Identification of transporters involved in excretion of toxic sulfate and borate by seawater fish
Project/Area Number |
22370029
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Animal physiology/Animal behavior
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
HIROSE Shigehisa 東京工業大学, 大学院・生命理工学研究科, 教授 (10134199)
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Co-Investigator(Renkei-kenkyūsha) |
KATO Akira 東京工業大学, 大学院・生命理工学研究科, 助教 (40311336)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | 動物生理化学 / ホウ酸 / 輸送体 / 海水適応 / Slc4a11 / アクアポリン / AQP / 魚類 / 近位尿細管 / メフグ / 硫酸イオン輸送体 / 腎臓 / ホウ酸イオン輸送体 / Slc26a6A / 局在部位 |
Research Abstract |
Sulfate and borate are abundant anion in seawater (SW), and excretion of excess sulfate and borate from ingested SW is essential for marine fish to survive because they are toxic. Marine teleosts excrete sulfate and borate via the urine produced in the kidney. The transporters that secrete and concentrate sulfate and borate in the urine have not previously been identified. Here, we have identified and characterized candidates for the long-sought transporters by using euryhaline pufferfish mefugu.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Rhesus glycoprotein p2(Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney2010
Author(s)
Nakada, T., Westhoff, C. M., Yamaguchi, Y., Hyodo, S., Li, X., Muro, T., Kato, A., Nakamura, N., Hirose, S.
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Journal Title
J. Biol. Chem
Volume: 285
Issue: 4
Pages: 2653-2664
DOI
Related Report
Peer Reviewed
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