Comprehensive natural products study for development of small molecules targeting signaling pathways
Project/Area Number |
19310136
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Chiba University |
Principal Investigator |
ISHIBASHI Masami Chiba University, 大学院・薬学研究院, 教授 (90212927)
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Co-Investigator(Kenkyū-buntansha) |
A. ARAI Midori 千葉大学, 大学院・薬学研究院, 准教授 (40373261)
OHTSUKI Takashi 千葉大学, 大学院・薬学研究院, 助教 (30401011)
|
Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
|
Keywords | 天然物有機化学 / 天然物 / 低分子化合物 / 創薬 / スクリーニング / シグナル伝達 / アッセイ / 癌 / 植物 / 小分子 / 合成ライブラリー |
Research Abstract |
In our laboratory, we are interested in comprehensive natural products chemistry study based on search for bioactive small molecules from unexplored natural resources. We recently examined extracts of various natural resources including unexplored myxomycetes, marine organisms, as well as several medicinal plants collected in South Asia. Recently we are particularly interested in screening studies targeting TRAIL, Wnt, and Hedgehog signaling pathways which are related to cancer diseases. As a result of these screening programs we have isolated a number of new bioactive natural products and investigated their unique biological effects.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] Activity of mangosteen xanthones and teleocidin A-2 in death-receptor expression enhancement and tumor necrosis-factor related apoptosis-inducing ligand assays2010
Author(s)
Kikuchi, H., Ohtsuki, T., Koyano, T., Kowithayakorn, T., Sakai, T., Ishibashi, M.
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Journal Title
J.Nat.Prod. 73
Pages: 452-455
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[Journal Article] A method for the rapid discovery of naturally occurring products by proteins immobilized on magnetic beads and reverse affinity chromatography2009
Author(s)
Arai, M. A., Kobatake, E., Koyano, T., Kowithayakorn, T., Kato, S., Ishibashi, M.
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Journal Title
Chem.Asian J. 4
Pages: 1802-1808
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[Journal Article] Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis2009
Author(s)
Ohtsuki, T., Kikuchi, H., Koyano, T., Kowithayakorn, T., Sakai, T., Ishibashi, M.
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Journal Title
Bioorg.Med.Chem. 17
Pages: 6748-6754
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[Journal Article] Fuligoic acid, a new yellow pigment with a chlorinated polyene-pyrone acid structure isolated from the myxomycete Fuligo septica f. flava2009
Author(s)
Shintani, A., Ohtsuki, T., Yamamoto, Y., Hakamatsuka, T., Kawahara, N., Goda, Y., Ishibashi, M.
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Journal Title
Tetrahedron Lett. 50
Pages: 3189-3190
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[Journal Article] Death receptor 5 targeting activity-guided isolation of isoflavones from Millettia brandisiana and Ardisia colorata and evaluation of ability to induce TRAIL-mediated apoptosis2009
Author(s)
Kikuchi, H., Ohtsuki, T., Koyano, T., Kowithayakorn, T., Sakai, T., Ishibashi, M.
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Journal Title
Bioorg.Med.Chem. 17
Pages: 1181-1186
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[Journal Article] Isolation of new carbamate-or pyridine-containing natural products, fuzanins A, B, C, and D from Kitasatospora sp. IFM109172009
Author(s)
Aida, W., Ohtsuki, T., Li, X., Ishibashi, M.
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Journal Title
Tetrahedron 65
Pages: 369-373
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[Journal Article] Two new cadinane sesquiterpenes from Curcuma parviflora2009
Author(s)
Sadhu, S. K., Tamaki, M., Ohtsuki, T., Toume, K., Koyano, T., Kowithayakorn, T., Ishibashi, M.
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Journal Title
J.Nat.Prod. 72
Pages: 782-783
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[Journal Article] Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana2008
Author(s)
Arai, M. A., Tateno, C., Hosoya, T., Koyano, T., Kowithayakorn, T., Ishibashi, M.
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Journal Title
Bioorg.Med.Chem. 16
Pages: 9420-9424
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[Journal Article] Brandisianins A-F, isoflavonoids isolated from Millettia brandisiana in a screening program for death-receptor expression enhancement activity2007
Author(s)
Kikuchi, H., Ohtsuki, T., Koyano, T., Kowithayakorn, T., Sakai, T., Ishibashi, M.
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Journal Title
J.Nat.Prod. 70
Pages: 1910-1914
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[Journal Article] A novel natural compound, a cycloanthranilylproline-derivative (Fuligocandin B), sensitizes leukemia cells to TRAIL-induced apoptosis through 15d-PGJ_2 production2007
Author(s)
Hasegawa, H., Yamada, Y., Komiyama, K., Hayashi, M., Ishibashi, M., Sunazuka, T., Izuhara, T., Sugahara, K., Tsuruda, K., Masuda, M., Takasu, N., Tsukasaki, K., Tomonaga, M., Kamihira, S.
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Journal Title
Blood 110
Pages: 1664-1674
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[Book] ソレル有機化学(上)2009
Author(s)
村田道雄, 石橋正己, 木越英夫, 佐々木誠, 監訳 荒井孝義, 荒井緑, 有本博一, 石橋正己, 及川雅人, 大石徹, 木越英夫, 北将樹, 此木敬一, 佐竹真幸, 佐々木誠, 末永聖武, 早川一郎, 松岡茂, 松森信明, 村田道雄, 共訳
Publisher
東京化学同人
Related Report
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[Book] ソレル有機化学(下)2009
Author(s)
村田道雄, 石橋正己, 木越英夫, 佐々木誠, 監訳 荒井孝義, 荒井緑, 有本博一, 石橋正己, 及川雅人, 大石徹, 木越英夫, 北将樹, 此木敬一, 佐竹真幸, 佐々木誠, 末永聖武, 早川一郎, 松岡茂, 松森信明, 村田道雄, 共訳
Publisher
東京化学同人
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