The mechanisms of bone-selective cancer metastases based on the pre-metastatic bone niche hypothesis
Project/Area Number |
23659883
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Pathobiological dentistry/Dental radiology
|
Research Institution | Matsumoto Dental University |
Principal Investigator |
HIRAGA TORU 松本歯科大学, 歯学部, 准教授 (70322170)
|
Co-Investigator(Kenkyū-buntansha) |
HOSOYA Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
NINOMIYA Tadashi 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 癌 / 骨転移 / 前転移ニッチ |
Research Abstract |
In the present study, we examined whether the changes in bone marrow cell population in tumor-bearing mice affect the development of bone metastases. Both in the bone marrow in the tumor-bearing mice and in the bone marrow with tumor metastases, the ratio of Gr-1+/CD11b+ cells was markedly increased. Furthermore, the inoculation of tumor cells with Gr-1+/CD11b+ cells isolated from tumor-bearing mice enhanced the formation of subcutaneous tumors. However, bone metastases were not increased in the presence of subcutaneous tumors. Further studies are required to fully define the relationship between bone marrow Gr-1+/CD11b+ cells and the development of bone metastases.
|
Report
(4 results)
Research Products
(74 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] a b-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo2011
Author(s)
Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT. Harmine
-
Journal Title
Eur J Pharmacol
Volume: 650(2-3)
Pages: 511-8
Related Report
Peer Reviewed
-
-
[Journal Article] Hypergravity suppresses bone resorption in ovariectomized rat2011
Author(s)
Ikawa T, Kawaguchi A, Okabe T, Ninomiya T, Nakamichi Y, Nakamura M, Uehara S, Nakamura H, Udagawa N, Takahashi N, Nakamura H, Wakitani S
-
Journal Title
Adv Space Res
Volume: 47(7)
Pages: 1214-24
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 癌骨転移のメカニズム
Author(s)
平賀 徹
Organizer
北海道大学大学院歯学研究科 大学院特別セミナー
Place of Presentation
北海道大学(北海道)
Related Report
Invited
-
[Presentation] 骨転移の基礎
Author(s)
平賀 徹
Organizer
第11回 日本臨床腫瘍学会学術集会
Place of Presentation
仙台国際センター(宮城県)
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-