Simple Synthesis of Deuterium and 13C Labeled Trifluoromethyl Phenyldiazirine Derivatives as Stable Isotope Tags for Mass Spectrometry

  • Hashimoto Makoto
    Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
  • Hatanaka Yasumaru
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

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Abstract

The synthesis of trifluoromethyl diazirine with a stable isotope tag is reported. We found that both Friedel–Crafts acylation and reduction of aryl carbonyl to methylene, using commercially available stable-isotope reagents, were utilized for the synthesis of diazirinyl fatty acid derivatives. The stable isotope labeled diazirine may be valuable for identifying binding sites by mass spectrometry.

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