Physiological and pathophysilogical roles of acinar-like cell cluster touching Langerhans islet with thin interstitial surrounding (ATLANTIS) on regeneration and maintenance of beta cell.
Project/Area Number |
15K09406
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Okinaka Memorial Institute for Medical Research |
Principal Investigator |
Kobayashi Tetsuro (財)冲中記念成人病研究所, その他部局等, 研究員 (30113442)
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Co-Investigator(Kenkyū-buntansha) |
永淵 正法 佐賀大学, 医学部, 客員研究員 (00150441)
雨宮 三千代 (財)冲中記念成人病研究所, その他部局等, 研究員 (00288101)
會田 薫 山梨大学, 大学院総合研究部, 医学研究員 (50184015)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 糖尿病 / ウイルス / 再生医学 / EMCウイルス / REGIα / BrdU / インスリン / REGⅠα |
Outline of Final Research Achievements |
We examined 1) the presence or absence of acinar-like cell clusters touching Langerhans islets with thin interstitial surrounding (ATLANTIS) in homozygous Reg I deficient (Reg I-/-) and wild-type mice, and 2) the possible role of ATLANTIS in the regeneration of beta cell clusters after encephalomyocarditis (EMC) virus (D-variant) infection in Reg I-/- and wild-type mice. ATLANTIS was found in both wild-type and Reg I-/- mice. At 12 days after EMC virus infection, lower BrdU labeling indices were observed in islet beta cells of Reg I-/- mice compared to wild-type mice. Beta cell volume 12 days after EMC virus infection in Reg I-/- mice did not differ from that of wild-type mice. These results suggest that Reg I, which is released from ATLANTIS to islet beta cell clusters, has a crucial role in beta cell regeneration in EMC virus-induced diabetes. The presence of mechanism(s) other than that mediated by Reg I in beta cell restoration after destruction by EMC virus was also suggested.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Predictive value of titer of GAD antibodies for further progression of beta cell dysfunction in slowly progressive insulin-dependent (type 1) diabetes (SPIDDM).2016
Author(s)
Tanaka S, Okubo M, Nagasawa K, Takizawa S, Ichijo M, Ichijo S, Kaneshige M, Aida K, Shimura H, Mori Y, Kobayashi T.
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Journal Title
Diabetol Int
Volume: 7
Issue: 1
Pages: 42-52
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Diagnostic criteria for slowly progressive insulin-dependent (type 1) diabetes ellitus (SPIDDM) (2012): report by the Committee on Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus of the Japan Diabetes Society.2015
Author(s)
Tanaka S, Ohmori M, Awata T, Simada A, Mrrao S, Maruyama T, Kamoi K, Kawasaki E, Nakanishi K, Nagata M, Fujii S, Ikegami H, Imagawa A, Uchigata Y, Okubo M, Osawa H, Kajio H, Kawaguchi A, Kawabata Y, Satoh J, Shimizu I, Takahashi K, Makino H, Iwahashi H, Mirra J, Yasuda K, Hanafusa T, Kobayashi T
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Journal Title
Diabetol Int
Volume: 6
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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