Elucidation of the pathogenesis of disuse osteoporosis and steroid-induced osteoporosis using Fkbp5 knockout mice
Project/Area Number |
26670811
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
|
Research Institution | Nagasaki University |
Principal Investigator |
KOMORI Toshihisa 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00252677)
|
Co-Investigator(Renkei-kenkyūsha) |
MORIISHI Takeshi 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (20380983)
FUKUYAMA Ryo 広島国際大学, 薬学部, 講師 (20389117)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | グルココルチコイド / ステロイド性骨粗鬆症 / Fkbp5 / 骨細胞 / メカルカルストレス / 骨粗鬆症 / Bcl2 / 非荷重 |
Outline of Final Research Achievements |
We are clarifying the functions of osteocyte network using osteoblast-specific Bcl2 transgenic mice, in which osteocyte network is completely disrupted. We identified Fk506 binding protein 5 (Fkbp5), which was induced in osteoblasts and osteocytes on unloaded condition in the presence of osteocyte network. Fkbp5 is a chaperon molecule, which binds to steroid receptor. To investigate the functions of Fkbp5 in bone, we generated Fkbp5 knockout (Fkbp5-/-) mice. Fkbp5-/- mice showed more severe reductions of bone mass at unloaded condition and in the treatment of glucocorticoid as compared with those in wild-type mice.
|
Report
(3 results)
Research Products
(18 results)
-
-
-
[Journal Article] Cbfb regulates bone development by stabilizing Runx family proteins.2015
Author(s)
Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T.
-
Journal Title
Journal of bone and mineral research
Volume: 30
Issue: 4
Pages: 706-714
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.2015
Author(s)
Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC
-
Journal Title
American Journal of Pathology
Volume: 185
Issue: 2
Pages: 305-313
DOI
Related Report
Peer Reviewed
-
[Journal Article] Overexpression of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin Type O-glycans and Reduction of Glycosaminoglycans.2014
Author(s)
Yoshida CA, Kawane T, Moriishi T, Purushothaman A, Miyazaki T, Komori H, Mori M, Qin X, Hashimoto A, Sugahara K, Yamana K, Takada K, Komori T.
-
Journal Title
The Journal of biological chemistry
Volume: 289
Issue: 38
Pages: 26584-26596
DOI
NAID
Related Report
Peer Reviewed
-
-
[Presentation] Cbfb plays important roles in bone development through the stabilization of Run family proteins.2015
Author(s)
2.Qin X,Jiang Q,Matsuo Y,Kawane T,Komori H,Moriishi T,Taniuchi I, Ito K,Kawai Y,Rokutanda S,Izumi S, Komori T
Organizer
The RUNX Transcription Factors in Development and Disease
Place of Presentation
Weizmann Institude of Science,Rehovot,Israel
Year and Date
2015-10-18
Related Report
Int'l Joint Research
-
-
-
-
[Presentation] 骨細胞と骨代謝制御2014
Author(s)
小守 壽文
Organizer
第32回日本骨代謝学会学術集会(招待講演)
Place of Presentation
大阪市 大阪国際会議場
Year and Date
2014-07-24 – 2014-07-26
Related Report
Invited
-
-
-
-
-