Takahashi Kohei 高橋浩平

Researcher Number	90846411
Other IDs	https://orcid.org/0000-0002-2588-8427
Affiliation (Current)	2025: 国際医療福祉大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 国際医療福祉大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 48030:Pharmacology-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator 神経新生 / うつ病 / AMPK / うつ / 神経炎症 / 潰瘍性大腸炎 / 脳腸相関 / BDNF / 腸内毒素症 / 炎症 … More / オ－トファジ－ / LC3Ⅱ/Ⅰ / p62 / Iba1 / resveratrol / iNOS / オートファジー / ミクログリア分極 / Autophagy / Resveratrol / デキストラン硫酸ナトリウム / 炎症性サイトカイン / 行動薬理 … More Except Principal Investigator 海馬 / うつ病 / ストレス適応 / ミエリン / オリゴデンドロサイト / うつ病動物モデル / アンジオテンシン変換酵素２ / Mas受容体 / アンジオテンシン１－７ / アンジオテンシン変換酵素2 / 精神神経薬理学 / 抑肝散 / 低酸素ストレス / ストレス科学 / 情動行動 / 不安 / HIF1α / 低酸素曝露 / 妊娠期ストレス / 低酸素誘導因子 / 雌 / 雌性 / ストレス / 抗うつ薬 / マウス / アストロサイト / GSK3β / 5-HT1A受容体 / 白血病阻止因子 / ストレス適応障害 Less

Mechanism of depression induced by gut microbiota imbalance: involvement of hippocampus AMPK and development of a novel treatmentPrincipal Investigator
- Principal Investigator
  
  高橋浩平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  International University of Health and Welfare
妊娠期の低酸素状態が子の情動的ストレス応答に及ぼす影響と抑肝散の治療効果
- Principal Investigator
  
  宮川和也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  International University of Health and Welfare
Functional analysis of angiotensin-converting enzyme 2 in the brain and development of novel therapeutic agents for depression
- Principal Investigator
  
  中川西修
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
新規抗うつ薬開発を指向したアストロサイト由来LIFのストレス適応促進作用の証明
- Principal Investigator
  
  辻稔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  International University of Health and Welfare
Effect of running exercise on myelin damage caused by maladaptation to stress in female mice
- Principal Investigator
  
  黒川和宏
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  International University of Health and Welfare
Elucidation of a mechanism of developing depression in colitis: association with brain-gut AMPK and development of novel therapyPrincipal Investigator
- Principal Investigator
  
  Takahashi Kohei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  International University of Health and Welfare
Elucidation of a pathogenic mechanism of colitis-induced depression based on concept for brain-gut associationPrincipal Investigator
- Principal Investigator
  
  Takahashi Kohei
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  International University of Health and Welfare

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction2024
- Author(s)
  Takahashi Kohei、Tsuji Minoru、Nakagawasai Osamu、Katsuyama Soh、Miyagawa Kazuya、Kurokawa Kazuhiro、Mochida-Saito Atsumi、Takeda Hiroshi、Tadano Takeshi
- Journal Title
  
  Neurochemistry International
  
  Volume: 175 Pages: 105723-105723
- DOI
  10.1016/j.neuint.2024.105723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15351
[Journal Article] Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice2024
- Author(s)
  Takahashi Kohei、Kurokawa Kazuhiro、Miyagawa Kazuya、Mochida-Saito Atsumi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Neuroscience Letters
  
  Volume: 825 Pages: 137711-137711
- DOI
  10.1016/j.neulet.2024.137711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15351
[Journal Article] Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy2024
- Author(s)
  Takahashi Kohei、Kurokawa Kazuhiro、Hong Lihua、Miyagawa Kazuya、Mochida-Saito Atsumi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Experimental Neurology
  
  Volume: 373 Pages: 114671-114671
- DOI
  10.1016/j.expneurol.2023.114671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K16824, KAKENHI-PROJECT-22K06682, KAKENHI-PROJECT-21K15351
[Journal Article] Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice2023
- Author(s)
  Nakagawasai Osamu、Takahashi Kohei、Koyama Taisei、Yamagata Ryota、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Molecular Brain
  
  Volume: 16 Issue: 1 Pages: 52-52
- DOI
  10.1186/s13041-023-01040-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06866, KAKENHI-PROJECT-21K15351
[Journal Article] Possible involvement of inflammasomes on the post-stroke cognitive impairment in a mouse model of embolic cerebral infarct2023
- Author(s)
  Nomura Ayae、Kurokawa Kazuhiro、Takahashi Kohei、Miyagawa Kazuya、Mochida-Saito Atsumi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Physiology & Behavior
  
  Volume: 271 Pages: 114348-114348
- DOI
  10.1016/j.physbeh.2023.114348
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K16824, KAKENHI-PROJECT-21K11732
[Journal Article] Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex2023
- Author(s)
  Takahashi Kohei、Hong Lihua、Kurokawa Kazuhiro、Miyagawa Kazuya、Mochida-Saito Atsumi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Progress in Neuro-Psychopharmacology and Biological Psychiatry
  
  Volume: 121 Pages: 110666-110666
- DOI
  10.1016/j.pnpbp.2022.110666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06682, KAKENHI-PROJECT-21K15351, KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-21K06806
[Journal Article] Peptides obtained by enzymatic decomposition of mackerel induce recovery from physical fatigue by enhancing the SIRT1-mediated antioxidant effect in the soleus muscle of mice2023
- Author(s)
  Nakagawasai Osamu、Takahashi Kohei、Sakuma Wakana、Nemoto Wataru、Kobayashi Ruka、Hoshi Tomohiro、Matsumoto Satoshi、Tadano Takeshi、Tan-No Koichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 152 Issue: 1 Pages: 61-67
- DOI
  10.1016/j.jphs.2023.03.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06866, KAKENHI-PROJECT-21K15351
[Journal Article] Effect of Globin Digests on Physical Fatigue in Mice2023
- Author(s)
  Nakagawasai Osamu、Yamada Kotaro、Takahashi Kohei、Oshima Yuko、Hayasaka Sena、Shoji Kazuaki、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 7 Pages: 1027-1030
- DOI
  10.1248/bpb.b23-00193
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06866, KAKENHI-PROJECT-21K15351
[Journal Article] Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice2023
- Author(s)
  Takahashi Kohei、Tsuji Minoru、Nakagawasai Osamu、Katsuyama Soh、Hong Lihua、Miyagawa Kazuya、Kurokawa Kazuhiro、Mochida-Saito Atsumi、Takeda Hiroshi、Tadano Takeshi
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 438 Pages: 114175-114175
- DOI
  10.1016/j.bbr.2022.114175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15351, KAKENHI-PROJECT-20K23258
[Journal Article] Trichostatin A, a histone deacetylase inhibitor, alleviates the emotional abnormality induced by maladaptation to stress in mice2022
- Author(s)
  Kimijima Hidenao、Miyagawa Kazuya、Kurokawa Kazuhiro、Mochida-Saito Atsumi、Takahashi Kohei、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Neuroscience Letters
  
  Volume: 766 Pages: 136340-136340
- DOI
  10.1016/j.neulet.2021.136340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-21K11732, KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-21K06806
[Journal Article] ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum2022
- Author(s)
  Nakagawasai Osamu、Takahashi Kohei、Miura Yuki、Nemoto Wataru、Obara Yutaro、Tan-No Koichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 148 Issue: 3 Pages: 326-330
- DOI
  10.1016/j.jphs.2022.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15351
[Journal Article] Antidepressant Effect of Intracerebroventricularly Administered Deltorphin Analogs in the Mouse Tail Suspension Test2022
- Author(s)
  Nakagawasai Osamu、Takahashi Kohei、Ambo Akihiro、Onuma Kentaro、Takahashi Naruya、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 4 Pages: 538-541
- DOI
  10.1248/bpb.b21-01078
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15351
[Journal Article] Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice2022
- Author(s)
  Takahashi Kohei、Kurokawa Kazuhiro、Hong Lihua、Miyagawa Kazuya、Mochida-Saito Atsumi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Neuroscience Research
  
  Volume: 182 Pages: 76-80
- DOI
  10.1016/j.neures.2022.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15351, KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-20K23258
[Journal Article] Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice2022
- Author(s)
  Takahashi Kohei、Kurokawa Kazuhiro、Hong Lihua、Miyagawa Kazuya、Mochida-Saito Atsumi、Iwasa Masahiro、Iwasa Hiroyuki、Nakagawasai Osamu、Tadano Takeshi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 148 Pages: 137-148
- DOI
  10.1016/j.jpsychires.2022.01.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-21K11732, KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-21K06806, KAKENHI-PROJECT-21K15351
[Journal Article] Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice2022
- Author(s)
  Miyagishi Hiroko、Tsuji Minoru、Miyagawa Kazuya、Kurokawa Kazuhiro、Mochida-Saito Atsumi、Takahashi Kohei、Kosuge Yasuhiro、Ishige Kumiko、Takeda Hiroshi
- Journal Title
  
  Brain Research
  
  Volume: 1783 Pages: 147859-147859
- DOI
  10.1016/j.brainres.2022.147859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-21K06620, KAKENHI-PROJECT-21K11732, KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-21K06806
[Journal Article] Alterations in prefrontal cortical neuregulin-1 levels in post-pubertal rats with neonatal ventral hippocampal lesions2022
- Author(s)
  Watanabe Kenya、Nakagawasai Osamu、Kanno Syu-ichi、Mitazaki Satoru、Onogi Hiroshi、Takahashi Kohei、Watanabe Kei-ichiro、Tan-No Koichi、Ishikawa Masaaki、Srivastava Lalit K.、Quirion Remi、Tadano Takeshi
- Journal Title
  
  Frontiers in Behavioral Neuroscience
  
  Volume: 16 Pages: 1008623-1008623
- DOI
  10.3389/fnbeh.2022.1008623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15351
[Journal Article] Intracerebroventricular Administration of Dermorphin-Dynorphin Analogs Producing Antidepressant-Like Effects through Activation of μ<sub>1</sub>- and κ-Opioid Receptors in Mice2022
- Author(s)
  Nakagawasai Osamu、Ambo Akihiro、Takahashi Kohei、Onogi Hiroshi、Nishimura Yuki、Okubo Myu、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 8 Pages: 1203-1207
- DOI
  10.1248/bpb.b22-00164
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15351
[Journal Article] Activation of cholinergic system partially rescues olfactory dysfunction-induced learning and memory deficit in mice2021
- Author(s)
  Takahashi Kohei、Tsuji Minoru、Nakagawasai Osamu、Katsuyama Soh、Miyagawa Kazuya、Kurokawa Kazuhiro、Mochida-Saito Atsumi、Iwasa Masahiro、Iwasa Hiroyuki、Takeda Hiroshi、Tadano Takeshi
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 408 Pages: 113283-113283
- DOI
  10.1016/j.bbr.2021.113283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-19K23808
[Journal Article] A novel dipeptide derived from porcine liver hydrolysate induces recovery from physical fatigue in a mouse model2021
- Author(s)
  Nakagawasai Osamu、Yamada Kotaro、Sakuma Wakana、Takahashi Kohei、Odaira Takayo、Yamagata Ryota、Nemoto Wataru、Ejima Akika、Sato Kenji、Tan-No Koichi
- Journal Title
  
  Journal of Functional Foods
  
  Volume: 76 Pages: 104312-104312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23808
[Journal Article] Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus2021
- Author(s)
  Kurokawa Kazuhiro、Takahashi Kohei、Miyagawa Kazuya、Mochida-Saito Atsumi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Neurochemistry International
  
  Volume: 151 Pages: 105213-105213
- DOI
  10.1016/j.neuint.2021.105213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-21K06806, KAKENHI-PROJECT-21K11732, KAKENHI-PROJECT-20K23258
[Journal Article] Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior2021
- Author(s)
  Takahashi Kohei、Kurokawa Kazuhiro、Hong Lihua、Miyagawa Kazuya、Mochida-Saito Atsumi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Neurochemistry International
  
  Volume: 148 Pages: 105112-105112
- DOI
  10.1016/j.neuint.2021.105112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-21K11732, KAKENHI-PROJECT-20K23258
[Journal Article] Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice2020
- Author(s)
  Takahashi Kohei、Nakagawasai Osamu、Nakajima Takeharu、Okubo Myu、Nishimura Yuki、Sakuma Wakana、Yamagata Ryota、Nemoto Wataru、Miyagawa Kazuya、Kurokawa Kazuhiro、Mochida-Saito Atsumi、Tsuji Minoru、Takeda Hiroshi、Tadano Takeshi、Tan-No Koichi
- Journal Title
  
  Brain Research
  
  Volume: 1746 Pages: 147015-147015
- DOI
  10.1016/j.brainres.2020.147015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-18K06687, KAKENHI-PROJECT-19K23808
[Journal Article] Liver hydrolysate prevents depressive-like behavior in an animal model of colitis: Involvement of hippocampal neurogenesis via the AMPK/BDNF pathway2020
- Author(s)
  Nakagawasai Osamu、Yamada Kotaro、Takahashi Kohei、Odaira Takayo、Sakuma Wakana、Ishizawa Daisuke、Takahashi Naruya、Onuma Kentaro、Hozumi Chikako、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 390 Pages: 112640-112640
- DOI
  10.1016/j.bbr.2020.112640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06687, KAKENHI-PROJECT-19K23808
[Journal Article] Scabronine G Methyl Ester Improves Memory-Related Behavior and Enhances Hippocampal Cell Proliferation and Long-Term Potentiation via the BDNF-CREB Pathway in Olfactory Bulbectomized Mice2020
- Author(s)
  Nakagawasai Osamu、Lin Jia-Rong、Odaira Takayo、Takahashi Kohei、Nemoto Wataru、Moriguchi Shigeki、Yabuki Yasushi、Kobayakawa Yu、Fukunaga Kohji、Nakada Masahisa、Tan-No Koichi
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 11 Pages: 583291-583291
- DOI
  10.3389/fphar.2020.583291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06687, KAKENHI-PROJECT-18K06887, KAKENHI-PROJECT-19K23808
[Journal Article] Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice2020
- Author(s)
  Takahashi Kohei、Kurokawa Kazuhiro、Miyagawa Kazuya、Mochida-Saito Atsumi、Nemoto Yukio、Iwasa Hiroyuki、Nakagawasai Osamu、Tadano Takeshi、Takeda Hiroshi、Tsuji Minoru
- Journal Title
  
  Physiology & Behavior
  
  Volume: 223 Pages: 112997-112997
- DOI
  10.1016/j.physbeh.2020.112997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-19K23808
[Journal Article] Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway2020
- Author(s)
  Nakagawasai Osamu, Yamada Kotaro, Odaira Takayo, Takahashi Kohei, Nemoto Wataru, Sakuma Wakana, Wakou Miharu, Lin Jia-Rong, Tan-No Koichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 143 Issue: 1 Pages: 52-55
- DOI
  10.1016/j.jphs.2020.01.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23808, KAKENHI-PROJECT-18K06687
[Presentation] 新規抗うつ薬の開発に資するミエリン障害モデルマウスを用いたストレス適応障害機構の解明2023
- Author(s)
  辻稔、黒川和宏、高橋浩平、宮川和也、持田（齋藤）淳美、武田弘志
- Organizer
  第13回国際医療福祉大学学会
- Data Source
  KAKENHI-PROJECT-21K06806
[Presentation] 妊娠期におけるストレス曝露が誘発する仔の情動障害に対する抑肝散母仔同服の治療効果2023
- Author(s)
  宮川和也, 持田淳美, 黒川和宏, 高橋浩平, 梅田啓, 武田弘志, 辻　稔
- Organizer
  第13回国際医療福祉大学学会
- Data Source
  KAKENHI-PROJECT-22K06682
[Presentation] 5-HT1A受容体刺激がオリゴデンドロサイト発現調節因子に及ぼす影響2023
- Author(s)
  黒川和宏、高橋浩平、宮川和也、持田（齋藤）淳美、武田弘志、辻稔
- Organizer
  第13回国際医療福祉大学学会
- Data Source
  KAKENHI-PROJECT-21K06806
[Presentation] ストレス適応と5-HT1A受容体を介した髄鞘形成との関連性2023
- Author(s)
  黒川和宏、高橋浩平、宮川和也、持田(斎藤)淳美、武田弘志、辻稔
- Organizer
  次世代薬理学セミナー2023 in 東京
- Invited
- Data Source
  KAKENHI-PROJECT-21K11732
[Presentation] Effect of simultaneous mother-offspring administration of the traditional herbal medicine yokukansan on emotional abnormality induced by prenatal stress in mice2023
- Author(s)
  Kazuya Miyagawa, Atsumi Mochida-Saito, Kazuhiro Kurokawa, Kohei Takahashi, Hiroshi Takeda, Minoru Tsuji
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K06682
[Presentation] 5-HT1A受容体の刺激はストレス非適応モデルマウスにおいてGSK3βを介してオリゴデンドロサイト転写因子を誘導する2023
- Author(s)
  黒川和宏、高橋浩平、野村彩衣、宮川和也、持田(斎藤)淳美、武田弘志、辻稔
- Organizer
  第39回日本ストレス学会学術総会
- Data Source
  KAKENHI-PROJECT-21K11732
[Presentation] Brexpiprazole prevents colitis-induced depressive-like behavior by regulating myelination through the activation of ERK1/2-CREB-BDNF-TrkB pathway in the prefrontal cortex2022
- Author(s)
  Kohei Takahashi, Lihua Hong, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji
- Organizer
  第95回薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15351
[Presentation] Brexpiprazole prevents colitis-induced depressive-like behavior by regulating myelination through the activation of ERK1/2-CREB-BDNF-TrkB pathway in the prefrontal cortex2022
- Author(s)
  高橋浩平、洪麗花、黒川和宏、宮川和也、持田（斎藤）淳美、武田弘志、辻稔
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06806
[Presentation] Resveratrol prevents dextran sulfate sodium-induced colitis-like symptoms and depressive-like behavior by activation of AMP-activated protein kinase pathways in the brain-gut2022
- Author(s)
  Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji
- Organizer
  第96回薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15351
[Presentation] Enterococcus faecalis 2001 prevents colitis and depressive-like behavior in dextran sulfate sodium-treated mice via the brain-gut axis.2021
- Author(s)
  Kohei Takahashi
- Organizer
  The 42nd Annual Meeting and Expo of KSFP
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15351
[Presentation] Changes in prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior2020
- Author(s)
  Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji
- Organizer
  第93回薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K23808
[Presentation] Schizophrenia-like alternations in the offspring of methylazoxymethanol treated in mice2019
- Author(s)
  Kohei Takahashi, Osamu Nakagawasai, Wakana Sakuma, Wataru Nemoto, Takayo Odaira, Lin Jia-Rong, Hiroshi Onogi, Lalit K Srivastava, Minoru Tsuji, Hiroshi Takeda, Koichi Tan-No.
- Organizer
  Asian College of Neuropsychopharmacology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23808

1. 辻稔 (70297307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. 宮川和也 (10453408)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. 黒川和宏 (30454846)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
4. 持田淳美 (80709022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 中川西修 (50296018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 大河原雄一 (40333801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小野木弘志 (50610200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 根本亙 (80635136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Takahashi Kohei 高橋 浩平

Research Projects

Research Products

Co-Researchers

Mechanism of depression induced by gut microbiota imbalance: involvement of hippocampus AMPK and development of a novel treatmentPrincipal Investigator

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妊娠期の低酸素状態が子の情動的ストレス応答に及ぼす影響と抑肝散の治療効果

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Functional analysis of angiotensin-converting enzyme 2 in the brain and development of novel therapeutic agents for depression

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新規抗うつ薬開発を指向したアストロサイト由来LIFのストレス適応促進作用の証明

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Effect of running exercise on myelin damage caused by maladaptation to stress in female mice

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Elucidation of a mechanism of developing depression in colitis: association with brain-gut AMPK and development of novel therapyPrincipal Investigator

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Elucidation of a pathogenic mechanism of colitis-induced depression based on concept for brain-gut associationPrincipal Investigator

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[Journal Article] Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction2024

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[Journal Article] Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice2024

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[Journal Article] Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy2024

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[Journal Article] Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice2023

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[Journal Article] Possible involvement of inflammasomes on the post-stroke cognitive impairment in a mouse model of embolic cerebral infarct2023

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[Journal Article] Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex2023

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[Journal Article] Peptides obtained by enzymatic decomposition of mackerel induce recovery from physical fatigue by enhancing the SIRT1-mediated antioxidant effect in the soleus muscle of mice2023

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Takahashi Kohei 高橋浩平