Nii Teruki 新居輝樹

Researcher Number	90908419
Other IDs
Affiliation (Current)	2025: 九州大学, 工学研究院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 九州大学, 工学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Medium-sized Section 90:Biomedical engineering and related fields / 0403:Biomedical engineering and related fields / Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator ドラッグデリバリーシステム / がん治療 / マクロファージ / ゼラチン / 薬物徐放 / 細胞医薬 / 基質 / 抗がん剤 / プロドラッグ / 酵素 … More / 分極 / CRISPR-Cas9 / 免疫 / バイオマテリアル / がん微小環境 / 三次元培養 / 3次元組織体 / 生体材料 / 組織工学 / 3次元培養 / がん / 炎症 / ターゲティング / 免疫制御 Less

Universalization of Innovative Macrophage Medicines to Reverse Cancer Survival StrategiesPrincipal Investigator
- Principal Investigator
  
  新居輝樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyushu University
薬効の適切なon-offスイッチを細胞が担うがん治療戦略Principal Investigator
- Principal Investigator
  
  新居輝樹
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kyushu University
Development of allergy therapeutics based on allergen sustained release in target cellsPrincipal Investigator
- Principal Investigator
  
  Nii Teruki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kyushu University
Design of three-dimensional tissue models for anti-cancer drug screening utilizing growth factor release systemPrincipal Investigator
- Principal Investigator
  
  Nii Teruki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0403:Biomedical engineering and related fields
- Research Institution
  Kyushu University

All 2025 2024 2022

All Journal Article Presentation Book Patent

[Book] Therapeutic concept of cancers based on cells themselves as biomaterials2025
- Author(s)
  新居　輝樹
- Total Pages
  2
- Publisher
  日本バイオマテリアル学術誌
- Data Source
  KAKENHI-PROJECT-24K21087
[Book] 腫瘍がまとう防具を取り払う細胞医薬「マックトリガー」2025
- Author(s)
  新居　輝樹、片山　佳樹
- Total Pages
  6
- Publisher
  日本薬学会「ファルマシア」
- Data Source
  KAKENHI-PROJECT-24K21087
[Book] JCRだより2024
- Author(s)
  片山　佳樹、新居　輝樹
- Total Pages
  1
- Publisher
  日本DDS学会機関誌「Drug Delivery System」
- Data Source
  KAKENHI-PROJECT-24K21087
[Book] 生体に腫瘍を排除させトリガーとして機能する遺伝子改変マクロファージ「マックトリガー」2024
- Author(s)
  新居　輝樹
- Total Pages
  9
- Publisher
  月刊BIOINDUSTRY
- Data Source
  KAKENHI-PROJECT-24K21087
[Book] DDS技術に基づく3次元培養システム2022
- Author(s)
  新居　輝樹
- Total Pages
  2
- Publisher
  日本DDS学会機関誌「Drug Delivery System」
- Data Source
  KAKENHI-PROJECT-21K20517
[Journal Article] Inflammation-triggering Engineered Macrophages (MacTriggers) Are Promising Cell-based Therapeutic Avenues for Chemoresistant Solid Tumors2025
- Author(s)
  NII TERUKI、YOSHIMI TOMA、TANITO KENTA、HIJII SHOICHI、TAKATA HARUKA、KISHIMURA AKIHIRO、MORI TAKESHI、ISHIDA TATSUHIRO、KATAYAMA YOSHIKI
- Journal Title
  
  Anticancer Research
  
  Volume: 45 Issue: 4 Pages: 1395-1405
- DOI
  10.21873/anticanres.17525
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21087
[Journal Article] The effect of Fc region affinity of protein-based antibody-recruiting molecules on antibody-dependent cellular cytotoxicity2024
- Author(s)
  H. Tagawa, R. Saeki, C. Yamamoto, K. Tanito, S. Munekawa, T. Nii, A. Kishimura, H. Murakami, T. Mori, Y. Katayama
- Journal Title
  
  RSC Advances
  
  Volume: 14 Issue: 32 Pages: 22860-22866
- DOI
  10.1039/d4ra03391d
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21251, KAKENHI-PROJECT-24K21087
[Journal Article] Oral Administration of PLGA Nanoparticles to Deliver Antisense Oligonucleotides to Inflammatory Lesions in the Gastrointestinal Tract2024
- Author(s)
  Yagi Yuta、Liu Yiwei、Li Jinting、Shimada Shunsuke、Ohkouchi Munetaka、Taguchi Yasushi、Nii Teruki、Mori Takeshi、Katayama Yoshiki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 4 Pages: 848-855
- DOI
  10.1248/bpb.b23-00769
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-04-15
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ2442, KAKENHI-PROJECT-24K21087
[Journal Article] Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths2024
- Author(s)
  Aulia Fadlina、Matsuba Hiroaki、Adachi Shoya、Yamada Takumi、Nakase Ikuhiko、Nii Teruki、Mori Takeshi、Katayama Yoshiki、Kishimura Akihiro
- Journal Title
  
  Journal of Materials Chemistry B
  
  Volume: 12 Issue: 7 Pages: 1826-1836
- DOI
  10.1039/d3tb02049e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21087
[Journal Article] Inflammation-Triggering Engineered Macrophages (MacTriggers) Enhance Reactivity of Immune Checkpoint Inhibitor Only in Tumor Tissues2024
- Author(s)
  Kenta Tanito, Teruki Nii, Kanae Wakuya, Yusuke Hamabe, Toma Yoshimi, Takanatsu Hosokawa, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 22 Pages: 3787-3804
- DOI
  10.3390/cancers16223787
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21251, KAKENHI-PROJECT-24K21087
[Journal Article] In vitro evaluation of novel SN-38 prodrug activated by α-rhamnosidase of exogenous enzyme2024
- Author(s)
  Nii Teruki、Hijii Shoichi、Kaneko Ryosuke、Tanito Kenta、Yamanaka Kota、Kishimura Akihiro、Mori Takeshi、Katayama Yoshiki
- Journal Title
  
  Analytical Sciences
  
  Volume: 40 Issue: 8 Pages: 1529-1535
- DOI
  10.1007/s44211-024-00593-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21087
[Journal Article] Three-dimensional culture system utilizing DDS technology2022
- Author(s)
  Nii Teruki
- Journal Title
  
  Drug Delivery System
  
  Volume: 37 Issue: 3 Pages: 270-271
- DOI
  10.2745/dds.37.270
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2022-07-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K20517
[Patent] 免疫原性複合体およびその製造方法、並びに医薬組成物2025
- Inventor(s)
  新居　輝樹、森　健、李　晋廷、片山　佳樹、田畑　泰彦
- Industrial Property Rights Holder
  新居　輝樹、森　健、李　晋廷、片山　佳樹、田畑　泰彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2025-018233
- Filing Date
  2025
- Data Source
  KAKENHI-PROJECT-24K21087
[Patent] 腫瘍組織内においてM2マクロファージに分化することができ、M2マクロファージに分化すると炎症性サイトカインを発現する細胞、および当該細胞を含む組成物2024
- Inventor(s)
  新居　輝樹、谷戸　謙太、片山　佳樹
- Industrial Property Rights Holder
  新居　輝樹、谷戸　謙太、片山　佳樹
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] マックトリガーの実用化に向けて2025
- Author(s)
  新居　輝樹
- Organizer
  第3回 FBCAP Innovation Event
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] ヒト直交性酵素α-ラムノシダーゼを用いたSN-38プロドラッグの開発2025
- Author(s)
  肘井翔一、谷戸謙太、新居輝樹、岸村顕広、森健、片山佳樹
- Organizer
  日本薬学会145年会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] マックトリガー2025
- Author(s)
  新居　輝樹
- Organizer
  日本薬学会第145年会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がんの免疫抑制を解除する遺伝子組換えマクロファージ『マックトリガー』とその活用法2025
- Author(s)
  嘉亨真、浜辺祐輔、谷戸謙太、肘井翔一、和久屋奏絵、岸村顕広、森健、新居輝樹、片山佳樹
- Organizer
  日本薬学会145年会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] Novel therapeutic concept of cancer using engineered macrophages (MacTrigger)2025
- Author(s)
  Teruki Nii
- Organizer
  4th Korea-Japan Young Scientists Workshop on Pharmaceutics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 革新的な難治性固形がん治療戦略「マックトリガー」2025
- Author(s)
  新居　輝樹
- Organizer
  インターフェックス Week 東京/再生医療 EXPO 東京 -2025
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] マックトリガー:がんの生き残り戦略を逆手に2025
- Author(s)
  新居　輝樹
- Organizer
  第33 回次世代医工学研究会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がんの免疫抑制環境を破壊して治療する細胞医薬「マックトリガー」2025
- Author(s)
  新居　輝樹、片山　佳樹
- Organizer
  日本薬学会第145年会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がん特異的に免疫抑制を解除して治療する遺伝子組換えマクロファージ「マックトリガー」2025
- Author(s)
  新居　輝樹、谷戸　謙太、片山　佳樹
- Organizer
  第34回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] Therapeutic concept based on genetically engineered macrophages-MacTrigger-2024
- Author(s)
  Teruki Nii
- Organizer
  日本薬剤学会global education seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 医・工・薬の異分野融合によるライフサイエンス研究2024
- Author(s)
  新居　輝樹
- Organizer
  日本技術士会2024年度九州本部年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がんの生き残り戦略を逆手にとって退治する細胞医薬「マックトリガー」2024
- Author(s)
  新居　輝樹
- Organizer
  2024年度オープンイノベーションワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 腫瘍で炎症のトリガーとして機能するマクロファージ医薬「マックトリガー」とその応用2024
- Author(s)
  浜辺祐輔、嘉亨真、谷戸謙太、肘井翔一、岸村顕広、森健、新居輝樹、片山佳樹
- Organizer
  バイオメディカルフォーラム2024
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] マックトリガーが拓くがん治療戦略2024
- Author(s)
  新居　輝樹
- Organizer
  徳島大学大学院医歯薬学研究部DDS研究センター2024年度第1回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がんを炎症組織に変換して治療する組み換えマクロファージMacTrigger2024
- Author(s)
  新居輝樹、谷戸謙太、和久屋奏絵、浜辺祐輔、森健、岸村顕広、片山佳樹
- Organizer
  第34回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 新たながん治療コンセプトを拓く遺伝子改変マクロファージ”マックトリガー”2024
- Author(s)
  谷戸　謙太、新居　輝樹、片山　佳樹
- Organizer
  第52回放射線による制癌シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 腫瘍で炎症のトリガーとして機能する遺伝子改変マクロファージ「マックトリガー」とその活用法2024
- Author(s)
  新居輝樹、谷戸謙太、岸村顕広、森健、片山佳樹
- Organizer
  第45回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] マックトリガー2024
- Author(s)
  新居　輝樹
- Organizer
  福岡バイオコミュニティフォーラム2024
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] Therapeutic concept of cancers based on cells themselves as biomaterials2024
- Author(s)
  Teruki Nii
- Organizer
  日韓バイオマテリアル学会若手研究者交流Awardシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] Therapeutic concept of cancers based on cells themselves as biomaterials2024
- Author(s)
  Teruki Nii
- Organizer
  KSBM fall meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 遺伝子改変マクロファージ『マックトリガー』は抗体医薬の効果を増強させる2024
- Author(s)
  浜辺祐輔、谷戸謙太、岸村顕広、森健、新居輝樹、片山佳樹
- Organizer
  第61回化学関連支部合同九州大会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 再生医療研究を通してOBからのメッセージ2024
- Author(s)
  新居　輝樹
- Organizer
  大濠高等学校進路説明会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がん治療用細胞医薬「マックトリガー」の実用化に向けて2024
- Author(s)
  新居　輝樹
- Organizer
  九州大学発スタートアップマッチングセミナー2024
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 腫瘍で炎症のトリガーとして機能するマクロファージ医薬開発2024
- Author(s)
  新居　輝樹
- Organizer
  第2回 FBCAP Innovation Event
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] ヒト直交性酵素α-ラムノシダーゼを用いた新規SN-38プロドラッグの作成とin vitroでの評価2024
- Author(s)
  肘井翔一, 金子諒右, 谷戸謙太, 新居輝樹, 岸村顕広, 森健, 片山佳樹
- Organizer
  第40回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がんの生き残り戦略を逆手にとって退治する細胞医薬「マックトリガー」2024
- Author(s)
  新居　輝樹
- Organizer
  第12回TR推進合同フォーラム・ライフサイエンス技術交流会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 「マックトリガー」の実用化に向けて2024
- Author(s)
  新居　輝樹
- Organizer
  福岡BIO NIGHT
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 腫瘍組織特異的に炎症を誘導する細胞医薬の開発2024
- Author(s)
  谷戸謙太、新居輝樹、横山祐太、柴田真由香、肘井翔一、伊藤祥子、岸村顕広、森健、片山佳樹
- Organizer
  第38回日本薬剤学会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 腫瘍で炎症のトリガーとして機能する遺伝子改変マクロファージ「マックトリガー」とその活用法2024
- Author(s)
  新居　輝樹、谷戸　謙太、岸村　顕広、森　健、片山　佳樹
- Organizer
  第73回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 遺伝子改変マクロファージが拓くがん治療コンセプト2024
- Author(s)
  新居　輝樹、谷戸　謙太、岸村　顕広、森　健、片山　佳樹
- Organizer
  第74回医用高分子研究会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 腫瘍で炎症のトリガーとして機能する遺伝子改変マクロファージ「マックトリガー」2024
- Author(s)
  新居　輝樹
- Organizer
  第21回日本免疫治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] MacTriggerは抗PD-1抗体の薬効を向上させる2024
- Author(s)
  谷戸謙太、新居輝樹、和久屋奏絵、岸村顕広、森健、片山佳樹
- Organizer
  第40回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] 腫瘍で炎症のトリガーとして機能する遺伝子改変マクロファージ「マックトリガー」とその活用法2024
- Author(s)
  新居輝樹、谷戸謙太、岸村顕広、森健、片山佳樹
- Organizer
  第40回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] がんの免疫抑制環境を破壊する細胞医薬「マックトリガー」2024
- Author(s)
  新居　輝樹
- Organizer
  2025バイオメディカルフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-24K21087
[Presentation] Drug Screening Model Utilizing 3D Cell Culture And Drug Delivery System2022
- Author(s)
  Teruki Nii
- Organizer
  Functional Materials and Chemical Engineering
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20517

1. 片山佳樹 (70284528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 岩森巨樹 (70647362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nii Teruki 新居 輝樹

Research Projects

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Co-Researchers

Universalization of Innovative Macrophage Medicines to Reverse Cancer Survival StrategiesPrincipal Investigator

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薬効の適切なon-offスイッチを細胞が担うがん治療戦略Principal Investigator

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Development of allergy therapeutics based on allergen sustained release in target cellsPrincipal Investigator

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Design of three-dimensional tissue models for anti-cancer drug screening utilizing growth factor release systemPrincipal Investigator

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[Book] Therapeutic concept of cancers based on cells themselves as biomaterials2025

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[Book] 腫瘍がまとう防具を取り払う細胞医薬「マックトリガー」2025

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[Book] JCRだより2024

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[Book] 生体に腫瘍を排除させトリガーとして機能する遺伝子改変マクロファージ「マックトリガー」2024

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[Book] DDS技術に基づく3次元培養システム2022

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[Journal Article] Inflammation-triggering Engineered Macrophages (MacTriggers) Are Promising Cell-based Therapeutic Avenues for Chemoresistant Solid Tumors2025

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[Journal Article] The effect of Fc region affinity of protein-based antibody-recruiting molecules on antibody-dependent cellular cytotoxicity2024

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[Journal Article] Oral Administration of PLGA Nanoparticles to Deliver Antisense Oligonucleotides to Inflammatory Lesions in the Gastrointestinal Tract2024

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[Journal Article] Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths2024

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[Journal Article] Inflammation-Triggering Engineered Macrophages (MacTriggers) Enhance Reactivity of Immune Checkpoint Inhibitor Only in Tumor Tissues2024

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Nii Teruki 新居輝樹