IL13Ra2, therapeutic target of melanoma, identified by unique antibody screening technology.
Project/Area Number |
25830123
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor therapeutics
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | IL13Ra2 / イムノトキシン / 悪性黒色腫 / モノクローナル抗体 / scFv / 血管新生 |
Outline of Final Research Achievements |
Current approach of cancer therapy, such as chemotherapy, radiotherapy and surgery, has been treated for many years, but it is still hard to cure completely. Especially in chemotherapy, one of long-lasting problem is the side effect of administrated drug, following the interference of regimen. To overcome this issue, we developed unique targeting technology coupled with monoclonal antibody (MoAb) screening system that enable us to utilize both selectivity and specificity. To establish selective and specific antibody that target cancer biomarker, classical hybridoma library was upgraded with our unique probe that is recombinant toxin protein fused with Fc-binding protein (DT3C), to generate immunotoxin library. Here we present; (A) principle of our targeting technology, and (B) discovery of anti-IL13Ra2 MoAb (clone NS66) that has potent activity as DT3C-based immunotoxin, (C) characterization of IL13Ra2 as novel melanoma biomarker as well as therapeutic target.
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Report
(3 results)
Research Products
(9 results)
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[Presentation] Identification of Interleukin 13 Receptor alpha 2 (IL13Rα2) as a novel marker of human melanoma.2015
Author(s)
Mao Komai, Akiko Kunita, Teppei Morikawa, Hayato Okamoto, Moegi Sato, Hiroaki Uchida, Yasuhiro Yoshimatsu, Takeshi Fukuhara, Masashi Fukayama, Tetsuro Watabe
Organizer
Joint International Symposium on TGF-β Family and Cancer
Place of Presentation
tsukuba, JAPAN
Year and Date
2015-01-12 – 2015-01-13
Related Report
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