Investigation of the brain and cell injury responsible for depression with immune-challenged animal model
Project/Area Number |
22390226
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
ONITSUKA Toshiaki 九州大学, 病院, 講師 (00398059)
MOTOMURA Keisuke 九州大学, 病院, 助教 (60432944)
MIURA Tomofumi 九州大学, 大学院・医学研究院, 助 (90404053)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | うつ病 / サイトカイン / 精神疾患 / 神経科学 / 脳 / 動物モデル |
Research Abstract |
By systemic injection of bacterial endotoxin into mice, we generated an animal model of depression which showed depressive behavior and microglial activation in the regions around the periventricular organs. In another experiment on forced swim test, some
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] A Population-Specific Uncommon Variant in GRIN3A Associated with Schizophrenia.2013
Author(s)
Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, YamadaK, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T.
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Journal Title
Biol Psychiatry.
Volume: 73(6)
Issue: 6
Pages: 532-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia.2011
Author(s)
Kato TA, Monji A, Yasukawa K, Mizouchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, *Kanba S
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Journal Title
Schizophr Res
Volume: 29(2-3)
Pages: 172-82
Related Report
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[Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated micro glia in vitro : implication for antioxidative psychotropic actions via microglia2011
Author(s)
Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S
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Journal Title
Schizophr Res
Volume: 129
Pages: 172-182
Related Report
Peer Reviewed
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[Journal Article] Inhibitory effects of SSRIs on IFN-y induced microglial activation through the regulation of intracellular calcium2010
Author(s)
Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha M, Ueda T, Hashioka S, *Kanba S.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry.
Volume: 34(7)
Pages: 1306-16
Related Report
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[Journal Article] Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium.2010
Author(s)
Horikawa H, Kato T, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha Y, Ueda T, Hashioka S, Kanba S.
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Journal Title
Progress in Neurosychopharmacology & Biological psychiatry
Volume: 34(7)
Pages: 1306-1316
Related Report
Peer Reviewed
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