The elucidation of novel function of urotensin II and URP in the chondrocytes
Project/Area Number |
25440152
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
|
Research Institution | University of Toyama |
Principal Investigator |
KONNO NORIFUMI 富山大学, 大学院理工学研究部(理学), 講師 (50507051)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | ウロテンシンⅡ / URP / 軟骨 / アフリカツメガエル / UTR / urantide / ウロテンシンII / コラーゲン |
Outline of Final Research Achievements |
In the present study, we examined the relation between UⅡ-UTR system and chondrogenesis using the cartilage tissues of Xenopus laevis, aim to clear the function of UⅡ-UTR system in the chondrocytes. As the results, we found the levels of UTR mRNA expression in the early process of chondrogenesis is significantly higher than that in the mature cartilage tissue. The treatment of UII for the isolated cartilage tissue significantly increased the gene expression of the type2 collagen and TGF-β1. Furthermore, the treatment of UTR antagonist (urantide) inhibited the formation of the spike cartilage tissue after amputation of the froglet limb. These results suggest that the UⅡ-UTR system is involved in the early process of the chondrogenesis.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Urotensin II upregulates migration and cytokine gene expression in leukocytes of the African clawed frog, Xenopus laevis.2015
Author(s)
Tomiyama, S., Nakamachi, T., Uchiyama, M., Matsuda, K., and Konno, N.
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Journal Title
Gen. Comp. Endocrinol.
Volume: in press
Pages: 54-63
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Morphological and molecular investigations of the holocephalan elephant fish nephron: the existence of a countercurrent-like configuration and two separate diluting segments in the distal tubule.2015
Author(s)
Kakumura, K., Takabe, S., Takagi, W., Hasegawa, K., Konno, N., Bell, J., Toop, T., Donald, J., Kaneko, T., and Hyodo, S.
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Journal Title
Cell and Tissue Research
Volume: 362
Issue: 3
Pages: 677-688
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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