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Koh IsabelSiewYin  Koh IsabelSiewYin

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KOH Isabel Siew Yin  Koh IsabelSiewYin

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Researcher Number 90868415
Other IDs
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員
2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 特別研究員
2021 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 特別研究員
Review Section/Research Field
Principal Investigator
Basic Section 90110:Biomedical engineering-related / Basic Section 46010:Neuroscience-general-related
Except Principal Investigator
Medium-sized Section 90:Biomedical engineering and related fields
Keywords
Principal Investigator
In vitro modelling / Muti-organ / Spinal cord / Ventralisation / Neural tube / オルガノイド血管形成 / Vascularisation / Multi-directional / Cube device / Blood-brain barrier … More / Tissue interaction / Organ-on-a-chip / Organ-organ interaction / 3D culture / Organoid / Organ-on-a-Chip … More
Except Principal Investigator
PEG / 体軸形成 / 尾頭軸 / 背腹軸 / 濃度勾配 / 脊髄オルガノイド / ミクログリア / 神経オルガノイド / 血液脳関門 / Organ-on-a-Chip Less
  • Research Projects

    (5 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (2 People)
  •  Development of an In Vitro Disease Model Incorporating Organ-Organ Interaction

    • Principal Investigator
      萩原 将也
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Reconstruction of the Thalamocortical Pathway in vitro to Model Neuropsychiatric DisordersPrincipal Investigator

    • Principal Investigator
      Koh IsabelSiewYin
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Construction of a multi-organ neural network with independent sensory and motor neuronsPrincipal Investigator

    • Principal Investigator
      Koh IsabelSiewYin
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development of Spinal Cord Organoids using Body Axis Formation Platform

    • Principal Investigator
      萩原 将也
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Fund for the Promotion of Joint International Research (International Collaborative Research)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Construction of a multi-organ interaction model via the controlled vascularisation of modular organoidsPrincipal Investigator

    • Principal Investigator
      KOH Isabel Siew Yin
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Institute of Physical and Chemical Research

All 2024 2023 2022 2021

All Journal Article Presentation Patent

  • [Journal Article] Modular Tissue-in-a-CUBE Platform to Model Blood-brain-Barrier (BBB) and Brain Interaction2023

    • Author(s)
      Koh Isabel、Hagiwara Masaya
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2023.02.25.529996

    • Open Access
    • Data Source
      KAKENHI-PROJECT-21H01299, KAKENHI-PROJECT-21K18048
  • [Journal Article] Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation2023

    • Author(s)
      Koh Isabel、Hagiwara Masaya
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1

    • DOI

      10.1038/s42003-023-04694-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H01299, KAKENHI-PROJECT-21K18048
  • [Journal Article] 3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device2022

    • Author(s)
      Atsushi Takano, Isabel Koh, Masaya Hagiwara
    • Journal Title

      Micromachines

      Volume: 13 Issue: 2 Pages: 156-156

    • DOI

      10.3390/mi13020156

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20463, KAKENHI-PROJECT-21K18048, KAKENHI-PROJECT-21K18061, KAKENHI-PROJECT-21H01299, KAKENHI-PROJECT-19KK0129
  • [Patent] 観察用切片作製用のブロック、及びその利用2022

    • Inventor(s)
      萩原将也 , コウイザベルシュイン
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-140997
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-21K18048
  • [Presentation] A cube-in-a-chip platform to localise signalling molecule source, mimicking the notochord during formation of neural tube organoid2024

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      ISSCR Cincinnati International Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K17204
  • [Presentation] Integration platform for organoids and organ-on-a-Chip by modularized technologies to control and sensing microenvironments with CUBE2023

    • Author(s)
      Isabel Koh, Kasinan Suthiwanich, Masaya Hagiwara
    • Organizer
      MPS World Summit 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23KK0205
  • [Presentation] Gradient Culture Platform to Generate Asymmetric Organoids with Two Locally Differentiated Regions2023

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      RIKEN BDR-CuSTOM Joint Organoid Symposium
    • Data Source
      KAKENHI-PROJECT-21K18048
  • [Presentation] Differentiation of Neural Organoid with Dorsal-Ventral Axis2023

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      The Molecular Biology Society of Japan Annual Meeting
    • Data Source
      KAKENHI-PROJECT-23K17204
  • [Presentation] 成長因子勾配によるオルガノイドの分化を制御するCube-in-Chipプラットフォーム2023

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      Japanese Society for Regenerative Medicine
    • Data Source
      KAKENHI-PROJECT-21K18048
  • [Presentation] Differentiation of Neural Organoid with Dorsal-Ventral Axis2023

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-23KK0205
  • [Presentation] Cube-in-Chip: An in vitro Platform to Control Organoid Differentiation by Morphogen Gradient2022

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      Development Journal Meeting 2022 - From Stem Cells to Human Development
    • Data Source
      KAKENHI-PROJECT-21K18048
  • [Presentation] Development of an in vitro Platform to Control iPSC Differentiation by Morphogen Gradient2022

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      Japan Neuroscience Society Annual Meeting
    • Data Source
      KAKENHI-PROJECT-21K18048
  • [Presentation] Next generation organ-on-a-chip platform: Merging modular 3D tissue-in-a-cube with microfluidics for a blood-brain barrier (BBB) model2021

    • Author(s)
      Isabel Koh, Masaya Hagiwara
    • Organizer
      The Japanese Society for the Study of Xenobiotics
    • Data Source
      KAKENHI-PROJECT-21K18048
  • [Presentation] Designing Organoid Architecture: Introducing an Integrative Platform to Control Cellular Distribution, ECM Environment, and Morphogen Gradient in Organoid Culture2021

    • Author(s)
      Isabel Koh, Kasinan Suthiwanich, Atsushi Takano, Masaya Hagiwara
    • Organizer
      The Molecular Biology Society of Japan
    • Data Source
      KAKENHI-PROJECT-21K18048
  • [Presentation] BBB-on-a-Chip Model by Integration of Tissue-in-a-Cube with Fluidic Device2021

    • Author(s)
      Isabel Koh, Waki Sekine, Masaya Hagiwara
    • Organizer
      CHEMINAS
    • Data Source
      KAKENHI-PROJECT-21K18048
  • 1.  萩原 将也 (00705056)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 2.  坂口 秀哉 (30779153)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results

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