Diacetylspermine in urine, a tumor marker: studies on its clinical usefulness, metabolism, and simple and rapid determination
Project/Area Number |
25460714
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
HIRAMATSU Kyoko 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (80181189)
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Co-Investigator(Kenkyū-buntansha) |
川喜田 正夫 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 (00012740)
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Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Keiichi 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 客員研究員 (60443115)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | ジアセチルスペルミン / 腫瘍マーカー / 尿検査 / 大腸癌 / 肺癌 / イムノクロマト / 癌の早期発見 / 癌のフォローアップ |
Outline of Final Research Achievements |
This study was conducted to establish N1,N12-diacetylspermine (DiAcSpm) as a useful tumor marker, and to develop a simple and rapid procedure for DiAcSpm determination. Our study revealed that DiAcSpm was increased in early cancer tissues, and that this increase is responsible for the increased excretion of DiAcSpm in the urine of patients with early colorectal cancer patients. Further study indicated that preoperative urinary DiAcSpm level was significantly related with the risk of early recurrence of completely resected colorectal cancer and non-small cell lung cancer patients. We also developed an immunochromatographic device for simple and rapid determination of urinary DiAcSpm. The simplicity of the procedure is a definite merit in promoting wider use of urinary DiAcSpm testing, a non-invasive and sensitive measure for early cancers.
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma2015
Author(s)
Saulnier Sholler GL, Gerner EW, Bergendahl G, MacArthur RB, VanderWerff A, Ashikaga T, Bond JP, Ferguson W, Roberts W, Wada RK, Eslin D, Kraveka JM, Kaplan J, Mitchell D, Parikh NS, Neville K, Sender L, Higgins T, Kawakita M, Hiramatsu K, Moriya S, Bachmann AS
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Journal Title
Plos One
Volume: 10
Issue: 5
Pages: e0127246-e0127246
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Increase of N1,N12-diacetylspermine in tissues from colorectal cancer and its liver metastasis.2013
Author(s)
Go Kuwata, Kyoko Hiramatsu, Keijiro Samejima, Kaori Iwasaki, Kei-ichi Takahashi, Koichi Koizumi, Shin-ichiro Horiguchi, Shun-suke Moriya, Masaki Kobayashi, Masao Kawakita
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Journal Title
J. Cancer Res. Clin. Oncol.,
Volume: 139
Issue: 6
Pages: 925-932
DOI
Related Report
Peer Reviewed
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[Presentation] 手術前尿中N1,N12-ジアセチルスペルミンと非小細胞肺癌の予後2015
Author(s)
平松恭子,高橋祐介,堀尾裕俊,高橋慶一,坂口幸治,斉藤文江,高岡恵美,森谷俊介,寺岡秀興,川喜田正夫
Organizer
日本ポリアミン学会第7回年会
Place of Presentation
京都工芸繊維大学 松ヶ崎キャンパス(京都市左京区)
Year and Date
2015-11-13
Related Report
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[Presentation] 安定同位体標識基質を用いたポリアミン合成2014
Author(s)
森谷俊介,寺岡秀興,鮫島啓二郞,平松恭子,川喜田正夫
Organizer
第87回日本生化学会
Place of Presentation
国立京都国際会館・グランドプリンスホテル京都(京都府京都市)
Year and Date
2014-10-15 – 2014-10-18
Related Report
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[Presentation] 癌患者における尿および組織中のN 1,N12-ジアセチルスペルミンの増加.2013
Author(s)
川喜田正夫,桑田 剛,八杉利治,堀口慎一郎,森谷俊介,鮫島啓二郞,三浦俊之,小泉浩一,高橋慶一,平松恭子
Organizer
第86回日本生化学会大会
Place of Presentation
横浜
Related Report
Invited
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[Book] Polyamines A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism(Kusano,T., Suzuki,H.eds)2015
Author(s)
Kawakita M, Hiramatsu K, Moriya S, Samejima K, Takahashi K,
Publisher
Springer
Related Report
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