Adiponectin as a Biomarker of the Metabolic Syndrome

  • Ryo Miwa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
  • Nakamura Tadashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
  • Kihara Shinji
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
  • Kumada Masahiro
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
  • Shibazaki Satomi
    Department of Public Health, Saitama Medical School
  • Takahashi Mihoko
    Department of Public Health, Saitama Medical School
  • Nagai Masaki
    Department of Public Health, Saitama Medical School
  • Matsuzawa Yuji
    Sumitomo Hospital
  • Funahashi Tohru
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

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Abstract

Background The metabolic syndrome, a cluster of abdominal obesity, dyslipidemia, hypertension and hyperglycemia, is a common basis for atherosclerotic vascular diseases in industrial countries exposed to overnutrition. Adiponectin is an adipose-derived plasma protein with anti-atherogenic and insulin-sensitizing activities. Methods and Results A total of 661 Japanese adults (479 men, 53±10 years; 182 women 56±10 years) were enrolled. Plasma adiponectin concentrations correlated negatively with waist circumference, visceral fat area, serum triglyceride concentration, fasting plasma glucose, fasting plasma insulin, and systolic and diastolic blood pressure in both sexes. A positive correlation was found between plasma adiponectin and high-density lipoprotein cholesterol concentrations in both sexes. The mean number of components of the metabolic syndrome increased as the plasma adiponectin concentration decreased: 2.57±1.34 for men and 2.00±1.51 for women with adiponectin concentrations <4.0 μg/ml. In all, 52.3% of men and 37.5% of women with adiponectin concentrations <4.0 μg/ml fulfilled the criteria for metabolic syndrome. Conclusion Hypoadiponectinemia is closely associated with the clinical phenotype of the metabolic syndrome and measuring the plasma concentration of adiponectin may be useful for management of the metabolic syndrome. (Circ J 2004; 68: 975 - 981)<br>

Journal

  • Circulation Journal

    Circulation Journal 68 (11), 975-981, 2004

    The Japanese Circulation Society

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