Differentiation of resident epidermal T cells into IL-13-producing cells in the perinatal epidermis
Project/Area Number |
15K09773
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Kagoshima University |
Principal Investigator |
KAWAI Kazuhiro 鹿児島大学, 医歯学総合研究科, 客員研究員 (90242411)
|
Research Collaborator |
IBUSUKI Atsuko 鹿児島大学, 医歯学域附属病院, 助教 (10596109)
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | IL-13 / CD27 / γδT細胞 / T細胞レセプター / T細胞分化 / 樹枝状表皮T細胞 |
Outline of Final Research Achievements |
Resident epidermal T cells of the murine skin express an invariant γδ T-cell receptor (Vγ3 TCR) that recognizes an undetermined self ligand expressed on epidermal keratinocytes, and the TCR stimulation triggers rapid production of IL-13. In contrast, their fetal thymic precursors (Vγ3 TCR+ fetal thymocytes) produce IFN-γ but not IL-13. Analyses of the cytokine production pattern by the Vγ3 TCR+ cells during development revealed that Vγ3 TCR+ cells acquire IL-13-producing capacity in the perinatal epidermis. Resident epidermal T cells in γδ T-cell-deficient mice that express diverse αβ TCRs but cannot recognize the self ligand on epidermal keratinocytes produced IFN-γ but not IL-13. Therefore, TCR-mediated signals might be involved in the differentiation of epidermal T cells into IL-13-producing cells.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Dermal Vγ4(+) γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8(+) T-Cell Activity through TNF-α Production.2015
Author(s)
Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
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Journal Title
Journal of Investigative Dermatology
Volume: 135
Issue: 4
Pages: 1007-1015
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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