Ishino Takamasa 石野貴雅

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ISHINO Takamasa 石野貴雅

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Researcher Number	90907792
Other IDs
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 研究准教授
Affiliation (based on the past Project Information) *help	2024: 岡山大学, 医歯薬学域, 研究准教授 2021 – 2022: 千葉大学, 大学院医学研究院, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator がん免疫 / 肝細胞癌 / 免疫チェックポイント阻害薬 / 肝細胞がん / MSI-high大腸癌 / 大腸がん / 大腸癌 / ネオ抗原 / 免疫チェックポイント阻害剤 / 腫瘍免疫

肝細胞癌における背景肝代謝環境に基づいた抗腫瘍免疫応答の解明Principal Investigator
- Principal Investigator
  
  石野貴雅
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Elucidation of anti-tumor immune response through qualitative evaluation of neoantigensPrincipal Investigator
- Principal Investigator
  
  ISHINO Takamasa
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Chiba University

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Immune evasion through mitochondrial transfer in the tumour microenvironment2025
- Author(s)
  Ikeda H, Kawase K, Nishi T, Watanabe T, Takenaga K, Inozume T, Ishino T, Aki S, Lin J, Kawashima S, Togashi Y, et al
- Journal Title
  
  Nature
  
  Volume: 638 Issue: 8049 Pages: 225-236
- DOI
  10.1038/s41586-024-08439-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K18234, KAKENHI-PROJECT-22KJ0489, KAKENHI-PROJECT-23K24337, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-23K07303, KAKENHI-PROJECT-24K10137, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells2025
- Author(s)
  Matsuura Hiroaki、Ishino Takamasa、Ninomiya Toshifumi、Ninomiya Kiichiro、Tachibana Kota、Honobe‐Tabuchi Akiko、Muto Yoshinori、Inozume Takashi、Ueda Youki、Ohashi Kadoaki、Maeda Yoshinobu、Nagasaki Joji、Togashi Yosuke
- Journal Title
  
  Cancer Science
  
  Volume: 116 Issue: 5 Pages: 1214-1226
- DOI
  10.1111/cas.70029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15607, KAKENHI-PROJECT-23K24339, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy2025
- Author(s)
  Ninomiya Toshifumi、Kemmotsu Naoya、Mukohara Fumiaki、Magari Masaki、Miyamoto Ai、Ueda Youki、Ishino Takamasa、Nagasaki Joji、Fujiwara Tomohiro、Yamamoto Hidetaka、Hayashi Hidetoshi、Tachibana Kota、Ishida Joji、Otani Yoshihiro、Tanaka Shota、Toyooka Shinichi、Okamoto Isamu、Togashi Yosuke
- Journal Title
  
  Cancer Research
  
  Volume: 85 Issue: 6 Pages: 1082-1096
- DOI
  10.1158/0008-5472.can-24-2274
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma2024
- Author(s)
  Fujiwara Kisako、Kondo Takayuki、Ogasawara Sadahisa、Kato Naoya、et al.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 59 Issue: 6 Pages: 515-525
- DOI
  10.1007/s00535-024-02097-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577, KAKENHI-PROJECT-24K18933
[Journal Article] Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity2024
- Author(s)
  Mukohara F、Iwata K、Ishino T、Inozume T、Nagasaki J、Ueda Y、Suzawa K、Ueno T、Ikeda H、Kawase K、Saeki Y、Kawashima S、Yamashita K、Kawahara Y、Nakamura Y、Honobe-Tabuchi A、Watanabe H、Dansako H、Kawamura T、Suzuki Y、Honda H、Mano H、Toyooka S、Kawazu M、Togashi Y
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 35
- DOI
  10.1073/pnas.2320189121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-22KJ0489, KAKENHI-PROJECT-23K27442, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K11468, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023
- Author(s)
  Ishino Takamasa、Kawashima Shusuke、Tanji Etsuko、Ueno Toshihide、Ueda Youki、Ogasawara Sadahisa、Sato Kazuhito、Mano Hiroyuki、Ishihara Soichiro、Kato Naoya、Kawazu Masahito、Togashi Yosuke
- Journal Title
  
  British Journal of Cancer
  
  Volume: 128 Issue: 6 Pages: 1166-1175
- DOI
  10.1038/s41416-023-02165-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08049, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K20859, KAKENHI-PROJECT-21K12117
[Journal Article] Activated CTLA‐4‐independent immunosuppression of Treg cells disturbs CTLA‐4 blockade‐mediated antitumor immunity2023
- Author(s)
  Watanabe T、Ishino T、Ueda Y、Nagasaki J、Sadahira T、Dansako H、Araki M、Togashi Y
- Journal Title
  
  Cancer Science
  
  Volume: In press Issue: 5 Pages: 1859-1870
- DOI
  10.1111/cas.15756
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21K20859, KAKENHI-PROJECT-22K15472
[Journal Article] Mechanisms of resistance to immune checkpoint inhibitors2022
- Author(s)
  Nagasaki J、Ishino T、Togashi Y
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 10 Pages: 3303-3312
- DOI
  10.1111/cas.15497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21K20859
[Presentation] Impact of Somatic Mutations in Tumor-Infiltrating Lymphocytes on Antitumor Immunity2024
- Author(s)
  Ishino T, Mukohara F, Iwata K, Inozume T, Nagasaki J, Ueda Y, Ueno T, Ikeda H, Kawashima S, Watanabe H, Honda H, Toyooka S, Kawazu M, Togashi Y
- Organizer
  SITC's 39th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K18933
[Presentation] Paradoxical neoantigens; neoantigenic mutations can paradoxically induce a noninflamed tumor microenvironment via their original functions2022
- Author(s)
  Takamasa Ishino, Toshihide Ueno, Youki Ueda, Hiroyuki Mano, Soichiro Ishihara, Naoya Kato, Masahito Kawazu, Yosuke Togashi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K20859
[Presentation] Neoantigen paradox; neoantigen do not always induce an inflamed tumor microenvironment2022
- Author(s)
  Takamasa Ishino, Shusuke Kawashima, Etsuko Tanji, Toshihide Ueno, Youki Ueda, Sadahisa Ogasawara, Kazuhito Sato, Soichiro Ishihara, Naoya Kato, Masahito Kawazu, Yosuke Togashi
- Organizer
  第12回日米癌合同会議
- Data Source
  KAKENHI-PROJECT-21K20859

1. 渡邊毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小笠原定久

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 冨樫庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 二宮貴一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 加藤直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 上野敏秀

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# of Collaborated Products: 1 results

Ishino Takamasa 石野 貴雅

ISHINO Takamasa 石野 貴雅

Research Projects

Research Products

Co-Researchers

肝細胞癌における背景肝代謝環境に基づいた抗腫瘍免疫応答の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of anti-tumor immune response through qualitative evaluation of neoantigensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Immune evasion through mitochondrial transfer in the tumour microenvironment2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated CTLA‐4‐independent immunosuppression of Treg cells disturbs CTLA‐4 blockade‐mediated antitumor immunity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of resistance to immune checkpoint inhibitors2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Impact of Somatic Mutations in Tumor-Infiltrating Lymphocytes on Antitumor Immunity2024

Author(s)

Organizer

Data Source

[Presentation] Paradoxical neoantigens; neoantigenic mutations can paradoxically induce a noninflamed tumor microenvironment via their original functions2022

Author(s)

Organizer

Data Source

[Presentation] Neoantigen paradox; neoantigen do not always induce an inflamed tumor microenvironment2022

Author(s)

Organizer

Data Source

Ishino Takamasa 石野貴雅

ISHINO Takamasa 石野貴雅