Development of novel molecular targeting therapy using an herbal medicine for post-surgical liver dysfunction associated with cholestasis
Project/Area Number |
19791054
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | University of Tsukuba |
Principal Investigator |
OSAKA Yoshiko University of Tsukuba, 大学院・人間総合科学研究科, 講師 (40447256)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
Keywords | 胆汁うっ滞 / 周術期 / 漢方製剤 / 分子標的治療 |
Research Abstract |
漢方製剤のインチンコウ湯(ICKT)は胆汁うっ滞や黄疸の治療薬に広く使用されている.我々は本剤生薬成分のgeniposideとその活性体であるgenipinの急性投与は有機陰イオン輸送蛋白のmultidrug resistance-associated protein 2(Mrp2)を介在した胆汁酸非依存性の強力な胆汁分泌促進 (利胆)作用を発揮することが明らかにした.本剤はラットおよびヒト肝において胆汁酸非依存性に胆汁分泌を強力に促進することも判明した.ICKTは胆汁うっ滞性肝胆道疾患の治療薬として高い有用性が示唆された.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Ursodeoxycholic acid exerts Nrf2-mediated stimulation of hepatobiliary transport, detoxification and antioxidative stress systems2008
Author(s)
Okada, K. , Shoda, J. , Taguchi, K. , Goto, N. , Takeda, K. , Utsunomiya, H. , Oda, K. , Warabi, E. , Ishii, T. , Osaka, K. , Yamamoto, M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Inchinkoto, an herbal medicine, and its ingredients dually exerts Mrp2/MRP2- mediated choleresis and Nrf2-mediated antioxidative action in rat livers2007
Author(s)
Okada, K. , Shoda, J. , Kano, M. , Suzuki, S. , Ohtake, N. , Yamamoto, M. , Takahashi, H. , Utsunomiya, H. , Oda, K. , Sato, K. , Watanabe, A. , Ishii, T. , Itoh, K. , Yamamoto, M. , Yokoi T. ,Yoshizato, K. , Sugiyama, Y. , Suzuki, H.
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Journal Title
Related Report
Peer Reviewed