The roles of growth factors in neuromuscular junction
Project/Area Number |
15K06707
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurophysiology / General neuroscience
|
Research Institution | Nagoya University |
Principal Investigator |
Ohkawara Bisei 名古屋大学, 医学系研究科, 准教授 (80589606)
|
Project Period (FY) |
2015-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 神経筋接合部 / シグナル伝達経路 / 増殖因子 |
Outline of Final Research Achievements |
The neuromuscular junction (NMJ) is a synapse that connects the spinal motor and skeletal muscle fiber. Factors involved in NMJ morphogenesis and maturation has not been yet elucidated, and the mechanism of the known factors in NMJ has not been fully elucidated. In this study, we investigated to identify growth factors involved in NMJ formation and signal transduction pathways downstream of them. We showed that the secretion factors such as Rspo2 and FGF18 are required for NMJ function to activate MuSK activation and/or AChR. We also showed that these factors are involved in the maturation and maintenance of NMJ. In addition, we suggested that IGF, TGFbeta and hedgehog may be involved in NMJ formation.
|
Academic Significance and Societal Importance of the Research Achievements |
NMJの増殖因子の機能を知ることで、神経シナプス形成における増殖因子の役割を知るための基盤となる知識を得られる。AChRなどNMJで機能する分子の先天的な遺伝子変異によってもたらされる先天性筋無力症候群の病態研究にもつながる。
|
Report
(5 results)
Research Products
(24 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.2016
Author(s)
Nakashima H., Ohkawara B., Ishigaki S., Fukudome T., Ito K., Tsushima M., Konishi H., Okuno T., Yoshimura T., Ito M., Masuda A., Sobue G., Kiyama H., Ishiguro N., Ohno K.
-
Journal Title
Sci Rep
Volume: 22
Issue: 1
Pages: 28512-28512
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model.2015
Author(s)
Yagi H, Ohkawara B, Nakashima H, Ito K, Tsushima M, Ishii H, Noto K, Ohta K, Masuda A, Imagama S, Ishiguro N, Ohno K.
-
Journal Title
PLoS One.
Volume: 10(11)
Issue: 11
Pages: e0142786-e0142786
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling.2015
Author(s)
Otsuka K, Ito M, Ohkawara B, Masuda A, Kawakami Y, Sahashi K, Nishida H, Mabuchi N, Takano A, Engel AG, Ohno K.
-
Journal Title
Sci Rep.
Volume: 5
Issue: 1
Pages: 13928-13928
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space.2015
Author(s)
Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K.
-
Journal Title
Neuromuscul Disord.
Volume: 25(8)
Issue: 8
Pages: 667-71
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-