Development of monoclonal antibodies therapy for cerebral infarction and cerebral edema in primate animal mode
Project/Area Number |
24590658
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Okayama University |
Principal Investigator |
RYU katsuyaku 岡山大学, 医歯(薬)学総合研究科, 助教 (40432637)
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Co-Investigator(Kenkyū-buntansha) |
NISHIBORI Masahiro 岡山大学, 医歯(薬)学総合研究科, 教授 (50135943)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 霊長類動物 / 脳梗塞 / 脳浮腫 / 抗体医薬 / 血液-脳関門 / HMGB1 / 血液ー脳関門 |
Outline of Final Research Achievements |
We developed cerebral ischemia and reperfusion injury model using primate animal. In this model, we demonstrated that Anti-HMGM1 monoclonal antibody (mAb) is able to effectively inhibit the development of brain edema in the ischemic region. This edema inhibitory effect is most likely achieved through the protection of the blood brain barrier (BBB) structure in the ischemic region. We also found that HMGB1 was transported from nuclear to the extracellular space likely due to ischemic vascular lesion, and probably transported to the cell organelles as well. The results suggest that the brain tissue protection effect of HMGB1 mAb may be due to its ability to block HMGB1 nuclear-cytoplasmic translocation in the early reperfusion phase following the focal ischemia in the brain tissue.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction.2014
Author(s)
OkumaY, Liu K, Wake H, Liu R, Nishimura Y, Zhong H, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M.
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Journal Title
Neuropharmacology
Volume: 85
Pages: 18-26
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury2013
Author(s)
Okuma Y, Wang F, Toyoshima A, Kameda M, Hishikawa T, Tokunaga K, Sugiu K, Liu K, Haruma J, Nishibori M, Yasuhara T, Date I
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Journal Title
Neurosci Letters
Volume: 554
Pages: 156-161
Related Report
Peer Reviewed
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[Journal Article] Anti-high mobility group box-1 antibody therapy for traumatic brain injury2012
Author(s)
Okuma Y, Liu K, Wake H, Zhang J, Maruo T, Date I, Yoshino T, Ohtsuka A, Otani N, Tomura S, Shima K, Yamamoto Y, Yamamoto H, Takahashi H K, Mori S, Nishibori M
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Journal Title
Annals of Neurology
Volume: 72
Issue: 3
Pages: 373-384
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Histidine-rich glycoprotein prevents septic lethality through neutrophil regulation2014
Author(s)
Nishibori M, Wake H, Mori S, Liu K, Morioka Y, Teshigawara K, Sakagichi M, Kuroda K, Takahashi H, Ohtsuka A, Yoshino T, Morimatsu H
Organizer
SEPSIS 2014
Place of Presentation
Institut Pasteur, Paris, France
Year and Date
2014-12-03 – 2014-12-05
Related Report
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