The role of macrophage inhibitory factor (MIF) in NASH
Project/Area Number |
25460976
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Gunma University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
山田 英二郎 群馬大学, 医学部附属病院, 助教 (60645563)
柿崎 暁 群馬大学, 大学院医学系研究科, 講師 (80344935)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | MIF / NASH / 肝線維化 / 脂質沈着 / 線維化 / 肝癌 / 非アルコール性脂肪性肝炎 / マクロファージ遊走阻止因子 / 高脂肪食 / MIF マクロファージ遊走阻止因子 / NASH 非アルコール性脂肪性肝炎 / 肝腫瘍 / MIF(マクロファージ遊走阻止因子) |
Outline of Final Research Achievements |
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, which is involved in inflammatory response and regulates macrophage accumulation. However, the precise role of MIF in NAFLD is not clear. In this study, we have shown MIF plays an important role in the hepatic steatosis and fibrosis in high fat diet mode. These results suggest MIF might be the therapeutic target against non-alcoholic liver diseases.
|
Report
(5 results)
Research Products
(6 results)
-
-
[Journal Article] MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice.2014
Author(s)
Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M.
-
Journal Title
World J Gastroenterol
Volume: 20
Issue: 43
Pages: 16227-35
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-