Effects of aging and menopause on women's vascular systems
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- Maeda Miki
- School of Health and Nursing Science, Wakayama Medical University
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- Nakamura Chigusa
- Seto Hospital
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- Uchigaki Akiko
- Master of Health and Nursing Science, Wakayama Medical University
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- Yuba Kimiko
- Town Katsuragi Hanazono Branch Office
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- Utsumi Miyoko
- School of Health and Nursing Science, Wakayama Medical University
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- Siba Mitsuru
- School of Health and Nursing Science, Wakayama Medical University
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- Sanke Tokio
- Department of Clinical Laboratory Medicine, Faculty of Medicine, Wakayama Medical University
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- Miyai Nobuyuki
- Osaka Kyoiku University
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- Arita Mikio
- School of Health and Nursing Science, Wakayama Medical University
Bibliographic Information
- Other Title
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- 女性における加齢および更年期の血管系に及ぼす影響
- ジョセイ ニ オケル カレイ オヨビ コウネンキ ノ ケッカンケイ ニ オヨボス エイキョウ
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Abstract
Aim: The morbidity of hypertension increases with aging although the exact relationship between hypertension and menopause has not been clearly elucidated. Therefore we set out to clarify the effects of aging and menopause upon women's vascular systems.<br> Methods: We divided 151 elderly and middle-aged women into 3 groups (premenopause group, menopause group and post-menopause group). We measured height, weight, blood pressure (BP), total cholesterol (T-chol), HDL-cholesterol (HDL-chol), LDL-cholesterol (LDL-chol), high sensitivity C-reactive protein (hsCRP), creatinine (Cr), triglyceride (TG), fasting blood glucose (FPG), IRI, HOMA-R, brachial-ankle pulse wave velocity (baPWV), augmentation index (AI), percentage of flow-mediated dilatation (%FMD), and echocardiography.<br> Results: In the post-menopause and menopause groups systolic BP and AI were significantly higher than those in the pre-menopause group. There was a significant difference in systolic BP between the post-menopause group and menopause group. In the post-menopause group, baPWV, Cr, and hsCRP were significantly higher than those in the pre-menopause group. There was significant difference in baPWV between the post-menopause group and menopause group. In the post-menopause group, %FMD and eGFR were significantly lower than those in other 2 groups. In the post-menopause group and the menopause group, E/A was significantly lower than in the pre-menopause group. There was also a significant difference in E/A between the post-menopause group and the menopause group.<br> Conclusions: Elevated blood pressure, atherosclerosis and endothelial dysfunction were associated with aging and menopause in their present study. These results suggest that understanding women's cardiovascular changes which accompany aging are important for women's health care and prevention of cardiovascular events.<br>
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 48 (2), 158-162, 2011
The Japan Geriatrics Society
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Details
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- CRID
- 1390001205025729408
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- NII Article ID
- 10030469412
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- NII Book ID
- AN00199010
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- NDL BIB ID
- 11105211
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- ISSN
- 03009173
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed