Detecting cortical gamma band oscillation deficit in first-episode schizophrenia and clinical high risk subjects
Project/Area Number |
15K09836
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kyushu University |
Principal Investigator |
Hirano Yoji 九州大学, 大学病院, 助教 (90567497)
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Co-Investigator(Kenkyū-buntansha) |
神庭 重信 九州大学, 医学研究院, 教授 (50195187)
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Research Collaborator |
Onitsuka Toshiaki
Oribe Naoya
Spencer Kevin
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 初発統合失調症 / クリニカルハイリスク群 / ガンマ帯域皮質活動 / ガンマオシレーション / 脳波 / バイオマーカー / 脳機能 / 進行性の障害 / 統合失調症 / ハイリスク群 / 神経発達障害仮説 / 脳磁図 / 認知機能 / 未治療群 / ガンマ帯皮質活動 |
Outline of Final Research Achievements |
We detected neurophysiological changes of auditory cortex function (early auditory-evoked gamma-band oscillation) in first episode schizophrenia patients during a one-year period, which were not observed in individuals at clinical high risk. These progressive functional gamma-band oscillation abnormalities may underlie neurodevelopmental models of schizophrenia, which would be a useful biomarker for early detection and intervention.
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、統合失調症の発症後に、既に報告されている進行性の脳構造異常に加え、進行性の聴覚情報処理に関わる脳機能異常が生じていることが示唆され、統合失調症の進行性の神経発達障害仮説を脳の機能面からも裏付ける重要な知見が得られた。つまり、統合失調症の進行性の脳機能異常を食い止めるためにも、早期の治療介入が重要であり、本研究で用いた指標であるガンマオシレーションが、早期の診断や脳機能評価に関わるバイオマーカーとして有用であることが示された。
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Report
(5 results)
Research Products
(54 results)
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[Journal Article] Abnormalities of eye movement are associated with work hours in schizophrenia.2018
Author(s)
Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
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Journal Title
Schizophr Res
Volume: 202
Pages: 420-422
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia2017
Author(s)
Isomura S, Hashimoto R, Nakamura M, Yamashita F, Jimbo S, Hirano Y, Yamamori H, Fujimoto M, Yasuda Y, Mears R, Onitsuka T
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Journal Title
nature partner journal Schizophrenia
Volume: 3
Issue: 1
Pages: 1-4
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Progressive Reduction of Visual P300 Amplitude in Patients With First-Episode Schizophrenia: An ERP Study2015
Author(s)
Oribe N, Hirano Y, Kanba S, Del Re E, Seidman L, Mesholam-Gately R, Goldstein JM, Shenton M, Spencer KM, McCarley RW, Niznikiewicz M
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Journal Title
Schizophrenia Bulletin
Volume: 41
Issue: 2
Pages: 460-470
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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