Identification of a histone modifier regulating hepatocarcinogenesis
Project/Area Number |
23590962
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TATEISHI Keisuke 東京大学, 医学部附属病院, 講師 (20396948)
ASAOKA Yoshinari 東京大学, 医学部附属病院, 助教 (90431858)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 肝がん / ヒストン修飾 / 肝癌 |
Research Abstract |
We established the Alb-Cre/PIK3CA-TG mice that showed hepatic fat deposition at 12w after birth and developed liver tumors including hepatocellular carcinoma by 52w. The PI3K activity was enhanced and tumor suppressor genes including PTEN, ARID3B, XPO4 and DLC1 were downregulated in the tumors. The tumors included a high amount of fatty acids, especially oleic acids. We showed that oleic acids exacerbate the colony formation of immortalized liver cells and reduce the expression of tumor suppressors described above. Furthermore, we have found a chromatin regulator that regulates the tumor formation of Alb-Cre/PIK3CA-TG mice.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection2014
Author(s)
Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K
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Journal Title
J Gastroenterol
Volume: 49(4)
Issue: 4
Pages: 748-54
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.2013
Author(s)
Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K.
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Journal Title
Hepatol Res.
Volume: :
Issue: 10
DOI
Related Report
Peer Reviewed
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[Journal Article] Changes in risk of immediate adverse reactions to iodinated contrast media by repeated administrations in patients with hepatocellular carcinoma.2013
Author(s)
Fujiwara N, Tateishi R, Akahane M, Taguri M, Minami T, Mikami S, Sato M, Uchino K, Enooku K, Kondo Y, Asaoka Y, Yamashiki N, Goto T, Shiina S, Yoshida H, Ohtomo K, Koike K.
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Journal Title
PLoS One
Volume: :
Issue: 10
Pages: e76018-e76018
DOI
Related Report
Peer Reviewed
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[Journal Article] Spontaneous clearance of serum hepatitis C virus RNA during the clinical course of hepatocellular carcinoma in patients with chronic hepatitis C.2013
Author(s)
Minami T, Tateishi R, Shiina S, Fujiwara N, Mikami S, Sato M, Uchino K, Enooku K, Asaoka Y, Kondo Y, Yoshida H, Koike K.
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Journal Title
Hepatol Res.
Volume: :
Issue: 10
DOI
Related Report
Peer Reviewed
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[Journal Article] CT with hepatic arterioportography as a pretreatment examination for hepatocellular carcinoma patients : a randomized controlled trial2013
Author(s)
Ohki T, Tateishi R, Akahane M, Mikami S, Sato M, Uchino K, Arano T, Enooku K, Kondo Y, Yamashiki N, Goto T, Shiina S, Yoshida H, Matsuyama Y, Omata M, Ohtomo K, Koike K
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Journal Title
Am JGastroenterol
Volume: 108(8)
Issue: 8
Pages: 1305-13
DOI
Related Report
Peer Reviewed
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[Journal Article] Frequency, risk factors and survival associated with an intrasubsegmental recurrence after radiofrequency ablation for hepatocellular carcinoma.2013
Author(s)
Tateishi R, Shiina S, Akahane M, Sato J, Kondo Y, Masuzaki R, Nakagawa H, Asaoka Y, Goto T, Otomo K, Omata M, Yoshida H, Koike K.
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Journal Title
PLoS One
Volume: 8
Issue: 4
Pages: e59040-e59040
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan.2013
Author(s)
Sato A, Sata M, Ikeda K, Kumada T, Izumi N, Asahina Y, Osaki Y, Chayama K, Kaneko S, Sakai A, Onji M, Hiasa Y, Omura T, Ozeki I, Yokosuka O, Shiina S, Itsubo M, Nishiguchi S, Hirano K, Ide T, Sakisaka S, Yamasaki T, Hidaka I, Tanaka M, Kim SR, Ichida T.
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Journal Title
Intern Med
Volume: 52
Pages: 2701-6
Related Report
Peer Reviewed
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[Journal Article] IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.2013
Author(s)
Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K.
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Journal Title
J Gastroenterol.
Volume: :
Related Report
Peer Reviewed
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[Journal Article] CT with hepatic arterioportography as a pretreatment examination for hepatocellular carcinoma patients: a randomized controlled trial.2013
Author(s)
Ohki T, Tateishi R, Akahane M, Mikami S, Sato M, Uchino K, Arano T, Enooku K, Kondo Y, Yamashiki N, Goto T, Shiina S, Yoshida H, Matsuyama Y, Omata M, Ohtomo K, Koike K.
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Journal Title
Am J Gastroenterol.
Volume: 108
Pages: 1305-13
Related Report
Peer Reviewed
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[Journal Article] IGF-II Producing Hepatocellular Carcinoma Treated with Sorafenib: Metabolic Complications and a Foresight to Molecular Targeting Therapy to the IGF Signal.2012
Author(s)
Okushin K, Asaoka Y, Fukuda I,Fujiwara N, Minami T, Sato M, Mikami S,Uchino K, Enooku K, Kondo Y, Tateishi R, Goto T, Shiina S, Yoshida H, Koike K.
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Journal Title
Case Rep Gastroenterol
Volume: 6(3)
Issue: 3
Pages: 784-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Percutaneous ethanol injection for hepatocellular carcinoma : 20-year outcome and prognostic factors2012
Author(s)
Shiina S, Tateishi R, Imamura M, Teratani T, Koike Y, Sato S, Obi S, Kanai F, Kato N, Yoshida H, Omata M, Koike K
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Journal Title
Liver Int
Volume: 32(9)
Issue: 9
Pages: 1434-42
DOI
Related Report
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[Journal Article] Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence2012
Author(s)
Soroida Y, Ohkawa R, Nakagawa H, Satoh Y, Yoshida H, Kinoshita H, Tateishi R, Masuzaki R, Enooku K, Shiina S, Sato T, Obi S, Hoshino T, Nagatomo R, Okubo S, Yokota H, Koike K, Yatomi Y, Ikeda H
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Journal Title
J Hepatol
Volume: 57(2)
Issue: 2
Pages: 330-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography2012
Author(s)
Masuzaki R, Tateishi R, Yoshida H, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Asaoka Y, Kondo Y, Goto T, Ikeda H, Shiina S, Omata M, Koike K
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Journal Title
World J Gastroenterol
Volume: 18(12)
Issue: 12
Pages: 1385-90
DOI
Related Report
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[Journal Article] Percutaneous ethanol injection for hepatocellular carcinoma: 20-year outcome and prognostic factors.2012
Author(s)
Shiina S, Tateishi R, Imamura M, Teratani T, Koike Y, Sato S, Obi S, Kanai F, Kato N, Yoshida H, Omata M, Koike K.
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Journal Title
Liver Int
Volume: 32
Pages: 1434-42
Related Report
Peer Reviewed
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[Journal Article] Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors.2012
Author(s)
Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Sato T, Masuzaki R, Kondo Y, Goto T, Yoshida H, Omata M, Koike K.
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Journal Title
Am J Gastroenterol.
Volume: 107
Pages: 569-77
Related Report
Peer Reviewed
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[Journal Article] Characteristics of hepatocellular carcinoma nodules newly detected by computed tomography during arteriography and arterial portography : preliminary report of a randomized controlled trial2011
Author(s)
Ohki T, Tateishi R, Akahane M, Shiina S, Yamashiki N, Mikami S, Enooku K, Goto E, Masuzaki R, Kondo Y, Goto T, Inoo S, Ohtomo K, Omata M, Yoshida H, Koike K
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Journal Title
Related Report
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[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS 13 in chronic hepatitis B and C2011
Author(s)
Ikeda H, Tateishi R, Enooku K, Yoshida H, nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
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Journal Title
Cancer Epidemiol Biomarkers Prev.
Volume: 20
Issue: 10
Pages: 2204-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway2011
Author(s)
Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, Isomura Y, Seto M, Nakagawa H, Asaoka Y, Tada M, Ohta M, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Maeda S, Shiina S, Yoshida H, Nakajima O, Kanai F, Omata M, Koike K
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Journal Title
J Hepatol
Volume: 55(6)
Pages: 1400-8
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[Journal Article] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines2011
Author(s)
Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K
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Journal Title
Related Report
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[Journal Article] Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation2011
Author(s)
Goto T, Yoshida H, Tateishi R, Enooku K, Goto E, Sato T, Ohki T, Masuzaki R, Imamura J, Shiina S, Koike K, Omata M
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Journal Title
Hepatol Int
Volume: 5(3)
Issue: 3
Pages: 767-73
DOI
Related Report
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[Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients.2011
Author(s)
Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
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Journal Title
Int J Cancer
Volume: 129(9)
Issue: 9
Pages: 2226-35
DOI
Related Report
Peer Reviewed
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[Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis.2011
Author(s)
Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
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Journal Title
Liver Int
Volume: 31(2)
Issue: 2
Pages: 197-205
DOI
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Peer Reviewed
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[Journal Article] Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma2011
Author(s)
Masuzaki R, Shiina S, Tateishi R, Yoshida H, Goto E, Sugioka Y, Kondo Y, Goto T, Ikeda H, Omata M, Koike K
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Journal Title
J Gastroenterol Hepatol
Volume: 26(4)
Issue: 4
Pages: 759-64
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[Presentation] 膵発癌モデルマウスを用いたゲムシタビンとエルロチニブの効果・メカニズムの検討膵癌:基礎研究2012
Author(s)
宮林弘至,伊地知秀明,毛利大,多田素久,山本恵介,浅岡良成,池上恒雄,立石敬介,中井陽介,伊佐山浩通,多田稔,小池和彦
Organizer
第43回日本膵臓学会大会
Place of Presentation
山形
Year and Date
2012-06-29
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[Presentation] Hippoシグナル異常を伴う肝細胞癌における受容体型チロシンキナーゼに関する検討2011
Author(s)
浅岡良成,池上恒雄,多田素久,建石良介,伊地知秀明,立石敬介,金井文彦,椎名秀一朗,吉田晴彦,小俣政男,小池和彦
Organizer
第19回JDDW/第15回日本肝臓学会大会
Place of Presentation
福岡
Year and Date
2011-10-20
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[Presentation] 肝細胞癌におけるHippoシグナルの異常に関する検討肝発癌研究の新展開2011
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浅岡良成,池上恒雄,多田素久,後藤絵理子,建石良介,伊地知秀明,立石敬介,金井文彦,椎名秀一朗,吉田晴彦,小俣政男,小池和彦
Organizer
第47回日本肝臓学会総会
Place of Presentation
東京
Year and Date
2011-06-03
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