Simple Synthesis of Deuterium and 13C Labeled Trifluoromethyl Phenyldiazirine Derivatives as Stable Isotope Tags for Mass Spectrometry
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- Hashimoto Makoto
- Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
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- Hatanaka Yasumaru
- Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Abstract
The synthesis of trifluoromethyl diazirine with a stable isotope tag is reported. We found that both Friedel–Crafts acylation and reduction of aryl carbonyl to methylene, using commercially available stable-isotope reagents, were utilized for the synthesis of diazirinyl fatty acid derivatives. The stable isotope labeled diazirine may be valuable for identifying binding sites by mass spectrometry.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 52 (11), 1385-1386, 2004
The Pharmaceutical Society of Japan
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Details
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- CRID
- 1390282679146358016
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- NII Article ID
- 110003665458
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DC%2BD2MXhtl2h
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- ISSN
- 13475223
- 00092363
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- PubMed
- 15516771
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed