Peripheral Response to Tastant Signals and Central Cognition for Analysis of Their Coordination and its Application to the Science of Food for Life
Project/Area Number |
26242007
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Eating habits
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Research Institution | The University of Tokyo |
Principal Investigator |
Abe Keiko 東京大学, 大学院農学生命科学研究科(農学部), 特任教授 (10151094)
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Co-Investigator(Kenkyū-buntansha) |
井深 章子 新潟薬科大学, 応用生物科学部, 教授 (60301420)
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Co-Investigator(Renkei-kenkyūsha) |
ASAKURA Tomiko 東京大学, 大学院農学生命科学研究科, 特任教授 (20259013)
MISAKA Takumi 東京大学, 大学院農学生命科学研究科, 准教授 (40373196)
ISHIMARU Yoshiro 東京大学, 大学院農学生命科学研究科, 特任准教授 (10451840)
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
|
Keywords | 味覚シグナル / Skn-1マウス / 刷子細胞 / 味物質科学 / エネルギー代謝 / 食品機能 / 食と栄養 / 脳腸軸 / SKn-1マウス / 食と健康 |
Outline of Final Research Achievements |
We constructed Skn-1a knocked-out (S-KO) mice and found the absence of this transcription factor in the gut. The S-KO mice and wild type (WT) mice were similar in diet intake, but the former mice were distinctly lower than the latter mice in terms of body weight. While there was no difference in lipid absorption between S-KO and WT mice, the S-KO mice were characterized by a larger degree of obesity suppression at the age of 16 weeks. The S-KO mice were also characterized by the activation of hyperpressure and gastrocnemius mitochondrial copy number. Also, an oral glucose charge test showed that there was no blood glucose level difference between S-KO and WT mice, the former mice had a larger insulin secretion. This means that the lower body weight observed for S-KO mice is due to catecholamine-induced activation of lipolysis.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1-deficient mice.2016
Author(s)
Ushiama, S., Ishimaru, Y., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H., and Abe, K.
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Journal Title
EBioMedicine
Volume: 8
Pages: 60-71
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high-fat diet.2016
Author(s)
Kamei, A., Watanabe, Y., Shinozaki, F., Yasuoka, A., Shimada, K., Kondo, K., Ishijima, T., Toyoda, T., Arai, S., Kondo, T., and Abe, K.
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Journal Title
Mol. Nutr. Food Res.
Volume: 61
Issue: 2
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A high phosphorus diet affects lipid metabolism in rat liver: a DNA microarray analysis.2016
Author(s)
Chun, S., Bamba, T., Suyama, T., Ishijima, T., Fukusaki, E., Abe, K., and Nakai, Y.
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Journal Title
PLoS ONE
Volume: 11
Issue: 5
Pages: e0155386-e0155386
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs.2016
Author(s)
Soulika, M., Kaushik, A-L., Mathieu, B., Lourenco, R., Komisarczuk, A.Z., Romano, S.A., Jouary, A., Lardennois, A., Tissot, N., Okada, S., Abe, K., Becker, T.S., and Kapsimali, M.
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Journal Title
Development
Volume: 143
Pages: 2012-2024
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effect of proteolytic modification on texture and mastication of heat-treated egg white gels.2016
Author(s)
Funaki, J., Minami, M., Abe, S., Ueda, R., Eto, W., Kugino, K., Kugino, M., Abe, K., Toko, K., and Asakura, T.
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Journal Title
J. Food Process. Preserv.
Volume: 41
Issue: 1
Pages: e12857-e12857
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Expression of serotonin receptor genes in cranial ganglia.2016
Author(s)
Maeda, N., Ohmoto, M., Yamamoto, K., Kurokawa, A., Narukawa, M., Ishimaru, Y., Misaka, T., Matsumoto, I., Abe, K.
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Journal Title
Neurosci Lett
Volume: 617
Pages: 46-51
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Preparation of an Aroma Fraction from Dried Bonito by Steam Distillation and Its Effect on Modification of Salty and Umami Taste Qualities.2016
Author(s)
Ogasawara, Y., Mochimaru, S., Ueda, R., Ban, M., Kabuto, S., and Abe, K.
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Journal Title
J. Food Sci.
Volume: 81
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Administration of a maple syrup extract to mitigate their hepatic inflammation induced by a high-fat diet: a transcriptome analysis.2015
Author(s)
Kamei, A., Watanabe, Y., Shinozaki, F., Yasuoka, A., Kondo, T., Ishijima, T., Toyoda, T., Arai, S., and Abe, K.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 79
Issue: 11
Pages: 1893-1897
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury.2015
Author(s)
Yoshida, K., Ushida, Y., Ishijima, T., Suganuma, H., Inakuma, T., Yajima, N., Abe, K., and Nakai, Y.
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Journal Title
World J. Gastroenterol.
Volume: 21
Issue: 35
Pages: 10091-10103
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of key neoculin residues responsible for the binding and activation of the sweet taste receptor.2015
Author(s)
Koizumi, T., Terada, T., Nakajima, K., Kojima, M., Koshiba, S., Matsumura, Y., Kaneda, K., Asakura, T., Shimizu, A., Abe, K., and Misaka, T.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 12947-12947
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis.2015
Author(s)
Oba, C., Ito, K., Ichikawa, S., Morifuji, M., Nakai, Y., Ishijima, T., Abe, K., and Kawahata, K.
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Journal Title
Physiol. Genomics
Volume: 47
Issue: 8
Pages: 355-363
DOI
Related Report
Peer Reviewed
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[Journal Article] Rapid Expansion of Phenylthiocarbamide Non-Tasters among Japanese Macaques.2015
Author(s)
Suzuki-Hashido, N., Hayakawa, T., Matsui, A., Go, Y., Ishimaru, Y., Misaka, T., Abe, K., Hirai, H., Satta, Y., and Imai, H.
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Journal Title
PLoS ONE
Volume: 22
Issue: 7
Pages: e0132016-e0132016
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-Chain Fatty Acids Elicit a Bitterness-Masking Effect on Quinine and Other Nitrogenous Bitter Substances by Formation of Insoluble Binary Complexes.2015
Author(s)
Ogi, K., Yamashita, H., Terada, T., Homma, R., Shimizu-Ibuka, A., Yoshimura, E., Ishimaru, Y., Abe, K., and Asakura, T.
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Journal Title
J. Agric. Food Chem.
Volume: 63
Issue: 38
Pages: 8493-8500
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Anti-allergenic Activity of Polymethoxyflavones from Kaempferia parviflora,2015
Author(s)
Kobayashi, S., Kato, T., Azuma, T., Kikuzaki, H., Abe, K.
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Journal Title
Journal of Functional Foods
Volume: 印刷中
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages.2014
Author(s)
Yao, R., Yasuoka, A., Kamei, A., Ushiama, S., Kitagawa, Y., Rogi, T., Shibata, H., Abe, K., and Misaka, T.
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Journal Title
PLoS ONE
Volume: e87142
Issue: 2
Pages: e87142-e87142
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sequential gene expression profiling in the mouse spleen during 14 d feeding with Lactobacillus brevis KB290.2014
Author(s)
Fukui, Y., Sasaki, E., Fuke, N., Nakai, Y., Ishijima, T., Abe, K., and Yajima, N.
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Journal Title
Br. J. Nutr.
Volume: 111
Issue: 11
Pages: 1957-1966
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Administered Chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis.2014
Author(s)
Honda, S., Kawamoto, S., Tanaka, H., Kishida, H., Kitagawa, M., Nakai, Y., Abe, K., and Hirata, D.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 78
Issue: 4
Pages: 655-661
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Additional nitrogen fertilization at heading time of rice down-regulates cellulose synthesis in seed endosperm.2014
Author(s)
Midorikawa, K., Kuroda, M., Terauchi, K., Hoshi, M., Ikenaga, S., Ishimaru, Y., Abe, K., Asakura, T.
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Journal Title
PLoS One
Volume: 9
Issue: 6
Pages: e98738-e98738
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oral administration of the AYA strain of Lactobachillus plantarum modulates expression of immunity-related genes in the murine Peyer’s patch: a DNA microarray analysis.2014
Author(s)
Kikuchi, Y., Toyoda, T., Ishijima T., Abe, K., Nakai, Y., and Fukudome, S.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 78
Issue: 11
Pages: 1935-1938
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Loss of brush cells and taste cells in the gastrointestinal tract alters energy metabolism in Skn-1- deficient mice2015
Author(s)
Ishimaru, Y., Ushiama, S., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Osakabe, N., Asakura, T., Masuzaki, H., and Abe, K.
Organizer
ECRO2015 European Chemoreception Research Organization
Place of Presentation
Istanbul, Republic of Turkey
Year and Date
2015-09-01
Related Report
Int'l Joint Research
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[Presentation] DNA microarray analysis of labial salivary glands in patients with Sjögren’s syndrome: comparison with IgG4-related disease2015
Author(s)
Takahashi, H., Tsuboi, H., Nakai, Y., Iizuka, M., Asashima, H., Hirota, T., Kondo, Y., Moriyama, M., Furukawa, S., Matsumoto, I., Nakamura, S., Yoshihara, T., Abe, K., and Sumida, T.
Organizer
The 13th International Symposium on Sjögren's Syndrome (ISSS, Bergen)
Place of Presentation
Bergen, Norway
Year and Date
2015-05-19
Related Report
Int'l Joint Research
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[Presentation] DNA microarray analysis of labial salivary glands in patients with Sjogren’s syndrome: comparison with IgG4-related disease2015
Author(s)
Takahashi, H., Tsuboi, H., Nakai, Y., Iizuka, M., Asashima, H., Hirota, T., Kondo, Y., Moriyama, M., Furukawa, S., Matsumoto, I., Nakamura, S., Yoshihara, T., Abe, K., and Sumida, T.
Organizer
The 13th International Symposium on Sjogren's Syndrome (ISSS, Bergen)
Place of Presentation
Bergen, Norway
Year and Date
2015-05-19
Related Report
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