Synthesis and Properties of Diazirinyl Organo-Platinum Compounds for Manipulations of Photoaffinity Labeled Components

  • Hashimoto Makoto
    Graduate School of Agriculture, Hokkaido University
  • Furukawa Keitaro
    Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
  • Tomohiro Takenori
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Hatanaka Yasumaru
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

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Abstract

Synthesis of diazirinyl organo-platinum complexes, which specifically interact with purine base, characterization of photoreactivity and interaction between guanosine 5′-monophosphate (GMP) were examined. The results indicated that the diazirinyl organo-platinum complex was useful for manipulations of photoaffinity labeled components.

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