Structural, functional, and pathological studies on a novel "post-phosphoryl sugar chain"
Project/Area Number |
24687017
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Functional biochemistry
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Research Institution | Kobe University |
Principal Investigator |
KANAGAWA Motoi 神戸大学, 医学(系)研究科(研究院), 講師 (00448044)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2013: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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Keywords | 糖鎖 / 筋ジストロフィー / ジストログリカン / 遺伝子治療 / 筋再生 / フクチン / 翻訳後修飾 |
Outline of Final Research Achievements |
This study aimed at understanding of structure, modification mechanism, and physiological roles of novel post-translational modification termed “post-phosphoryl sugar chain”. We also examined the pathogenesis of diseases caused by defects in post-phosphoryl modification in order to develop therapeutic strategies. Structural analysis on unique recombinant glycoprotein and functional analysis of the disease gene products opened a new roadmap toward full understanding of the molecular basis of post-phosphoryl modification. Analysis on disease mouse models revealed a new pathogenesis of muscular dystrophy, which led us to propose an effective therapeutic strategy for muscular dystrophy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] TRPV2 is critical for the maintenance of cardiac structure and function in mice.2014
Author(s)
Katanosaka Y, Iwasaki K, Ujihara Y, Takatsu S, Nishitsuji K, Kanagawa M, Sudo A, Toda T, Katanosaka K, Mohri S, Naruse K.
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Journal Title
Nat Comm
Volume: 5
Issue: 1
Pages: 3932-3932
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice.2014
Author(s)
Saito F, Kanagawa M, Ikeda M, Hagiwara H, Masaki T, Ohkuma H, Katanosaka Y, Shimizu T, Sonoo M, Toda T, Matsumura K.
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Journal Title
Hum Mol Genet
Volume: 23
Issue: 17
Pages: 4543-4558
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Pathophysiological roles for dystroglycan glycosylation in skeletal muscle and gene therapy challenge using glycosylation-deficient muscular dystrophy models2014
Author(s)
Kanagawa, M., Yu, C-C., Fukada, S-I., Ohtsuka, Y., Ito, C., Chiyo, T., Okada,T., Takeda, S’I., Toda, T.
Organizer
Society for Glycobiology (SFG) & Japanese Society of carbohydrate Research (JSCR) 2014 Joint Annual Meeting
Place of Presentation
Honolulu
Year and Date
2014-11-16 – 2014-11-19
Related Report
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[Presentation] Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression2014
Author(s)
Kanagawa, M., Yu, C-C., Ito, C., Fukada, S-I., Chiyo, T., Kobayashia, K., Okada, T., Takeda, S’I. Toda, T.
Organizer
13th International Congress on Neuromuscular Diseases
Place of Presentation
Nice
Year and Date
2014-07-05 – 2014-07-10
Related Report
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[Presentation] Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression2014
Author(s)
Kanagawa, M., Yu, C-C., Ito, C., Fukada, S-I., Chiyo, T., Kobayashia, K., Okada, T., Takeda, S’I. Toda, T.
Organizer
6th New Directions in Biology and Disease of Skeletal Muscle Conference
Place of Presentation
Chicago
Year and Date
2014-06-29 – 2014-07-02
Related Report
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[Presentation] Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression2013
Author(s)
Kanagawa, M., Yu, C-C., Ito, C., Fukada, S-I., Chiyo, T., Kobayashia, K., Okada, T., Takeda, S’I. Toda, T.
Organizer
18th International Congress of the World Muscle Society
Place of Presentation
Asilomar, California, USA
Related Report
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[Presentation] Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression2013
Author(s)
Kanagawa, M., Yu, C-C., Ito, C., Fukada, S-I., Chiyo, T., Kobayashia, K., Okada, T., Takeda, S’I. Toda, T.
Organizer
EMBO Workshop
Place of Presentation
Ascona, Switzerland
Related Report
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