Sakamoto Yuma 坂本祐真

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SAKAMOTO Yuma 坂本祐真

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Researcher Number	90865817
Other IDs	https://orcid.org/0000-0001-9916-4862
Affiliation (Current)	2024: 川崎医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 川崎医科大学, 医学部, 助教 2022: 岐阜大学, 大学院医学系研究科, 特任助教 2020 – 2021: 名古屋市立大学, 医薬学総合研究院(医学), 研究員
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 遺伝子異常 / ゲノム異常 / CCR7 / CCR4 / モガムリズマブ / 成人T細胞白血病/リンパ腫 / CRISPR/Cas / 遺伝子治療 / 造血器腫瘍 / 成人T細胞白血病 … More / 化学療法 / 骨髄移植 / mogamulizumab / NOTCH1 / 蛋白発現 / TP53 / CD28 / 造血幹細胞移植 … More Except Principal Investigator 自己炎症性疾患 / 自然免疫 / ケルビズム / 自己炎症 / 破骨細胞 / TRAPS / TNF / マクロファージ / TNF受容体関連周期性症候群 / TNFRSF1A / KIF7 / Cherubism / SH3BP2 / RNA編集 / VEXAS症候群 Less

成人自己炎症性疾患VEXAS症候群の病態解明およびCas13を用いた革新的遺伝子治療の開発
- Principal Investigator
  
  向井知之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kawasaki Medical School
成人T細胞白血病に対するCRISPR-Cas13を用いた遺伝子治療戦略の開発Principal Investigator
- Principal Investigator
  
  坂本祐真
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kawasaki Medical School
個別化治療を見据えた成人T細胞白血病/リンパ腫の分子病理学的解析Principal Investigator
- Principal Investigator
  
  坂本祐真
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kawasaki Medical School
  Gifu University
自己炎症性疾患関連遺伝子SH3BP2およびKIF7の炎症惹起メカニズムの解明
- Principal Investigator
  
  向井知之
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kawasaki Medical School
Elucidation of genomic alterations and the clinicopathological significance in adult T-cell leukemia/lymphomaPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Yuma
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Gifu University
  Nagoya City University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model2023
- Author(s)
  Takezaki Daiki、Morizane Shin、Ikeda Kenta、Iseki Masanori、Sakamoto Yuma、Kawakami Yoshio、Hashiguchi Taishi、Shirakata Yuka、Nishina Sohji、Mukai Tomoyuki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1214623-1214623
- DOI
  10.3389/fimmu.2023.1214623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07917, KAKENHI-PROJECT-21K08484, KAKENHI-PROJECT-22K15426
[Journal Article] Introduce My Article: Clinical significance of TP53 mutations in adult T-cell leukemia/lymphoma2022
- Author(s)
  Yuma Sakamoto
- Journal Title
  
  臨床血液
  
  Volume: 63 Pages: 69-69
- Data Source
  KAKENHI-PROJECT-22K15426
[Journal Article] <i>CCR7</i> alterations associated with inferior outcome of adult T‐cell leukemia/lymphoma under mogamulizumab treatment2022
- Author(s)
  Sakamoto Yuma、Ishida Takashi、Masaki Ayako、Murase Takayuki、Ohtsuka Eiichi、Takeshita Morishige、Muto Reiji、Iwasaki Hiromi、Ito Asahi、Kusumoto Shigeru、Nakano Nobuaki、Tokunaga Masahito、Yonekura Kentaro、Tashiro Yukie、Iida Shinsuke、Utsunomiya Atae、Ueda Ryuzo、Inagaki Hiroshi
- Journal Title
  
  Hematological Oncology
  
  Volume: 40 Issue: 5 Pages: 876-884
- DOI
  10.1002/hon.3072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15426, KAKENHI-PROJECT-21H02704, KAKENHI-PROJECT-18K16095, KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-23K24179
[Journal Article] 7-Amino-4-methylcoumarin as a fluorescent substitute for Schiff’s reagent: a new method that can be combined with hemalum and eosin staining on the same tissue section2022
- Author(s)
  Takase Hiroshi、Murase Takayuki、Hachisuka Daisuke、Sakamoto Yuma、Sugiura Mariko、Nakano Satsuki、Fujii Keiichiro、Masaki Ayako、Inagaki Hiroshi
- Journal Title
  
  Biotechnic & Histochemistry
  
  Volume: 98 Issue: 1 Pages: 54-61
- DOI
  10.1080/10520295.2022.2101144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15405, KAKENHI-PROJECT-22K15426, KAKENHI-PROJECT-21H02704, KAKENHI-PROJECT-18K16095, KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-23K06469
[Journal Article] Introduce My Article: Clinical significance of TP53 mutations in adult T-cell leukemia/lymphoma2022
- Author(s)
  Yuma Sakamoto
- Journal Title
  
  臨床血液
  
  Volume: 63 Pages: 69-69
- Data Source
  KAKENHI-PROJECT-20K16177
[Journal Article] Clinical significance of TP53 mutations in adult T‐cell leukemia/lymphoma2021
- Author(s)
  Sakamoto Yuma、Ishida Takashi、Masaki Ayako、Murase Takayuki、Takeshita Morishige、Muto Reiji、Iwasaki Hiromi、Ito Asahi、Kusumoto Shigeru、Nakano Nobuaki、Tokunaga Masahito、Yonekura Kentaro、Tashiro Yukie、Iida Shinsuke、Utsunomiya Atae、Ueda Ryuzo、Inagaki Hiroshi
- Journal Title
  
  British Journal of Haematology
  
  Volume: 195 Issue: 4 Pages: 571-584
- DOI
  10.1111/bjh.17749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02704, KAKENHI-PROJECT-18K16095, KAKENHI-PROJECT-20K16177
[Journal Article] Mutation Profile of Thymic Carcinoma and Thymic Neuroendocrine Tumor by Targeted Next-generation Sequencing2021
- Author(s)
  Sakane Tadashi, Sakamoto Yuma, Masaki Ayako, Murase Takayuki, Okuda Katsuhiro, Nakanishi Ryoichi, Inagaki Hiroshi.
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 22 Issue: 2 Pages: 92-99
- DOI
  10.1016/j.cllc.2020.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-20K17755, KAKENHI-PROJECT-18H02633, KAKENHI-PROJECT-21H02704
[Journal Article] Clinicopathological significance of CD28 overexpression in adult T‐cell leukemia/lymphoma2021
- Author(s)
  Sakamoto Yuma、Ishida Takashi、Masaki Ayako、Takeshita Morishige、Iwasaki Hiromi、Yonekura Kentaro、Tashiro Yukie、Ito Asahi、Kusumoto Shigeru、Iida Shinsuke、Utsunomiya Atae、Ueda Ryuzo、Inagaki Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 1 Pages: 349-361
- DOI
  10.1111/cas.15191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02704, KAKENHI-PROJECT-18K16095, KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-22K15426, KAKENHI-PROJECT-23K24179
[Journal Article] Immunohistochemistry for CCR4 C‐terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T‐cell leukemia/lymphoma2020
- Author(s)
  Fujii Keiichiro、Sakamoto Yuma、Masaki Ayako、Murase Takayuki、Tashiro Yukie、Yonekura Kentaro、Utsunomiya Atae、Ito Asahi、Kusumoto Shigeru、Iida Shinsuke、Ueda Ryuzo、Ishida Takashi、Inagaki Hiroshi
- Journal Title
  
  The Journal of Pathology: Clinical Research
  
  Volume: 7 Issue: 1 Pages: 52-60
- DOI
  10.1002/cjp2.180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16095, KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-18H02633
[Journal Article] Clinical significance of CD28 gene‐related activating alterations in adult T‐cell leukaemia/lymphoma2020
- Author(s)
  Sakamoto Yuma、Ishida Takashi、Masaki Ayako、Takeshita Morishige、Iwasaki Hiromi、Yonekura Kentaro、Tashiro Yukie、Ito Asahi、Kusumoto Shigeru、Utsunomiya Atae、Iida Shinsuke、Ueda Ryuzo、Inagaki Hiroshi
- Journal Title
  
  British Journal of Haematology
  
  Volume: 192 Issue: 2 Pages: 281-291
- DOI
  10.1111/bjh.17211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16095, KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-18H02633
[Journal Article] Clinicopathological significance of EGFR pathway gene mutations and CRTC1/3‐MAML2 fusions in salivary gland mucoepidermoid carcinoma2020
- Author(s)
  Morita Maki、Murase Takayuki、Okumura Yoshihide、Ueda Kaori、Sakamoto Yuma、Masaki Ayako、Kawakita Daisuke、Tada Yuichiro、Nibu Ken‐Ichi、Shibuya Yasuyuki、Inagaki Hiroshi
- Journal Title
  
  Histopathology
  
  Volume: X Issue: 7 Pages: 1013-1022
- DOI
  10.1111/his.14100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09386, KAKENHI-PROJECT-18K16095, KAKENHI-PROJECT-20K10508, KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-18H02633
[Journal Article] Next-generation sequencing assay in salivary gland cytology: A pilot study2020
- Author(s)
  Yamamoto S, Sakamoto Y, Nakano S, Fujii K, Ueda K, Okumura Y, Tsuda K, Masaki A, Kawakita D, Murase T, Inagaki H.
- Journal Title
  
  Journal of Oral Pathology & Medicine
  
  Volume: 49(10) Issue: 10 Pages: 1037-1043
- DOI
  10.1111/jop.13109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10508, KAKENHI-PROJECT-20K16177, KAKENHI-PROJECT-18H02633
[Presentation] The cytokine component Epstein-Barr virus induced 3 (EBI3) promotes systemic inflammation induced by TLR7 ligand2024
- Author(s)
  Masanori Iseki, Yuma Sakamoto, Daiki Takezaki, Shin Morizane, Tomoyuki Mukai
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08484
[Presentation] Concomitant Nonalcoholic Steatohepatitis Worsens Psoriasis Associated with Decreased Adiponectin Expression in a Mouse Model2024
- Author(s)
  Daiki Takezaki, Shin Morizane, Kenta Ikeda, Masanori Iseki, Yuma Sakamoto, Yoshio Kawakami, Taishi Hashiguchi, Yuka Shirakata, Sohji Nishina, Tomoyuki Mukai
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08484
[Presentation] サイトカイン構成要素EBI3はTLR7リガンドによって誘導される全身性炎症を促進する2023
- Author(s)
  井関將典, 坂本祐真, 竹﨑大輝, 森実真, 向井知之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08484
[Presentation] 非アルコール性脂肪性肝炎の併存はマウスモデルにおける乾癬を悪化させる2023
- Author(s)
  竹﨑大輝, 森実真, 池田賢太, 井関將典, 坂本佑真, 川上佳夫, 橋口太志, 白方有香, 仁科惣治, 向井知之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08484
[Presentation] 複雑核型を有する骨髄異形成症候群に合併した巨細胞性動脈炎症例2023
- Author(s)
  福田大晃,　藤田俊一,　小出侑佳,　長洲晶子,　浅野澄恵,　赤木貴彦,　坂本祐真,　向井知之,　守田吉孝,　中野和久
- Organizer
  第34回日本リウマチ学会中国・四国支部学術集会
- Data Source
  KAKENHI-PROJECT-21K08484
[Presentation] NOTCH1 and FBXW7 gene alterations in adult T-cell leukemia/lymphoma2023
- Author(s)
  Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase, Eiichi Ohtsuka, Morishige Takeshita, Reiji Muto, Ilseung Choi, Hiromi Iwasaki, Asahi Ito, Shigeru Kusumoto, Nobuaki Nakano, Masahito Tokunaga, Kentaro Yonekura, Yukie Tashiro, Youko Suehiro, Shinsuke Iida, Atae Utsunomiya, Ryuzo Ueda, and Hiroshi Inagaki
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15426
[Presentation] 成人T細胞白血病/リンパ腫におけるB7/CD28異常の臨床病理学的検討2022
- Author(s)
  坂本祐真, 石田高司, 稲垣宏
- Organizer
  第54回日本臨床分子形態学会総会
- Data Source
  KAKENHI-PROJECT-22K15426
[Presentation] 成人T細胞白血病/リンパ腫におけるB7/CD28異常の臨床病理学的検討2022
- Author(s)
  坂本祐真、石田高司、稲垣宏
- Organizer
  第54回日本臨床分子形態学会総会
- Data Source
  KAKENHI-PROJECT-20K16177
[Presentation] Clinical significance of TP53 mutations in adult T-cell leukemia/lymphoma2021
- Author(s)
  坂本祐真、石田高司、正木彩子、村瀬貴幸、竹下盛重、岩崎浩己、田代幸恵、米倉健太郎、徳永雅仁、伊藤旭、楠本茂、飯田真介、宇都宮與、上田龍三、稲垣宏
- Organizer
  第61回日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-20K16177
[Presentation] 成人T細胞白血病/リンパ腫における遺伝子学的異常とその臨床病理学的意義の解明2021
- Author(s)
  坂本祐真
- Organizer
  第72回名古屋市立大学医学会総会
- Data Source
  KAKENHI-PROJECT-20K16177
[Presentation] 成人T細胞白血病/リンパ腫におけるCD28遺伝子異常の臨床的意義2020
- Author(s)
  坂本祐真、石田高司、宇都宮與、稲垣宏
- Organizer
  2020年度国立がん研究センター研究開発費（重点課題）研究課題 2020-J-3「成人固形がんに対する標準治療確立のための基盤研究」班（大江班）の「難治性リンパ腫小班」（山口小班）令和2年度小班会議
- Data Source
  KAKENHI-PROJECT-20K16177
[Presentation] 唾液腺腫瘍における穿刺吸引細胞診検体を用いた遺伝子解析の臨床的意義2020
- Author(s)
  坂本祐真、丸山信秋、蜂須賀大輔、正木彩子、村瀬貴幸、稲垣宏
- Organizer
  第61回日本臨床細胞学会総会
- Data Source
  KAKENHI-PROJECT-20K16177

1. 向井知之 (00454421)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. 伊藤達男 (80789123)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 清水由梨香 (80963355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 近藤英生 (30379747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 井関將典 (30532353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 山崎聡士 (30367388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 守田吉孝 (50346441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 井田弘明 (60363496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 浅野澄恵 (80816497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KANO Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. MORIZANA Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 村瀬貴幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 正木彩子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
14. 稲垣宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 多田雄一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 藤井慶一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 川北大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakamoto Yuma 坂本 祐真

SAKAMOTO Yuma 坂本 祐真

Research Projects

Research Products

Co-Researchers

成人自己炎症性疾患VEXAS症候群の病態解明およびCas13を用いた革新的遺伝子治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

成人T細胞白血病に対するCRISPR-Cas13を用いた遺伝子治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

個別化治療を見据えた成人T細胞白血病/リンパ腫の分子病理学的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自己炎症性疾患関連遺伝子SH3BP2およびKIF7の炎症惹起メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of genomic alterations and the clinicopathological significance in adult T-cell leukemia/lymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Introduce My Article: Clinical significance of TP53 mutations in adult T-cell leukemia/lymphoma2022

Author(s)

Journal Title

Data Source

[Journal Article] <i>CCR7</i> alterations associated with inferior outcome of adult T‐cell leukemia/lymphoma under mogamulizumab treatment2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 7-Amino-4-methylcoumarin as a fluorescent substitute for Schiff’s reagent: a new method that can be combined with hemalum and eosin staining on the same tissue section2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Introduce My Article: Clinical significance of TP53 mutations in adult T-cell leukemia/lymphoma2022

Author(s)

Journal Title

Data Source

[Journal Article] Clinical significance of TP53 mutations in adult T‐cell leukemia/lymphoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation Profile of Thymic Carcinoma and Thymic Neuroendocrine Tumor by Targeted Next-generation Sequencing2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinicopathological significance of CD28 overexpression in adult T‐cell leukemia/lymphoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunohistochemistry for CCR4 C‐terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T‐cell leukemia/lymphoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of CD28 gene‐related activating alterations in adult T‐cell leukaemia/lymphoma2020

Author(s)

Sakamoto Yuma 坂本祐真

SAKAMOTO Yuma 坂本祐真