source
      KAKENHI-PROJECT-19K23904
  • []

  • []

  • 1.  SHIMADA Muneaki (40362892)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 2.  TOKUNAGA Hideki (30595559)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 9 results
  • 3.  北谷 和之 (40539235)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  TSUJI Keita (10835341)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  伊藤 潔 (50201926)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  橋本 千明 (50821625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  石橋 ますみ (20821383)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  西田 健太朗 (20533805)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  菱沼 英史 (10824609)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  安田 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  八重樫 伸生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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